A Role for K2P Channels in the Operation of Somatosensory Nociceptors

scientific article published on 05 March 2012

A Role for K2P Channels in the Operation of Somatosensory Nociceptors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FNMOL.2012.00021
P932PMC publication ID3293133
P698PubMed publication ID22403526
P5875ResearchGate publication ID221689404

P2093author name stringLeigh D Plant
P2860cites workHuman TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptorsQ22254402
The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and SelectivityQ22337058
A quantitative description of membrane current and its application to conduction and excitation in nerveQ22337072
POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANESQ22337178
A Novel Two-pore Domain K+ Channel, TRESK, Is Localized in the Spinal CordQ24302058
Crystal structure of the human two-pore domain potassium channel K2P1Q24303649
Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channelQ24303662
p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1Q24305279
TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemiaQ24306072
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitabilityQ24311712
Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type IQ24312557
TASK, a human background K+ channel to sense external pH variations near physiological pHQ24314854
Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulationQ24318495
TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structureQ24323355
A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids.Q24533254
Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton.Q24539089
Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channelQ24561735
Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channelsQ24622936
Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3Q24641890
Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2Q24642277
Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complexQ24683784
A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem.Q27933854
Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3Q28140649
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KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channelQ28185346
Annexin II light chain regulates sensory neuron-specific sodium channel expressionQ28202799
TREK-1, a K+ channel involved in polymodal pain perceptionQ41962937
Crystal-induced inflammation in canine joints. I. An experimental model with quantification of the host responseQ42153566
Block of Kcnk3 by protons. Evidence that 2-P-domain potassium channel subunits function as homodimers.Q43612382
KCNQ/M currents in sensory neurons: significance for pain therapy.Q44540560
Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK.Q45080383
Characterization and function of TWIK-related acid sensing K+ channels in a rat nociceptive cellQ45110559
Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anestheticsQ45161464
PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels.Q45242239
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TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones.Q46930538
Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells.Q47839556
Expression of TWIK-related acid sensitive K+ channels in capsaicin sensitive and insensitive cells of rat dorsal root gangliaQ48521759
Intracellular traffic of the K+ channels TASK-1 and TASK-3: role of N- and C-terminal sorting signals and interaction with 14-3-3 proteinsQ48729332
Does sumoylation control K2P1/TWIK1 background K+ channels?Q48785878
Formation of functional heterodimers between the TASK-1 and TASK-3 two-pore domain potassium channel subunitsQ48873005
General anesthetics hyperpolarize neurons in the vertebrate central nervous systemQ48897652
A non-inactivating K+ current sensitive to muscarinic receptor activation in rat cultured cerebellar granule neurons.Q49073273
Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESK.Q50651251
TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons.Q50738522
The pH of local anesthetic solutions.Q51865072
pH-dependent electrophysiological effects of quinidine and lidocaine on canine cardiac purkinje fibers.Q51869528
Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones.Q52219678
A novel oxygen-sensitive potassium current in rat carotid body type I cells.Q52276626
Action potentials of embryonic dorsal root ganglion neurones in Xenopus tadpolesQ52303849
Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel.Q52448076
Forward Transport of K2p3.1: mediation by 14-3-3 and COPI, modulation by p11.Q52582531
Voltage dependence of membrane properties of trigeminal root ganglion neurons.Q52593631
A G Protein Mediates the Inhibition of the Voltage-Dependent Potassium M Current by Muscarine, LHRH, Substance P and UTP in Bullfrog Sympathetic Neurons.Q54344802
On the resting potential of isolated frog sympathetic neurons.Q54348359
Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neuroneQ59066538
Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotypeQ60710783
Bradykinin inhibits a potassium M-like current in rat pheochromocytoma PC12 cellsQ69749648
Responses of adult human dorsal root ganglion neurons in culture to capsaicin and low pHQ71578958
Resting membrane potentials and excitability at different regions of rat dorsal root ganglion neurons in cultureQ72111217
Potassium leak channels and the KCNK family of two-P-domain subunitsQ28205333
Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of actionQ28206083
Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signalsQ28215227
The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurinQ28246530
Concepts in sumoylation: a decade onQ28257220
Crystal structure of a mammalian voltage-dependent Shaker family K+ channelQ28260421
Annexin II light chain p11 promotes functional expression of acid-sensing ion channel ASIC1aQ28272902
Molecular background of leak K+ currents: two-pore domain potassium channelsQ28279763
Transient receptor potential cation channels in diseaseQ28284143
International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channelsQ28289202
Alterations in 5-HT1B receptor function by p11 in depression-like statesQ28290425
The neuronal background K2P channels: focus on TREK1Q28294077
Kcnkø: single, cloned potassium leak channels are multi-ion poresQ28346209
