Drug and metabolite concentrations in tissues in relationship to tissue adverse findings: a review

scientific article published on February 2011

Drug and metabolite concentrations in tissues in relationship to tissue adverse findings: a review is ā€¦
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1517/17425255.2011.545053
P698PubMed publication ID21241198

P2093author name stringMario Pellegatti
Sabrina Pagliarusco
P2860cites workGene expression in distinct regions of the heartQ28142086
Drug-induced phospholipidosis: issues and future directionsQ28246047
Membrane transporters in drug developmentQ29616802
Autoradiography, MALDI-MS, and SIMS-MS imaging in pharmaceutical discovery and developmentQ30890487
Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissues.Q33269196
Imaging mass spectrometry for visualization of drug and endogenous metabolite distribution: toward in situ pharmacometabolomesQ33465087
Amiodarone and its desethyl metabolite: tissue distribution and morphologic changes during long-term therapy.Q50913576
Kinetics of distribution and elimination of DDE in rats.Q52448099
Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma.Q53524045
Tissue distribution of arsenic species in rabbits after single and multiple parenteral administration of arsenic trioxide: tissue accumulation and the reversibility after washout are tissue-selectiveQ58215262
Non-invasive monitoring of intra-tumor drug concentration and therapeutic response using optical spectroscopyQ33708056
The significance of excursions above the ADI: duration in relation to pivotal studiesQ33794199
Metabolic disposition of casopitant, a potent neurokinin-1 receptor antagonist, in mice, rats, and dogs.Q34125466
Health risks and benefits of bis(4-chlorophenyl)-1,1,1-trichloroethane (DDT).Q34446186
Differential sensitivity of rat kidney and liver to fumonisin toxicity: organ-specific differences in toxin accumulation and sphingoid base metabolismQ34513658
Postmortem drug analysis: analytical and toxicological aspects.Q34565977
Comparative ototoxicity of ribostamycin, dactimicin, dibekacin, kanamycin, amikacin, tobramycin, gentamicin, sisomicin and netilmicin in the inner ear of guinea pigsQ34644823
Casopitant: a new warrior in the antiemetic crusadeQ34981239
Comparative uptake of gentamicin, netilmicin, and amikacin in the guinea pig cochlea and vestibuleQ35574233
Delivering antibacterials to the lungs: considerations for optimizing outcomes.Q35627814
Methods to assess tissue-specific distribution and metabolism of drugs.Q35971915
Drug localization and targeting with receptor microscopic autoradiographyQ35982251
Drug tissue distribution: study methods and therapeutic implicationsQ36321098
Tissue distribution and pharmacodynamics: a complicated relationshipQ36384775
Requirements for bioanalytical procedures in postmortem toxicologyQ36766468
Post-mortem clinical pharmacologyQ36922235
Amiodarone concentrations in plasma and fat tissue during chronic treatment and related toxicityQ37201673
Toxicity testing in the 21st century: bringing the vision to lifeQ37346896
Modelling and PBPK simulation in drug discoveryQ37413064
Physiologically based pharmacokinetics (PBPK).Q37550553
Tachykinin receptor antagonists in clinical trialsQ37638682
Role of reactive metabolites in drug-induced hepatotoxicityQ37658448
Approaches for minimizing metabolic activation of new drug candidates in drug discoveryQ37658491
Rate and extent of drug accumulation after multiple dosing revisited.Q37763073
Human accumulation potential of xenobiotics: potential of catamphiphilic drugs to promote their accumulation via inducing lipidosis or mucopolysaccharidosisQ37831728
Interspecies comparisons in toxicology: the utility and futility of plasma concentrations of the test substanceQ38011036
Autoradiography: high-resolution molecular imaging in pharmaceutical discovery andĀ developmentQ38088766
Imaging mass spectrometry: hype or hope?Q38451237
Binding of drugs to eye melanin is not predictive of ocular toxicityQ40826253
Progressive application of autoradiography in pharmacokinetic and metabolic studies for the development of new drugsQ40955682
Relations between toxicity and altered tissue distribution and urinary excretion of nicotine, cotinine, and hydroxycotinine after chronic oral administration of nicotine in rats.Q43122195
Phase III trial of casopitant, a novel neurokinin-1 receptor antagonist, for the prevention of nausea and vomiting in patients receiving moderately emetogenic chemotherapyQ43266783
Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes(1).Q43832307
Species specificity in the metabolism of nabilone. Relationship between toxicity and metabolic routesQ44828810
Myopathy related to administration of a cationic amphiphilic drug and the use of multidose drug distribution analysis to predict its occurrenceQ44942448
Lack of stability of topotecan in heart tissue homogenates: is it an analytical dilemma or a real phenomenon?Q46240427
Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testingQ46267572
Impact of differential recovery in bioanalysis: the example of bortezomib in whole blood.Q50705385
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)137-146
P577publication date2011-02-01
P1433published inExpert Opinion on Drug Metabolism & ToxicologyQ5421205
P1476titleDrug and metabolite concentrations in tissues in relationship to tissue adverse findings: a review
P478volume7

Reverse relations

cites work (P2860)
Q308285113D Mass Spectrometry Imaging Reveals a Very Heterogeneous Drug Distribution in Tumors
Q33553411A Nanostructured Matrices Assessment to Study Drug Distribution in Solid Tumor Tissues by Mass Spectrometry Imaging.
Q35825043An introduction to MS imaging in drug discovery and development
Q35704471Drug compound characterization by mass spectrometry imaging in cancer tissue
Q34646772Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.
Q38182903Foamy macrophage responses in the rat lung following exposure to inhaled pharmaceuticals: a simple, pragmatic approach for inhaled drug development
Q37522770Heterogeneity of paclitaxel distribution in different tumor models assessed by MALDI mass spectrometry imaging
Q39033781Imaging mass spectrometry in drug development and toxicology
Q27314740In situ mass spectrometry imaging and ex vivo characterization of renal crystalline deposits induced in multiple preclinical drug toxicology studies
Q39018486Mass spectrometry imaging: a novel technology in rheumatology
Q35936145Novel insights in drug metabolism by MS imaging
Q38123694Qualitative and quantitative mass spectrometry imaging of drugs and metabolites in tissue at therapeutic levels
Q35213962Spatial distribution of theobromine--a low MW drug--in tissues via matrix-free NALDI-MS imaging

Search more.