Thromboxane A2 receptor: biology and function of a peculiar receptor that remains resistant for therapeutic targeting.

scientific article

Thromboxane A2 receptor: biology and function of a peculiar receptor that remains resistant for therapeutic targeting. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1177/1074248411424145
P698PubMed publication ID22064668

P50authorJohn P MuradQ56997598
P2093author name stringFadi T Khasawneh
Harold J Ting
Enma V P Espinosa
P2860cites workDifferential Suppression of Thromboxane Biosynthesis by Indobufen and Aspirin in Patients With Unstable AnginaQ58230345
BM 13.177, A SELECTIVE BLOCKER OF PLATELET AND VESSEL WALL THROMBOXANE RECEPTORS, IS ACTIVE IN MANQ58481581
Aggregation of Blood Platelets by Adenosine Diphosphate and its ReversalQ59065336
Cloning and expression of cDNA for a human thromboxane A2 receptorQ24311759
G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase CQ24324791
COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expressionQ24536398
Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutationQ24562692
Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formationQ24596717
Antithrombotic effects of S 18886, a novel orally active thromboxane A2 receptor antagonistQ28167658
Role of prostacyclin in the cardiovascular response to thromboxane A2Q28192832
Improved endothelial function by the thromboxane A2 receptor antagonist S 18886 in patients with coronary artery disease treated with aspirinQ28195607
Mapping of a ligand-binding site for the human thromboxane A2 receptor proteinQ28205029
G13-mediated signaling as a potential target for antiplatelet drugsQ28211909
Molecular analysis of the interaction between the intracellular loops of the human serotonin receptor type 6 (5-HT6) and the alpha subunit of GS proteinQ28237275
Apigenin inhibits platelet adhesion and thrombus formation and synergizes with aspirin in the suppression of the arachidonic acid pathwayQ28276490
Mechanism of action of fibrates on lipid and lipoprotein metabolismQ28288187
GR32191, a highly potent and specific thromboxane A2 receptor blocking drug on platelets and vascular and airways smooth muscle in vitroQ28341988
Evidence that phospholipase delta1 is the effector in the Gh (transglutaminase II)-mediated signalingQ28571919
Inositol trisphosphate, a novel second messenger in cellular signal transductionQ29618048
The role of protein kinase C in cell surface signal transduction and tumour promotionQ29618532
Thromboxane and the thromboxane receptor in cardiovascular diseaseQ33899567
An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitroQ34185192
GAPs for rho-related GTPasesQ34319579
Aspirin as an antiplatelet drugQ34338650
Signaling and regulation of the platelet glycoprotein Ib-IX-V complexQ34616663
Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamideQ34986893
Acetylation of prostaglandin synthase by aspirinQ35085661
Heterodimerization of the alpha and beta isoforms of the human thromboxane receptor enhances isoprostane signalingQ35579014
Roles of G-protein-coupled receptor dimerizationQ35622424
Thromboxane, prostacyclin and isoprostanes: therapeutic targets in atherogenesisQ36294176
Antagonism of thromboxane receptors by diclofenac and lumiracoxibQ36358638
From the design to the clinical application of thromboxane modulatorsQ36419627
Protease activated receptors: clinical relevance to hemostasis and inflammationQ36720123
Site-directed mutagenesis of cysteinyl and serine residues of human thromboxane A2 receptor in insect cellsQ36823316
Characterization of isoprostane signaling: evidence for a unique coordination profile of 8-iso-PGF(2alpha) with the thromboxane A(2) receptor, and activation of a separate cAMP-dependent inhibitory pathway in human plateletsQ37010020
Aspirin resistance: focus on clinical endpointsQ37334879
13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptorQ37341093
Prevention of nonsteroidal anti-inflammatory drug-induced gastropathy.Q37370008
Determinants of bleeding risk in patients on antithrombotic and antifibrinolytic drugs.Q37392176
The thromboxane/endoperoxide receptor (TP): the common villainQ37737688
Antiplatelet drugs--do we need new options? With a reappraisal of direct thromboxane inhibitorsQ37738868
Platelets at work in primary hemostasis.Q37865759
Thromboxane, prostaglandin and leukotriene receptorsQ38272494
Differential signaling by the thromboxane receptor isoforms via the novel GTP-binding protein, Gh.Q38325669
Repurposing an old drug for a new use: glybenclamide exerts antiplatelet activity by interacting with the thromboxane A(2) receptorQ39019862
The opsin family of proteinsQ39480645
Clinical implications of prostaglandin and thromboxane A2 formation (2).Q39519430
Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomesQ40133308
Differential mapping of the amino acids mediating agonist and antagonist coordination with the human thromboxane A2 receptor proteinQ40256331
The G12 family of G proteins as a reporter of thromboxane A2 receptor activityQ40328440
Oligomerization of the alpha and beta isoforms of the thromboxane A2 receptor: relevance to receptor signaling and endocytosisQ40422541
Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generationQ40506646
Effect of genistein and daidzein on platelet aggregation and monocyte and endothelial functionQ40651409
Antiarrhythmic drugs and torsade de pointesQ40807714
Phosphorylation of the thromboxane receptor alpha, the predominant isoform expressed in human platelets.Q40978901
Expression and tissue distribution of the mRNAs encoding the human thromboxane A2 receptor (TP) alpha and beta isoformsQ40990740
Role of proaggregatory and antiaggregatory prostaglandins in hemostasis. Studies with combined thromboxane synthase inhibition and thromboxane receptor antagonismQ41015991
Mutagenic analysis of platelet thromboxane receptor cysteines. Roles in ligand binding and receptor-effector couplingQ41216013
Further evidence that thromboxane exacerbates arrhythmias: effects of UK38485 during coronary artery occlusion and reperfusion in anaesthetized greyhoundsQ41572758
14-3-3zeta interacts with human thromboxane receptors and is involved in the agonist-induced activation of the extracellular-signal-regulated kinaseQ42170095
Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3′-pyridinylmethyl)benzofuran-2-carboxylateQ42246687
Suppression of thromboxane A2 but not of systemic prostacyclin by controlled-release aspirinQ42472257
Labeling of human platelet plasma membrane thromboxane A2/prostaglandin H2 receptors using SQB, a novel biotinylated receptor probeQ42554632
Functional comparison of the antagonistic properties of some Angiotensin II type 1 receptor blockers on the contraction elicited by Angiotensin II and thromboxane A2 on human saphenous veins.Q42602291
Glybenclamide: an antidiabetic with in vivo antithrombotic activityQ42880731
Activity of a novel dual thromboxane A(2)receptor antagonist and thromboxane synthase inhibitor (BM-573) on platelet function and isolated smooth musclesQ43730032
Angiotensin receptor blocker losartan suppresses platelet activity by interfering with thromboxane signalingQ43860082
Angiotensin II AT1 receptor antagonists inhibit platelet adhesion and aggregation by nitric oxide releaseQ44167942
Pharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet functionQ44284991
Identification of residues important for ligand binding of thromboxane A2 receptor in the second extracellular loop using the NMR experiment-guided mutagenesis approachQ44292843
TRA-418, a novel compound having both thromboxane A(2) receptor antagonistic and prostaglandin I(2) receptor agonistic activities: its antiplatelet effects in human and animal plateletsQ44545094
Characterization of a new compound, S-145, as a specific TXA2 receptor antagonist in plateletsQ44730150
Structural and functional characterization of the first intracellular loop of human thromboxane A2 receptorQ44786762
Mutational analysis of the highly conserved ERY motif of the thromboxane A2 receptor: alternative role in G protein-coupled receptor signaling.Q44960382
Factor XI interacts with the leucine-rich repeats of glycoprotein Ibalpha on the activated plateletQ45064186
Effects of KP-496, a novel dual antagonist for cysteinyl leukotriene receptor 1 and thromboxane A2 receptor, on Sephadex-induced airway inflammation in rats.Q45989071
Antithrombotic and antiplatelet activities of fenofibrate, a lipid-lowering drugQ46061444
A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoidsQ46307406
Effect of inhibitors of arachidonic acid conversion in platelets on thrombin-fibrinogen interaction and thrombin toleranceQ46472175
The Lsc RhoGEF mediates signaling from thromboxane A2 to actin polymerization and apoptosis in thymocytesQ46482145
The specific thromboxane receptor antagonist S18886: pharmacokinetic and pharmacodynamic studies.Q46566202
Coupling interaction between thromboxane A2 receptor and alpha-13 subunit of guanine nucleotide-binding proteinQ46741746
Gbeta 5gamma 2 is a highly selective activator of phospholipid-dependent enzymes.Q52972449
P433issue3
P304page(s)248-259
P577publication date2011-11-07
P1433published inJournal of Cardiovascular Pharmacology and TherapeuticsQ1855644
P1476titleThromboxane A2 receptor: biology and function of a peculiar receptor that remains resistant for therapeutic targeting
P478volume17

Reverse relations

cites work (P2860)
Q35772240Brain changes associated with thromboxane receptor antagonist SQ 29,548 treatment in a mouse model
Q34389439Impact of vascular thromboxane prostanoid receptor activation on hemostasis, thrombosis, oxidative stress, and inflammation.
Q30360845Invited review: GPCR structural characterization: Using fragments as building blocks to determine a complete structure.
Q42017198Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists
Q27023818Primary Nephrotic Syndrome in Adults as a Risk Factor for Pulmonary Embolism: An Up-to-Date Review of the Literature
Q38899898Regulation of inflammation by lipid mediators in oral diseases
Q90227640Structural basis for ligand recognition of the human thromboxane A2 receptor
Q58794697TBXA2R gene variants associated with bleeding
Q46974995The association of thromboxane A2 receptor with lipid rafts is a determinant for platelet functional responses
Q41002708Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration

Search more.