Functional domains and motifs of bacterial type III effector proteins and their roles in infection

scientific article published on 18 May 2011

Functional domains and motifs of bacterial type III effector proteins and their roles in infection is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1574-6976.2011.00271.X
P698PubMed publication ID21517912
P5875ResearchGate publication ID51074897

P50authorPaul DeanQ57269178
P2860cites workCapping of actin filaments by vinculin activated by the Shigella IpaA carboxyl-terminal domainQ24296359
Structural mimicry for vinculin activation by IpaA, a virulence factor of Shigella flexneriQ24296380
Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assemblyQ24307857
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligaseQ24313174
Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formationQ24315675
Shigella flexneri type III secretion system effectors OspB and OspF target the nucleus to downregulate the host inflammatory response via interactions with retinoblastoma proteinQ24315859
AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signalingQ24318895
A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cyclingQ24338298
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphologyQ24534908
Not all J domains are created equal: implications for the specificity of Hsp40-Hsp70 interactionsQ24644464
Structure and distribution of pentapeptide repeats in bacteriaQ24673061
An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their disseminationQ24678382
The Salmonella SPI2 effector SseI mediates long-term systemic infection by modulating host cell migrationQ27316052
Sequence-based prediction of type III secreted proteinsQ27317165
How the Pseudomonas aeruginosa ExoS toxin downregulates RacQ27629091
Crystal structure of the Yersinia pestis GTPase activator YopEQ27637326
Shigella protein IpaH(9.8) is secreted from bacteria within mammalian cells and transported to the nucleusQ46202980
The amino-terminal non-catalytic region of Salmonella typhimurium SigD affects actin organization in yeast and mammalian cellsQ46694995
Host-mediated phosphorylation of type III effector AvrPto promotes Pseudomonas virulence and avirulence in tomato.Q46884639
A type III secretion system in Vibrio cholerae translocates a formin/spire hybrid-like actin nucleator to promote intestinal colonization.Q46898413
Effector proteins encoded by Salmonella pathogenicity island 2 interfere with the microtubule cytoskeleton after translocation into host cellsQ47757738
AvrXa10 contains an acidic transcriptional activation domain in the functionally conserved C terminusQ47796484
Biophysical characterization of the catalytic domain of guanine nucleotide exchange factor BopE from Burkholderia pseudomallei.Q47824038
Two novel proteins, PopB, which has functional nuclear localization signals, and PopC, which has a large leucine-rich repeat domain, are secreted through the hrp-secretion apparatus of Ralstonia solanacearumQ47863693
GTPase-activating proteins and their complexes.Q47959655
Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cellsQ48042079
Type III secretion effectors of the IpaH family are E3 ubiquitin ligases.Q50066742
Analysis of functional domains present in the N-terminus of the SipB protein.Q50068971
Salmonella type III effectors PipB and PipB2 are targeted to detergent-resistant microdomains on internal host cell membranes.Q50103373
Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella.Q50107182
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.Q50124353
Role of the S. typhimurium actin-binding protein SipA in bacterial internalization.Q50127062
IpaA targets beta1 integrins and rho to promote actin cytoskeleton rearrangements necessary for Shigella entry.Q50710653
Dimerization of the bacterial effector protein AvrBs3 in the plant cell cytoplasm prior to nuclear import.Q50772960
Common features of the NAD-binding and catalytic site of ADP-ribosylating toxins.Q52540113
The pseudomonas AvrPto protein is differentially recognized by tomato and tobacco and is localized to the plant plasma membrane.Q52541964
Co-ordinate regulation of distinct host cell signalling pathways by multifunctional enteropathogenic Escherichia coli effector molecules.Q52546261
The Pseudomonas syringae pv. tomato DC3000 type III effector HopF2 has a putative myristoylation site required for its avirulence and virulence functions.Q52569219
Eukaryotic localization, activation and ubiquitinylation of a bacterial type III secreted toxin.Q53607803
Targeting of an enteropathogenic Escherichia coli (EPEC) effector protein to host mitochondria.Q53898008
Type III-dependent translocation of the Xanthomonas AvrBs3 protein into the plant cell.Q53956677
A carboxy-terminal domain of Tir from enterohemorrhagic Escherichia coli O157:H7 (EHEC O157:H7) required for efficient type III secretion.Q54492076
Intracellular localization and processing of Pseudomonas aeruginosa ExoS in eukaryotic cells.Q54569560
Eukaryotic Fatty Acylation Drives Plasma Membrane Targeting and Enhances Function of Several Type III Effector Proteins from Pseudomonas syringaeQ57266282
A type III effector ADP-ribosylates RNA-binding proteins and quells plant immunityQ59049221
