The small molecular mass antifungal protein of Penicillium chrysogenum--a mechanism of action oriented review

scientific article published on 21 July 2011

The small molecular mass antifungal protein of Penicillium chrysogenum--a mechanism of action oriented review is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1002/JOBM.201100041
P698PubMed publication ID21780144
P5875ResearchGate publication ID51512557

P50authorFlorentine MarxQ56600460
Hubertus HaasQ87841757
Tamás EmriQ88229506
P2093author name stringIstván Pócsi
Gyula Batta
Jae-Hyuk Yu
László Csernoch
Nak-Jung Kwon
Barbara Kovács
Eva Leiter
Nikoletta Hegedus
Valéria Tomori
P2860cites workEffects of mutations in the GanB/RgsA G protein mediated signalling on the autolysis of Aspergillus nidulans.Q52000374
Rust and downy mildew resistance in pearl millet (Pennisetum glaucum) mediated by heterologous expression of the afp gene from Aspergillus giganteus.Q52014736
Characterization of bZip-type transcription factor AtfA with reference to stress responses of conidia of Aspergillus nidulans.Q54046839
Heterotrimeric G-proteins of a filamentous fungus regulate cell wall composition and susceptibility to a plant PR-5 protein.Q54053025
Progress in understanding molecular mechanisms and evolution of resistance to succinate dehydrogenase inhibiting (SDHI) fungicides in phytopathogenic fungiQ56455122
Characterization of the novel antifungal protein PgAFP and the encoding gene of Penicillium chrysogenum.Q46173134
Annotation of stress-response proteins in the aspergilliQ46429617
Engineering Fusarium head blight resistance in wheat by expression of a fusion protein containing a Fusarium-specific antibody and an antifungal peptideQ46431608
In vitro activity of Penicillium chrysogenum antifungal protein (PAF) and its combination with fluconazole against different dermatophytesQ46522595
The appearances of autolytic and apoptotic markers are concomitant but differently regulated in carbon-starving Aspergillus nidulans culturesQ46705654
Regulation of autolysis in Aspergillus nidulansQ46848581
In vitro analysis of His-Asp phosphorelays in Aspergillus nidulans: the first direct biochemical evidence for the existence of His-Asp phosphotransfer systems in filamentous fungiQ46956434
The antifungal protein AFP secreted by Aspergillus giganteus does not cause detrimental effects on certain mammalian cells.Q46962838
Regulators of G-protein signalling in Aspergillus nidulans: RgsA downregulates stress response and stimulates asexual sporulation through attenuation of GanB (Galpha) signallingQ47261602
Transgenic rice plants expressing the antifungal AFP protein from Aspergillus giganteus show enhanced resistance to the rice blast fungus Magnaporthe griseaQ47436964
Asexual sporulation signalling regulates autolysis of Aspergillus nidulans via modulating the chitinase ChiB productionQ47680246
A mitogen-activated protein kinase (MPKA) is involved in polarized growth in the filamentous fungus, Aspergillus nidulansQ47968910
Cloning, structural organization and regulation of expression of the Penicillium chrysogenum paf gene encoding an abundantly secreted protein with antifungal activity.Q48068189
Pathogen-induced production of the antifungal AFP protein from Aspergillus giganteus confers resistance to the blast fungus Magnaporthe grisea in transgenic riceQ48120886
SakA MAP kinase is involved in stress signal transduction, sexual development and spore viability in Aspergillus nidulans.Q48287453
brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulansQ48318765
The Penicillium chrysogenum-derived antifungal peptide shows no toxic effects on mammalian cells in the intended therapeutic concentrationQ49066113
Purification of alpha-sarcin and an antifungal protein from Aspergillus giganteus by blue sepharose CL-6B affinity chromatography.Q50522087
Biotechnologically relevant enzymes and proteins. Antifungal mechanism of the Aspergillus giganteus AFP against the rice blast fungus Magnaporthe grisea.Q50735744
Antifungal peptides secreted by filamentous fungi as promising new agents in human therapy.Q51748050
