Laquinimod: a promising oral medication for the treatment of relapsing-remitting multiple sclerosis

scientific article published on 10 February 2011

Laquinimod: a promising oral medication for the treatment of relapsing-remitting multiple sclerosis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1517/17425255.2011.556618
P698PubMed publication ID21306281

P50authorRalf GoldQ99630149
P2093author name stringJan Thöne
P2860cites workLaquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis ratsQ45090895
Cytochrome P450 3A4 is the major enzyme responsible for the metabolism of laquinimod, a novel immunomodulatorQ46375399
Multiple sclerosisQ28299151
Oral laquinimod therapy in relapsing multiple sclerosisQ33467515
Treatment with laquinimod reduces development of active MRI lesions in relapsing MS.Q34405210
Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study.Q34788240
From genes to function: the next challenge to understanding multiple sclerosisQ37483492
New drug therapies for multiple sclerosis.Q37736234
Oral laquinimod in patients with relapsing-remitting multiple sclerosis: 36-week double-blind active extension of the multi-centre, randomized, double-blind, parallel-group placebo-controlled studyQ42909983
Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitisQ42946709
Laquinimod suppress antigen presentation in relapsing-remitting multiple sclerosis: in-vitro high-throughput gene expression studyQ43116803
Suppression of experimental autoimmune neuritis by ABR-215062 is associated with altered Th1/Th2 balance and inhibited migration of inflammatory cells into the peripheral nerve tissueQ43977414
The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitisQ44133715
Synthesis and biological evaluation of new 1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationshipQ44823676
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectmultiple sclerosisQ8277
relapsing-remitting multiple sclerosisQ18555066
P304page(s)365-370
P577publication date2011-02-10
P1433published inExpert Opinion on Drug Metabolism & ToxicologyQ5421205
P1476titleLaquinimod: a promising oral medication for the treatment of relapsing-remitting multiple sclerosis
P478volume7