AeromonasExoenzyme T ofAeromonas salmonicidaIs a Bifunctional Protein That Targets the Host CytoskeletonQ59271393
The Salmonella effector protein PipB2 is a linker for kinesin-1Q35037325
Dissecting the catalytic mechanism of protein-tyrosine phosphatasesQ35063279
OspF and OspC1 are Shigella flexneri type III secretion system effectors that are required for postinvasion aspects of virulenceQ35073836
A Salmonella enterica serovar typhimurium translocated leucine-rich repeat effector protein inhibits NF-kappa B-dependent gene expression.Q35106240
The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU.Q35107685
Chlamydial TARP is a bacterial nucleator of actinQ35108349
Salmonella maintains the integrity of its intracellular vacuole through the action of SifA.Q35114802
Physical interaction between RRS1-R, a protein conferring resistance to bacterial wilt, and PopP2, a type III effector targeted to the plant nucleusQ35147632
A distinctive role for the Yersinia protein kinase: actin binding, kinase activation, and cytoskeleton disruption.Q35206375
SseL, a Salmonella deubiquitinase required for macrophage killing and virulence.Q35645616
Getting into position: the catalytic mechanisms of protein ubiquitylationQ35681247
Myristoylation of viral and bacterial proteinsQ35722249
The adenylate cyclase toxinsQ35921318
Process of protein transport by the type III secretion systemQ35980175
AvrPtoB: a bacterial type III effector that both elicits and suppresses programmed cell death associated with plant immunityQ36083138
The eukaryotic host factor that activates exoenzyme S of Pseudomonas aeruginosa is a member of the 14-3-3 protein familyQ36167740
Substrate recognition of type III secretion machines--testing the RNA signal hypothesis.Q36228152
Tyrosine-phosphorylated bacterial effector proteins: the enemies withinQ36229117
Type III secretion: more systems than you thinkQ36262580
A Salmonella protein causes macrophage cell death by inducing autophagyQ36324680
Cytoskeletal rearrangements and the functional role of T-plastin during entry of Shigella flexneri into HeLa cellsQ36382504
Dynamic nuclear pore complexes: life on the edge.Q36508009
Reciprocal secretion of proteins by the bacterial type III machines of plant and animal pathogens suggests universal recognition of mRNA targeting signalsQ36559367
Catching a GEF by its tailQ36663439
ExoY, an adenylate cyclase secreted by the Pseudomonas aeruginosa type III systemQ36809802
Type III secretion systems and diseaseQ36969851
Metropolitan microbes: type III secretion in multihost symbiontsQ37001780
A family of bacterial cysteine protease type III effectors utilizes acylation-dependent and -independent strategies to localize to plasma membranes.Q37257375
Common themes in the design and function of bacterial effectorsQ37312444
Multiple activities of the plant pathogen type III effector proteins WtsE and AvrE require WxxxE motifsQ37356201
Pseudomonas syringae type III secretion system effectors: repertoires in search of functionsQ37377069
Ubiquitination of the bacterial inositol phosphatase, SopB, regulates its biological activity at the plasma membrane.Q37387728
Pathogen trafficking pathways and host phosphoinositide metabolism.Q37390009
Actin filament nucleation and elongation factors--structure-function relationshipsQ37455891
The crystal structure of Pseudomonas avirulence protein AvrPphB: A papain-like fold with a distinct substrate-binding siteQ27642849
Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyaseQ27649217
Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligaseQ27649240
Structural and Functional Studies Indicate That Shigella VirA Is Not a Protease and Does Not Directly Destabilize Microtubules ‡Q27651916
Novel fold of VirA, a type III secretion system effector protein fromShigella flexneriQ27652112
Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulationQ27652828
Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligasesQ27652850
Structure of a Shigella effector reveals a new class of ubiquitin ligasesQ27652851
Structural insights into host GTPase isoform selection by a family of bacterial GEF mimicsQ27656575
Computational prediction of type III and IV secreted effectors in gram-negative bacteriaQ27692827
Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstateQ27730850
The protein kinase family: conserved features and deduced phylogeny of the catalytic domainsQ27860528
Mechanisms underlying ubiquitinationQ27860656
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-boxQ27936367
PDZ domains: structural modules for protein complex assemblyQ28210680
The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesionsQ28239729
A simple cipher governs DNA recognition by TAL effectorsQ28265506
Breaking the code of DNA binding specificity of TAL-type III effectorsQ28265515
A secreted protein kinase of Yersinia pseudotuberculosis is an indispensable virulence determinantQ28266681
The Yersinia YpkA Ser/Thr kinase is translocated and subsequently targeted to the inner surface of the HeLa cell plasma membraneQ28286030
GDSL family of serine esterases/lipasesQ28291336
GEFs and GAPs: critical elements in the control of small G proteinsQ28304540
SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphataseQ28369269
