The use of cultured epithelial and endothelial cells for drug transport and metabolism studies

scientific article published on May 1990

The use of cultured epithelial and endothelial cells for drug transport and metabolism studies is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1023/A:1015800312910
P698PubMed publication ID2195492

P2093author name stringR T Borchardt
K L Audus
I J Hidalgo
R L Bartel
P2860cites workMetabolism of tobacco-specific nitrosamines by cultured rat nasal mucosaQ71788724
Endothelial cell cultures derived from isolated cerebral microvesselsQ72424293
Isolation and Characterization of Brain Endothelial Cells: Morphology and Enzyme ActivityQ72444752
Enhancement of rectal absorption of insulin using salicylates in dogsQ72551025
Cell proliferation studies in the intestinal epithelium of the rat. I. Determination of the kinetic parametersQ72577948
Cell proliferation studies in the intestinal epithelium of the rat II. Theoretical aspectsQ72577952
Structural and functional aspects of cells in the nasal mucociliary systemQ72587986
Changes in keratin gene expression during terminal differentiation of the keratinocyteQ72609330
Chapter 2 Identification and Culture of Human Bronchial Epithelial CellsQ72616975
Intrinsic and extrinsic regulation of the differentiation of skin, corneal and esophageal epithelial cellsQ72619924
Structure-activity relationships of retinoids in hamster tracheal organ cultureQ72622083
Metabolism of benzo[a]pyrene and DNA adduct formation in cultured human epidermal keratinocytesQ72643866
Primary culture of capillary endothelium from rat brainQ72894785
A tissue culture technique for growing corneal epithelial, stromal, and endothelial tissues separatelyQ78413318
Culture of human nasal epithelial cells on collagen matrix supports. A comparison of bioelectric properties of normal and cystic fibrosis epitheliaQ93656541
One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice23Q28294341
Expression and intracellular transport of microvillus membrane hydrolases in human intestinal epithelial cellsQ28636987
Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cellsQ29614425
Growth of cultured human epidermal cells into multiple epithelia suitable for graftingQ33979849
Isolation and characterization of endothelial cells from rat and cow brain white matterQ34039442
Permeability of oral mucosaQ34042997
Tight junction dynamics: is paracellular transport regulated?Q34049445
The Reconstitution of Living SkinQ34055289
Capacity for energy metabolism in microvessels isolated from rat brainQ34055360
Human stratum corneum lipids: characterization and regional variationsQ34271278
Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeabilityQ34561438
Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayersQ34567309
Loosening tight junctions. Lessons from the intestineQ34569725
Transepithelial transport of epidermal growth factor by absorptive cells of suckling rat ileumQ35575217
Hematopoietic growth factor production by cultured cells of human nasal polyp epithelial scrapings: kinetics, cell source, and relationship to clinical statusQ35848869
Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteriaQ36200458
Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: further evidence that the cytoskeleton may influence paracellular permeability and junctional charge selectivityQ36215124
Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cellsQ36217700
Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-cultureQ36220333
A simplified technique for the short-term tissue culture of rabbit corneal cellsQ36417063
HT-29 cells are an in vitro model for the generation of cell polarity in epithelia during embryonic differentiationQ37480275
The human colon carcinoma cell lines HT-29 and Caco-2: two in vitro models for the study of intestinal differentiationQ39591706
The epidermal permeability barrierQ39644186
Computer-aided drug designQ39767340
Methods for Cultivation of Keratinocytes with an Air-Liquid InterfaceQ40107150
Phenotypic expression of epidermal cells in vitro: a reviewQ40151465
Cyclic nucleotides in rabbit corneal endothelial cells: Fresh tissue vs. tissue cultureQ40223663
Cerebral microvessels and derived cells in tissue culture: Isolation and preliminary characterizationQ40285716
