Possibility of a new anti-alzheimer's disease pharmaceutical composition combining memantine and vitamin D.

scientific article published on February 2012

Possibility of a new anti-alzheimer's disease pharmaceutical composition combining memantine and vitamin D. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1015567489
P356DOI10.2165/11597550-000000000-00000
P698PubMed publication ID22233455

P50authorCédric AnnweilerQ30762971
Olivier BeauchetQ61628802
P2860cites workAlzheimer's disease--input of vitamin D with mEmantine assay (AD-IDEA trial): study protocol for a randomized controlled trialQ21203743
Alzheimer's DiseaseQ22248111
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The effects of vitamin D receptor silencing on the expression of LVSCC-A1C and LVSCC-A1D and the release of NGF in cortical neuronsQ33847890
Parvalbumin increases in the caudate putamen of rats with vitamin D hypervitaminosisQ33859664
Microglia activation and anti-inflammatory regulation in Alzheimer's diseaseQ33943873
Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worseQ34007194
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell culturesQ34032447
New clues about vitamin D functions in the nervous systemQ34118382
Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicityQ34260540
The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's diseaseQ34268122
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Vitamin D-mentia: randomized clinical trials should be the next step.Q50978800
Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of AβPP transgenic mice.Q51016105
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A Novel Perspective for Alzheimer's Disease: Vitamin D Receptor Suppression by Amyloid-β and Preventing the Amyloid-β Induced Alterations by Vitamin D in Cortical NeuronsQ52604567
High prevalence of vitamin D deficiency and reduced bone mass in elderly women with Alzheimer's disease.Q53225654
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Profile of French community-dwelling older adults supplemented with vitamin D: Findings and lessonsQ56088923
SEVERE VITAMIN D DEFICIENCY IS ASSOCIATED WITH ADVANCED-STAGE DEMENTIA IN GERIATRIC INPATIENTSQ56088925
25-hydroxyvitamin D, 24, 25-dihydroxyvitamin D and 1,25-dihydroxyvitamin D in human cerebrospinal fluidQ70230440
Amyloid-beta promotes calcium influx and neurodegeneration via stimulation of L voltage-sensitive calcium channels rather than NMDA channels in cultured neuronsQ74736159
Association between vitamin D receptor gene polymorphism and Alzheimer's diseaseQ80528542
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Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseasesQ34606186
Coupling of the NMDA receptor to neuroprotective and neurodestructive eventsQ35012580
1α,25-Dihydroxyvitamin D3 enhances cerebral clearance of human amyloid-β peptide(1-40) from mouse brain across the blood-brain barrier.Q35183393
Glutamatergic systems in Alzheimer's disease.Q35218753
Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficitsQ35234934
Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's diseaseQ35246412
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Neurosteroid hormone vitamin D and its utility in clinical nutritionQ36672359
Vitamin D and human health: lessons from vitamin D receptor null mice.Q36973933
Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction?Q37023280
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Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer diseaseQ37156208
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Excitatory amino acid neurotoxicity and neurodegenerative diseaseQ37989602
Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genesQ38323931
A radical hypothesis for neurodegenerationQ40385988
Developmental Vitamin D3 deficiency alters the adult rat brain.Q40447667
Vitamin D3 and brain developmentQ40652918
Does oxidative stress participate in nerve cell death in Parkinson's disease?Q40848260
Vitamin D(3) attenuates cortical infarction induced by middle cerebral arterial ligation in ratsQ40896377
1Alpha, 25 dihydroxyvitamin D3-dependent up-regulation of calcium-binding proteins in motoneuron cellsQ41068068
Nitric oxide actions in neurochemistryQ41136024
1,25-Dihydroxyvitamin D3 is a potent inducer of nerve growth factor synthesisQ41703229
Apoptotic signals within the basal forebrain cholinergic neurons in Alzheimer's diseaseQ42482311
1,25-Dihydroxyvitamin D3 regulates the expression of the low-affinity neurotrophin receptor.Q42552926
25-hydroxyvitamin D in cerebrospinal fluid during relapse and remission of multiple sclerosisQ43266202
Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons.Q43517443
Protective effects of 1 alpha,25-(OH)(2)D(3) against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic cultureQ43614886
Cell biology. Apoptosis--the calcium connection.Q44391381
Treatment of experimental autoimmune encephalomyelitis in rat by 1,25-dihydroxyvitamin D3 leads to early effects within the central nervous systemQ44391600
1,25-dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons.Q44448707
1,25-Dihydroxyvitamin D3 treatment results in increased choline acetyltransferase activity in specific brain nucleiQ44545860
NMDA application potentiates synaptic transmission in the hippocampusQ44731160
Maternal vitamin D3 deprivation and the regulation of apoptosis and cell cycle during rat brain developmentQ45089334
Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.Q45288480
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer diseaseQ45883058
1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients.Q46015814
Higher serum vitamin D3 levels are associated with better cognitive test performance in patients with Alzheimer's diseaseQ46575382
1,25-dihydroxyvitamin D3 regulates the synthesis of nerve growth factor in primary cultures of glial cells.Q48096904
Expression of inducible nitric oxide synthase during rat brain inflammation: regulation by 1,25-dihydroxyvitamin D3.Q48524232
1,25-Dihydroxyvitamin D3 inhibits the expression of inducible nitric oxide synthase in rat central nervous system during experimental allergic encephalomyelitisQ48720312
P433issue2
P921main subjectAlzheimer's diseaseQ11081
vitaminQ34956
vitamin DQ175621
P304page(s)81-91
P577publication date2012-02-01
P1433published inDrugs & AgingQ5308946
P1476titlePossibility of a new anti-alzheimer's disease pharmaceutical composition combining memantine and vitamin D.
P478volume29

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cites work (P2860)
Q364135483,5,4'-trihydroxy-6,7,3'-trimethoxyflavone protects against beta amyloid-induced neurotoxicity through antioxidative activity and interference with cell signaling
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Q37522446Vitamin D supplements: a novel therapeutic approach for Alzheimer patients
Q53353882[Vitamin D and Alzheimer's disease: from an intriguing idea to a therapeutic option].

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