Telaprevir: a novel NS3/4 protease inhibitor for the treatment of hepatitis C.

scientific article published on October 2011

Telaprevir: a novel NS3/4 protease inhibitor for the treatment of hepatitis C. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1592/PHCO.31.10.951
P698PubMed publication ID21950642
P5875ResearchGate publication ID51676691

P50authorStephen VickeryQ59166446
P2093author name stringJacqueline L Olin
Lisa S Smith
Olga M Klibanov
Shannon H Williams
P2860cites workBoceprevir for previously treated chronic HCV genotype 1 infectionQ24620576
Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitroQ27472610
Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine proteaseQ27473126
SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cellsQ27473129
Phenotypic Characterization of Resistant Val36 Variants of Hepatitis C Virus NS3-4A Serine ProteaseQ27485288
Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patientsQ27487949
Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alphaQ27645411
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infectionQ27860901
Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trialQ27860949
Replication of hepatitis C virusQ27860957
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearanceQ28255243
Peginterferon Alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV-infected patientsQ28274666
Peginterferon Alfa-2a plus ribavirin versus interferon alfa-2a plus ribavirin for chronic hepatitis C in HIV-coinfected personsQ28274676
Pegylated interferon alfa-2b vs standard interferon alfa-2b, plus ribavirin, for chronic hepatitis C in HIV-infected patients: a randomized controlled trialQ28298301
Diagnosis, management, and treatment of hepatitis C: an updateQ29619682
Telaprevir for retreatment of HCV infectionQ29619799
Telaprevir for previously untreated chronic hepatitis C virus infectionQ29619800
The prevalence of hepatitis C virus infection in the United States, 1999 through 2002Q29619974
Boceprevir for untreated chronic HCV genotype 1 infectionQ29620617
Telaprevir for previously treated chronic HCV infectionQ34109057
Peginterferon alfa-2b and ribavirin for the treatment of chronic hepatitis C in blacks and non-Hispanic whitesQ34323105
Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infectionQ34607097
Pharmacokinetics of peginterferonsQ35204875
The hepatitis C virus life cycle as a target for new antiviral therapiesQ36813367
Hepatitis C: viral and host factors associated with non-response to pegylated interferon plus ribavirin.Q37772959
New direct-acting antivirals in the development for hepatitis C virus infectionQ37823323
Hepatitis C and progression of HIV diseaseQ39607141
Mutations conferring resistance to a potent hepatitis C virus serine protease inhibitor in vitroQ40882812
Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trialQ42943536
Antiviral effects and safety of telaprevir, peginterferon alfa-2a, and ribavirin for 28 days in hepatitis C patientsQ42978510
Telaprevir and peginterferon with or without ribavirin for chronic HCV infectionQ42987218
In vitro studies of cross-resistance mutations against two hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061.Q42994273
The impact of interferon plus ribavirin on response to therapy in black patients with chronic hepatitis C. The International Hepatitis Interventional Therapy GroupQ43000743
Telaprevir is effective given every 8 or 12 hours with ribavirin and peginterferon alfa-2a or -2b to patients with chronic hepatitis C.Q43001141
Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase Ib, placebo-controlled, randomized studyQ43032179
Effect of ribavirin in genotype 1 patients with hepatitis C responding to pegylated interferon alfa-2a plus ribavirinQ43032187
Hepatitis C Virus prevalence among patients infected with Human Immunodeficiency Virus: a cross-sectional analysis of the US adult AIDS Clinical Trials GroupQ43036483
Hepatitis C Virus Infection in Patients Infected with the Human Immunodeficiency VirusQ43039164
Pharmacokinetic enhancement of the hepatitis C virus protease inhibitors VX-950 and SCH 503034 by co-dosing with ritonavirQ43039208
Antiviral activity of telaprevir (VX-950) and peginterferon alfa-2a in patients with hepatitis C.Q43040809
Influence of coinfection with hepatitis C virus on morbidity and mortality due to human immunodeficiency virus infection in the era of highly active antiretroviral therapyQ43041935
Hepatitis C virus co-infection is a negative prognostic factor for clinical evolution in human immunodeficiency virus-positive patientsQ45741644
Coinfection of hepatitis C virus with human immunodeficiency virus and progression to AIDS. Italian Seroconversion Study.Q45788301
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)951-974
P577publication date2011-10-01
P1433published inPharmacotherapyQ7180800
P1476titleTelaprevir: a novel NS3/4 protease inhibitor for the treatment of hepatitis C
P478volume31

Reverse relations

cites work (P2860)
Q34709772In Silico screening on the three-dimensional model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compound
Q37699271MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo
Q38095820Telaprevir: clinical pharmacokinetics, pharmacodynamics, and drug-drug interactions

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