Interleukin-33 biology with potential insights into human diseases

scientific article published on 26 April 2011

Interleukin-33 biology with potential insights into human diseases is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1038/NRRHEUM.2011.53
P698PubMed publication ID21519352

P50authorCem GabayQ66753936
P2093author name stringGaby Palmer
P2860cites workIL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokinesQ24294720
Nuclear expression of interleukin-33 in pancreatic stellate cells.Q54657851
Tissue Distribution and Subcellular Localization of a Variant Form of the Human ST2 Gene Product, ST2VQ56593773
IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapyQ57231967
Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by MacrophagesQ57273017
IL-33 can promote survival, adhesion and cytokine production in human mast cellsQ57273112
The IL1-like cytokine IL33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosisQ61733657
T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensisQ74164997
Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbationQ74235980
T1/ST2 expression on Th2 cells negatively regulates allergic pulmonary inflammationQ80094797
Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune systemQ81191920
IL-33 induces IL-13-dependent cutaneous fibrosisQ82370239
Association of serum interleukin-33 level and the interleukin-33 genetic variant with Japanese cedar pollinosisQ82747179
Increased serum levels of soluble ST2 in birch pollen atopics and individuals working in laboratory animal facilitiesQ82793259
CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammationQ82873698
CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9Q83009701
Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritisQ83398961
Over-expression of IL-33 leads to spontaneous pulmonary inflammation in mIL-33 transgenic miceQ84095633
IL-33 raises alarmQ84233658
Contribution of IL-33 to induction and augmentation of experimental allergic conjunctivitisQ84299751
Elevated Serum Interleukin 33 Is Associated with Autoantibody Production in Patients with Rheumatoid ArthritisQ84650982
IL-33 Exacerbates Eosinophil-Mediated Airway InflammationQ84698017
Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signalingQ84916626
Active caspase-1 is a regulator of unconventional protein secretionQ24308770
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammationQ24309034
Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocketQ24321867
A novel IL-1 family cytokine, IL-33, potently activates human eosinophilsQ24647672
Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexesQ24649639
The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1Q24651453
T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector functionQ24651566
IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cellsQ24652221
Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venulesQ24685626
IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complexQ28239351
ST2: a novel remodeling biomarker in acute and chronic heart failureQ28280799
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systemsQ28294477
IL-33 mediates inflammatory responses in human lung tissue cellsQ28295034
IL-33, a potent inducer of adaptive immunity to intestinal nematodesQ28505946
IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cellsQ28513686
Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptorQ28579840
IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling systemQ28585033
Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammationQ28586791
The cloning and nucleotide sequence of human ST2L cDNAQ28593027
IL-33 reduces the development of atherosclerosisQ28594104
Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritisQ30434426
The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?Q33374001
Association of increased serum IL-33 levels with clinical and laboratory characteristics of systemic lupus erythematosus in Chinese populationQ33392397
Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cellsQ33508406
Soluble ST2 plasma concentrations predict mortality in severe sepsisQ33722112
Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophagesQ33722773
IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas aeruginosa keratitisQ33845161
The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of Th2 immune responseQ33936725
IL-33 is a crucial amplifier of innate rather than acquired immunityQ34276672
Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts.Q34358060
Expression of ST2, an interleukin-1 receptor homologue, is induced by proinflammatory stimuliQ34431061
Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarctionQ34603397
The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responsesQ34708854
IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivoQ35575987
T1/ST2--an IL-1 receptor-like modulator of immune responses.Q35757164
Interleukin-33 stimulates formation of functional osteoclasts from human CD14(+) monocytesQ36101730
Alarmins: chemotactic activators of immune responsesQ36162859
IL-33 mediates antigen-induced cutaneous and articular hypernociception in miceQ36497523
IL-33 exacerbates antigen-induced arthritis by activating mast cellsQ36800502
Induction of IL-33 expression and activity in central nervous system gliaQ36838536
Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation.Q36891595
Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33.Q37100750
The cytokine interleukin-33 mediates anaphylactic shockQ37238924
IL-33-activated dendritic cells induce an atypical TH2-type responseQ37265087
A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathwaysQ37267214
Interleukin-33 is biologically active independently of caspase-1 cleavageQ37339298
IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathwayQ37362940
Interleukin-33 - cytokine of dual function or novel alarmin?Q37440227
IL-33 and IL-33 receptors in host defense and diseasesQ37736212
The biological paths of IL-1 family members IL-18 and IL-33Q37800776
Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33: implications for allergic inflammationQ39026926
Interleukin-33, a target of parathyroid hormone and oncostatin m, increases osteoblastic matrix mineral deposition and inhibits osteoclast formation in vitroQ39583710
Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cellsQ39645392
A novel method for procuring a large quantity of mature murine eosinophils in vivoQ39648956
IL-33 reduces macrophage foam cell formation.Q39693915
KU812 cells provide a novel in vitro model of the human IL-33/ST2L axis: functional responses and identification of signaling pathwaysQ39712768
Expression and regulation of interleukin-33 in human monocytes.Q39752500
Caspase 3 inactivates biologically active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocationQ39758961
Mature interleukin-33 is produced by calpain-mediated cleavage in vivoQ39825950
IL-33 enhances lipopolysaccharide-induced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complexQ39833597
TRAF6 is a critical signal transducer in IL-33 signaling pathwayQ39964682
The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33.Q39986449
Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cellsQ40049209
Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide productionQ42629896
IL-33 activates unprimed murine basophils directly in vitro and induces their in vivo expansion indirectly by promoting hematopoietic growth factor productionQ42630793
Treatment-recalcitrant chronic rhinosinusitis with polyps is associated with altered epithelial cell expression of interleukin-33.Q42733194
IL-33 is expressed in human osteoblasts, but has no direct effect on bone remodelingQ42816541
Murine ST2 gene is a member of the primary response gene family induced by growth factorsQ42819569
JAK2 is an important signal transducer in IL-33-induced NF-κB activationQ42819596
T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responsesQ42944108
Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses.Q42947124
The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector functionQ42947210
Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infectionQ43062147
IL-33 prolongs murine cardiac allograft survival through induction of TH2-type immune deviationQ43134557
The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells.Q43143737
IL-33 exacerbates autoantibody-induced arthritisQ43170043
Serum levels of IL-33 and soluble ST2 and their association with disease activity in systemic lupus erythematosusQ43212382
ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosisQ43583400
IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signalsQ43690957
Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.Q44030778
Serum levels of the interleukin-1 receptor family member ST2 predict mortality and clinical outcome in acute myocardial infarctionQ44245130
IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4.Q45067212
An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptorQ46305097
A novel therapy of murine collagen-induced arthritis with soluble T1/ST2.Q47310105
IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes.Q47944333
Increased levels of soluble ST2 protein and IgG1 production in patients with sepsis and traumaQ48022100
IL-33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected with Toxoplasma gondiiQ48393870
The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production.Q51780702
Distinct serum and synovial fluid interleukin (IL)-33 levels in rheumatoid arthritis, psoriatic arthritis and osteoarthritis.Q53258549
Increased levels of interleukin 33 in sera and synovial fluid from patients with active rheumatoid arthritis.Q53359649
Modulation of interleukin signalling and gene expression in cardiac myocytes by endothelin-1.Q53363430
IL-33 is a chemoattractant for human Th2 cells.Q53528244
IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells.Q54421098
Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis.Q54431742
Increased IL-33 expression by epithelial cells in bronchial asthma.Q54441538
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectinterleukinsQ194908
P304page(s)321-329
P577publication date2011-04-26
P1433published inNature Reviews RheumatologyQ2107227
P1476titleInterleukin-33 biology with potential insights into human diseases
P478volume7

Reverse relations

cites work (P2860)
Q58115501A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs
Q26823326A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis
Q53070656A network map of IL-33 signaling pathway.
Q41871362A20-deficient mast cells exacerbate inflammatory responses in vivo
Q35699580AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites
Q36744984Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33.
