Stem cell therapy for multiple sclerosis: preclinical evidence beyond all doubt?

scientific article published on March 2012

Stem cell therapy for multiple sclerosis: preclinical evidence beyond all doubt? is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2217/RME.12.5
P8608Fatcat IDrelease_o7i5go5wkjbyhak23ryb32pqvu
P698PubMed publication ID22397612

P50authorPeter PonsaertsQ37831161
Annemie Van der LindenQ51729679
Zwi N BernemanQ79741950
P2093author name stringJasmijn Daans
Jelle Praet
Kristien Reekmans
Nathalie De Vocht
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TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosisQ33281667
Plasmid-based genetic modification of human bone marrow-derived stromal cells: analysis of cell survival and transgene expression after transplantation in rat spinal cord.Q33310220
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The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessmentsQ34686955
Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II studyQ34934840
Autologous haematopoietic stem-cell transplantation in multiple sclerosis: benefits and risks.Q35010891
Multi-peptide coupled-cell tolerance ameliorates ongoing relapsing EAE associated with multiple pathogenic autoreactivitiesQ35792672
Mouse mesenchymal stem cells suppress antigen-specific TH cell immunity independent of indoleamine 2,3-dioxygenase 1 (IDO1).Q36041377
Intense T cell depletion followed by autologous bone marrow transplantation for severe multiple sclerosisQ36226307
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CD11c+CD11b+ dendritic cells play an important role in intravenous tolerance and the suppression of experimental autoimmune encephalomyelitisQ37178367
Stem cells ameliorate EAE via an indoleamine 2,3-dioxygenase (IDO) mechanismQ37189921
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Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis.Q37253314
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Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivoQ39823115
Intracerebroventricular transplantation of human mesenchymal stem cells induced to secrete neurotrophic factors attenuates clinical symptoms in a mouse model of multiple sclerosisQ39930711
Sarcoma derived from cultured mesenchymal stem cellsQ40220522
Serial in vivo MR tracking of magnetically labeled neural spheres transplanted in chronic EAE mice.Q40257049
CNS-targeted LIF expression improves therapeutic efficacy and limits autoimmune-mediated demyelination in a model of multiple sclerosisQ40295296
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Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity.Q41985283
Intraventricular transplantation of neural precursor cell spheres attenuates acute experimental allergic encephalomyelitisQ42454885
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Human mesenchymal stem cells abrogate experimental allergic encephalomyelitis after intraperitoneal injection, and with sparse CNS infiltrationQ43195511
Transplanted myogenic progenitor cells express neuronal markers in the CNS and ameliorate disease in experimental autoimmune encephalomyelitisQ43274246
Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitisQ43831215
Dendritic cells exposed to estrogen in vitro exhibit therapeutic effects in ongoing experimental allergic encephalomyelitisQ45090901
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Immune ablation followed by autologous hematopoietic stem cell transplantation for the treatment of poor prognosis multiple sclerosisQ46045097
Human bone marrow stromal cell treatment improves neurological functional recovery in EAE miceQ46499204
Overexpression of CNTF in Mesenchymal Stem Cells reduces demyelination and induces clinical recovery in experimental autoimmune encephalomyelitis miceQ46587731
Transplanted neural precursor cells reduce brain inflammation to attenuate chronic experimental autoimmune encephalomyelitisQ46940191
Safety and feasibility of autologous bone marrow cellular therapy in relapsing-progressive multiple sclerosis.Q47586113
Magnetic-resonance-based tracking and quantification of intravenously injected neural stem cell accumulation in the brains of mice with experimental multiple sclerosisQ48122196
Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitisQ48227850
MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brainQ48275815
Autologous haematopoietic stem cell transplantation fails to stop demyelination and neurodegeneration in multiple sclerosisQ48276129
Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosisQ48332405
Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis miceQ48497239
Cytokine-mediated modulation of MMPs and TIMPs in multipotential neural precursor cellsQ48597221
Regulatory T cell vaccination without autoantigen protects against experimental autoimmune encephalomyelitisQ50074143
Labeling of Luciferase/eGFP-expressing bone marrow-derived stromal cells with fluorescent micron-sized iron oxide particles improves quantitative and qualitative multimodal imaging of cellular grafts in vivo.Q50283926
Variable behavior and complications of autologous bone marrow mesenchymal stem cells transplanted in experimental autoimmune encephalomyelitis.Q50524244
Clinical potential of intravenous neural stem cell delivery for treatment of neuroinflammatory disease in mice?Q50534121
Time-dependent fate of transplanted neural precursor cells in experimental autoimmune encephalomyelitis mice.Q50555364
Neuroprotection and immunomodulation with mesenchymal stem cells in chronic experimental autoimmune encephalomyelitis.Q50632074
Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy.Q50767537
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Survival of neural precursor cells in growth factor-poor environment: implications for transplantation in chronic disease.Q54627067
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P433issue2
P921main subjectmultiple sclerosisQ8277
P304page(s)245-259
P577publication date2012-03-01
P1433published inRegenerative MedicineQ19921466
P1476titleStem cell therapy for multiple sclerosis: preclinical evidence beyond all doubt?
P478volume7

Reverse relations

cites work (P2860)
Q42208013Distinct spatial distribution of microglia and macrophages following mesenchymal stem cell implantation in mouse brain.
Q36264901In vivo differentiation of induced pluripotent stem cells into neural stem cells by chimera formation.
Q34852908Injury-dependent retention of intraportally administered mesenchymal stromal cells following partial hepatectomy of steatotic liver does not lead to improved liver recovery
Q37576255Intraspinal transplantation of mouse and human neural precursor cells
Q37585439Mesenchymal stromal cells mediate Aspergillus hyphal extract-induced allergic airway inflammation by inhibition of the Th17 signaling pathway.
Q42361828Metabolic pathways as possible therapeutic targets for progressive multiple sclerosis
Q39279957Neural Stem Cell-Based Regenerative Approaches for the Treatment of Multiple Sclerosis
Q36633053Spatiotemporal evolution of early innate immune responses triggered by neural stem cell grafting

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