Androgen regulation of prostate cancer: where are we now?

scientific article published on 04 February 2011

Androgen regulation of prostate cancer: where are we now? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/BF03347072
P698PubMed publication ID21297383

P2093author name stringM Maggi
G Corona
E Baldi
P2860cites workAdverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-AnalysisQ22306210
Identification of a cell of origin for human prostate cancerQ24594400
Metabolic complications of androgen deprivation therapy for prostate cancerQ24616159
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.Q27824849
Molecular determinants of resistance to antiandrogen therapyQ28236889
Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)Q29619860
Effect of dutasteride on the risk of prostate cancerQ30010961
Androgen receptor mediates the reduced tumor growth, enhanced androgen responsiveness, and selected target gene transactivation in a human prostate cancer cell line.Q30308002
Neuroendocrine cells in prostate cancerQ30435708
Cathepsin D and chromogranin A as predictors of long term disease specific survival after radical prostatectomy for localized carcinoma of the prostateQ30471390
A systematic review and meta-analysis of bone metabolism in prostate adenocarcinomaQ33581390
Current status of 5alpha-reductase inhibitors in the management of lower urinary tract symptoms and BPH.Q33602452
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesisQ33685619
Role of androgens and the androgen receptor in epithelial-mesenchymal transition and invasion of prostate cancer cellsQ33694557
Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the Prostate-Specific Antigen Working Group.Q33767866
Complete androgen blockade for prostate cancer: what went wrong?Q33935479
EGF receptor (EGFR) signaling promoting invasion is disrupted in androgen-sensitive prostate cancer cells by an interaction between EGFR and androgen receptor (AR).Q33980606
Testosterone administration to men with testosterone deficiency syndrome after external beam radiotherapy for localized prostate cancer: preliminary observationsQ46451575
Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men.Q46570705
Cardiovascular mortality and duration of androgen deprivation for locally advanced prostate cancer: analysis of RTOG 92-02.Q46776039
Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studiesQ46784184
Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapyQ46875718
Insulin sensitivity during combined androgen blockade for prostate cancerQ46909972
Circulating steroid hormones and the risk of prostate cancerQ46910105
Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism.Q51464753
Lipoprotein profile in men with prostate cancer undergoing androgen deprivation therapy.Q51499900
Low bone density and high percentage of body fat among men who were treated with androgen deprivation therapy for prostate carcinoma.Q52548115
Independent origin of multiple foci of prostatic intraepithelial neoplasia: comparison with matched foci of prostate carcinoma.Q53429294
Her-2-neu expression and progression toward androgen independence in human prostate cancer.Q53800928
Resistance Exercise in Men Receiving Androgen Deprivation Therapy for Prostate CancerQ53932137
Androgen receptor mutations in prostate cancer.Q54060047
NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice.Q54707681
Chemoprevention of Prostate CancerQ56483585
Serum androgens and prostate cancer among 643 cases and 643 controls in the European Prospective Investigation into Cancer and NutritionQ56988228
Influence of Androgen Suppression Therapy for Prostate Cancer on the Frequency and Timing of Fatal Myocardial InfarctionsQ58229260
Androgen Receptor: Good Guy or Bad Guy in Prostate Cancer Invasion?Q63187482
Circulating testosterone, prostatic nuclear androgen receptor and time to progression in patients with metastatic disease of the prostate treated by orchiectomyQ63359315
Changes in plasma lipoproteins during various androgen suppression therapies in men with prostatic carcinoma: effects of orchiectomy, estrogen, and combination treatment with luteinizing hormone-releasing hormone agonist and flutamideQ68125383
Neuroendocrine differentiation in prostate cancer: enhanced prediction of progression after radical prostatectomyQ71235330
Prostate volume in testosterone-treated and untreated hypogonadal men in comparison to age-matched normal controlsQ71624041
Serum testosterone as a prognostic factor in patients with advanced prostatic carcinomaQ72751447
Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancerQ72989706
Testosterone replacement for hypogonadism after treatment of early prostate cancer with brachytherapyQ79446008
Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancerQ80285083
Changes in bone mineral density and body composition during initial and long-term gonadotropin-releasing hormone agonist treatment for prostate carcinomaQ81100244
Androgen deprivation therapy for localized prostate cancer and the risk of cardiovascular mortalityQ81415275
Pathology of benign prostatic hyperplasiaQ82570613
Immediate or deferred androgen deprivation for patients with prostate cancer not suitable for local treatment with curative intent: European Organisation for Research and Treatment of Cancer (EORTC) Trial 30891Q83170866
Hormonal therapy use for prostate cancer and mortality in men with coronary artery disease-induced congestive heart failure or myocardial infarctionQ84464972
TMPRSS2:ERG fusion gene and androgen-ablation therapy in prostate cancerQ84497817
Identification of late-onset hypogonadism in middle-aged and elderly men.Q34022776
A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort ConsortiumQ34113217
In vivo amplification of the androgen receptor gene and progression of human prostate cancerQ34314274
Preoperative PSA velocity and the risk of death from prostate cancer after radical prostatectomyQ34332665
Neuroendocrine differentiation in prostate cancer: implications for new treatment modalitiesQ34386388
Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysisQ34502187
The influence of finasteride on the development of prostate cancerQ34534815
Persistent intraprostatic androgen concentrations after medical castration in healthy men.Q34553305
Prostate cancer risk in testosterone-treated men.Q34582772
Androgen deprivation therapy for prostate cancer: new concepts and concernsQ34617845
Roles for the stem cell associated intermediate filament Nestin in prostate cancer migration and metastasisQ34768932
Shifting the paradigm of testosterone and prostate cancer: the saturation model and the limits of androgen-dependent growthQ34846764
Androgen deprivation therapy for the treatment of prostate cancer: consider both benefits and risksQ34960686