The enteropathogenic E. coli effector EspF targets and disrupts the nucleolus by a process regulated by mitochondrial dysfunctionQ28474712
The inflammation-associated Salmonella SopA is a HECT-like E3 ubiquitin ligaseQ28490017
SopD2 is a novel type III secreted effector of Salmonella typhimurium that targets late endocytic compartments upon delivery into host cellsQ28490058
Involvement of targeted proteolysis in plant genetic transformation by AgrobacteriumQ28492363
The type III effector HopF2Pto targets Arabidopsis RIN4 protein to promote Pseudomonas syringae virulenceQ28492430
A J domain virulence effector of Pseudomonas syringae remodels host chloroplasts and suppresses defensesQ28492431
SteC is a Salmonella kinase required for SPI-2-dependent F-actin remodellingQ28563583
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factorsQ29547630
Protein import into mitochondriaQ29620420
A bacterial effector acts as a plant transcription factor and induces a cell size regulatorQ30319733
New type III effectors from Xanthomonas campestris pv. vesicatoria trigger plant reactions dependent on a conserved N-myristoylation motifQ30319751
Temporal regulation of salmonella virulence effector function by proteasome-dependent protein degradationQ44668051
The J-domain family and the recruitment of chaperone powerQ45068628
Targeting of enteropathogenic Escherichia coli EspF to host mitochondria is essential for bacterial pathogenesis: critical role of the 16th leucine residue in EspF.Q45144471
Activation of a phytopathogenic bacterial effector protein by a eukaryotic cyclophilinQ45299707
Binding to Na(+) /H(+) exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH.Q34462401
A bacterial inhibitor of host programmed cell death defenses is an E3 ubiquitin ligaseQ34479090
Type III effector AvrPtoB requires intrinsic E3 ubiquitin ligase activity to suppress plant cell death and immunity.Q34479457
Biochemical analysis of SopE from Salmonella typhimurium, a highly efficient guanosine nucleotide exchange factor for RhoGTPasesQ34505359
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylationQ34530978
Amino acids of the bacterial toxin SopE involved in G nucleotide exchange on Cdc42.Q34533184
Yersinia virulence depends on mimicry of host Rho-family nucleotide dissociation inhibitors.Q34564396
Ralstonia solanacearum requires F-box-like domain-containing type III effectors to promote disease on several host plantsQ34566984
Trafficking and signaling by fatty-acylated and prenylated proteinsQ34575170
Yersinia effectors target mammalian signalling pathwaysQ34600556
Diverse evolutionary mechanisms shape the type III effector virulence factor repertoire in the plant pathogen Pseudomonas syringaeQ34645388
The discovery of SycO highlights a new function for type III secretion effector chaperones.Q34767708
Translocated effectors of YersiniaQ34934549
Dynamics of the WPD loop of the Yersinia protein tyrosine phosphataseQ35023836
Arp2/3-independent assembly of actin by Vibrio type III effector VopL.Q30365230
The Salmonella effector PipB2 affects late endosome/lysosome distribution to mediate Sif extensionQ30476107
The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways.Q30480560
The C terminus of YopT is crucial for activity and the N terminus is crucial for substrate bindingQ30813319
A C-terminal class I PDZ binding motif of EspI/NleA modulates the virulence of attaching and effacing Escherichia coli and Citrobacter rodentiumQ30835474
Pseudomonas aeruginosa ExoT ADP-ribosylates CT10 regulator of kinase (Crk) proteinsQ31146461
Identification of residues in the N-terminal domain of the Yersinia tyrosine phosphatase that are critical for substrate recognitionQ31538666
Actin is ADP-ribosylated by the Salmonella enterica virulence-associated protein SpvB.Q31906961
S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells.Q32060838
Delineation and characterization of the actin nucleation and effector translocation activities of Salmonella SipC.Q33212064
Membrane release and destabilization of Arabidopsis RIN4 following cleavage by Pseudomonas syringae AvrRpt2.Q33233873
Terminal reassortment drives the quantum evolution of type III effectors in bacterial pathogensQ33260347
Exploitation of eukaryotic ubiquitin signaling pathways by effectors translocated by bacterial type III and type IV secretion systemsQ33270514
A nonphosphorylated 14-3-3 binding motif on exoenzyme S that is functional in vivoQ33292512
Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cellsQ33292526
Fido, a novel AMPylation domain common to fic, doc, and AvrB.Q33463423
Functional regions of the Pseudomonas aeruginosa cytotoxin ExoUQ33558698
Bordetella evades the host immune system by inducing IL-10 through a type III effector, BopNQ33590435
The Pseudomonas syringae type III effector HopG1 targets mitochondria, alters plant development and suppresses plant innate immunity.Q33651072
The Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activationQ33772090
Molecular characterization of proteolytic cleavage sites of the Pseudomonas syringae effector AvrRpt2.Q33830678
Salmonella pathogenesis and processing of secreted effectors by caspase-3Q33859408
