BRAFmutation testing in clinical practice

scientific article published on March 1, 2012

BRAFmutation testing in clinical practice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1586/ERM.12.1
P953full work available at URLhttp://www.future-drugs.com/doi/abs/10.1586/erm.12.1
http://www.tandfonline.com/doi/pdf/10.1586/erm.12.1
P698PubMed publication ID22369373

P2093author name stringPei Hui
James Ziai
P2860cites workCancer ResearchQ326097
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BRAF mutation testing of thyroid fine-needle aspiration specimens enhances the predictability of malignancy in thyroid follicular lesions of undetermined significanceQ82885422
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Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAFQ24298749
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactionsQ24532168
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activationQ24534094
BRAF mutations in hairy-cell leukemiaQ24609980
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulationQ24629474
Improved survival with vemurafenib in melanoma with BRAF V600E mutationQ24631953
Targeting BRAF in thyroid cancerQ24653496
Differential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanismsQ24674150
MEK1 mutations confer resistance to MEK and B-RAF inhibitionQ27777362
Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancerQ27824825
Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancerQ27851456
BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutationQ27851610
Inhibition of Mutated, Activated BRAF in Metastatic MelanomaQ27860458
Mutations of the BRAF gene in human cancerQ27860760
Determinants of BRAF mutations in primary melanomasQ28191720
Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancersQ28206482
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAFQ28251989
Colorectal cancer due to deficiency in DNA mismatch repair function: a reviewQ28262308
Detection of BRAF V600E mutation by pyrosequencingQ28277357
Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerizationQ28287759
Guilty as charged: B-RAF is a human oncogeneQ28288202
MEK kinase activity is not necessary for Raf-1 functionQ28362229
B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouseQ28476616
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3KQ29614757
Distinct sets of genetic alterations in melanomaQ29614965
BRAFE600-associated senescence-like cell cycle arrest of human naeviQ29619550
Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation statusQ29619648
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)Q29620033
Rapid, efficient genotyping of clinical tumor samples by laser-capture microdissection/PCR/SSCP.Q30663120
Mutations of the BRAF gene in benign and malignant melanocytic lesionsQ33196532
Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma.Q33296950
Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signalingQ33613978
The use of COLD-PCR and high-resolution melting analysis improves the limit of detection of KRAS and BRAF mutations in colorectal cancer.Q34084873
Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancerQ34094717
BRAF V600E maintains proliferation, transformation, and tumorigenicity of BRAF-mutant papillary thyroid cancer cellsQ34123904
High frequency of BRAF mutations in neviQ34160519
BRAF mutation is rare in advanced-stage low-grade ovarian serous carcinomasQ34162272
BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomasQ34543110
High prevalence and possible de novo formation of BRAF mutation in metastasized papillary thyroid cancer in lymph nodes.Q34559036
BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancerQ34560988
BRAF mutation is a powerful prognostic factor in advanced and recurrent colorectal cancerQ34621860
Utility of BRAF V600E mutation detection in cytologically indeterminate thyroid nodulesQ34690607
Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problemsQ34998994
Clinical Characteristics of Patients With Lung Adenocarcinomas Harboring BRAF MutationsQ35023498
BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor siteQ35024230
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BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testingQ35446668
Application of a BRAF pyrosequencing assay for mutation detection and copy number analysis in malignant melanomaQ35988122
Detection of BRAF V600E activating mutation in papillary thyroid carcinoma using PCR with allele-specific fluorescent probe melting curve analysisQ36172170
Distinct clinical and pathological features are associated with the BRAF(T1799A(V600E)) mutation in primary melanomaQ36679188
The mouse B-raf gene encodes multiple protein isoforms with tissue-specific expression.Q36681724
BRAFV600E mutation is associated with preferential sensitivity to mitogen-activated protein kinase kinase inhibition in thyroid cancer cell linesQ36732681
BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implicationsQ36972859
Therapeutic strategies for targeting BRAF in human cancerQ37161265
BRAF mutation testing of thyroid fine-needle aspiration biopsy specimens for preoperative risk stratification in papillary thyroid cancerQ37242277
Targeting BRAF for patients with melanoma.Q37817713
Molecular analysis of thyroid tumorsQ37860130
Potential Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant CancersQ37866945
Diagnostic value of pyrosequencing for the BRAF V600E mutation in ultrasound-guided fine-needle aspiration biopsy samples of thyroid incidentalomas.Q38501157
BRAF mutations in non-Hodgkin's lymphomaQ38603361
Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.Q39568646
The brothers RAF.Q39742018
Braf(V600E) cooperates with Pten loss to induce metastatic melanomaQ39873596
Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanomaQ39971699
Selective growth inhibition in BRAF mutant thyroid cancer by the mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244.Q40079043
Tumor necrosis factor-alpha blocks apoptosis in melanoma cells when BRAF signaling is inhibitedQ40185394
Mutational analysis of BRAF and K-ras in gastric cancers: absence of BRAF mutations in gastric cancersQ40630939
Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytomaQ42636358
BRAF targeted therapy changes the treatment paradigm in melanomaQ42733647
KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trialQ43250046
Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells.Q43251079
Absence of exon 15 BRAF germline mutations in familial melanomaQ44347453
Germline mutation in BRAF codon 600 is compatible with human development: de novo p.V600G mutation identified in a patient with CFC syndromeQ44394416
BRAF and KRAS mutations in stomach cancerQ44611189
Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells.Q45917382
The prevalence and prognostic value of BRAF mutation in thyroid cancerQ46200580
BRAF T1796A transversion mutation in various thyroid neoplasms.Q47998621
A new technology for mutation detectionQ51647425
Selection of patients with germline MLH1 mutated Lynch syndrome by determination of MLH1 methylation and BRAF mutationQ51772302
Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodulesQ51847642
Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancerQ51916596
Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancerQ52846071
Molecular Characterization of 103 Ovarian Serous and Mucinous TumorsQ53292665
Consistent absence of BRAF mutations in cervical and endometrial cancer despite KRAS mutation status.Q53352988
BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumorsQ53356308
BRAF mutation in endometrial carcinoma and hyperplasia: correlation with KRAS and p53 mutations and mismatch repair protein expressionQ53817965
Reflex BRAF testing in thyroid fine-needle aspiration biopsy with equivocal and positive interpretation: a prospective studyQ54373285
BRAFV600E detection in melanoma is highly improved by COLD-PCR.Q54391292
NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: a study based on mutation screening by pyrosequencing.Q54570448
Influence of the BRAF V600E mutation on expression of vascular endothelial growth factor in papillary thyroid cancer.Q54597071
High incidence of thyroid cancer in long-standing goiters with thyroglobulin mutations.Q54640145
RAF/RAS oncogenes and mismatch-repair statusQ57281056
Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumorsQ58024790
Low Frequency of BRAF Mutations in Endometrial and in Cervical CarcinomasQ59123138
BRAF Mutations in Papillary Thyroid Carcinomas Inhibit Genes Involved in Iodine MetabolismQ61951314
Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinomaQ73144573
BRAF Mutation in Papillary Thyroid CarcinomaQ73276150
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)127-138
P577publication date2012-03-01
P1433published inExpert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcareQ15756305
P1476titleBRAF mutation testing in clinical practice
BRAFmutation testing in clinical practice
P478volume12