Testosterone as a predictor of pathological stage in clinically localized prostate cancerQ35758294
Androgen replacement after curative radical prostatectomy for prostate cancer in hypogonadal men.Q35862931
Androgen receptor cross-talk with cell signalling pathwaysQ35934837
Increasing use of gonadotropin-releasing hormone agonists for the treatment of localized prostate carcinomaQ36059488
The human PC346 xenograft and cell line panel: a model system for prostate cancer progressionQ36368670
Androgen receptor is a tumor suppressor and proliferator in prostate cancerQ36858442
Targeting the stromal androgen receptor in primary prostate tumors at earlier stagesQ36858449
Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growthQ36876865
Cancer treatment-induced bone loss: pathophysiology and clinical perspectivesQ37096405
Cardiovascular mortality after androgen deprivation therapy for locally advanced prostate cancer: RTOG 85-31.Q37103095
Androgen deprivation therapy in prostate cancer and metabolic risk for atherosclerosisQ37113079
Progression to androgen-independent LNCaP human prostate tumors: cellular and molecular alterations.Q37195196
Androgen deprivation therapy, insulin resistance, and cardiovascular mortality: an inconvenient truthQ37196025
The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunctionQ37222063
Hypogonadism, ED, metabolic syndrome and obesity: a pathological link supporting cardiovascular diseasesQ37396049
5alpha-reductase isozymes and androgen actions in the prostateQ37403620
Testosterone and prostate cancer: revisiting old paradigmsQ37450000
Chronic inflammation in the pathogenesis of benign prostatic hyperplasia.Q37512391
Targeting the PI3K/AKT pathway for the treatment of prostate cancerQ37564760
Molecular biology underlying the clinical heterogeneity of prostate cancer: an updateQ37566547
Update on chemoprevention for prostate cancer.Q37705965
Abiraterone acetate for castration resistant prostate cancerQ37708308
Endocrine aspects of male sexual dysfunctionsQ37730212
Vitamin D receptor agonists target static, dynamic, and inflammatory components of benign prostatic hyperplasiaQ37732379
Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer failsQ37741773
New agents and strategies for the hormonal treatment of castration-resistant prostate cancerQ37762808
Influence of sex hormones on cancer progressionQ37774171
Testosterone, cardiovascular disease and the metabolic syndromeQ37852330
Functional androgen receptor confers sensitization of androgen-independent prostate cancer cells to anticancer therapy via caspase activationQ38350323
Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trialQ38402163
Testosterone replacement in prostate cancer survivors with hypogonadal symptomsQ39295915
Androgen-responsive and -unresponsive prostate cancer cell lines respond differently to stimuli inducing neuroendocrine differentiationQ39749979
Evidence of limited contributions for intratumoral steroidogenesis in prostate cancerQ39750288
Prevalence of prostate cancer among hypogonadal men with prostate-specific antigen levels of 4.0 ng/mL or lessQ39778629
Hormonal predictors of prostate cancerQ39804755
Recent studies on the mechanism of action of testosteroneQ39868192
Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancerQ39954334
Altered endocytosis of epidermal growth factor receptor in androgen receptor positive prostate cancer cell linesQ40180311
The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits prostate cancer cell migration through activation of the estrogen receptor beta subtypeQ40408878
Influence of serum testosterone on urinary continence and sexual activity in patients undergoing radical prostatectomy for clinically localized prostate cancer.Q40590766
Ligand activation of the androgen receptor downregulates E-cadherin-mediated cell adhesion and promotes apoptosis of prostatic cancer cellsQ40631293
Androgen receptor expression in prostate carcinoma cells suppresses alpha6beta4 integrin-mediated invasive phenotypeQ40857949
The evolutionary impact of androgen levels on prostate cancer in a multi-scale mathematical modelQ41054535
Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step processQ41695916
Changes in body composition during androgen deprivation therapy for prostate cancerQ42166232
Androgen-induced differentiation and tumorigenicity of human prostate epithelial cellsQ42801295
Serum prostate‐specific antigen levels reflect the androgen milieu in patients with localized prostate cancer receiving androgen deprivation therapy: Tumor malignant potential and androgen milieuQ42945647
Androgen-suppression therapy for prostate cancer and the risk of death in men with a history of myocardial infarction or strokeQ43129404
The relationship of testosterone to prostate-specific antigen in men with sexual dysfunctionQ43242616
A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapyQ43627769
The effects of induced hypogonadism on arterial stiffness, body composition, and metabolic parameters in males with prostate cancerQ43732433
Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941.Q44018378
Long-term effects of androgen deprivation therapy in prostate cancer patientsQ44033179
Testosterone suppression in men with prostate cancer leads to an increase in arterial stiffness and hyperinsulinaemiaQ44290482
Pretreatment total testosterone level predicts pathological stage in patients with localized prostate cancer treated with radical prostatectomyQ44398102
Inhibition of spontaneous and androgen-induced prostate growth by a nonhypercalcemic calcitriol analogQ44480642
Androgen deprivation therapy increases cardiovascular morbidity in men with prostate cancerQ44855302
Mechanisms of androgen-refractory prostate cancerQ45094999
Testosterone replacement therapy after primary treatment for prostate cancerQ45219185
Endogenous sex hormones and metabolic syndrome in aging men.Q45248596
Pretreatment serum testosterone level as a predictive factor of pathological stage in localized prostate cancer patients treated with radical prostatectomyQ45269738
Type 2 diabetes mellitus and testosterone: a meta-analysis study.Q45921938
Short-term neoadjuvant androgen deprivation therapy and external-beam radiotherapy for locally advanced prostate cancer: long-term results of RTOG 8610.Q45956742
Testosterone replacement therapy following radical prostatectomyQ46126585
Absence of relationship between steroid hormone levels and prostate cancer tumor gradeQ46226739
Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA, and ASA recommendationsQ46388553
P433issue3
P921main subjectprostate cancerQ181257
P304page(s)232-243
P577publication date2011-02-04
P1433published inJournal of Endocrinological InvestigationQ15766847
P1476titleAndrogen regulation of prostate cancer: where are we now?
P478volume34

