Non-hematopoietic stem cells as factories for in vivo therapeutic protein production.

scientific article published on 12 May 2011

Non-hematopoietic stem cells as factories for in vivo therapeutic protein production. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1038/GT.2011.68
P698PubMed publication ID21562594
P5875ResearchGate publication ID51117498

P50authorLuis Alvarez-VallinaQ55834901
Marta CompteQ59554011
Laura SanzQ37830681
P2093author name stringI Guijarro-Muñoz
P2860cites workPulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effectQ24635138
Progress and prospects: immune responses to viral vectorsQ28264531
Hierarchical scaffold design for mesenchymal stem cell-based gene therapy of hemophilia BQ28294014
Mesenchymal stem cells within tumour stroma promote breast cancer metastasisQ29614303
Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6Q29620590
Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNgamma-transduced tumor cell immunotherapy of experimental gliomaQ30885561
Anti-angiogenesis therapy based on the bone marrow-derived stromal cells genetically engineered to express sFlt-1 in mouse tumor modelQ33378960
Bone marrow multipotent mesenchymal stroma cells act as pericyte-like migratory vehicles in experimental gliomasQ33382708
Neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodiesQ33519052
Toward brain tumor gene therapy using multipotent mesenchymal stromal cell vectorsQ33560685
Casting doubt on the safety of "off-the-shelf" mesenchymal stem cells for cell therapyQ33713210
Mesenchymal stromal cells engineered to express erythropoietin induce anti-erythropoietin antibodies and anemia in allorecipientsQ33713301
Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigmsQ33713663
Autologous bone marrow stromal cells genetically engineered to secrete an igf-I receptor decoy prevent the growth of liver metastasesQ33713800
Intravenous mesenchymal stem cell therapy for traumatic brain injuryQ33929697
Therapeutic potential of mesenchymal stem cells producing interferon-alpha in a mouse melanoma lung metastasis modelQ34133208
Trafficking mesenchymal stem cell engraftment and differentiation in tumor-bearing mice by bioluminescence imagingQ34164696
Cell encapsulation: promise and progressQ34168860
Concise review: stem cells as an emerging platform for antibody therapy of cancerQ34414838
Erythropoietin delivery by genetically engineered bone marrow stromal cells for correction of anemia in mice with chronic renal failure.Q45857983
A neovascularized organoid derived from retrovirally engineered bone marrow stroma leads to prolonged in vivo systemic delivery of erythropoietin in nonmyeloablated, immunocompetent miceQ45859123
Ex vivo gene therapy for hemophilia A that enhances safe delivery and sustained in vivo factor VIII expression from lentivirally engineered endothelial progenitorsQ45869403
Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells.Q45870174
Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma modelQ45875290
Use of blood outgrowth endothelial cells for gene therapy for hemophilia A.Q45882442
Marrow stromal cells for interleukin-2 delivery in cancer immunotherapyQ47305010
Neo-organoid of marrow mesenchymal stromal cells secreting interleukin-12 for breast cancer therapy.Q47631011
Human bone marrow-derived mesenchymal stem cells in the treatment of gliomasQ48926056
Mesenchymal Stem Cells: Potential Precursors for Tumor Stroma and Targeted-Delivery Vehicles for Anticancer AgentsQ58828469
Anti-tumor activity of mesenchymal stem cells producing IL-12 in a mouse melanoma modelQ79142180
Distribution of circulation-derived endothelial progenitors following systemic deliveryQ79963887
Long-term in vivo imaging of human angiogenesis: critical role of bone marrow-derived mesenchymal stem cells for the generation of durable blood vesselsQ80638852
Human-compatible collagen matrix for prolonged and reversible systemic delivery of erythropoietin in mice from gene-modified marrow stromal cellsQ80794400
Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principalsQ34575418
Cells as vehicles for cancer gene therapy: the missing link between targeted vectors and systemic delivery?Q34774078
Encapsulated human mesenchymal stem cells: a unique hypoimmunogenic platform for long-term cellular therapyQ35000974
Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomasQ35827956
Immune responses to gene therapy vectors: influence on vector function and effector mechanismsQ35904408
Gene therapy: can neural stem cells deliver?Q36350210
Genetically engineered stem cells for therapeutic gene deliveryQ36985452
