Metabolism of ophthalmic timolol: new aspects of an old drug

scientific article published on May 2011

Metabolism of ophthalmic timolol: new aspects of an old drug is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/J.1742-7843.2011.00694.X
P698PubMed publication ID21385322
P5875ResearchGate publication ID50347478

P50authorOlavi PelkonenQ28028673
P2093author name stringJukka Hakkola
Heikki Vapaatalo
Jukka Mäenpää
Marjo Volotinen
P2860cites workSequence analysis and homology modeling suggest that primary congenital glaucoma on 2p21 results from mutations disrupting either the hinge region or the conserved core structures of cytochrome P4501B1.Q24538817
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Ocular beta-blockers in glaucoma management. Clinical pharmacological aspectsQ35257739
Ophthalmic drug delivery considerations at the cellular level: drug-metabolising enzymes and transportersQ36316835
Glaucoma screening: current trends, economic issues, technology, and challengesQ36427904
Ophthalmic timolol: plasma concentration and systemic cardiopulmonary effects.Q36762112
Role of CYP1B1 in glaucomaQ36960115
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Expression of cytochrome P450 (CYP) enzymes in human nonpigmented ciliary epithelial cells: induction of CYP1B1 expression by TCDD.Q39867733
Pharmacokinetics of topically applied ophthalmic drugsQ40328899
The mechanism of timolol in lowering intraocular pressure. In the normal eye.Q40963886
Recent advances in molecular genetics of glaucomasQ41595926
Transport of timolol and tilisolol in rabbit corneal epitheliumQ42502203
Association of CYP2D6 single-nucleotide polymorphism with response to ophthalmic timolol in primary open-angle Glaucoma--a pilot study.Q42868524
Effects of selective serotonin reuptake inhibitors on timolol metabolism in human liver microsomes and cryo-preserved hepatocytesQ43242688
Drug transporter and cytochrome P450 mRNA expression in human ocular barriers: implications for ocular drug dispositionQ43452684
Rate of response to latanoprost or timolol in patients with ocular hypertension or glaucomaQ44674915
Cytochrome oxidase 2D6 gene polymorphism in primary open-angle glaucoma with various effects to ophthalmic timololQ46089600
Pharmacokinetic interactions of timolol with vasodilating drugs, food and phenobarbitone in healthy human volunteers.Q51648124
Association between low plasma levels of ophthalmic timolol and haemodynamics in glaucoma patients.Q53855923
Prevalence of open-angle glaucoma in central Sweden. The Tierp Glaucoma Survey.Q53989484
Timolol Metabolism in Human Liver Microsomes Is Mediated Principally by CYP2D6Q58734950
P433issue5
P304page(s)297-303
P577publication date2011-05-01
P1433published inBasic and Clinical Pharmacology and ToxicologyQ15724438
P1476titleMetabolism of ophthalmic timolol: new aspects of an old drug
P478volume108