Reverse relations

cites work (P2860)
Q412071245α-Reductase inhibitors increase acute coronary syndrome risk in patients with benign prostate hyperplasia
Q85068495Abiraterone acetate: in metastatic castration-resistant prostate cancer
Q38738470Aging and sexual health: getting to the problem
Q39003600Androgen deprivation therapy with Leuprolide acetate for treatment of advanced prostate cancer
Q41548112Are biomarkers evaluated in biopsy specimens predictive of prostate cancer aggressiveness?
Q50662671Association between testosterone levels and the metabolic syndrome in adult men.
Q37618958Benign prostatic hyperplasia: a new metabolic disease of the aging male and its correlation with sexual dysfunctions.
Q38181426Benign prostatic hyperplasia: a new metabolic disease?
Q34449941Characterization of tumor differentiation factor (TDF) and its receptor (TDF-R).
Q33767832Curcumin Inhibits Prostate Cancer Bone Metastasis by Up-Regulating Bone Morphogenic Protein-7 in Vivo
Q44747186Ductal carcinoma of the prostate shows a different immunophenotype from high grade acinar cancer
Q38088550Effect of metabolic syndrome and its components on prostate cancer risk: meta-analysis
Q58279991Effects of long-acting testosterone undecanoate on bone mineral density in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 36 months controlled study
Q38811041Endocrine control of benign prostatic hyperplasia.
Q47174327Estrogens and Body Weight Regulation in Men.
Q38235669Injectable testosterone undecanoate for the treatment of hypogonadism
Q38692706Lower urinary tract symptoms, benign prostatic hyperplasia and metabolic syndrome
Q39192939MicroRNA-185 suppresses proliferation, invasion, migration, and tumorigenicity of human prostate cancer cells through targeting androgen receptor
Q26864777Outcomes of androgen replacement therapy in adult male hypogonadism: recommendations from the Italian society of endocrinology
Q39870160Predictors and clinical consequences of starting androgen therapy in men with low testosterone: results from the SIAMO-NOI registry
Q37686901Quality of Life and Sexual Health in the Aging of PCa Survivors
Q36287950Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men.
Q57582323Risk and Benefit of Androgen Deprivation Therapy in Prostate Cancer
Q37165019Risks and benefits of late onset hypogonadism treatment: an expert opinion
Q28554489Sexual Dysfunction in Type 2 Diabetes at Diagnosis: Progression over Time and Drug and Non-Drug Correlated Factors
Q58590625Sexual desire of French representative prostate cancer survivors 2 years after diagnosis (the VICAN survey)
Q38814349Sexual dysfunction in subjects treated with inhibitors of 5α-reductase for benign prostatic hyperplasia: a comprehensive review and meta-analysis
Q39302080Testosterone Replacement Therapy: Long-Term Safety and Efficacy
Q34332054Testosterone and cardiovascular risk
Q38848541Testosterone supplementation and body composition: results from a meta-analysis of observational studies.
Q50046284The safety of available treatments of male hypogonadism in organic and functional hypogonadism.
Q37148238The significance of galectin-3 as a new basal cell marker in prostate cancer
Q57278844Therapeutic implications of autophagy modulation in prostate cancer
Q37137452Type I Collagen Synthesis Marker Procollagen I N-Terminal Peptide (PINP) in Prostate Cancer Patients Undergoing Intermittent Androgen Suppression

Search more.