APC as a mobile scaffold: regulation and function at the nucleus, centrosomes, and mitochondria

scientific article published on 09 December 2011

APC as a mobile scaffold: regulation and function at the nucleus, centrosomes, and mitochondria is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/IUB.599
P698PubMed publication ID22162224
P5875ResearchGate publication ID51871766

P2093author name stringManisha Sharma
Kate Mills
Beric R Henderson
Christina Lui
Mariana G Brocardo
P2860cites workThe many ways of Wnt in cancerQ36701583
Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epitheliaQ36850782
A novel function of adenomatous polyposis coli (APC) in regulating DNA repairQ36977775
Oncogenes and tumour suppressors take on centrosomesQ37001380
APC shuttling to the membrane, nucleus and beyondQ37291638
Role of APC and its binding partners in regulating microtubules in mitosisQ37635941
The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminusQ39418451
Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coliQ39985730
Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survivalQ40030761
Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of APC in apoptosisQ40171605
Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent mannerQ40190301
Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability.Q40488542
Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonateQ40490855
The APC protein binds to A/T rich DNA sequencesQ42478800
Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnoverQ42796363
Mitotic spindle misorientation in cancer--out of alignment and into the fireQ47793757
Microtubule assembly by the Apc protein is regulated by importin-beta--RanGTP.Q51915518
Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC.Q52002352
The APC tumour suppressor has a nuclear export function.Q52582485
Truncated APC is required for cell proliferation and DNA replication.Q53638372
The APC Tumor Suppressor Promotes Transcription-Independent Apoptosis In vitroQ58918633
Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasmQ24290419
A role for the Adenomatous Polyposis Coli protein in chromosome segregationQ24291074
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosisQ24293237
Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entryQ27324750
Aneuploid colon cancer cells have a robust spindle checkpointQ28343940
Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarityQ28568803
APC nuclear membrane association and microtubule polarityQ28570942
Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stressQ33496409
Novel association of APC with intermediate filaments identified using a new versatile APC antibodyQ33511677
Adenomatous polyposis coli protein regulates the cellular response to DNA replication stressQ33929860
ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A.Q34093651
Redefining the subcellular location and transport of APC: new insights using a panel of antibodies.Q34166592
LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins.Q34521711
APC, signal transduction and genetic instability in colorectal cancerQ34568154
A Nup133-dependent NPC-anchored network tethers centrosomes to the nuclear envelope in prophase.Q34637848
The ins and outs of APC and beta-catenin nuclear transportQ34838428
Nup358 interacts with APC and plays a role in cell polarizationQ34995571
Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli proteinQ35818475
Adenomatous polyposis coli and EB1 localize in close proximity of the mother centriole and EB1 is a functional component of centrosomes.Q36012450
Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein.Q36075807
Versatility at the nuclear pore complex: lessons learned from the nucleoporin Nup153.Q36245336
The mitochondrial protein hTID-1 partners with the caspase-cleaved adenomatous polyposis cell tumor suppressor to facilitate apoptosisQ36541337
Wnt signalling and the actin cytoskeletonQ36672682
P433issue3
P921main subjectmitochondrionQ39572
P304page(s)209-214
P577publication date2011-12-09
P1433published inIUBMB LifeQ15764029
P1476titleAPC as a mobile scaffold: regulation and function at the nucleus, centrosomes, and mitochondria
P478volume64

Reverse relations

cites work (P2860)
Q36574676APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane
Q37464115Cell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc.
Q42760874Characterization of Adenomatous Polyposis Coli Protein Dynamics and Localization at the Centrosome.
Q34612194Gas2l3, a novel constriction site-associated protein whose regulation is mediated by the APC/C Cdh1 complex
Q37585218Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice
Q36853315Interaction between APC and Fen1 during breast carcinogenesis
Q64968927Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters.
Q39105478Metabolic zonation of the liver: The oxygen gradient revisited.
Q38514865Shaping of interphase chromosomes by the microtubule network.
Q34654741Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy
Q26774420The Ran Pathway in Drosophila melanogaster Mitosis
Q42865710α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes
Q38117291β-catenin at the centrosome: discrete pools of β-catenin communicate during mitosis and may co-ordinate centrosome functions and cell cycle progression

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