scholarly article | Q13442814 |
P50 | author | Michele Vendruscolo | Q28322492 |
Chris Dobson | Q1982431 | ||
P2093 | author name string | Tuomas P J Knowles | |
Samuel I A Cohen | |||
P433 | issue | 2-3 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | protein aggregation | Q7251455 |
P1104 | number of pages | 12 | |
P304 | page(s) | 160-171 | |
P577 | publication date | 2012-03-08 | |
P1433 | published in | Journal of Molecular Biology | Q925779 |
P1476 | title | From macroscopic measurements to microscopic mechanisms of protein aggregation | |
P478 | volume | 421 |
Q46274343 | A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP. |
Q36146824 | A Kinetic Model for Cell Damage Caused by Oligomer Formation |
Q51074523 | A fine-tuned composition of protein nanofibrils yields an upgraded functionality of displayed antibody binding domains. |
Q54977494 | A hydrophobic low complexity region regulates the aggregation of the yeast pyruvate kinase Cdc19 into amyloid-like aggregates in vitro. |
Q43026275 | A minichaperone-based fusion system for producing insoluble proteins in soluble stable forms |
Q38528499 | A minimal conformational switching-dependent model for amyloid self-assembly. |
Q33583650 | A resorcinarene for inhibition of Aβ fibrillation |
Q37367600 | AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species. |
Q90841052 | Alpha-synuclein stepwise aggregation reveals features of an early onset mutation in Parkinson's disease |
Q57373316 | Amyloid Beta Aggregation in the Presence of Temperature-Sensitive Polymers |
Q42998962 | Amyloid oligomers and protofibrils, but not filaments, self-replicate from native lysozyme |
Q47141146 | An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation |
Q36593553 | An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease |
Q92783536 | Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro |
Q96129239 | Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases |
Q47102016 | Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state |
Q46316131 | Cellular prion protein targets amyloid-β fibril ends via its C-terminal domain to prevent elongation |
Q38817593 | Charge dependent retardation of amyloid β aggregation by hydrophilic proteins |
Q57986255 | Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes |
Q36727420 | Clusterin Binds to Aβ1-42 Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation. |
Q47190991 | Communication: Non-monotonic supersaturation dependence of the nucleus size of crystals with anisotropically interacting molecules |
Q57986226 | Cooperative Assembly of Hsp70 Subdomain Clusters |
Q46323407 | Critical Influence of Cosolutes and Surfaces on the Assembly of Serpin-Derived Amyloid Fibrils. |
Q37601148 | DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios. |
Q58074760 | Defining the Dynamic Conformational Networks of Cross-β Peptide Assembly |
Q39027744 | Differences in Protein Concentration Dependence for Nucleation and Elongation in Light Chain Amyloid Formation |
Q33854089 | Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides |
Q30374807 | Differential effects of glycation on protein aggregation and amyloid formation. |
Q57816241 | Direct observation of murine prion protein replication in vitro |
Q47826829 | Direct observation of oligomerization by single molecule fluorescence reveals a multi-step aggregation mechanism for the yeast prion protein Ure2. |
Q33795294 | Direct observations of amyloid β self-assembly in live cells provide insights into differences in the kinetics of Aβ(1-40) and Aβ(1-42) aggregation. |
Q64114173 | Directing curli polymerization with DNA origami nucleators |
Q53336268 | Dynamic Landau theory for supramolecular self-assembly. |
Q42352231 | Effect of the surface charge distribution on the fluid phase behavior of charged colloids and proteins. |
Q36396401 | Effects of intramolecular distance between amyloidogenic domains on amyloid aggregation |
Q42124387 | Effects of polyamino acids and polyelectrolytes on amyloid β fibril formation |
Q36007352 | Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits. |
Q38044424 | Evolutionary selection for protein aggregation |
Q38123130 | Exploring critical determinants of protein amyloidogenesis: a review |
Q50614621 | Fluctuations in the Kinetics of Linear Protein Self-Assembly. |
