From macroscopic measurements to microscopic mechanisms of protein aggregation

scientific article published on 08 March 2012

From macroscopic measurements to microscopic mechanisms of protein aggregation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.JMB.2012.02.031
P698PubMed publication ID22406275
P5875ResearchGate publication ID221692288

P50authorMichele VendruscoloQ28322492
Chris DobsonQ1982431
P2093author name stringTuomas P J Knowles
Samuel I A Cohen
P433issue2-3
P407language of work or nameEnglishQ1860
P921main subjectprotein aggregationQ7251455
P1104number of pages12
P304page(s)160-171
P577publication date2012-03-08
P1433published inJournal of Molecular BiologyQ925779
P1476titleFrom macroscopic measurements to microscopic mechanisms of protein aggregation
P478volume421

Reverse relations

cites work (P2860)
Q46274343A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP.
Q36146824A Kinetic Model for Cell Damage Caused by Oligomer Formation
Q51074523A fine-tuned composition of protein nanofibrils yields an upgraded functionality of displayed antibody binding domains.
Q54977494A hydrophobic low complexity region regulates the aggregation of the yeast pyruvate kinase Cdc19 into amyloid-like aggregates in vitro.
Q43026275A minichaperone-based fusion system for producing insoluble proteins in soluble stable forms
Q38528499A minimal conformational switching-dependent model for amyloid self-assembly.
Q33583650A resorcinarene for inhibition of Aβ fibrillation
Q37367600AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species.
Q90841052Alpha-synuclein stepwise aggregation reveals features of an early onset mutation in Parkinson's disease
Q57373316Amyloid Beta Aggregation in the Presence of Temperature-Sensitive Polymers
Q42998962Amyloid oligomers and protofibrils, but not filaments, self-replicate from native lysozyme
Q47141146An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation
Q36593553An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease
Q92783536Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro
Q96129239Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases
Q47102016Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state
Q46316131Cellular prion protein targets amyloid-β fibril ends via its C-terminal domain to prevent elongation
Q38817593Charge dependent retardation of amyloid β aggregation by hydrophilic proteins
Q57986255Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
Q36727420Clusterin Binds to Aβ1-42 Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation.
Q47190991Communication: Non-monotonic supersaturation dependence of the nucleus size of crystals with anisotropically interacting molecules
Q57986226Cooperative Assembly of Hsp70 Subdomain Clusters
Q46323407Critical Influence of Cosolutes and Surfaces on the Assembly of Serpin-Derived Amyloid Fibrils.
Q37601148DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios.
Q58074760Defining the Dynamic Conformational Networks of Cross-β Peptide Assembly
Q39027744Differences in Protein Concentration Dependence for Nucleation and Elongation in Light Chain Amyloid Formation
Q33854089Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides
Q30374807Differential effects of glycation on protein aggregation and amyloid formation.
Q57816241Direct observation of murine prion protein replication in vitro
Q47826829Direct observation of oligomerization by single molecule fluorescence reveals a multi-step aggregation mechanism for the yeast prion protein Ure2.
Q33795294Direct observations of amyloid β self-assembly in live cells provide insights into differences in the kinetics of Aβ(1-40) and Aβ(1-42) aggregation.
Q64114173Directing curli polymerization with DNA origami nucleators
Q53336268Dynamic Landau theory for supramolecular self-assembly.
Q42352231Effect of the surface charge distribution on the fluid phase behavior of charged colloids and proteins.
Q36396401Effects of intramolecular distance between amyloidogenic domains on amyloid aggregation
Q42124387Effects of polyamino acids and polyelectrolytes on amyloid β fibril formation
Q36007352Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits.
Q38044424Evolutionary selection for protein aggregation
Q38123130Exploring critical determinants of protein amyloidogenesis: a review
Q50614621Fluctuations in the Kinetics of Linear Protein Self-Assembly.
Q36141488Fluorescent filter-trap assay for amyloid fibril formation kinetics in complex solutions
Q55421516Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins.
Q42065939Formation of dynamic soluble surfactant-induced amyloid β peptide aggregation intermediates
Q39647688Glycerol inhibits the primary pathways and transforms the secondary pathway of insulin aggregation
Q50718725Hamiltonian Dynamics of Protein Filament Formation.
Q38815318Heat shock proteins as potential targets for protective strategies in neurodegeneration
Q47811451High Throughput Prediction Approach for Monoclonal Antibody Aggregation at High Concentration.
Q41780708High-throughput analysis of ultrasonication-forced amyloid fibrillation reveals the mechanism underlying the large fluctuation in the lag time
Q92643434High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain
Q47449222Imaging Aβ(1-42) fibril elongation reveals strongly polarised growth and growth incompetent states
Q38905586Inferring Mechanistic Parameters from Amyloid Formation Kinetics by Approximate Bayesian Computation
Q28247808Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation
Q35009596Intrinsically disordered and aggregation prone regions underlie β-aggregation in S100 proteins
Q39867365Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation
Q100316468Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
Q51125807Kinetic modelling indicates that fast-translating codons can coordinate cotranslational protein folding by avoiding misfolded intermediates.
Q57370500Kinetic theory of protein filament growth: Self-consistent methods and perturbative techniques
Q41065976Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
Q39203824Mapping amyloid-β(16-22) nucleation pathways using fluorescence lifetime imaging microscopy.
Q49477647Mathematical Modeling of Protein Misfolding Mechanisms in Neurological Diseases: A Historical Overview.
