Prognostic implications of genetic aberrations in acute myelogenous leukemia with normal cytogenetics

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Prognostic implications of genetic aberrations in acute myelogenous leukemia with normal cytogenetics is …
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scholarly articleQ13442814

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P356DOI10.1002/AJH.22197
P698PubMed publication ID22072438
P5875ResearchGate publication ID51785907

P2093author name stringImad A Tabbara
Hady Ghanem
Niki Tank
P2860cites workDominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemiaQ24290910
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Recurring mutations found by sequencing an acute myeloid leukemia genomeQ24634204
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Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotypeQ27824827
RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 yearsQ27824840
Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutationsQ27824843
Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotypeQ27824844
Implications of NRAS mutations in AML: a study of 2502 patientsQ27824859
Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).Q27824861
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Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B.Q27851460
Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML.Q27851476
Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B studyQ27851545
Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factorQ27851558
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Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemiaQ27851562
Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic valueQ27851569
IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 statusQ27851581
TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B studyQ27851621
Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome.Q45929224
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Elevated expression of the AF1q gene, an MLL fusion partner, is an independent adverse prognostic factor in pediatric acute myeloid leukemiaQ47290549
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Elevated AF1q expression is a poor prognostic marker for adult acute myeloid leukemia patients with normal cytogeneticsQ47935030
BAALC is an important predictor of refractoriness to chemotherapy and poor survival in intermediate-risk acute myeloid leukemia (AML).Q48396875
BAALC expression and FLT3 internal tandem duplication mutations in acute myeloid leukemia patients with normal cytogenetics: prognostic implicationsQ48684574
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The clinical significance of karyotype in acute myelogenous leukemia.Q53408893
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Quantitative monitoring of NPM1 mutations provides a valid minimal residual disease parameter following allogeneic stem cell transplantation.Q54501898
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High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated.Q54546717
WT1 mutation in 470 adult patients with acute myeloid leukemia: stability during disease evolution and implication of its incorporation into a survival scoring system.Q54682896
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Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1)Q57740694
The prognostic significance of IDH2 mutations in AML depends on the location of the mutationQ27851649
TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogeneticsQ27851661
High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patientsQ28209409
Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)Q28209814
The protein Id: a negative regulator of helix-loop-helix DNA binding proteinsQ28237471
A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERGQ28252253
Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell linesQ28281211
Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemiasQ28301353
A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.Q33716570
IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B studyQ33897586
The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription.Q34175340
Cytogenetics in acute leukemiaQ34304230
The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation.Q34418458
The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trialQ34517235
The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the UniteQ34517403
Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosisQ34523534
BAALC and ERG expression levels are associated with outcome and distinct gene and microRNA expression profiles in older patients with de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B studyQ34541748
No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials.Q34559865
Age and acute myeloid leukemiaQ34564663
Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1.Q34568861
Patients with acute myeloid leukemia and RAS mutations benefit most from postremission high-dose cytarabine: a Cancer and Leukemia Group B studyQ34593276
MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.Q34627288
Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemiaQ34630212
A clinical overview of WT1 gene mutationsQ34738955
Genetics of myeloid leukemiasQ34795893
Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcomeQ34930673
Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B studyQ35839909
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.Q36141686
Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML.Q36303442
Comparison of autologous stem cell transplantation versus consolidation chemotherapy for patients with cytogenetically normal acute myeloid leukemia (CN-AML) and FLT3ITD.Q36390379
Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutationQ36498807
Nucleophosmin and cancerQ36516405
Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical featuresQ36606696
High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CALQ36677320
Influence of new molecular prognostic markers in patients with karyotypically normal acute myeloid leukemia: recent advancesQ36719212
The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesisQ36831216
Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cellsQ36843769
Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasisQ37089529
Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B StudyQ37119445
Prognostic implications of gene mutations in acute myeloid leukemia with normal cytogeneticsQ37240557
The role of multiparameter flow cytometry for detection of minimal residual disease in acute myeloid leukemia.Q37354544
Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B studyQ38319029
Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission.Q38343881
Prognostic value of minimal residual disease quantification by real-time reverse transcriptase polymerase chain reaction in patients with core binding factor leukemiasQ38347392
Single nucleotide polymorphism in the mutational hotspot of WT1 predicts a favorable outcome in patients with cytogenetically normal acute myeloid leukemiaQ38347620
FLT3 inhibition as therapy in acute myeloid leukemia: a record of trials and tribulationsQ39513601
Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: a study from the German-Austrian acute myeloid leukemia study groupQ39752289
EVI1 induces myelodysplastic syndrome in miceQ39951095
Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancerQ40599938
Role of NADP+-dependent isocitrate dehydrogenase (NADP+-ICDH) on cellular defence against oxidative injury by gamma-raysQ42820711
The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD statusQ42962021
Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association groupQ42972388
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplicationQ43010371
A novel prognostic model in elderly patients with acute myeloid leukemia: results of 909 patients entered into the prospective AML96 trialQ43074202
Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation.Q43185220
Sensitive measurement of quantity dynamics of FLT3 internal tandem duplication at early time points provides prognostic informationQ43649404
Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: the results of the United Kingdom Medical Research Council AML11 trialQ43718516
Integrative prognostic risk score in acute myeloid leukemia with normal karyotypeQ43816333
High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogeneticsQ44034346
Molecular stratification model for prognosis in cytogenetically normal acute myeloid leukemiaQ44073895
Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitQ44142819
Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm.Q44189526
Quantitative real-time RT-PCR analysis of PML-RAR alpha mRNA in acute promyelocytic leukemia: assessment of prognostic significance in adult patients from intergroup protocol 0129.Q44240279
Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.Q44401465
BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: a Cancer and Leukemia Group B StudyQ44443179
Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemiaQ44646947
Variable prognostic value of FLT3 internal tandem duplications in patients with de novo AML and a normal karyotype, t(15;17), t(8;21) or inv(16).Q44758612
Phase III study of all-trans retinoic acid in previously untreated patients 61 years or older with acute myeloid leukemiaQ45073090
ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: a comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarraysQ45113427
Risk assessment in patients with acute myeloid leukemia and a normal karyotypeQ45299096
High Id1 expression is associated with poor prognosis in 237 patients with acute myeloid leukemia.Q45915572
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
P304page(s)69-77
P577publication date2011-11-10
P1433published inAmerican Journal of HematologyQ4744246
P1476titlePrognostic implications of genetic aberrations in acute myelogenous leukemia with normal cytogenetics
P478volume87

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cites work (P2860)
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