In vitro penetration of tritiated dextrans through rabbit oral mucosaQ40330134
Characterization of bile acid absorption across the unstirred water layer and brush border of the rat jejunumQ40528124
Cultured epithelial cells of cornea, conjunctiva and skin: absence of marked intrinsic divergence of their differentiated statesQ40658138
The permeability barrier in mammalian epidermisQ41314701
Keratin filaments of cultured human epidermal cells. Formation of intermolecular disulfide bonds during terminal differentiationQ41377299
Carrier-mediated transport of baclofen across monolayers of bovine brain endothelial cells in primary cultureQ41419038
Structural basis for physiological regulation of paracellular pathways in intestinal epitheliaQ41442657
Studies on drug absorption from oral cavity: physicochemical factors affecting absorption from hamster cheek pouchQ41470296
Demonstration of acid hydrolase activity in primary cultures of bovine brain microvessel endotheliumQ41790532
Effect of growth and sodium butyrate on brush border membrane-associated hydrolases in human colorectal cancer cell lines.Q53759908
Rabbit corneal endothelial cell surface glycoproteins.Q53760717
Isolation and long-term culture of rat, rabbit, and human nasal turbinate epithelial cells.Q53817714
Effect of hydrocortisone on corneal endothelial cells in vitro.Q54217840
Epithelial properties of human colonic carcinoma cell line Caco-2: electrical parameters.Q54469239
Electrical properties of dog tracheal epithelial cells grown in monolayer cultureQ54478847
γ-Glutamyl Transpeptidase in Isolated Brain Endothelial Cells: Induction by Glial Cells in VitroQ55491040
Metabolic characterization of isolated cerebral microvessels: ATP and ADP concentrationsQ58108543
Biochemical Evidence for Keratinization by Mouse Epidermal Cells in CultureQ67015683
Ultrastructural changes in contents of membrane-coating granules after extrusion from epithelial cells of hamster cheek pouchQ67288874
The mammalian cutaneous permeability barrier: defective barrier function is essential fatty acid deficiency correlates with abnormal intercellular lipid depositionQ67437829
Membrane coating granules: The fate of the discharged lamellaeQ67445244
Isolation and long-term cultivation of human corneal endothelial cellsQ67954878
Cultured human and canine endothelial cells from brain microvesselsQ68020785
The in vitro permeability of skin and buccal mucosa to selected drugs and tritiated waterQ68289583
Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the ratQ68541193
Effect of pentagastrin on adult rat duodenal cells in cultureQ68664379
Fluid-phase endocytosis by primary cultures of bovine brain microvessel endothelial cell monolayersQ68730242
Effect of in vivo carcinogen exposure on colony formation and growth of hamster buccal pouch keratinocytes in cultureQ68958643
Adult human keratinocytes migrating over nonviable dermal collagen produce collagenolytic enzymes that degrade type I and type IV collagenQ68971542
Macromolecules can pass through occluding junctions of rat ileal epithelium during cholinergic stimulationQ68985661
The growth and structure of human oral keratinocytes in cultureQ68985846
Taurocholate transport by human ileal brush border membrane vesiclesQ69005246
Macromolecular metabolism of a differentiated rat keratinocyte culture system following exposure to sulfur mustardQ69024949
Differentiation of normal and tumoral human keratinocytes cultured on dermis: reconstruction of either normal or tumoral architectureQ69033228
Lipid composition of cultured human keratinocytes in relation to their differentiationQ69036768
Penetration of water through human and rabbit oral mucosa in vitroQ69063257
Growth of human corneal endothelial cells in cultureQ69175664
Characterization of gamma-glutamyl transpeptidase activity of cultured endothelial cells from porcine brain capillariesQ69369408
The permeability of skin and oral mucosa to water and horseradish peroxidase as related to the thickness of the permeability barrierQ69381251
Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigsQ69394232
Chemical injury to an in vitro ocular system: differential release of plasminogen activatorQ69544460