Q90233789Measuring the Energy Barrier of the Structural Change That Initiates Amyloid Formation
Q27679527Mechanism of Protein Kinetic Stabilization by Engineered Disulfide Crosslinks
Q48053823Mechanisms and rates of nucleation of amyloid fibrils
Q38669148Methods of probing the interactions between small molecules and disordered proteins
Q37622574Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell
Q64882394Molecular insights into the surface-catalyzed secondary nucleation of amyloid-β40 (Aβ40) by the peptide fragment Aβ16–22.
Q40133096Molecular mechanisms of protein aggregation from global fitting of kinetic models.
Q41579457Monomer-dependent secondary nucleation in amyloid formation
Q36569893Monomeric Aβ(1-40) and Aβ(1-42) Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil
Q41256308Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates
Q42252589Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway
Q34538864Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation
Q33626314N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42
Q86697618Negative thermal expansibility change for dissociation of lysozyme variant amyloid protofibril
Q99710980Network Hamiltonian models reveal pathways to amyloid fibril formation
Q42559329Nucleation of polymorphic amyloid fibrils
Q46905865Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters
Q53073171Oil Palm Phenolics Inhibit the In Vitro Aggregation of β-Amyloid Peptide into Oligomeric Complexes.
Q38365518On the lag phase in amyloid fibril formation
Q88539088Parallel chromatography and in situ scattering to interrogate competing protein aggregation pathways
Q49550316Peptides as Potential Therapeutics for Alzheimer's Disease.
Q26823798Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)
Q47988521Polylogarithmic equilibrium treatment of molecular aggregation and critical concentrations
Q92740047Polypeptide templating for designer hierarchical materials
Q37049183Probing amyloid protein aggregation with optical superresolution methods: from the test tube to models of disease.
Q34346440Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
Q50134449Propagation of an Aβ Dodecamer Strain Involves a Three-Step Mechanism and a Key Intermediate.
Q39097864Protein aggregation, misfolding and consequential human neurodegenerative diseases.
Q41880004Protein fibrillation lag times during kinetic inhibition
Q42174627Protein structural dynamics at the gas/water interface examined by hydrogen exchange mass spectrometry
Q64107562Quantitative Characterization of α-Synuclein Aggregation in Living Cells through Automated Microfluidics Feedback Control
Q40116497Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide
Q52804126Quantitative mass imaging of single biological macromolecules.
Q64072874RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43
Q47321010Recent progress on understanding the mechanisms of amyloid nucleation
Q37141705Recruitment of Light Chains by Homologous and Heterologous Fibrils Shows Distinctive Kinetic and Conformational Specificity
Q36772928Resolution of oligomeric species during the aggregation of Aβ1-40 using (19)F NMR.
Q41611893Role of aromatic side chains in amyloid β-protein aggregation
Q39257498S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation
Q57369244Scaling and dimensionality in the chemical kinetics of protein filament formation
Q46242764Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification
Q41074700Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
Q97569156Self-assembled poly-catenanes from supramolecular toroidal building blocks
Q39322110Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology.
Q33694368Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
Q57986454Spatial Propagation of Protein Polymerization
Q34402886Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly
Q33882262Stability analysis of 4-species Aβ aggregation model: A novel approach to obtaining physically meaningful rate constants
Q33561356Stable polyglutamine dimers can contain β-hairpins with interdigitated side chains-but not α-helices, β-nanotubes, β-pseudohelices, or steric zippers
Q42099746Stable, metastable, and kinetically trapped amyloid aggregate phases
Q48342632Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein
Q30152665Structural coalescence underlies the aggregation propensity of a β-barrel protein motif
Q90189862Structure and Aggregation Mechanisms in Amyloids
Q37312131Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin: roles of shear flow, hydrophobic surfaces, and α-crystallin.
Q33990939Sulfate anion delays the self-assembly of human insulin by modifying the aggregation pathway
Q28468287Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease
Q60958643Tannic Acid-Induced Surface-Catalyzed Secondary Nucleation during the Amyloid Fibrillation of Hen Egg-White Lysozyme
Q57159243Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms
Q39071444The Amyloid Phenomenon and Its Links with Human Disease
Q47110086The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation.
Q92642050The Early Phase of β2m Aggregation: An Integrative Computational Study Framed on the D76N Mutant and the ΔN6 Variant
Q46302852The Physiological and Pathological Implications of the Formation of Hydrogels, with a Specific Focus on Amyloid Polypeptides
Q34421102The amyloid state and its association with protein misfolding diseases.
Q38343014The effect of glycosaminoglycans (GAGs) on amyloid aggregation and toxicity
Q40371204The length distribution of frangible biofilaments.
Q38548820The route to protein aggregate superstructures: Particulates and amyloid-like spherulites.
Q92893110Total proteome turbidity assay for tracking global protein aggregation in the natural cellular environment
Q98463556Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
Q98906844Tryptophan-galactosylamine conjugates inhibit and disaggregate amyloid fibrils of Aβ42 and hIAPP peptides while reducing their toxicity
Q90858074Versatile format of minichaperone-based protein fusion system
Q30382591Wetting of nonconserved residue-backbones: A feature indicative of aggregation associated regions of proteins.
Q35566949Zinc as chaperone-mimicking agent for retardation of amyloid β peptide fibril formation

Search more.