Trypanosoma cruzi-Derived Neurotrophic Factor: Role in Neural Repair and Neuroprotection

scientific article published on July 2010

Trypanosoma cruzi-Derived Neurotrophic Factor: Role in Neural Repair and Neuroprotection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4303/JNP/N100507
P932PMC publication ID3092389
P698PubMed publication ID21572925

P2093author name stringMercio Pereiraperrin
Marina V Chuenkova
P2860cites workThe Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas DiseaseQ22065799
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Trypanosoma cruzi subverts host cell sialylation and may compromise antigen-specific CD8+ T cell responsesQ33809905
Trypanosoma cruzi trans-sialidase: a potent and specific survival factor for human Schwann cells by means of phosphatidylinositol 3-kinase/Akt signalingQ33934677
Functional diversity in the trans-sialidase and mucin families in Trypanosoma cruziQ33945620
Heterologous expression of Trypanosoma cruzi trans-sialidase in Leishmania major enhances virulenceQ34004312
Apoptosis modulators in the therapy of neurodegenerative diseasesQ34074800
Chagas' disease parasite promotes neuron survival and differentiation through TrkA nerve growth factor receptorQ45077696
Involvement of the beta-adrenergic system in the cardiac chronic form of experimental Trypanosoma cruzi infection.Q45971072
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The Chagas' disease parasite Trypanosoma cruzi exploits nerve growth factor receptor TrkA to infect mammalian hostsQ46898405
A single tyrosine differentiates active and inactive Trypanosoma cruzi trans-sialidases.Q48072224
Enhancement of tyrosine hydroxylase expression and activity by Trypanosoma cruzi parasite-derived neurotrophic factorQ48485287
Cardiac sympathetic-parasympathetic balance in rats with experimentally-induced acute chagasic myocarditis.Q51610609
Expression of trypomastigote trans-sialidase in metacyclic forms of Trypanosoma cruzi increases parasite escape from its parasitophorous vacuole.Q51806092
A Developmentally Regulated Neuraminidase Activity in Trypanosoma cruziQ52282101
Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infectionQ57034149
Characterization of enteroglial cells and denervation process in chagasic patients with and without megaesophagusQ58844129
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A synthetic peptide modeled on PDNF, Chagas' disease parasite neurotrophic factor, promotes survival and differentiation of neuronal cells through TrkA receptorQ58845452
Pathology of intracardiac nerves in experimental Chagas diseaseQ58846160
Changes in choline acetyltransferase activity of rat tissues during Chagas' diseaseQ58846161
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The trans-sialidase of Trypanosoma cruzi is anchored by two different lipidsQ58855157
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Mediation of Trypanosoma cruzi invasion by sialic acid on the host cell and trans-sialidase on the trypanosomeQ72857017
Signal transduction in human macrophages by gp83 ligand of Trypanosoma cruzi: trypomastigote gp83 ligand up-regulates trypanosome entry through protein kinase C activationQ73098076
Distribution of the neurotrophin receptors p75 and trkB in peripheral mechanoreceptors; observations on changes after injuryQ73503384
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A trypanosomal protein synergizes with the cytokines ciliary neurotrophic factor and leukemia inhibitory factor to prevent apoptosis of neuronal cellsQ34707755
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The Trypanosoma cruzi trans-sialidase, through its COOH-terminal tandem repeat, upregulates interleukin 6 secretion in normal human intestinal microvascular endothelial cells and peripheral blood mononuclear cellsQ36375616
Trypanosoma cruzi surface mucins: host-dependent coat diversityQ36401388
The causation and importance of nervous lesions in American trypanosomiasisQ36539518
Human autoantibodies specific for neurotrophin receptors TrkA, TrkB, and TrkC protect against lethal Trypanosoma cruzi infection in miceQ36943082
Preferential brain homing following intranasal administration of Trypanosoma cruziQ37145066
Neurotrophins and target interactions in the development and regulation of sympathetic neuron electrical and synaptic propertiesQ37395764
Chagasic encephalitis in HIV patients: common presentation of an evolving epidemiological and clinical associationQ37459842
Trypanosoma cruzi infection activates extracellular signal-regulated kinase in cultured endothelial and smooth muscle cellsQ37521693
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The chronic gastrointestinal manifestations of Chagas diseaseQ37663591
Chagas cardiomyopathy--where do we stand after a hundred years?Q37683028
Enzymatically inactive trans-sialidase from Trypanosoma cruzi binds sialyl and beta-galactopyranosyl residues in a sequential ordered mechanism.Q38347663
Auto-antibodies to receptor tyrosine kinases TrkA, TrkB and TrkC in patients with chronic Chagas' diseaseQ39581241
Trypanosoma cruzi: Acetylcholine content and cholinergic innervation of the heart in ratsQ39649378
Trypanosoma cruzi promotes neuronal and glial cell survival through the neurotrophic receptor TrkCQ39889598
Trypanosome trans-sialidase mediates neuroprotection against oxidative stress, serum/glucose deprivation, and hypoxia-induced neurite retraction in Trk-expressing PC12 cellsQ40153692
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Trypanosoma cruziin the Cerebrospinal Fluid during the Acute Stage of Chagas' DiseaseQ41369034
Trypanosoma cruzi trans-sialidase and neuraminidase activities can be mediated by the same enzymesQ42029468
Chagas' disease parasite-derived neurotrophic factor activates cholinergic gene expression in neuronal PC12 cellsQ42049103
Experimental American trypanomiasis in rats: sympathetic denervation, parasitism and inflammatory processQ42095059
Neuronal plasticity of the enteric nervous system is correlated with chagasic megacolon developmentQ43592922
The Trypanosoma cruzi trans-sialidase is a T cell-independent B cell mitogen and an inducer of non-specific Ig secretionQ43898130
Poly(ADP-ribose) polymerase inhibition prevents both apoptotic-like delayed neuronal death and necrosis after H(2)O(2) injuryQ44046046
Heart autonomic innervation during the acute phase of experimental American trypanosomiasis in the dog.Q44190688
The trans-sialidase from Trypanosoma cruzi triggers apoptosis by target cell sialylationQ44620292
PDNF, a human parasite-derived mimic of neurotrophic factors, prevents caspase activation, free radical formation, and death of dopaminergic cells exposed to the Parkinsonism-inducing neurotoxin MPP+Q44641786
Cardiovascular autonomic function testing in asymptomatic T. cruzi carriers: a sensitive method to identify subclinical Chagas' diseaseQ44771286
Trypanosoma cruzi trans-sialidase potentiates T cell activation through antigen-presenting cells: role of IL-6 and Bruton's tyrosine kinaseQ44888998
Trypanosome trans-sialidase targets TrkA tyrosine kinase receptor and induces receptor internalization and activation.Q44968686
P921main subjectTrypanosoma cruziQ150162
P304page(s)55-60
P577publication date2010-07-01
P1433published inJournal of neuroparasitologyQ27723570
P1476titleTrypanosoma cruzi-Derived Neurotrophic Factor: Role in Neural Repair and Neuroprotection
P478volume1

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cites work (P2860)
Q28391025Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease
Q54264504Gene and Chromosomal Copy Number Variations as an Adaptive Mechanism Towards a Parasitic Lifestyle in Trypanosomatids.
Q34298453Parasite-derived neurotrophic factor/trans-sialidase of Trypanosoma cruzi links neurotrophic signaling to cardiac innate immune response
Q61798673Theft and Reception of Host Cell's Sialic Acid: Dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like Molecules on Chagas' Disease Immunomodulation

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