Telavancin for the treatment of serious gram-positive infections, including hospital acquired pneumonia

scientific article published on December 2011

Telavancin for the treatment of serious gram-positive infections, including hospital acquired pneumonia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1517/14656566.2011.633511
P698PubMed publication ID22077833

P50authorEthan RubinsteinQ16105613
G Ralph CoreyQ115862748
Martin E StryjewskiQ115862786
P2093author name stringZeina A Kanafani
P2860cites workRed man syndromeQ21195101
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Pharmacokinetics, serum inhibitory and bactericidal activity, and safety of telavancin in healthy subjectsQ33554391
Efficacy of telavancin (TD-6424), a rapidly bactericidal lipoglycopeptide with multiple mechanisms of action, in a murine model of pneumonia induced by methicillin-resistant Staphylococcus aureusQ34077052
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Telavancin versus standard therapy for treatment of complicated skin and skin structure infections caused by gram-positive bacteria: FAST 2 studyQ34509652
Telavancin versus vancomycin for hospital-acquired pneumonia due to gram-positive pathogensQ34699108
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Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United StatesQ36744770
Impact of BAL data on the therapy and outcome of ventilator-associated pneumoniaQ36856249
Relationship between vancomycin MIC and failure among patients with methicillin-resistant Staphylococcus aureus bacteremia treated with vancomycinQ36870858
Interpretation of antibiotic concentration ratios measured in epithelial lining fluidQ36936597
Telavancin: an antimicrobial with a multifunctional mechanism of action for the treatment of serious gram-positive infectionsQ37117865
Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenoQ37144809
Identifying exposure targets for treatment of staphylococcal pneumonia with ceftobiproleQ37274678
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Concentrations in plasma, epithelial lining fluid, alveolar macrophages and bronchial mucosa after a single intravenous dose of 1.6 mg/kg of iclaprim (AR-100) in healthy men.Q37859444
Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infectionQ38371341
Telavancin penetration into human epithelial lining fluid determined by population pharmacokinetic modeling and Monte Carlo simulationQ39686295
In vitro activity of TD-6424 against Staphylococcus aureusQ40130630
Increased vancomycin MICs for Staphylococcus aureus clinical isolates from a university hospital during a 5-year periodQ41066970
Efficacy of Telavancin in a rabbit model of aortic valve endocarditis due to methicillin-resistant Staphylococcus aureus or vancomycin-intermediate Staphylococcus aureusQ41814975
Efficacy of telavancin against penicillin-resistant pneumococci and Staphylococcus aureus in a rabbit meningitis model and determination of kinetic parametersQ41831644
Telavancin disrupts the functional integrity of the bacterial membrane through targeted interaction with the cell wall precursor lipid II.Q42049579
Mass balance and pharmacokinetics of [14C]telavancin following intravenous administration to healthy male volunteersQ42576977
Pharmacodynamic effects of telavancin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains in the presence of human albumin or serum and in an in vitro kinetic modelQ42627265
Integrated Analysis of FOCUS 1 and FOCUS 2: Randomized, Doubled‐Blinded, Multicenter Phase 3 Trials of the Efficacy and Safety of Ceftaroline Fosamil versus Ceftriaxone in Patients with Community‐Acquired PneumoniaQ42822939
Telavancin activity against Gram-positive bacteria isolated from respiratory tract specimens of patients with nosocomial pneumoniaQ42905478
Comparison of tigecycline with imipenem/cilastatin for the treatment of hospital-acquired pneumoniaQ42905606
Activity of telavancin and comparator antimicrobial agents tested against Staphylococcus spp. isolated from hospitalised patients in Europe (2007-2008).Q42991022
Effect of Telavancin on the pharmacokinetics of the cytochrome P450 3A probe substrate midazolam: a randomized, double-blind, crossover study in healthy subjectsQ43184655
Telavancin versus standard therapy for treatment of complicated skin and soft-tissue infections due to gram-positive bacteriaQ43553034
Comparative killing kinetics of the novel des-fluoro(6) quinolone BMS-284756, fluoroquinolones, vancomycin and beta-lactamsQ43681777
Risk factors and treatment outcomes in osteomyelitisQ43727524
Intrapulmonary penetration of linezolidQ44440587
Penetration of vancomycin into human lung tissueQ44470518
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Comparative in vitro activity of telavancin (TD-6424), a rapidly bactericidal, concentration-dependent anti-infective with multiple mechanisms of action against Gram-positive bacteriaQ44803993
Single-dose pharmacokinetics and tolerability of telavancin in elderly men and womenQ44935039
Effects of a new antibacterial, telavancin, on cardiac repolarization (QTc interval duration) in healthy subjectsQ44938149
Linezolid and vancomycin for methicillin-resistant Staphylococcus aureus nosocomial pneumonia: the subtleties of subgroup analysesQ44975087
Hydrophobic vancomycin derivatives with improved ADME properties: discovery of telavancin (TD-6424).Q45013095
High-dose vancomycin therapy for methicillin-resistant Staphylococcus aureus infections: efficacy and toxicityQ45302930
Lack of effect of moderate hepatic impairment on the pharmacokinetics of telavancinQ46489824
Inhibition of daptomycin by pulmonary surfactant: in vitro modeling and clinical impactQ46494181
Telavancin: in vitro activity against staphylococci in a biofilm modelQ46561648
Pharmacokinetics and intrapulmonary concentrations of linezolid administered to critically ill patients with ventilator-associated pneumoniaQ46589068
Effects of prior effective therapy on the efficacy of daptomycin and ceftriaxone for the treatment of community-acquired pneumoniaQ46620650
Telavancin versus vancomycin for the treatment of complicated skin and skin-structure infections caused by gram-positive organismsQ46620675
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectpneumoniaQ12192
hospital-acquired infectionQ215509
gram-positive bacteriaQ857288
P304page(s)2737-2750
P577publication date2011-12-01
P1433published inExpert Opinion on PharmacotherapyQ5421212
P1476titleTelavancin for the treatment of serious gram-positive infections, including hospital acquired pneumonia
P478volume12

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cites work (P2860)
Q34390763Efficacy and safety of telavancin in clinical trials: a systematic review and meta-analysis.
Q33429168Safety profiles of old and new antimicrobials for the treatment of MRSA infections.
Q28078557Systematic Review and Meta-Analysis of the Efficacy and Safety of Telavancin for Treatment of Infectious Disease: Are We Clearer?
Q38522574Telavancin (VIBATIV) for the treatment of complicated skin and skin structure infections
Q35905561Telavancin for the treatment of nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA).
Q33788308Telavancin: a novel semisynthetic lipoglycopeptide agent to counter the challenge of resistant Gram-positive pathogens
Q38159966Telavancin: a review of its use in patients with nosocomial pneumonia
Q34433066Vancomycin revisited - 60 years later

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