Reverse relations

cites work (P2860)
Q50500974Adrenal malignant melanoma masquerading as a pheochromocytoma in a patient with a history of a multifocal papillary and medullary thyroid carcinoma.
Q21198860B-Raf and the inhibitors: from bench to bedside
Q47906055BRAF V600E Mutation Analysis Simplifies the Testing Algorithm for Lynch Syndrome
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Q53265606BRAFV600E mutation in papillary thyroid microcarcinoma: a genotype-phenotype correlation
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Q36392912Competitive allele-specific TaqMan PCR (Cast-PCR) is a sensitive, specific and fast method for BRAF V600 mutation detection in Melanoma patients
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Q43109505Discrepant Results for BRAF V600E Mutation Among Different Specimens in a Case of Hairy Cell Leukemia
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Q45852947Synthesis of 2,6-difluoro-N-(3-[11C]methoxy-1H-pyrazolo[3,4-b]pyridine-5-yl)-3-(propylsulfonamidio)benzamide as a new potential PET agent for imaging of B-RafV600E in cancers
Q43740818The BRAF V600E mutation in papillary thyroid cancer with positive or suspected pre-surgical cytological finding is not associated with advanced stages or worse prognosis
Q55461604The diagnostic role and clinical relevance of determination of BRAF status in brain tumors.
Q44428665VE1 immunohistochemistry in pituitary adenomas is not associated with BRAF V600E mutation

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