Stem and progenitor cell-mediated tumor selective gene therapyQ37120161
Cell vehicle targeting strategiesQ37120169
Murine bone marrow-derived mesenchymal stem cells as vehicles for interleukin-12 gene delivery into Ewing sarcoma tumorsQ37120256
Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapyQ37140126
Tumor immunotherapy using gene-modified human mesenchymal stem cells loaded into synthetic extracellular matrix scaffolds.Q37312523
Cancer gene therapy using mesenchymal stem cells expressing interferon-beta in a mouse prostate cancer lung metastasis modelQ37398716
Mesenchymal stem cell homing: the devil is in the detailsQ37407769
Biological gene delivery vehicles: beyond viral vectorsQ37412239
Three-dimensional porous scaffolds at the crossroads of tissue engineering and cell-based gene therapy.Q37579760
Human bone marrow-derived mesenchymal stromal cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapyQ39245228
Antitumor treatment using interleukin- 12-secreting marrow stromal cells in an invasive glioma modelQ39844128
Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer.Q39852557
Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial gliomaQ39910399
Antitumoral activity and osteogenic potential of mesenchymal stem cells expressing the urokinase-type plasminogen antagonist amino-terminal fragment in a murine model of osteolytic tumorQ39945700
Adenoviral-mediated interleukin-18 expression in mesenchymal stem cells effectively suppresses the growth of glioma in ratsQ39947440
A tumor-selective biotherapy with prolonged impact on established metastases based on cytokine gene-engineered MSCsQ39999044
Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cellsQ40229749
PEX-producing human neural stem cells inhibit tumor growth in a mouse glioma modelQ40382315
Systemic inhibition of tumour angiogenesis by endothelial cell-based gene therapyQ41960388
Lentiviral-transduced human mesenchymal stem cells persistently express therapeutic levels of enzyme in a xenotransplantation model of human diseaseQ42092419
Long-term persistence of human bone marrow stromal cells transduced with factor VIII-retroviral vectors and transient production of therapeutic levels of human factor VIII in nonmyeloablated immunodeficient miceQ42486323
Interleukin-23-expressing bone marrow-derived neural stem-like cells exhibit antitumor activity against intracranial glioma.Q42804628
Targeted delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cellsQ42829407
Adipose-derived mesenchymal stem cells as stable source of tumor necrosis factor-related apoptosis-inducing ligand delivery for cancer therapyQ43100976
Insulin expressed from endogenously active glucose-responsive EGR1 promoter in bone marrow mesenchymal stromal cells as diabetes therapyQ43150773
The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion.Q43599448
Human mesenchymal stem cells (hMSCs) expressing truncated soluble vascular endothelial growth factor receptor (tsFlk-1) following lentiviral-mediated gene transfer inhibit growth of Burkitt's lymphoma in a murine model.Q44470878
Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution.Q44538164
Gene therapy of experimental brain tumors using neural progenitor cellsQ44761775
Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradationQ44786842
Efficient lentiviral transduction and improved engraftment of human bone marrow mesenchymal cellsQ45180575
P433issue1
P304page(s)1-7
P577publication date2011-05-12
P1433published inGene TherapyQ15763095
P1476titleNon-hematopoietic stem cells as factories for in vivo therapeutic protein production
P478volume19

Reverse relations

cites work (P2860)
Q99237969Engineering Immune Cells for in vivo Secretion of Tumor-Specific T Cell-Redirecting Bispecific Antibodies
Q34231663Human mesenchymal stem cells resolve airway inflammation, hyperreactivity, and histopathology in a mouse model of occupational asthma
Q42560301In vivo secretion of anti-CD3 × anti-tumor bispecific antibodies by gene-modified cells: over a decade of T-cell engagement.
Q43616044Nonviral gene delivery of erythropoietin by mesenchymal stromal cells
Q26741260Producer T cells: Using genetically engineered T cells as vehicles to generate and deliver therapeutics to tumors
Q39098665Targeted therapy by gene transfer of a monovalent antibody fragment against the Met oncogenic receptor.
Q45876898Tumor tropism of intravenously injected human-induced pluripotent stem cell-derived neural stem cells and their gene therapy application in a metastatic breast cancer model.

Search more.