Mechanisms maintaining genomic integrity in embryonic stem cells and induced pluripotent stem cells

scientific article published on 18 July 2011

Mechanisms maintaining genomic integrity in embryonic stem cells and induced pluripotent stem cells is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1258/EBM.2011.011107
P8608Fatcat IDrelease_mqm27mmkwfbj7kqbu3nxq5slae
P932PMC publication ID4077782
P698PubMed publication ID21768163

P2093author name stringElisia D Tichy
P2860cites workp53 has a direct apoptogenic role at the mitochondriaQ24298888
Embryonic stem cells and somatic cells differ in mutation frequency and typeQ24531480
Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiationQ24563808
Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaksQ24599990
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cellsQ24616059
DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cellsQ24644828
Establishment in culture of pluripotential cells from mouse embryosQ27860625
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsQ27860937
Embryonic stem cell lines derived from human blastocystsQ27861010
Generation of germline-competent induced pluripotent stem cellsQ28131699
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpointsQ28266170
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expressionQ28300071
The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damageQ28586234
Mouse mutants from chemically mutagenized embryonic stem cellsQ28593735
Epigenetic memory in induced pluripotent stem cellsQ29547892
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like stateQ29614212
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblastsQ29614794
Suppression of induced pluripotent stem cell generation by the p53-p21 pathwayQ29619160
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cellsQ29619469
Regulation of p53 in embryonic stem cellsQ42825893
Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repairQ42828839
Preparation of heteroduplex enhanced green fluorescent protein plasmid for in vivo mismatch repair activity assayQ42879912
Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forksQ44800025
Huntington's and myotonic dystrophy hESCs: down-regulated trinucleotide repeat instability and mismatch repair machinery expression upon differentiationQ45300062
The analysis of mitochondria and mitochondrial DNA in human embryonic stem cells.Q50929727
Synergistic action of Wnt and LIF in maintaining pluripotency of mouse ES cells.Q51249622
Transgenerational changes in somatic and germ line genetic integrity of first-generation offspring derived from the DNA damaged sperm.Q51627059
Two Supporting Factors Greatly Improve the Efficiency of Human iPSC GenerationQ57974225
Preservation of genomic integrity in mouse embryonic stem cellsQ64386960
Lower mutation frequencies are induced by ENU in undifferentiated embryonic cells than in differentiated cells of the mouse in vitroQ71626053
Regulation of apoptosis and differentiation by p53 in human embryonic stem cellsQ79441696
Visualizing loss of heterozygosity in living mouse cells and tissuesQ81792738
Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cellsQ82510190
Expression and loss of alleles in cultured mouse embryonic fibroblasts and stem cells carrying allelic fluorescent protein genesQ33260513
Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.Q33352584
Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damageQ33469925
Transcriptional signature and memory retention of human-induced pluripotent stem cellsQ33504601
Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendantsQ33549647
A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cellsQ33591375
DNA damage responses in human induced pluripotent stem cells and embryonic stem cellsQ33728554
Reactive oxygen species enhance differentiation of human embryonic stem cells into mesendodermal lineageQ33751376
Genetic analysis of mouse embryonic stem cells bearing Msh3 and Msh2 single and compound mutationsQ33961252
Survival responses of human embryonic stem cells to DNA damageQ34078474
ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damageQ34453891
Analysis of the cell cycle in mouse embryonic stem cells.Q34479274
Generation of human induced pluripotent stem cells from dermal fibroblastsQ34588555
Reprogramming the pluripotent cell cycle: restoration of an abbreviated G1 phase in human induced pluripotent stem (iPS) cellsQ34607206
Mismatch and base excision repair proficiency in murine embryonic stem cellsQ34709046
Homologous recombination conserves DNA sequence integrity throughout the cell cycle in embryonic stem cellsQ35084078
Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cellsQ35924505
A new role for p53 in maintaining genetic stability in embryonic stem cellsQ36035434
Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathwayQ36089263
Mutation frequency declines during spermatogenesis in young mice but increases in old miceQ36283159
Cell cycle control of embryonic stem cellsQ36672102
Human embryonic stem cells have enhanced repair of multiple forms of DNA damageQ36953410
DNA repair in mammalian cells: Base excision repair: the long and short of it.Q37372532
Induced pluripotent stem cells: epigenetic memories and practical implications.Q37808060
Human DNA ligase IV and the ligase IV/XRCC4 complex: analysis of nick ligation fidelity.Q38303059
Human embryonic stem cells are capable of executing G1/S checkpoint activation.Q39697555
DNA damage-induced degradation of Cdc25A does not lead to inhibition of Cdk2 activity in mouse embryonic stem cells.Q39747406
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signaturesQ39830573
Explanation for excessive DNA single-strand breaks and endogenous repair foci in pluripotent mouse embryonic stem cellsQ39893311
Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaksQ39965016
Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cellsQ40041320
Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phaseQ40232134
DNA mismatch repair mediates protection from mutagenesis induced by short-wave ultraviolet lightQ40249497
Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cellsQ40400343
Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cellsQ40493815
Alternative pathways for the repair of RAG-induced DNA breaksQ40724946
ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cellsQ42356980
MicroRNA profiling of human-induced pluripotent stem cellsQ42798873
P433issue9
P304page(s)987-996
P577publication date2011-07-18
P1433published inExperimental Biology and MedicineQ15716535
P1476titleMechanisms maintaining genomic integrity in embryonic stem cells and induced pluripotent stem cells
P478volume236

Reverse relations

cites work (P2860)
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Q51551337Future challenges for patient-specific induced pluripotent stem cells in cardiovascular medicine.
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Q37584840Mouse embryonic stem cells undergo charontosis, a novel programmed cell death pathway dependent upon cathepsins, p53, and EndoG, in response to etoposide treatment
Q34437223Rad51 regulates cell cycle progression by preserving G2/M transition in mouse embryonic stem cells
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Q38740922p53 and its mutants on the slippery road from stemness to carcinogenesis

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