Genetic mutations and mitochondrial toxins shed new light on the pathogenesis of Parkinson's disease

scientific article published on August 2011

Genetic mutations and mitochondrial toxins shed new light on the pathogenesis of Parkinson's disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.4061/2011/979231
P932PMC publication ID3153940
P698PubMed publication ID21860779
P5875ResearchGate publication ID51589485

P50authorNobutaka HattoriQ64780524
P2093author name stringShigeto Sato
P2860cites workPINK1 is selectively stabilized on impaired mitochondria to activate ParkinQ21145802
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesisQ22242250
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1Q24297155
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagyQ24299149
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stabilityQ24299939
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesisQ24304952
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1Q24312106
Parkin is recruited selectively to impaired mitochondria and promotes their autophagyQ24317471
The kinase domain of mitochondrial PINK1 faces the cytoplasmQ24321709
PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neuronsQ24322788
Mitochondrial localization of DJ-1 leads to enhanced neuroprotectionQ24324226
Hereditary early-onset Parkinson's disease caused by mutations in PINK1Q24337084
Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36Q24536382
Mutation in the alpha-synuclein gene identified in families with Parkinson's diseaseQ27860459
alpha-Synuclein locus triplication causes Parkinson's diseaseQ27860533
Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplicationsQ28241852
Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's diseaseQ28317593
Chronic parkinsonism secondary to intravenous injection of meperidine analoguesQ28323857
A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's DiseaseQ28371129
Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease.Q54626622
Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects.Q54651745
Deficiencies in complex I subunits of the respiratory chain in Parkinson's diseaseQ69356679
Mitochondrial complex I deficiency in Parkinson's diseaseQ69370277
Inhibition of mitochondrial NADH-ubiquinone oxidoreductase activity by 1-methyl-4-phenylpyridinium ionQ70330687
Role of parkin mutations in 111 community-based patients with early-onset parkinsonismQ74448267
DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonismQ79249169
Causal relation between alpha-synuclein gene duplication and familial Parkinson's diseaseQ80794093
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Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stressQ28592727
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.Q28593258
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementiaQ29547174
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's diseaseQ29547175
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkinQ29547423
Parkinson's disease: mechanisms and modelsQ29547424
Alpha-synuclein locus duplication as a cause of familial Parkinson's diseaseQ29614762
Chronic systemic pesticide exposure reproduces features of Parkinson's diseaseQ29614763
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutantsQ29615627
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkinQ29615684
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagyQ29616005
PINK1-dependent recruitment of Parkin to mitochondria in mitophagyQ29620567
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkinQ29622838
MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activityQ30502685
Novel PINK1 mutations in early-onset parkinsonismQ34345898
PINK1 (PARK6) associated Parkinson disease in IrelandQ34362007
Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.Q34394747
Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonismQ34426475
DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxinQ34520638
Protocol for the MPTP mouse model of Parkinson's diseaseQ34614573
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localizationQ34836156
Mitochondrial mechanisms of neural cell death and neuroprotective interventions in Parkinson's disease.Q35171006
Distribution, type, and origin of Parkin mutations: review and case studiesQ35897345
Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.Q36446511
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machineryQ36657599
A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridineQ37343442
Tickled PINK1: mitochondrial homeostasis and autophagy in recessive Parkinsonism.Q37466094
Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson diseaseQ37671552
PINK1 controls mitochondrial localization of Parkin through direct phosphorylationQ39924212
Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1.Q40046504
C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.Q40285081
Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonismQ42216349
Parkin disease: a phenotypic study of a large case seriesQ44451919
An inhibitor of mitochondrial complex I, rotenone, inactivates proteasome by oxidative modification and induces aggregation of oxidized proteins in SH-SY5Y cellsQ44642551
Basal lipid peroxidation in substantia nigra is increased in Parkinson's diseaseQ44808814
Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective functionQ46797053
Co-localization with DJ-1 is essential for the androgen receptor to exert its transcription activity that has been impaired by androgen antagonistsQ47842152
Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplicationQ48298527
Rotenone neurotoxicity: a new window on environmental causes of Parkinson's disease and related brain amyloidosesQ48418414
Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridineQ48477579
Homozygous PINK1 C-terminus mutation causing early-onset parkinsonismQ48581847
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectParkinson's diseaseQ11085
P304page(s)979231
P577publication date2011-08-01
P1433published inParkinson's diseaseQ27723341
P1476titleGenetic mutations and mitochondrial toxins shed new light on the pathogenesis of Parkinson's disease
P478volume2011

Reverse relations

cites work (P2860)
Q38370162Mitochondrial mechanisms of redox cycling agents implicated in Parkinson's disease
Q42180022Modulation of Neuronal Survival Factor MEF2 by Kinases in Parkinson's Disease
Q21563375Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria

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