The C-terminal tail of Yersinia pseudotuberculosis YopM is critical for interacting with RSK1 and for virulenceQ33877120
GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structureQ33904931
The Salmonella SPI-2 effector SseJ exhibits eukaryotic activator-dependent phospholipase A and glycerophospholipid : cholesterol acyltransferase activityQ33913059
SseJ deacylase activity by Salmonella enterica serovar Typhimurium promotes virulence in miceQ34033443
Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophilaQ34044433
Delineation of regions of the Yersinia YopM protein required for interaction with the RSK1 and PRK2 host kinases and their requirement for interleukin-10 production and virulenceQ34045022
The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymesQ34048081
Pseudomonas syringae hijacks plant stress chaperone machinery for virulence.Q34059507
EseG, an effector of the type III secretion system of Edwardsiella tarda, triggers microtubule destabilization.Q34309741
Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPasesQ34328046
Enteropathogenic Escherichia coli EspF is targeted to mitochondria and is required to initiate the mitochondrial death pathwayQ34356501
Relative contributions of Pseudomonas aeruginosa ExoU, ExoS, and ExoT to virulence in the lungQ37624028
The EspF effector, a bacterial pathogen's Swiss army knifeQ37777278
Activation of Akt/protein kinase B in epithelial cells by the Salmonella typhimurium effector sigD.Q38308519
Shigella deliver an effector protein to trigger host microtubule destabilization, which promotes Rac1 activity and efficient bacterial internalizationQ39647502
Analyses of the evolutionary distribution of Salmonella translocated effectorsQ39654360
The bacterial virulence factor NleA is required for the disruption of intestinal tight junctions by enteropathogenic Escherichia coli.Q39807355
SseG, a virulence protein that targets Salmonella to the Golgi networkQ39927890
Enteropathogenic Escherichia coli activates the RhoA signaling pathway via the stimulation of GEF-H1.Q39996509
Identification of a molecular target for the Yersinia protein kinase A.Q40127331
The phosphothreonine lyase activity of a bacterial type III effector familyQ40170436
Yersinia protein kinase YopO is activated by a novel G-actin binding processQ40205460
Mutational analysis of Salmonella translocated effector members SifA and SopD2 reveals domains implicated in translocation, subcellular localization and functionQ40253886
The proteasome pathway destabilizes Yersinia outer protein E and represses its antihost cell activitiesQ40284396
Identification of a bacterial type III effector family with G protein mimicry functions.Q40329601
A Salmonella typhimurium effector protein SifA is modified by host cell prenylation and S-acylation machinery.Q40458340
TccP is an enterohaemorrhagic Escherichia coli O157:H7 type III effector protein that couples Tir to the actin-cytoskeletonQ40495870
Inhibition of MAPK signaling pathways by VopA from Vibrio parahaemolyticusQ40508871
Identification of a nuclear targeting signal in YopM from Yersinia spp.Q40573814
The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities.Q40582422
EspM2 is a RhoA guanine nucleotide exchange factorQ40593889
Characterization of YopT effects on Rho GTPases in Yersinia enterocolitica-infected cells.Q40641826
Potential role of the EPEC translocated intimin receptor (Tir) in host apoptotic eventsQ40645212
Salmonella typhimurium SifA effector protein requires its membrane-anchoring C-terminal hexapeptide for its biological functionQ40672000
Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway.Q40705607
The secreted effector protein of Salmonella dublin, SopA, is translocated into eukaryotic cells and influences the induction of enteritisQ40826505
Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease.Q40840610
A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimuriumQ41178388
Identification of a Salmonella virulence gene required for formation of filamentous structures containing lysosomal membrane glycoproteins within epithelial cellsQ41207631
The Ser/Thr kinase activity of the Yersinia protein kinase A (YpkA) is necessary for full virulence in the mouse, mollifying phagocytes, and disrupting the eukaryotic cytoskeletonQ41454206
Proteomic and functional analysis of the suite of Ysp proteins exported by the Ysa type III secretion system of Yersinia enterocolitica Biovar 1B.Q41455571
Two substrate-targeting sites in the Yersinia protein tyrosine phosphatase co-operate to promote bacterial virulenceQ41459412
Site-specific antiphagocytic function of the Photorhabdus luminescens type III secretion system during insect colonizationQ41459779
Intracellular membrane localization of pseudomonas ExoS and Yersinia YopE in mammalian cellsQ41465027
A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis.Q41471661
Yersinia YopE is targeted for type III secretion by N-terminal, not mRNA, signalsQ41477291
The Yersinia Ser/Thr protein kinase YpkA/YopO directly interacts with the small GTPases RhoA and Rac-1.Q41478052
The Yersinia protein kinase A is a host factor inducible RhoA/Rac-binding virulence factorQ41478563