Comparison of gene expression signatures of diamide, H2O2 and menadione exposed Aspergillus nidulans cultures--linking genome-wide transcriptional changes to cellular physiologyQ25257237
Functional aspects of the solution structure and dynamics of PAF - a highly-stable antifungal protein fromPenicillium chrysogenumQ27655564
Survival strategies of yeast and filamentous fungi against the antifungal protein AFP.Q27933958
Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor.Q27936252
Isolation and characterization of a novel antifungal peptide from Aspergillus nigerQ28373709
Molecular cloning, structural analysis and modelling of the AcAFP antifungal peptide from Aspergillus clavatus.Q30157204
Aspergillus nidulans HOG pathway is activated only by two-component signalling pathway in response to osmotic stressQ30160244
Forest soil metagenome gene cluster involved in antifungal activity expression in Escherichia coliQ33309144
First isolation of a novel thermostable antifungal peptide secreted by Aspergillus clavatusQ33358583
Combinatorial chemistry in the agrosciencesQ33427315
Nutrient sensing G protein-coupled receptors: interesting targets for antifungals?Q33514909
Chitinase genes revealed and compared in bacterial isolates, DNA extracts and a metagenomic library from a phytopathogen-suppressive soilQ33516159
Natural products as antifungal agents against clinically relevant pathogensQ33582329
The antifungal protein PAF interferes with PKC/MPK and cAMP/PKA signalling of Aspergillus nidulans.Q33621572
Antifungal protein PAF severely affects the integrity of the plasma membrane of Aspergillus nidulans and induces an apoptosis-like phenotypeQ33836555
Apoptosis in yeast--a monocellular organism exhibits altruistic behaviourQ33913105
The pkaB gene encoding the secondary protein kinase A catalytic subunit has a synthetic lethal interaction with pkaA and plays overlapping and opposite roles in Aspergillus nidulansQ33995620
The antifungal activity of the Penicillium chrysogenum protein PAF disrupts calcium homeostasis in Neurospora crassa.Q34125452
Searching for new-type antifungal drugs (an outline for possible new strategies).Q34494198
Multiple roles of a heterotrimeric G-protein gamma-subunit in governing growth and development of Aspergillus nidulansQ34589137
The heterotrimeric G-protein GanB(alpha)-SfaD(beta)-GpgA(gamma) is a carbon source sensor involved in early cAMP-dependent germination in Aspergillus nidulansQ34589147
The Penicillium chrysogenum antifungal protein PAF, a promising tool for the development of new antifungal therapies and fungal cell biology studies.Q34707423
Mechanisms influencing the evolution of resistance to Qo inhibitor fungicidesQ34860139
Genomic pathways to antifungal discoveryQ35061094
Progress in functional genomics approaches to antifungal drug target discoveryQ35558620
Antifungal proteins: targets, mechanisms and prospective applicationsQ35681779
Small, basic antifungal proteins secreted from filamentous ascomycetes: a comparative study regarding expression, structure, function and potential application.Q35712331
Emerging fungal resistanceQ35869011
Glutathione, altruistic metabolite in fungiQ35935037
Defensins--components of the innate immune system in plantsQ36002910
Reactive oxygen species and development in microbial eukaryotes.Q36057668
Human defensinsQ36094398
Current state of three-dimensional characterisation of antifungal targets and its use for molecular modelling in drug designQ36313622
Anticandidal low molecular compounds from higher plants with special reference to compounds from essential oilsQ36332565
Impact of fungal drug transporters on fungicide sensitivity, multidrug resistance and virulenceQ36395321
Genomics, molecular targets and the discovery of antifungal drugsQ36405503
Epidemiology of Candida albicans infections and role of non-Candida-albicans yeastsQ36447065
Recent insights into the mechanisms of antifungal resistanceQ36634450
Candida glabrata: an emerging oral opportunistic pathogenQ36741765
Active internalization of the Penicillium chrysogenum antifungal protein PAF in sensitive aspergilli.Q36880553