Epidermal permeability barrier: transformation of lamellar granule-disks into intercellular sheets by a membrane-fusion process, a freeze-fracture studyQ69572245
Intracellular Cl- activity and cellular Cl- pathways in cultured human airway epitheliumQ69607249
Cellular Cl- transport in cultured cystic fibrosis airway epitheliumQ69607250
Transport of vasopressin fragments across the blood-brain barrier: in vitro studies using monolayer cultures of bovine brain endothelial cellsQ69630267
Metabolism of catecholamine esters by cultured bovine brain microvessel endothelial cellsQ69653625
The effect of epinephrine and benzalkonium chloride on cultured corneal endothelial and trabecular meshwork cellsQ69677771
Permeability and mechanism of albumin, cationized albumin, and glycosylated albumin transcellular transport across monolayers of cultured bovine brain capillary endothelial cellsQ69684839
Substrate specificity of phenol sulfotransferase from primary cultures of bovine brain microvessel endotheliumQ69727948
Characterization of specific receptors for atrial natriuretic factor on cultured bovine brain capillary endothelial cellsQ69844058
Enterocytic differentiation of a subpopulation of the human colon tumor cell line HT-29 selected for growth in sugar-free medium and its inhibition by glucoseQ69880878
Effects of fibroblastic and endothelial extracellular matrices on corneal endothelial cellsQ69886427
Growth and differentiation of human nasal epithelial cells in culture. Serum-free, hormone-supplemented medium and proteoglycan synthesisQ69903230
Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenateQ69945085
The transport of leucine and aminocyclopentanecarboxylate across the intact, energy-depleted rat blood-brain barrierQ69954979
Growth and differentiation of primary rat keratinocytes on synthetic membranesQ70017248
A tissue culture assay of corneal epithelial wound closureQ70118538
Sucrase-isomaltase: A marker of foetal and malignant epithelial cells of the human colonQ70282308
Toxic effects of two dental materials on human buccal epithelium in vitro and monkey buccal mucosa in vivoQ70371801
Cell attachment, growth characteristics and surface morphology of human upper-respiratory tract epithelium cultured on extracellular matrixQ70441066
Altered rabbit endothelial cell phenotypic expression in response to human fibronectinQ70537080
Ultrastructure of human nasal mucosaQ71110390
Human epidermal lipids: characterization and modulations during differentiationQ71689525
Binding of epidermal growth factor by human colon carcinoma cell (Caco-2) monolayersQ41913083
Establishment of a rat nasal epithelial tumor cell lineQ41967835
Human corneal endothelial cells: isolation, characterization and long-term cultivationQ42126729
Clotrimazole, an inhibitor of benzo[a]pyrene metabolism and its subsequent glucuronidation, sulfation, and macromolecular binding in BALB/c mouse cultured keratinocytesQ42222108
Benzo(a)pyrene metabolism in primary cultures of mouse epidermal cells and untransformed and transformed epidermal cell linesQ42245612
Ellagic acid: a potent naturally occurring inhibitor of benzo[a]pyrene metabolism and its subsequent glucuronidation, sulfation and covalent binding to DNA in cultured BALB/C mouse keratinocytesQ42247137
Synthesis of a collagenous basal membrane by rabbit corneal endothelial cells in vitroQ42440754
Different populations of pig epidermal cells: isolation and lipid compositionQ42448609
A technique for obtaining sheets of intact rabbit corneal epitheliumQ42467668
Ion contents and other properties of isolated cells from dog tracheal epitheliumQ42471775
Lamellar granule extrusion and stratum corneum intercellular lamellae in murine keratinocyte culturesQ42488632
Thermolysin treatment: a new method for dermo-epidermal separationQ42496606
Enterocytic differentiation and glucose utilization in the human colon tumor cell line Caco-2: modulation by forskolinQ42506949
Ciliated cells in vitamin A-deprived cultured hamster tracheal epithelium do divideQ42513814
Reconstitution of human epidermis in vitro is accompanied by transient activation of basal keratinocyte spreadingQ42523828
A novel cell line (Caco-2) for the study of intestinal lipoprotein synthesisQ42526651
Shunt resistance and ion permeabilities in normal and cystic fibrosis airway epitheliaQ42645983