The RhoGAP activity of the Yersinia pseudotuberculosis cytotoxin YopE is required for antiphagocytic function and virulenceQ41478657
Salmonella typhimurium leucine-rich repeat proteins are targeted to the SPI1 and SPI2 type III secretion systemsQ41481295
Targeting of the Yersinia pestis YopM protein into HeLa cells and intracellular trafficking to the nucleusQ41483776
Exoenzyme S shows selective ADP-ribosylation and GTPase-activating protein (GAP) activities towards small GTPases in vivoQ41769175
Binding of the Shigella protein IpaA to vinculin induces F-actin depolymerization.Q41810065
The HopZ family of Pseudomonas syringae type III effectors require myristoylation for virulence and avirulence functions in Arabidopsis thalianaQ41858898
The bacterial effectors EspG and EspG2 induce a destructive calpain activity that is kept in check by the co-delivered Tir effectorQ41971348
A C-terminal domain targets the Pseudomonas aeruginosa cytotoxin ExoU to the plasma membrane of host cellsQ42581042
Modulation of bacterial entry into epithelial cells by association between vinculin and the Shigella IpaA invasin.Q42618086
Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7.Q42620637
Direct nucleation and bundling of actin by the SipC protein of invasive SalmonellaQ42680869
The Salmonella translocated effector SopA is targeted to the mitochondria of infected cellsQ42754908
A bacterial E3 ubiquitin ligase targets a host protein kinase to disrupt plant immunityQ43072304
The Salmonella effector SptP dephosphorylates host AAA+ ATPase VCP to promote development of its intracellular replicative nicheQ43074065
The Salmonella spvB virulence gene encodes an enzyme that ADP-ribosylates actin and destabilizes the cytoskeleton of eukaryotic cellsQ43548955
A synaptojanin-homologous region of Salmonella typhimurium SigD is essential for inositol phosphatase activity and Akt activationQ43580834
The Pseudomonas syringae type III effector tyrosine phosphatase HopAO1 suppresses innate immunity in Arabidopsis thaliana.Q43801273
Auto-ADP-ribosylation of Pseudomonas aeruginosa ExoS.Q43872729
Complementary activities of SseJ and SifA regulate dynamics of the Salmonella typhimurium vacuolar membraneQ43982253
SifA, a type III secreted effector of Salmonella typhimurium, directs Salmonella-induced filament (Sif) formation along microtubules.Q43993314
Salmonella enterica serovar Typhimurium effector SigD/SopB is membrane-associated and ubiquitinated inside host cellsQ44053307
The Pseudomonas syringae type III-secreted protein HopPtoD2 possesses protein tyrosine phosphatase activity and suppresses programmed cell death in plantsQ44492738
In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitorsQ44547313
Genetic and molecular evidence that the Pseudomonas syringae type III effector protein AvrRpt2 is a cysteine proteaseQ44570299
Xanthomonas type III effector XopD targets SUMO-conjugated proteins in planta.Q44655603
P433issue6
P304page(s)1100-1125
P577publication date2011-05-18
P1433published inFEMS Microbiology ReviewsQ15762226
P1476titleFunctional domains and motifs of bacterial type III effector proteins and their roles in infection
P478volume35

Reverse relations

cites work (P2860)
Q38164827'Drugs from bugs': bacterial effector proteins as promising biological (immune-) therapeutics
Q288225723'-NADP and 3'-NAADP - Two Metabolites Formed by the Bacterial Type III Effector AvrRxo1
Q34782161A Ralstonia solanacearum type III effector directs the production of the plant signal metabolite trehalose-6-phosphate
Q30313747A TAL-Based Reporter Assay for Monitoring Type III-Dependent Protein Translocation in Xanthomonas
Q33894883A Transcription Activator-Like Effector Tal7 of Xanthomonas oryzae pv. oryzicola Activates Rice Gene Os09g29100 to Suppress Rice Immunity
Q37013790A Vibrio parahaemolyticus T3SS effector mediates pathogenesis by independently enabling intestinal colonization and inhibiting TAK1 activation
Q41847635A bacterial encoded protein induces extreme multinucleation and cell-cell internalization in intestinal cells
Q41791830A bacterial tyrosine phosphatase inhibits plant pattern recognition receptor activation
Q41381322A novel type 3 secretion system effector, YspI of Yersinia enterocolitica, induces cell paralysis by reducing total focal adhesion kinase
Q46272948A proteome view of structural, functional, and taxonomic characteristics of major protein domain clusters
Q34081736A simple yeast-based strategy to identify host cellular processes targeted by bacterial effector proteins
Q28538799A substrate-fusion protein is trapped inside the Type III Secretion System channel in Shigella flexneri
Q40080289A systematic analysis of the RNA-targeting potential of secreted bacterial effector proteins
Q38151981Aeromonas salmonicida subsp. salmonicida in the light of its type-three secretion system
Q104581364All Roads Lead to Susceptibility: The Many Modes of Action of Fungal and Oomycete Intracellular Effectors
Q35152952Amoebal endosymbiont Neochlamydia genome sequence illuminates the bacterial role in the defense of the host amoebae against Legionella pneumophila
Q41362622Analysis of Type III Secretion System Secreted Proteins
Q34447679Antibiotic adjuvants: diverse strategies for controlling drug-resistant pathogens.