Q36141488 | Fluorescent filter-trap assay for amyloid fibril formation kinetics in complex solutions |
Q55421516 | Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins. |
Q42065939 | Formation of dynamic soluble surfactant-induced amyloid β peptide aggregation intermediates |
Q39647688 | Glycerol inhibits the primary pathways and transforms the secondary pathway of insulin aggregation |
Q50718725 | Hamiltonian Dynamics of Protein Filament Formation. |
Q38815318 | Heat shock proteins as potential targets for protective strategies in neurodegeneration |
Q47811451 | High Throughput Prediction Approach for Monoclonal Antibody Aggregation at High Concentration. |
Q41780708 | High-throughput analysis of ultrasonication-forced amyloid fibrillation reveals the mechanism underlying the large fluctuation in the lag time |
Q92643434 | High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain |
Q47449222 | Imaging Aβ(1-42) fibril elongation reveals strongly polarised growth and growth incompetent states |
Q38905586 | Inferring Mechanistic Parameters from Amyloid Formation Kinetics by Approximate Bayesian Computation |
Q28247808 | Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation |
Q35009596 | Intrinsically disordered and aggregation prone regions underlie β-aggregation in S100 proteins |
Q39867365 | Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation |
Q100316468 | Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies |
Q51125807 | Kinetic modelling indicates that fast-translating codons can coordinate cotranslational protein folding by avoiding misfolded intermediates. |
Q57370500 | Kinetic theory of protein filament growth: Self-consistent methods and perturbative techniques |
Q41065976 | Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation |
Q39203824 | Mapping amyloid-β(16-22) nucleation pathways using fluorescence lifetime imaging microscopy. |
Q49477647 | Mathematical Modeling of Protein Misfolding Mechanisms in Neurological Diseases: A Historical Overview. |
Q90233789 | Measuring the Energy Barrier of the Structural Change That Initiates Amyloid Formation |
Q27679527 | Mechanism of Protein Kinetic Stabilization by Engineered Disulfide Crosslinks |
Q48053823 | Mechanisms and rates of nucleation of amyloid fibrils |
Q38669148 | Methods of probing the interactions between small molecules and disordered proteins |
Q37622574 | Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell |
Q64882394 | Molecular insights into the surface-catalyzed secondary nucleation of amyloid-β40 (Aβ40) by the peptide fragment Aβ16–22. |
Q40133096 | Molecular mechanisms of protein aggregation from global fitting of kinetic models. |
Q41579457 | Monomer-dependent secondary nucleation in amyloid formation |
Q36569893 | Monomeric Aβ(1-40) and Aβ(1-42) Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil |
Q41256308 | Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates |
Q42252589 | Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway |
Q34538864 | Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation |
Q33626314 | N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42 |
Q86697618 | Negative thermal expansibility change for dissociation of lysozyme variant amyloid protofibril |
Q99710980 | Network Hamiltonian models reveal pathways to amyloid fibril formation |
Q42559329 | Nucleation of polymorphic amyloid fibrils |
Q46905865 | Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters |
Q53073171 | Oil Palm Phenolics Inhibit the In Vitro Aggregation of β-Amyloid Peptide into Oligomeric Complexes. |
Q38365518 | On the lag phase in amyloid fibril formation |
Q88539088 | Parallel chromatography and in situ scattering to interrogate competing protein aggregation pathways |
Q49550316 | Peptides as Potential Therapeutics for Alzheimer's Disease. |
Q26823798 | Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs) |
Q47988521 | Polylogarithmic equilibrium treatment of molecular aggregation and critical concentrations |
Q92740047 | Polypeptide templating for designer hierarchical materials |
Q37049183 | Probing amyloid protein aggregation with optical superresolution methods: from the test tube to models of disease. |
Q34346440 | Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism |
