Targeting the HER2 pathway for the therapy of lower esophageal and gastric adenocarcinoma

scientific article published on 04 October 2011

Targeting the HER2 pathway for the therapy of lower esophageal and gastric adenocarcinoma is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1517/14656566.2011.605354
P698PubMed publication ID21967344

P2093author name stringConstantin A Dasanu
Antarpreet Kaur
P2860cites workHumanization of an anti-p185HER2 antibody for human cancer therapyQ24561842
Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancerQ27851553
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trialQ27851578
Untangling the ErbB signalling networkQ27860884
Role of receptor tyrosine kinases in gastric cancer: new targets for a selective therapyQ28242840
EGF receptorQ28646107
Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancerQ33389302
Assessing HER2 gene amplification as a potential target for therapy in invasive urothelial bladder cancer with a standardized methodology: results in 1005 patients.Q33751191
Kinase inhibitors in cancer therapy: a look aheadQ33897202
Phase I trial of the trifunctional anti-HER2 x anti-CD3 antibody ertumaxomab in metastatic breast cancerQ34527500
Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab.Q34554455
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapiesQ35179415
HER1/EGFR targeting: refining the strategyQ35644830
The role of HER2/neu expression and trastuzumab in non-small cell lung cancerQ35674579
Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancerQ35809752
The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factorsQ36334739
Targeting EGFR and HER-2 with cetuximab- and trastuzumab-mediated immunotherapy in oesophageal squamous cell carcinomaQ36611021
Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinomaQ36696088
Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell lineQ36911274
A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analysesQ37054957
Assessment of a HER2 scoring system for gastric cancer: results from a validation studyQ37142266
HER2 in gastric cancer: a new prognostic factor and a novel therapeutic targetQ37149210
Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapyQ37163797
Cardiotoxicity profile of trastuzumabQ37165488
Recent advances in systemic therapy: Advances in systemic therapy for HER2-positive metastatic breast cancerQ37360162
AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivoQ39745596
Trastuzumab in gastric cancerQ39864629
Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling.Q40216149
HER-2/neu amplification is an independent prognostic factor in gastric cancer.Q40303656
Trastuzumab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinomaQ40401124
Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptorQ41067751
Targeted HER2 treatment in advanced gastric cancerQ43148962
In vitro chemo- and radio-resistance in small cell lung cancer correlates with cell adhesion and constitutive activation of AKT and MAP kinase pathwaysQ44250297
Correlation of c-erbB-2 protein expression and lymph node status in early gastric cancerQ44265943
Prognostic significance of p53, nm23, PCNA and c-erbB-2 in gastric cancerQ44480885
Expression of the HER1-4 family of receptor tyrosine kinases in breast cancerQ44503047
Protein overexpression and gene amplification of HER-2 and EGFR in colorectal cancers: an immunohistochemical and fluorescent in situ hybridization studyQ47604705
A randomized, phase II, dose-finding study of the pan-ErbB receptor tyrosine-kinase inhibitor CI-1033 in patients with pretreated metastatic breast cancer.Q51763771
HER-2 amplification is highly homogenous in gastric cancer.Q51779078
2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial.Q53243856
Genetic alterations in gastric cancer: relation to histological subtypes, tumor stage, and Helicobacter pylori infection.Q53443853
EGFR family expression in breast carcinomas. c-erbB-2 and c-erbB-4 receptors have different effects on survival.Q53810400
Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma.Q54398738
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectadenocarcinomaQ356033
P304page(s)2493-2503
P577publication date2011-10-04
P1433published inExpert Opinion on PharmacotherapyQ5421212
P1476titleTargeting the HER2 pathway for the therapy of lower esophageal and gastric adenocarcinoma
P478volume12

Reverse relations

cites work (P2860)
Q36770491Correlation of human epidermal growth factor receptor 2 expression with clinicopathological characteristics and prognosis in gastric cancer
Q35998729Evaluation of Trastuzumab Anti-Tumor Efficacy and its Correlation with HER-2 Status in Patient-Derived Gastric Adenocarcinoma Xenograft Models
Q41205623Expression and prognostic value of HER-2/neu in primary breast cancer with sentinel lymph node metastasis
Q51219045Genetics of gastric cancer.
Q47764668Impact of HER2 expression on outcome in gastric cancer patients with liver metastasis
Q38075499Metastatic gastric cancer treatment: a little slow but worthy progress
Q95728277Prevalence of HER2 Expression and Its Correlation with Clinicopathological Parameters in Gastric or Gastroesophageal Junction Adenocarcinoma in North-East Indian Population
Q34222369Whole exome sequencing of pediatric gastric adenocarcinoma reveals an atypical presentation of Li-Fraumeni syndrome

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