Q38366322Approaches targeting the type III secretion system to treat or prevent bacterial infections
Q35668738Asian Citrus Psyllid Expression Profiles Suggest Candidatus Liberibacter Asiaticus-Mediated Alteration of Adult Nutrition and Metabolism, and of Nymphal Development and Immunity
Q46854918AvrXa7-Xa7 mediated defense in rice can be suppressed by transcriptional activator-like effectors TAL6 and TAL11a from Xanthomonas oryzae pv. oryzicola
Q35789603BEAN 2.0: an integrated web resource for the identification and functional analysis of type III secreted effectors
Q27026776Bacterial pathogens commandeer Rab GTPases to establish intracellular niches
Q34639643Bacterial secreted effectors and caspase-3 interactions
Q28068755Behind the lines-actions of bacterial type III effector proteins in plant cells
Q28535610BtcA, A class IA type III chaperone, interacts with the BteA N-terminal domain through a globular/non-globular mechanism
Q50114639CLIQ-BID: A method to quantify bacteria-induced damage to eukaryotic cells by automated live-imaging of bright nuclei.
Q40601360CRISPR/Cas9 Screens Reveal Requirements for Host Cell Sulfation and Fucosylation in Bacterial Type III Secretion System-Mediated Cytotoxicity
Q28485367Characterization of the N-terminal domain of BteA: a Bordetella type III secreted cytotoxic effector
Q44080780Characterization of the SPI-1 and Rsp type three secretion systems in Pseudomonas fluorescens F113.
Q46342451Comparative and bioinformatics analyses of pathogenic bacterial secretomes identified by mass spectrometry in Burkholderia species.
Q34751198Comparative genomics of Salmonella enterica serovars Derby and Mbandaka, two prevalent serovars associated with different livestock species in the UK
Q38023077Computational analysis of interactomes: current and future perspectives for bioinformatics approaches to model the host-pathogen interaction space.
Q36228807Computational approach to predict species-specific type III secretion system (T3SS) effectors using single and multiple genomes
Q27681220Crystal structure of the Yersinia enterocolitica type III secretion chaperone SycD in complex with a peptide of the minor translocator YopD
Q37150632Detecting N-myristoylation and S-acylation of host and pathogen proteins in plants using click chemistry
Q64903496Edwardsiella piscicida Type III Secretion System Effector EseK Inhibits Mitogen-Activated Protein Kinase Phosphorylation and Promotes Bacterial Colonization in Zebrafish Larvae.
Q92248420Edwardsiella piscicida: A versatile emerging pathogen of fish
Q35082975Effective identification of Gram-negative bacterial type III secreted effectors using position-specific residue conservation profiles
Q30356927Effector proteins support the asymmetric apportioning of Salmonella during cytokinesis.
Q37167670Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides
Q35091765Electroporation of functional bacterial effectors into mammalian cells
Q47126937Engineered Salmonella enterica serovar Typhimurium overcomes limitations of anti-bacterial immunity in bacteria-mediated tumor therapy
Q90424649EspH Suppresses Erk by Spatial Segregation from CD81 Tetraspanin Microdomains
Q34073801Expression of the bacterial type III effector DspA/E in Saccharomyces cerevisiae down-regulates the sphingolipid biosynthetic pathway leading to growth arrest.
Q34395262Five mechanisms of manipulation by bacterial effectors: a ubiquitous theme
Q39235366Functional Characterization of EscK (Orf4), a Sorting Platform Component of the Enteropathogenic Escherichia coli Injectisome
Q38633520Gene and transcript abundances of bacterial type III secretion systems from the rumen microbiome are correlated with methane yield in sheep
Q40988760Genome Sequence of Xanthomonas arboricola pv. Corylina, Isolated from Turkish Filbert in Colorado
Q47236641Genomic features of bacterial adaptation to plants.
Q37337255Genus-optimized strategy for the identification of chlamydial type III secretion substrates
Q26853211Greasy tactics in the plant-pathogen molecular arms race
Q36094297High-throughput genomic sequencing of cassava bacterial blight strains identifies conserved effectors to target for durable resistance
Q44862586Host-induced gene silencing: a tool for understanding fungal host interaction and for developing novel disease control strategies.