Pathogenicity and drug resistance in Candida albicans and other yeast species. A reviewQ36951859
Therapeutic potential of antifungal plant and insect defensinsQ36997515
A small protein that fights fungi: AFP as a new promising antifungal agent of biotechnological value.Q37027296
Regulation of Development in Aspergillus nidulans and Aspergillus fumigatusQ37090153
The mode of antifungal action of plant, insect and human defensinsQ37116868
Genomic and genetic approaches for the identification of antifungal drug targetsQ37161050
Recent approaches to antifungal therapy for invasive mycoses.Q37377752
Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulationQ37607324
Plant defensins: defense, development and application.Q37653904
Antifungals: need to search for a new molecular targetQ37666705
Natural products--antifungal agents derived from plantsQ37698380
A survey of yeast genomic assays for drug and target discoveryQ37764979
An insight into the antifungal pipeline: selected new molecules and beyond.Q37781273
The Aspergillus nidulans sfaD gene encodes a G protein beta subunit that is required for normal growth and repression of sporulationQ38319429
New insights into the target site and mode of action of the antifungal protein of Aspergillus giganteus.Q40456423
Cloning and nucleotide sequence of a cDNA encoding the antifungal-protein of Aspergillus giganteus and preliminary characterization of the native geneQ40518084
The paf gene product modulates asexual development in Penicillium chrysogenumQ41930172
The antifungal protein AFP from Aspergillus giganteus inhibits chitin synthesis in sensitive fungiQ42222332
Among developmental regulators, StuA but not BrlA is essential for penicillin V production in Penicillium chrysogenumQ42270892
MpkA-Dependent and -independent cell wall integrity signaling in Aspergillus nidulansQ42413123
Molecular cloning, sequence analysis and expression of the gene encoding an antifungal-protein from Aspergillus giganteusQ42600784
Aspergillus sporulation and mycotoxin production both require inactivation of the FadA G alpha protein-dependent signaling pathwayQ42627346
Response regulators SrrA and SskA are central components of a phosphorelay system involved in stress signal transduction and asexual sporulation in Aspergillus nidulansQ42628240
Oxygen stress: a regulator of apoptosis in yeastQ42797452
Potential basis for amphotericin B resistance in Aspergillus terreusQ43111760
The antifungal protein AFP from Aspergillus giganteus prevents secondary growth of different Fusarium species on barleyQ43136255
AtfA bZIP-type transcription factor regulates oxidative and osmotic stress responses in Aspergillus nidulansQ43174154
Production of the biotechnologically relevant AFP from Aspergillus giganteus in the yeast Pichia pastorisQ43246626
A protein from the mold Aspergillus giganteus is a potent inhibitor of fungal plant pathogensQ43837580
Proper folding of the antifungal protein PAF is required for optimal activity.Q43870544
Purification of alpha-sarcin and an antifungal protein from mold (Aspergillus giganteus) by chitin affinity chromatographyQ44032845
Transcriptional profiling for Aspergillusnidulans HogA MAPK signaling pathway in response to fludioxonil and osmotic stressQ44263997
Effect of the Penicillium chrysogenum antifungal protein (PAF) on barley powdery mildew and wheat leaf rust pathogensQ44522607
Influence of fadAG203R and deltaflbA mutations on morphology and physiology of submerged Aspergillus nidulans culturesQ45013981
The antifungal plant defensin RsAFP2 from radish induces apoptosis in a metacaspase independent way in Candida albicans.Q45930644
Characterization of NikA histidine kinase and two response regulators with special reference to osmotic adaptation and asexual development in Aspergillus nidulans.Q45936462
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectPenicillium chrysogenumQ137155
P304page(s)561-571
P577publication date2011-07-21
P1433published inJournal of Basic MicrobiologyQ6294827
P1476titleThe small molecular mass antifungal protein of Penicillium chrysogenum--a mechanism of action oriented review
P478volume51