Density-dependent variations in the lipid content and metabolism of cultured human keratinocytesQ42803550
Clonal growth of epithelial cells from normal adult human bronchusQ42826833
Cultured buccal epithelium: an in vitro model derived from the hamster pouch for studying drug transport and metabolismQ43573479
Polarized secretion of newly synthesized lipoproteins by the Caco-2 human intestinal cell lineQ43710445
Enhancement of blood-brain barrier permeability to sodium fluorescein by stimulation of mu opioid receptors in miceQ44343222
Evidence for the presence of viable endothelial cells in cultures derived from dissociated rat brainQ44621060
Murine keratinocyte cultures grown at the air/medium interface synthesize stratum corneum lipids and "recycle" linoleate during differentiationQ44660850
Sodium and potassium saturation kinetics of Na+K+-ATPase in plasma membranes from corneal endothelium: fresh tissue vs. tissue cultureQ44950888
Voltage-gated chloride currents in cultured canine tracheal epithelial cellsQ45126262
Tracheobronchial epithelium of the sheep: IV. Lectin histochemical characterization of secretory epithelial cells.Q46009883
Lipid content and metabolism of human keratinocyte cultures grown at the air-medium interfaceQ46318808
Separation and use of enterocytesQ46485656
Expression of high molecular weight (67K) keratin in human keratinocytes cultured on dead de-epidermized dermisQ47207617
The permeability of keratinized and nonkeratinized oral epithelium to horseradish peroxidaseQ47999429
Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation.Q48003784
Aluminum effects on growth of brain microvessel endothelial cells in primary cultureQ48090745
Characteristics of aminopeptidase activity from bovine brain microvessel endotheliumQ48172803
Culture of mouse brain capillary endothelial cell lines that express factor VIII, gamma-glutamyl transpeptidase, and form junctional complexes in vitroQ48190960
Tight junctions of brain endothelium in vitro are enhanced by astroglia.Q48197798
Bovine brain microvessel endothelial cell monolayers as a model system for the blood-brain barrierQ48241067
Characteristics of the large neutral amino acid transport system of bovine brain microvessel endothelial cell monolayersQ48314899
Catecholamine-metabolizing enzymes of bovine brain microvessel endothelial cell monolayersQ48341288
Establishment and preliminary growth characteristics of a transformed mouse cerebral microvessel endothelial cell lineQ48352076
Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolismQ48356189
Long-term serial cultivation of arterial and capillary endothelium from adult bovine brainQ48518329
Brain microvessel endothelial cells in tissue culture: a model for study of blood-brain barrier permeabilityQ48729747
In-vitro characterization of blood-brain barrier permeability to delta sleep-inducing peptideQ48934159
Studies on microsomal cytochrome P-450, monooxygenases and epoxide hydrolase in cultured keratinocytes and intact epidermis from BALB/C miceQ50213116
The application of bovine brain microvessel endothelial-cell monolayers grown onto polycarbonate membranes in vitro to estimate the potential permeability of solutes through the blood-brain barrier.Q50590761
In vitro drug absorption models. I. Brush border membrane vesicles, isolated mucosal cells and everted intestinal rings: characterization and salicylate accumulation.Q50913350
Effect of salicylate on the rectal absorption of lidocaine, levodopa, and cefmetazole in rats.Q51860134
Beta-adrenergic and serotonergic responsiveness of rabbit corneal epithelial cells in culture.Q52280459
Corneal epithelial wound closure in tissue culture: an in vitro model of ocular irritancy.Q52600856
The establishment of strains of human cells in tissue culture.Q52831945
Regulation of lipid synthesis in relation to keratinocyte differentiation capacity.Q53526801
P433issue5
P921main subjectendotheliumQ111140
P304page(s)435-451
P577publication date1990-05-01
P1433published inPharmaceutical ResearchQ7180737
P1476titleThe use of cultured epithelial and endothelial cells for drug transport and metabolism studies
P478volume7

Reverse relations

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