Q37527203How Bacteria Subvert Animal Cell Structure and Function
Q39682266Identification and Characterization of Putative Translocated Effector Proteins of the Edwardsiella ictaluri Type III Secretion System
Q92515642Identification and characterization of putative Aeromonas spp. T3SS effectors
Q35815841Identification of Critical Amino Acids Conferring Lethality in VopK, a Type III Effector Protein of Vibrio cholerae: Lessons from Yeast Model System
Q37349637Identification of Novel Host Interactors of Effectors Secreted by Salmonella and Citrobacter.
Q36281571Identification of effector-like proteins in Trichoderma spp. and role of a hydrophobin in the plant-fungus interaction and mycoparasitism
Q33653604Identification of microsporidia host-exposed proteins reveals a repertoire of rapidly evolving proteins
Q41143271Identification of novel Xanthomonas euvesicatoria type III effector proteins by a machine-learning approach
Q37168437Identification of the major ubiquitin-binding domain of the Pseudomonas aeruginosa ExoU A2 phospholipase
Q39180064Immunomodulatory Yersinia outer proteins (Yops)-useful tools for bacteria and humans alike
Q58692386Impact of Salmonella enterica Type III Secretion System Effectors on the Eukaryotic Host Cell
Q40509277Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis
Q35148051Interaction between the type III effector VopO and GEF-H1 activates the RhoA-ROCK pathway
Q35842267Interaction of Arabidopsis Trihelix-Domain Transcription Factors VFP3 and VFP5 with Agrobacterium Virulence Protein VirF.
Q55644920Intracellular Bacterial Infections: A Challenge for Developing Cellular Mediated Immunity Vaccines for Farmed Fish.
Q42618338Intrinsic disorder in pathogen effectors: protein flexibility as an evolutionary hallmark in a molecular arms race.
Q40454924Introduction to Type III Secretion Systems.
Q99604969Keeping in Touch with Type-III Secretion System Effectors: Mass Spectrometry-Based Proteomics to Study Effector-Host Protein-Protein Interactions
Q26822456Killing two birds with one stone: trans-kingdom suppression of PAMP/MAMP-induced immunity by T3E from enteropathogenic bacteria
Q38087113Lost after translation: post-translational modifications by bacterial type III effectors
Q36909558Magnaporthe oryzae Effector AVR-Pii Helps to Establish Compatibility by Inhibition of the Rice NADP-Malic Enzyme Resulting in Disruption of Oxidative Burst and Host Innate Immunity.
Q41357286Mechanism of host substrate acetylation by a YopJ family effector.
Q36994631Metabolic host responses to infection by intracellular bacterial pathogens
Q28080342Microsporidia: Why Make Nucleotides if You Can Steal Them?
Q36489643Mobile effector proteins on phage genomes
Q37548120New frontiers in type III secretion biology: the Chlamydia perspective
Q34868917New players in the same old game: a system level in silico study to predict type III secretion system and effector proteins in bacterial genomes reveals common themes in T3SS mediated pathogenesis
Q36653379New technologies in developing recombinant attenuated Salmonella vaccine vectors
Q47662391Novel T3SS effector EseK in Edwardsiella piscicida is chaperoned by EscH and EscS to express virulence.
Q47254500Novel insights into the mechanism of SepL-mediated control of effector secretion in enteropathogenic Escherichia coli.
Q51058305Parenteral immunization with IpaB/IpaD protects mice against lethal pulmonary infection by Shigella.
Q40099941Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins.
Q28542091Phytoplasma effector SAP54 hijacks plant reproduction by degrading MADS-box proteins and promotes insect colonization in a RAD23-dependent manner
Q34283923Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics
Q48102847Pore-forming activity of the Pseudomonas aeruginosa type III secretion system translocon alters the host epigenome
Q37498015Potential of known and short prokaryotic protein motifs as a basis for novel peptide-based antibacterial therapeutics: a computational survey.
Q64940791Prediction of bacterial E3 ubiquitin ligase effectors using reduced amino acid peptide fingerprinting.
Q39637757Probing the cellular effects of bacterial effector proteins with the Yersinia toolbox
Q64234386Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target
Q88011724Protein-Injection Machines in Bacteria
Q39407784Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants
Q37425003RalF-Mediated Activation of Arf6 Controls Rickettsia typhi Invasion by Co-Opting Phosphoinositol Metabolism
Q46904094Ralstonia solanacearum type III secretion system effector Rip36 induces a hypersensitive response in the nonhost wild eggplant Solanum torvum
Q34525626Regulation of cell wall-bound invertase in pepper leaves by Xanthomonas campestris pv. vesicatoria type three effectors
Q38079815Regulation of the Yersinia type III secretion system: traffic control
Q30432222Remodeling of the intestinal brush border underlies adhesion and virulence of an enteric pathogen
Q36727376RipAY, a Plant Pathogen Effector Protein, Exhibits Robust γ-Glutamyl Cyclotransferase Activity When Stimulated by Eukaryotic Thioredoxins.
