Cholesteryl ester transfer protein inhibition to reduce cardiovascular risk: where are we now?

scientific article published on November 14, 2011

Cholesteryl ester transfer protein inhibition to reduce cardiovascular risk: where are we now? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.TIPS.2011.07.004
P953full work available online athttps://api.elsevier.com/content/article/PII:S0165614711001350?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0165614711001350?httpAccept=text/xml
P698PubMed publication ID22088767

P2093author name stringKerry-Anne Rye
Philip Barter
P2860cites workA prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderlyQ23913851
Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levelsQ24562095
Safety and tolerability of dalcetrapib (RO4607381/JTT-705): results from a 48-week trialQ24648125
Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health StudyQ24649155
Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trialQ28236480
Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapibQ28240147
Effect of torcetrapib on the progression of coronary atherosclerosisQ28295023
Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemiaQ28295044
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trialsQ29617910
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Intensive versus moderate lipid lowering with statins after acute coronary syndromesQ29619716
Transfers and exchanges of esterified cholesterol between plasma lipoproteinsQ34662113
HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular eventsQ34693837
Major lipids, apolipoproteins, and risk of vascular diseaseQ35771393
Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosteroneQ36736504
Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary riskQ37193386
Rationale and design of dal-VESSEL: a study to assess the safety and efficacy of dalcetrapib on endothelial function using brachial artery flow-mediated vasodilatationQ38497153
Mechanisms underlying off-target effects of the cholesteryl ester transfer protein inhibitor torcetrapib involve L-type calcium channelsQ39700827
Torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibitionQ39891782
Inhibition of CETP activity by torcetrapib reduces susceptibility to diet-induced atherosclerosis in New Zealand White rabbitsQ40166036
A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbitsQ40866383
Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapibQ42562376
Safety of Anacetrapib in Patients with or at High Risk for Coronary Heart DiseaseQ42807626
Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibitionQ43201715
Rationale and design of the dal-OUTCOMES trial: efficacy and safety of dalcetrapib in patients with recent acute coronary syndrome.Q43230598
Lessons learned from the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) trialQ43246793
Cholesteryl ester transfer protein inhibition, high-density lipoprotein raising, and progression of coronary atherosclerosis: insights from ILLUSTRATE (Investigation of Lipid Level Management Using Coronary Ultrasound to Assess Reduction of AtheroscQ46231225
Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL.Q53569234
Increased atherosclerosis in ApoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expressionQ54419966
Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer proteinQ59070155
A Low Prevalence of Coronary Heart Disease among Subjects with Increased High-Density Lipoprotein Cholesterol Levels, Including Those with Plasma Cholesteryl Ester Transfer Protein DeficiencyQ61962950
Differences in plasma cholesteryl ester transfer activity in sixteen vertebrate speciesQ70283890
Effect of Antisense Oligonucleotides against Cholesteryl Ester Transfer Protein on the Development of Atherosclerosis in Cholesterol-fed RabbitsQ74230827
Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosisQ74290884
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectcirculatory systemQ11068
P304page(s)694-699
P577publication date2011-11-14
P1433published inTrends in Pharmacological SciencesQ2451474
P1476titleCholesteryl ester transfer protein inhibition to reduce cardiovascular risk: Where are we now?
Cholesteryl ester transfer protein inhibition to reduce cardiovascular risk: where are we now?
P478volume32

Reverse relations

cites work (P2860)
Q34658086A Mechanistic Systems Pharmacology Model for Prediction of LDL Cholesterol Lowering by PCSK9 Antagonism in Human Dyslipidemic Populations
Q57118481Alterations in gut microbial function following liver transplant
Q61800652Apolipoprotein A-I enhances insulin-dependent and insulin-independent glucose uptake by skeletal muscle
Q44749348Assessing the mechanisms of cholesteryl ester transfer protein inhibitors.
Q38546242Current Treatment of Dyslipidemia: Evolving Roles of Non-Statin and Newer Drugs
Q37118772Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR‐knockout mice
Q36037988Molecular mechanisms of vascular effects of High‐density lipoprotein: alterations in cardiovascular disease
Q37254899Molecular sources of residual cardiovascular risk, clinical signals, and innovative solutions: relationship with subclinical disease, undertreatment, and poor adherence: implications of new evidence upon optimizing cardiovascular patient outcomes
Q35477219New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity
Q97521140Plasma lipidomic biomarker analysis reveals distinct lipid changes in vascular dementia
Q35034769Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease
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Q30155210Structural features of cholesteryl ester transfer protein: a molecular dynamics simulation study
Q35958413The inhibition of cholesteryl ester transfer protein: a long and winding road
Q38122628Validating therapeutic targets through human genetics

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