Significance of tissue levels for prediction of antibiotic efficacy and determination of dosage

scientific article published on July 1990

Significance of tissue levels for prediction of antibiotic efficacy and determination of dosage is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/BF01964293
P698PubMed publication ID2226482

P2093author name stringC Carbon
P2860cites workThe relation between plasma and tissue concentrations of antibiotics. Description of a method.Q52599244
Absence of a postantibiotic effect in experimental Pseudomonas endocarditis treated with imipenem, with or without gentamicin.Q53749985
Correlates of therapeutic efficacy in experimental methicillin-resistant Staphylococcus aureus endocarditis.Q54393192
Simultaneous antibiotic levels in "breakthrough" gram-negative rod bacteremiaQ54608322
Benefit from high intrarenal levels of gentamicin in the treatment of E. coli pyelonephritis.Q54774748
Interstitial diffusion and accumulation of cephalothin according to various modes of intermittent administration to rabbitsQ67378718
Binding of antibiotics to a soluble protein from rat liverQ68682514
Dual individualization: antibiotic dosage calculation from the integration of in-vitro pharmacodynamics and in-vivo pharmacokineticsQ70073527
Disturbed intrarenal distribution of gentamicin in experimental pyelonephritis due to Escherichia coliQ70255014
In vivo postantibiotic effect in a thigh infection in neutropenic miceQ70370760
Principles of tissue penetration of antibioticsQ71044069
The influence of protein binding upon tissue fluid levels of six beta-lactam antibioticsQ71270451
Postantibiotic suppression of bacterial growthQ71543981
Treatment of experimental chronic osteomyelitis due to staphylococcus aureus with vancomycin and rifampinQ71668173
Effect of schedule of administration on the therapeutic efficacy of penicillin; importance of the aggregate time penicillin remains at effectively bactericidal levelsQ75452931
Studies on the relationship of tissue fluid and blood levels of penicillinQ75895541
Correlation of in vitro time-kill curves and kinetics of bacterial killing in cerebrospinal fluid during ceftriaxone therapy of experimental Escherichia coli meningitisQ30451339
Interaction of purulent material with antibiotics used to treat Pseudomonas infectionsQ34698744
Comparative efficacy of cefotiam, cefmenoxime, and ceftriaxone in experimental endocarditis and correlation with pharmacokinetics and in vitro efficacyQ35538447
Value of antibiotic levels in serum and cardiac vegetations for predicting antibacterial effect of ceftriaxone in experimental Escherichia coli endocarditisQ35542849
Comparative activities of ciprofloxacin and ceftazidime against Klebsiella pneumoniae in vitro and in experimental pneumonia in leukopenic ratsQ35543546
Influence of four modes of administration on penetration of aztreonam, cefuroxime, and ampicillin into interstitial fluid and fibrin clots and on in vivo efficacy against Haemophilus influenzaeQ35646823
Intrarenal concentrations of ampicillin in acute pyelonephritisQ35669567
Significance of Serum Protein and Tissue Binding of Antimicrobial AgentsQ37034927
Tissue penetration of antibioticsQ39733571
Pharmacokinetics and inflammatory fluid penetration of cefpodoxime proxetil in volunteersQ39815334
Pharmacokinetics and bacteriological efficacy of cefoperazone, ceftriaxone, and moxalactam in experimental Streptococcus pneumoniae and Haemophilus influenzae meningitisQ39856486
Dosage schedules of antimicrobial agents: a historical review.Q40350770
The antibacterial effects of low concentrations of antibiotics and host defence factors: a reviewQ40357179
Gentamicin intravenous infusion rate: effect on interstitial fluid concentrationQ40948418
Pharmacokinetics of gentamicin in the treatment of renal infection: A therapeutic anomaly explainedQ41135716
Evaluation of antibiotic diffusion into cardiac vegetations by quantitative autoradiographyQ41265449
Integration of Selected Pharmacologic and Microbiologic Properties of Three New -Lactam Antibiotics: A Hypothesis for Rational ComparisonQ41561127
Comparative antibiotic dose-effect relations at several dosing intervals in murine pneumonitis and thigh-infection modelsQ42169493
Treatment of experimental chronic osteomyelitis due to Staphylococcus aureus with teicoplaninQ43662138
"Continuous" vs. "discontinuous" therapy with penicillin; the effect of the interval between injections on therapeutic efficacyQ44157139
Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentrationQ44483617
Bacampicillin in acute exacerbations of chronic bronchitis--a dose-range studyQ44487609
Increased nephrotoxicity of gentamicin in pyelonephritic ratsQ44560841
Experimental Osteomyelitis. IV. Therapeutic Trials with Rifampin Alone and in Combination with Gentamicin, Sisomicin, and CephalothinQ46510301
P433issue7
P304page(s)510-516
P577publication date1990-07-01
P1433published inEuropean Journal of Clinical Microbiology & Infectious DiseasesQ15754378
P1476titleSignificance of tissue levels for prediction of antibiotic efficacy and determination of dosage
P478volume9

Reverse relations

cites work (P2860)
Q40087019Animal models in the evaluation of antimicrobial agents
Q34774058Clinical role of protein binding of quinolones
Q35609700Efficacy and safety of tamsulosin in the treatment of urological diseases
Q39471451Gastric penetration of amoxicillin in a human Helicobacter pylori-infected xenograft model.
Q43949659Penetration of prulifloxacin into sinus mucosa of patients undergoing paranasal sinus elective endoscopic surgery
Q35609667Pharmacodynamics of antibiotics in the respiratory tree
Q35688447Pharmacokinetic and pharmacodynamic issues in the treatment of bacterial infectious diseases
Q72507930Pharmacokinetics and suction blister fluid penetration of a semisynthetic injectable streptogramin RP 59500 (RP 57669/ RP 54476)
Q35661686Single-dose antibiotic therapy: what has the past taught us?
Q34804885The pharmacokinetic-pharmacodynamic approach to a rational dosage regimen for antibiotics

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