Q35621978SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors
Q36054725Salmonella effectors: important players modulating host cell function during infection
Q57114106Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway Infection in Mice
Q38418062Small regulatory RNAs and the fine-tuning of plant–bacteria interactions
Q35907031Specific Gene Loci of Clinical Pseudomonas putida Isolates.
Q37539390Staphylococcus aureus Infection Reduces Nutrition Uptake and Nucleotide Biosynthesis in a Human Airway Epithelial Cell Line.
Q38309987Structural insight into effector proteins of Gram-negative bacterial pathogens that modulate the phosphoproteome of their host
Q27727693Structure of a pathogen effector reveals the enzymatic mechanism of a novel acetyltransferase family
Q52674777Systematic Identification of Intracellular-Translocated Candidate Effectors in Edwardsiella piscicida.
Q47267267The Agrobacterium F-box protein effector VirF destabilizes the Arabidopsis GLABROUS1 enhancer/binding protein-like transcription factor VFP4, a transcriptional activator of defense response genes
Q41491066The Arf GTPase-activating protein family is exploited by Salmonella enterica serovar Typhimurium to invade nonphagocytic host cells
Q35738591The Bordetella Secreted Regulator BspR Is Translocated into the Nucleus of Host Cells via Its N-Terminal Moiety: Evaluation of Bacterial Effector Translocation by the Escherichia coli Type III Secretion System.
Q35856973The Burkholderia pseudomallei Proteins BapA and BapC Are Secreted TTSS3 Effectors and BapB Levels Modulate Expression of BopE.
Q37323304The Campylobacter jejuni CiaD effector protein activates MAP kinase signaling pathways and is required for the development of disease
Q39760246The Draft Genome Sequence of the Yersinia entomophaga Entomopathogenic Type Strain MH96T.
Q36631422The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species
Q37575990The PPE2 protein of Mycobacterium tuberculosis translocates to host nucleus and inhibits nitric oxide production.
Q30313661The Predicted Lytic Transglycosylase HpaH from Xanthomonas campestris pv. vesicatoria Associates with the Type III Secretion System and Promotes Effector Protein Translocation
Q47119631The Ralstonia solanacearum Type III Effector RipAY Is Phosphorylated in Plant Cells to Modulate Its Enzymatic Activity
Q27027103The SPI-1-like Type III secretion system: more roles than you think
Q41198238The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae.
Q35100520The Salmonella type III secretion system virulence effector forms a new hexameric chaperone assembly for export of effector/chaperone complexes
Q42328253The bacterial type III secretion system as a target for developing new antibiotics
Q36159095The effect of low shear force on the virulence potential of Yersinia pestis: new aspects that space-like growth conditions and the final frontier can teach us about a formidable pathogen
Q42573943The effector AWR5 from the plant pathogen Ralstonia solanacearum is an inhibitor of the TOR signalling pathway.
Q36211081The hydrophilic translocator for Vibrio parahaemolyticus, T3SS2, is also translocated
Q35149904The pathogenesis, detection, and prevention of Vibrio parahaemolyticus
Q34983708The role of autophagy in chloroplast degradation and chlorophagy in immune defenses during Pst DC3000 (AvrRps4) infection
Q40987468The small RNA Spot 42 regulates the expression of the type III secretion system 1 (T3SS1) chaperone protein VP1682 in Vibrio parahaemolyticus
Q40978693Type 3 Secretion System Island Encoded Proteins Required for Colonization by Non-O1/non-O139 Serogroup V. cholerae
Q39406159Type III Secretion in the Melioidosis Pathogen Burkholderia pseudomallei
Q38019015Type III effector-mediated processes in Salmonella infection
Q41504137Type III secretion system and virulence markers highlight similarities and differences between human- and plant-associated pseudomonads related to Pseudomonas fluorescens and P. putida.
Q92956497Unusual extracellular appendages deployed by the model strain Pseudomonas fluorescens C7R12
Q89820572Vibrio parahaemolyticus Infection in Mice Reduces Protective Gut Microbiota, Augmenting Disease Pathways
Q30370521Vibrio parahaemolyticus strengthens their virulence through modulation of cellular reactive oxygen species in vitro.
Q42315430VopE, a Vibrio cholerae Type III Effector, Attenuates the Activation of CWI-MAPK Pathway in Yeast Model System
Q35751326Which Way In? The RalF Arf-GEF Orchestrates Rickettsia Host Cell Invasion
Q26766358Yeast as a Heterologous Model System to Uncover Type III Effector Function
Q41380323Yersinia enterocolitica type III secretion injectisomes form regularly spaced clusters, which incorporate new machines upon activation
Q38991950YopJ Family Effectors Promote Bacterial Infection through a Unique Acetyltransferase Activity

Search more.