Q38287064Actual position of interleukin(IL)-33 in atherosclerosis and heart failure: Great Expectations or En attendant Godot?
Q34033407Alarmin IL-33 acts as an immunoadjuvant to enhance antigen-specific tumor immunity
Q38530106Alarmin' Immunologists: IL-33 as a Putative Target for Modulating T Cell-Dependent Responses
Q47347447Alarmins in Frozen Shoulder: A Molecular Association Between Inflammation and Pain
Q40473630Altered Treg and cytokine responses in RSV-infected infants.
Q42150863Atherosclerosis severity is not affected by a deficiency in IL-33/ST2 signaling
Q34304314Basophil modulation by cytokine instruction
Q38732306CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm
Q41464455Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation
Q53053910Changes in inflammatory mediators as a result of intermittent hypoxia in obstructive sleep apnea syndrome.
Q36618926Changes in serum Interleukin-33 concentration before and after treatment with pegylated interferon alfa-2a plus ribavirin in patients with chronic hepatitis C genotype 1b infection
Q36179133Cooperation between the bacterial-derived short-chain fatty acid butyrate and interleukin-22 detected in human Caco2 colon epithelial/carcinoma cells
Q37987351Current understanding of rheumatoid arthritis therapy
Q36903150Disease severity in K/BxN serum transfer-induced arthritis is not affected by IL-33 deficiency
Q34540500Disordered IL-33/ST2 activation in decidualizing stromal cells prolongs uterine receptivity in women with recurrent pregnancy loss
Q92251945Dynamic changes of soluble ST2 levels predicted fatality and were involved in coagulopathy in dengue fever in the elderly
Q36444778Emerging role of the interleukin (IL)-33/ST2 axis in gut mucosal wound healing and fibrosis.
Q41297752Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences
Q48120429Exogenous IL-33 Restores Dendritic Cell Activation and Maturation in Established Cancer.
Q35618798Experimental Models of Inflammatory Bowel Diseases
Q34149191Expression of IL-33 and its epigenetic regulation in Multiple Sclerosis
Q36025690Galectin-3 Ablation Enhances Liver Steatosis, but Attenuates Inflammation and IL-33-Dependent Fibrosis in Obesogenic Mouse Model of Nonalcoholic Steatohepatitis
Q37231684High-density genotyping study identifies four new susceptibility loci for atopic dermatitis
Q44761350Human mesenchymal stem cells overexpressing the IL-33 antagonist soluble IL-1 receptor-like-1 attenuate endotoxin-induced acute lung injury
Q36694205IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells
Q36005876IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance
Q38722744IL-33 acts as a foe to MIA PaCa-2 pancreatic cancer.
Q60909064IL-33 ameliorates experimental colitis involving regulation of autophagy of macrophages in mice
Q47718005IL-33 deficiency slows cancer growth but does not protect against cisplatin-induced AKI in mice with cancer
Q36512087IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms
Q53077975IL-33 enhances proliferation and invasiveness of decidual stromal cells by up-regulation of CCL2/CCR2 via NF-κB and ERK1/2 signaling.
Q35691155IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection
Q92335370IL-33/ST2 axis promotes glioblastoma cell invasion by accumulating tenascin-C
Q41036719IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function.
Q46866026IL‑33 enhances glioma cell migration and invasion by upregulation of MMP2 and MMP9 via the ST2-NF-κB pathway
Q34736360Impaired colonic B-cell responses by gastrointestinal Bacillus anthracis infection
Q36807908Implications for Interleukin-33 in solid organ transplantation
Q47106942Increased plasma IL-17, IL-31, and IL-33 levels in chronic spontaneous urticaria
Q33898659Indoleamine 2,3-dioxygenase-1 (IDO1) in human endometrial stromal cells induces macrophage tolerance through interleukin-33 in the progression of endometriosis
Q26858882Innate immunity in the central nervous system
Q36597506Interleukin 33 in tumor microenvironment is crucial for the accumulation and function of myeloid-derived suppressor cells
Q38702558Interleukin 33 is a guardian of barriers and a local alarmin
Q33987547Interleukin 33: a switch-hitting cytokine
Q60046076Interleukin-33 Contributes Toward Loss of Tolerance by Promoting B-Cell-Activating Factor of the Tumor-Necrosis-Factor Family (BAFF)-Dependent Autoantibody Production
Q36228512Interleukin-33 and RANK-L Interplay in the Alveolar Bone Loss Associated to Periodontitis
Q59351894Interleukin-33 and ST2 Signaling in Tumor Microenvironment
Q59354754Interleukin-33 contributes to disease severity in Dengue virus infection in mice
Q36751804Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer.