Q50134449 | Propagation of an Aβ Dodecamer Strain Involves a Three-Step Mechanism and a Key Intermediate. |
Q39097864 | Protein aggregation, misfolding and consequential human neurodegenerative diseases. |
Q41880004 | Protein fibrillation lag times during kinetic inhibition |
Q42174627 | Protein structural dynamics at the gas/water interface examined by hydrogen exchange mass spectrometry |
Q64107562 | Quantitative Characterization of α-Synuclein Aggregation in Living Cells through Automated Microfluidics Feedback Control |
Q40116497 | Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide |
Q52804126 | Quantitative mass imaging of single biological macromolecules. |
Q64072874 | RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43 |
Q47321010 | Recent progress on understanding the mechanisms of amyloid nucleation |
Q37141705 | Recruitment of Light Chains by Homologous and Heterologous Fibrils Shows Distinctive Kinetic and Conformational Specificity |
Q36772928 | Resolution of oligomeric species during the aggregation of Aβ1-40 using (19)F NMR. |
Q41611893 | Role of aromatic side chains in amyloid β-protein aggregation |
Q39257498 | S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation |
Q57369244 | Scaling and dimensionality in the chemical kinetics of protein filament formation |
Q46242764 | Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification |
Q41074700 | Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method |
Q97569156 | Self-assembled poly-catenanes from supramolecular toroidal building blocks |
Q39322110 | Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology. |
Q33694368 | Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation |
Q57986454 | Spatial Propagation of Protein Polymerization |
Q34402886 | Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly |
Q33882262 | Stability analysis of 4-species Aβ aggregation model: A novel approach to obtaining physically meaningful rate constants |
Q33561356 | Stable polyglutamine dimers can contain β-hairpins with interdigitated side chains-but not α-helices, β-nanotubes, β-pseudohelices, or steric zippers |
Q42099746 | Stable, metastable, and kinetically trapped amyloid aggregate phases |
Q48342632 | Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein |
Q30152665 | Structural coalescence underlies the aggregation propensity of a β-barrel protein motif |
Q90189862 | Structure and Aggregation Mechanisms in Amyloids |
Q37312131 | Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin: roles of shear flow, hydrophobic surfaces, and α-crystallin. |
Q33990939 | Sulfate anion delays the self-assembly of human insulin by modifying the aggregation pathway |
Q28468287 | Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease |
Q60958643 | Tannic Acid-Induced Surface-Catalyzed Secondary Nucleation during the Amyloid Fibrillation of Hen Egg-White Lysozyme |
Q57159243 | Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms |
Q39071444 | The Amyloid Phenomenon and Its Links with Human Disease |
Q47110086 | The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation. |
Q92642050 | The Early Phase of β2m Aggregation: An Integrative Computational Study Framed on the D76N Mutant and the ΔN6 Variant |
Q46302852 | The Physiological and Pathological Implications of the Formation of Hydrogels, with a Specific Focus on Amyloid Polypeptides |
Q34421102 | The amyloid state and its association with protein misfolding diseases. |
Q38343014 | The effect of glycosaminoglycans (GAGs) on amyloid aggregation and toxicity |
Q40371204 | The length distribution of frangible biofilaments. |
Q38548820 | The route to protein aggregate superstructures: Particulates and amyloid-like spherulites. |
Q92893110 | Total proteome turbidity assay for tracking global protein aggregation in the natural cellular environment |
Q98463556 | Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism |
Q98906844 | Tryptophan-galactosylamine conjugates inhibit and disaggregate amyloid fibrils of Aβ42 and hIAPP peptides while reducing their toxicity |
Q90858074 | Versatile format of minichaperone-based protein fusion system |
Q30382591 | Wetting of nonconserved residue-backbones: A feature indicative of aggregation associated regions of proteins. |
Q35566949 | Zinc as chaperone-mimicking agent for retardation of amyloid β peptide fibril formation |
Search more.