TASK-3, a new member of the tandem pore K(+) channel familyQ28374393
A TRP channel that senses cold stimuli and mentholQ28511363
A heat-sensitive TRP channel expressed in keratinocytesQ28512804
The retention factor p11 confers an endoplasmic reticulum-localization signal to the potassium channel TASK-1Q28568568
Hypoxic depolarization of cerebellar granule neurons by specific inhibition of TASK-1Q28569434
TREK-2, a new member of the mechanosensitive tandem-pore K+ channel familyQ28571535
Axonal transport of TREK and TRAAK potassium channels in rat sciatic nervesQ28573535
SUMOylation regulates kainate-receptor-mediated synaptic transmissionQ28576922
Identification of a cold receptor reveals a general role for TRP channels in thermosensationQ28580334
Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAKQ28580851
Synergistic interaction and the role of C-terminus in the activation of TRAAK K+ channels by pressure, free fatty acids and alkaliQ28582799
The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perceptionQ28591983
Cellular and Molecular Mechanisms of PainQ29011961
An introduction to TRP channelsQ29615753
TASK-1, a two-pore domain K+ channel, is modulated by multiple neurotransmitters in motoneuronsQ30305478
The TASK-1 two-pore domain K+ channel is a molecular substrate for neuronal effects of inhalation anesthetics.Q30306012
Cns distribution of members of the two-pore-domain (KCNK) potassium channel family.Q30307946
Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anestheticsQ30433922
Multiple ionic mechanisms mediate inhibition of rat motoneurones by inhalation anaestheticsQ30472667
Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodiumQ30483411
One SUMO is sufficient to silence the dimeric potassium channel K2P1Q30495084
Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit.Q30708737
TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensorQ31625560
Cold transduction by inhibition of a background potassium conductance in rat primary sensory neurones.Q31803977
Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel.Q33421003
A phospholipid sensor controls mechanogating of the K+ channel TREK-1.Q33432568
Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and peripheryQ33932328
Specificity of cold thermotransduction is determined by differential ionic channel expressionQ34113463
A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with auraQ34140189
Cloning of two transcripts, HKT4.1a and HKT4.1b, from the human two-pore K+ channel gene KCNK4. Chromosomal localization, tissue distribution and functional expressionQ34145553
Functional expression of TASK-1/TASK-3 heteromers in cerebellar granule cellsQ34284061
Molecular and cellular mechanisms of general anaesthesiaQ34291163
Functional expression of TRESK-2, a new member of the tandem-pore K+ channel familyQ34318305
Sumoylation silences the plasma membrane leak K+ channel K2P1.Q34410181
Sequence and function of the two P domain potassium channels: implications of an emerging superfamilyQ34455956
Pathways modulating neural KCNQ/M (Kv7) potassium channelsQ34464180
Overview of molecular relationships in the voltage-gated ion channel superfamily.Q34480285
TRAAK is a mammalian neuronal mechano-gated K+ channel.Q34486466
A di-acidic sequence motif enhances the surface expression of the potassium channel TASK-3.Q34634174
SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neuronsQ34865655
TRESK channel contribution to nociceptive sensory neurons excitability: modulation by nerve injury.Q34984122
Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencingQ35102221
A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neuronsQ35118431
SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5.Q35629481
Covalent modification of a volatile anesthetic regulatory site activates TASK-3 (KCNK9) tandem-pore potassium channelsQ35776793
TREK-1 is a heat-activated background K(+) channelQ36246837
Opening and closing of KCNKO potassium leak channels is tightly regulatedQ36436304
Transient receptor potential ion channels as participants in thermosensation and thermoregulationQ36594600
ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiaeQ36690601
Nociceptor sensitization in pain pathogenesisQ37254618
A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostaticsQ37267666
Phosphorus nuclear magnetic resonance of perfused working rat heartsQ39145840
Sustained graded pain and hyperalgesia from harmless experimental tissue acidosis in human skinQ39493670
A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open poreQ39777149
P304page(s)21
P577publication date2012-03-05
P1433published inFrontiers in Molecular NeuroscienceQ27721913
P1476titleA Role for K2P Channels in the Operation of Somatosensory Nociceptors
P478volume5

Reverse relations

cites work (P2860)
Q37058127Functional analysis of a migraine-associated TRESK K+ channel mutation
Q41983600Functional significance of M-type potassium channels in nociceptive cutaneous sensory endings
Q48278693GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability.
Q30459043Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation
Q57456146K2P channels: Emerging targets for novel analgesic drugs
Q34006322Nonmigraine-associated TRESK K+ channel variant C110R does not increase the excitability of trigeminal ganglion neurons
Q37623462Opening paths to novel analgesics: the role of potassium channels in chronic pain
Q46197109Piezo2 expression in corneal afferent neurons
Q37362041Potassium channels in peripheral pain pathways: expression, function and therapeutic potential
Q37502544TREK2 expressed selectively in IB4-binding C-fiber nociceptors hyperpolarizes their membrane potentials and limits spontaneous pain.
Q27021286Temperature sensitivity of two-pore (K2P) potassium channels
Q34396710The LQLP calcineurin docking site is a major determinant of the calcium-dependent activation of human TRESK background K+ channel
Q92402642The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing
Q38859500The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19.
Q37381403The fundamental unit of pain is the cell
Q26822748Two-pore domain potassium channels enable action potential generation in the absence of voltage-gated potassium channels
Q38270913Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain

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