Q35754479Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation
Q39653025Interleukin-33 in human gliomas: Expression and prognostic significance
Q36585708Interleukin-33 in the human placenta
Q40972417Interleukin-33 promotes Th2 immune responses in infected mice with Schistosoma japonicum
Q33678403Interleukin-33 regulates intestinal inflammation by modulating macrophages in inflammatory bowel disease
Q41945735Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis
Q38770982Interleukin-33: increasing role in dermatological conditions
Q34544863Intracellular function of interleukin-1 receptor antagonist in ischemic cardiomyocytes
Q41475075Loss of interleukin 33 expression in colonic crypts - a potential marker for disease remission in ulcerative colitis
Q40367971Maternal plasma-soluble ST2 concentrations are elevated prior to the development of early and late onset preeclampsia - a longitudinal study
Q92857768Memory CD8+ T Cell Protection From Viral Reinfection Depends on Interleukin-33 Alarmin Signals
Q92479800Molecular mechanisms regulating immune responses in thromboangiitis obliterans: A comprehensive review
Q37617670Murine mast cells secrete and respond to interleukin-33
Q37706803Positive selection of IL-33 in adaptive immunity of domestic Chinese goats.
Q37192446Potential of IL-33 for Preventing the Kidney Injury via Regulating the Lipid Metabolism in Gout Patients.
Q36516498Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses.
Q92862530Rheumatiod Arthritis: An Updated Overview of Latest Therapy and Drug Delivery
Q33854499Role of IL-33 and its receptor in T cell-mediated autoimmune diseases
Q37620811Role of the IL-33-ST2 axis in sepsis
Q27679811Structural insights into the interaction of IL-33 with its receptors
Q35279922T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses.
Q35972372TLR3 Agonist Poly-IC Induces IL-33 and Promotes Myelin Repair
Q30486741The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors
Q37174541The IL-33/ST2 axis is associated with human visceral leishmaniasis and suppresses Th1 responses in the livers of BALB/c mice infected with Leishmania donovani
Q40823404The TAK1→IKKβ→TPL2→MKK1/MKK2 Signaling Cascade Regulates IL-33 Expression in Cystic Fibrosis Airway Epithelial Cells Following Infection by Pseudomonas aeruginosa.
Q35116283The alarmin IL-33 promotes regulatory T-cell function in the intestine
Q38131032The alarmin functions of high-mobility group box-1 and IL-33 in the pathogenesis of systemic lupus erythematosus.
Q38979165The danger from within: alarmins in arthritis
Q38530866The diverse role of RIP kinases in necroptosis and inflammation
Q21131158The environment of regulatory T cell biology: cytokines, metabolites, and the microbiome
Q38967737The epithelial barrier and immunoglobulin A system in allergy
Q37085681The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation
Q24633658The immune pathogenesis of scleroderma: context is everything
Q42496270The mouse interleukin (Il)33 gene is expressed in a cell type- and stimulus-dependent manner from two alternative promoters
Q38424483The potential role of IL-33/ST2 signaling in fibrotic diseases
Q35373060The sterile inflammation in the exacerbation of HBV-associated liver injury
Q58104422Type 2 Innate Lymphoid Cells Impede IL-33-Mediated Tumor Suppression
Q28082245Type 2 responses at the interface between immunity and fat metabolism
Q30807010Use of whole-blood transcriptomic profiling to highlight several pathophysiologic pathways associated with response to rituximab in patients with rheumatoid arthritis: data from a randomized, controlled, open-label trial

Search more.