Stimulating axonal regeneration of mature retinal ganglion cells and overcoming inhibitory signaling

scientific article published on July 2012

Stimulating axonal regeneration of mature retinal ganglion cells and overcoming inhibitory signaling is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00441-011-1302-7
P698PubMed publication ID22293973
P5875ResearchGate publication ID221795201

P2093author name stringDietmar Fischer
P2860cites workPromoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathwayQ24644113
Glial inhibition of CNS axon regenerationQ24648851
Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1Q28144424
Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowthQ28204972
Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowthQ28216797
NgR RNA interference, combined with zymosan intravitreal injection, enhances optic nerve regeneration.Q45941078
Activated retinal glia promote neurite outgrowth of retinal ganglion cells via apolipoprotein E.Q46042909
Crystallins of the beta/gamma-superfamily mimic the effects of lens injury and promote axon regeneration.Q46820887
Different factors promote axonal regeneration of adult rat retinal ganglion cells after lens injury and intravitreal peripheral nerve graftingQ46854857
Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivoQ46897884
Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation.Q46923165
Ciliary neurotrophic factor is an axogenesis factor for retinal ganglion cellsQ48264237
Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivoQ48333202
Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult ratsQ48364946
CNTF promotes the regrowth of retinal ganglion cell axons into murine peripheral nerve graftsQ49012737
Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration.Q50668696
Regeneration beyond the glial scarQ28239915
Neurite outgrowth of mature retinal ganglion cells and PC12 cells requires activity of CK1δ and CK1εQ28573292
Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cellsQ28576390
Retinal ganglion cells do not extend axons by default: promotion by neurotrophic signaling and electrical activityQ28577774
Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactionsQ30484049
Overcoming macrophage-mediated axonal dieback following CNS injuryQ30491369
Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injuryQ30513561
Ocular neuroprotection by siRNA targeting caspase-2Q34192944
Nogo and axon regenerationQ34305577
Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion.Q34402481
Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS.Q35209949
Intrinsic neuronal regulation of axon and dendrite growth.Q35909227
Neuronal intrinsic barriers for axon regeneration in the adult CNS.Q37736896
Facilitating axon regeneration in the injured CNS by microtubules stabilization.Q37941706
Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation.Q38335683
Neuroprotective and axon growth promoting effects of intraocular inflammation do not depend on oncomodulin or the presence of large numbers of activated macrophagesQ40049702
ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cellsQ40146314
Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neuronsQ40248012
GDNF, Ret, GFRalpha1 and 2 in the adult rat retino-tectal system after optic nerve transectionQ40555790
Dose-dependent rescue of axotomized rat retinal ganglion cells by adenovirus-mediated expression of glial cell-line derived neurotrophic factor in vivo.Q40654725
Neurturin enhances the survival of axotomized retinal ganglion cells in vivo: combined effects with glial cell line-derived neurotrophic factor and brain-derived neurotrophic factorQ40743424
Effects of GDNF on retinal ganglion cell survival following axotomyQ41024849
Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growthQ41440802
Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerveQ42519727
What are the principal mediators of optic nerve regeneration after inflammatory stimulation in the eye?Q42912630
SOCS3 deletion promotes optic nerve regeneration in vivo.Q42949909
Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukemia inhibitory factorQ43244105
Stimulation of axon regeneration in the mature optic nerve by intravitreal application of the toll-like receptor 2 agonist Pam3Cys.Q43297236
Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo.Q43409496
Lens-injury-stimulated axonal regeneration throughout the optic pathway of adult ratsQ43804604
GM-CSF regulates the ERK1/2 pathways and protects injured retinal ganglion cells from induced deathQ44020853
Single cell RT-PCR analysis of tyrosine kinase receptor expression in adult rat retinal ganglion cells isolated by retinal sandwichingQ44216374
Immunohistochemical localization of CNTFRalpha in adult mouse retina and optic nerve following intraorbital nerve crush: evidence for the axonal loss of a trophic factor receptor after injuryQ44243398
Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axonsQ44321301
Cooperative effects of bcl-2 and AAV-mediated expression of CNTF on retinal ganglion cell survival and axonal regeneration in adult transgenic miceQ44321384
Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivoQ44492922
Cytokine-induced SOCS expression is inhibited by cAMP analogue: impact on regeneration in injured retinaQ44597893
Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF.Q44668186
Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injuryQ44686144
Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state.Q44770108
Ciliary neurotrophic factor and its receptors are differentially expressed in the optic nerve transected adult rat retina.Q44933380
Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats.Q45249968
Long-term in vivo inhibition of CNS neurodegeneration by Bcl-XL gene transferQ45280303
AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cellsQ45858441
Post-injury delivery of rAAV2-CNTF combined with short-term pharmacotherapy is neuroprotective and promotes extensive axonal regeneration after optic nerve traumaQ45872683
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectretinal ganglion cellQ927337
P304page(s)79-85
P577publication date2012-07-01
P1433published inCell and Tissue ResearchQ1524113
P1476titleStimulating axonal regeneration of mature retinal ganglion cells and overcoming inhibitory signaling
P478volume349

Reverse relations

cites work (P2860)
Q86666621Chapter 5 - Restoring Vision to the Blind: Endogenous Regeneration
Q38777316Exploring Optic Nerve Axon Regeneration
Q39019470Hyper-IL-6: a potent and efficacious stimulator of RGC regeneration
Q41949608Inflammatory stimulation preserves physiological properties of retinal ganglion cells after optic nerve injury.
Q37681884Ischemic injury leads to extracellular matrix alterations in retina and optic nerve.
Q48107051Microglia Are Irrelevant for Neuronal Degeneration and Axon Regeneration after Acute Injury.
Q37620258Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System.
Q38086746Neurotrophic molecules in the treatment of neurodegenerative disease with focus on the retina: status and perspectives
Q44539786Regulation and effects of GDF-15 in the retina following optic nerve crush
Q42104651Spatiotemporal alterations of presynaptic elements in the retina after high intraocular pressure
Q37129730Synergetic effects of ciliary neurotrophic factor and olfactory ensheathing cells on optic nerve reparation (complete translation)
Q47120318Tenascins in Retinal and Optic Nerve Neurodegeneration.
Q35805868The Acquisition of Target Dependence by Developing Rat Retinal Ganglion Cells(1,2,3).
Q91762184The role of muscle LIM protein in the nervous system

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