Safety of flecainide

scientific article published on April 2012

Safety of flecainide is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1020697966
P356DOI10.2165/11599950-000000000-00000
P698PubMed publication ID22435343
P5875ResearchGate publication ID221902034

P50authorPhilippe MaboQ114428170
P2093author name stringJuan Tamargo
Alessandro Capucci
P2860cites workHypertonic sodium bicarbonate in an acute flecainide overdoseQ77190220
ProarrhythmiaQ77535837
Torsade-de-pointes in a patient under flecainide treatment, an unusual case of proarrhythmicityQ79286425
Dose-response effect of flecainide in patients with symptomatic paroxysmal atrial fibrillation and/or flutter monitored with trans-telephonic electrocardiography: a multicenter, placebo-controlled, double-blind trialQ79831278
Evaluation of flecainide acetate in rapid atrial fibrillation complicating Wolff-Parkinson-White syndromeQ93571413
Management of atrial fibrillation: review of the evidence for the role of pharmacologic therapy, electrical cardioversion, and echocardiographyQ28166512
Clinical course and outcome in class IC antiarrhythmic overdoseQ28243514
Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression TrialQ28300531
Efficacy and safety of out-of-hospital self-administered single-dose oral drug treatment in the management of infrequent, well-tolerated paroxysmal supraventricular tachycardiaQ32055132
Efficacy of quinidine in high-risk patients with Brugada syndromeQ33151791
Flecainide cardiotoxicity precipitated by electrolyte imbalance. Caution with thiazide diureticsQ33155056
Intravenous administration of flecainide or propafenone in patients with recent-onset atrial fibrillation does not predict adverse effects during 'pill-in-the-pocket' treatmentQ33158584
The safety of flecainide treatment of atrial fibrillation: long-term incidence of sudden cardiac death and proarrhythmic eventsQ33160108
Physician stated atrial fibrillation management in light of treatment guidelines: data from an international, observational prospective surveyQ33541615
Issues in the use of generic antiarrhythmic drugsQ34109855
Antiarrhythmic agents: drug interactions of clinical significanceQ34122414
ProarrhythmiaQ34172223
Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarctionQ34415281
Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillationQ34505579
The haemodynamic effect of intravenous flecainide acetate in patients with coronary artery diseaseQ34512892
The influence of urinary pH on flecainide excretion and its serum pharmacokineticsQ34621131
Oral loading single dose flecainide for pharmacological cardioversion of recent-onset atrial fibrillationQ35057258
Old and new antiarrhythmic drugs for converting and maintaining sinus rhythm in atrial fibrillation: comparative efficacy and results of trialsQ35096843
Flecainide acetate for treatment of tachyarrhythmias in children: review of world literature on efficacy, safety, and dosingQ35589436
Pharmacological cardioversion of atrial fibrillation: current management and treatment optionsQ35962527
Proarrhythmia in patients treated for atrial fibrillation or flutterQ36212688
Acute electrophysiological effects of flecainide acetate on cardiac conduction and refractoriness in manQ36741131
Paranoid psychosis and myoclonus: flecainide toxicity in renal failureQ37122997
Pharmacokinetic interaction of flecainide and paroxetine in relation to the CYP2D6*10 allele in healthy Korean subjectsQ37142440
Effects of CYP2D6 genotypes on age-related change of flecainide metabolism: involvement of CYP1A2-mediated metabolismQ37321429
Fetal arrhythmia: prenatal diagnosis and perinatal managementQ37596538
Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I.Q37611786
Drug therapy. FlecainideQ39734380
Flecainide. A preliminary review of its pharmacodynamic properties and therapeutic efficacyQ39814750
Suppression of ventricular ectopic depolarizations by flecainide acetate, a new antiarrhythmic agentQ70333490
Successful use of flecainide in atrial fibrillation with rapid ventricular rate in the Wolff-Parkinson-White syndromeQ70390804
Oral digoxin pharmacokinetics during multiple-dose flecainide treatmentQ70576439
Clinical electrophysiologic study of antiarrhythmic properties of flecainide: acute intraventricular delayed conduction and prolonged repolarization in regular paced and premature beats using intracardiac monophasic action potentials with programmedQ70992150
Extracardiac adverse effects of flecainideQ71267296
Electrophysiologic properties of flecainide acetateQ71267301
Interaction of flecainide with digoxin and propranololQ71267311
Flecainide dose-response relations in stable ventricular arrhythmiasQ71267316
Flecainide: its proarrhythmic effect and expected changes on the surface electrocardiogramQ71267319
Relative role of alkalosis and sodium ions in reversal of class I antiarrhythmic drug-induced sodium channel blockade by sodium bicarbonateQ71691470
Electrophysiologic and antiarrhythmic effects of oral flecainide in patients with inducible ventricular tachycardiaQ71742056
Voltage- and time-dependent depression of maximum rate of depolarisation of guinea-pig ventricular action potentials by two new antiarrhythmic drugs, flecainide and lorcainideQ71821703
Variable disposition kinetics and electrocardiographic effects of flecainide during repeated dosing in humans: contribution of genetic factors, dose-dependent clearance, and interaction with amiodaroneQ72329234
Flecainide acetate: concentration-response relationships for antiarrhythmic and electrocardiographic effectsQ72346628
Biotransformation and elimination of 14C-flecainide acetate in humansQ72588317
Response of an Abnormal Sinus Node to Intravenous Flecainide AcetateQ72737178
Comparison of intravenous flecainide, propafenone, and amiodarone for conversion of acute atrial fibrillation to sinus rhythmQ73128790
A proposal for the clinical use of flecainideQ40169636
Metabolism of flecainideQ40169641
ECG findings in fatal flecainide intoxication.Q40694123
Newer antidepressants and the cytochrome P450 systemQ40976263
Using the right drug: a treatment algorithm for regular supraventricular tachycardiasQ41471350
Flecainide pharmacokinetics in healthy volunteers: the influence of urinary pH.Q41968501
Flecainide-induced sustained ventricular tachycardia successfully treated with lidocaineQ42208316
Electrophysiologic effects of flecainide acetate and its major metabolites in the canine heartQ42225717
Acute reversible ataxo-myoclonic encephalopathy with flecainide therapy.Q42275434
Prospective comparison of flecainide versus quinidine for the treatment of paroxysmal atrial fibrillation/flutter. The Flecainide Multicenter Atrial Fibrillation Study GroupQ42556865
Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC).Q42923039
Flecainide toxicityQ42965248
Flecainide for cardioversion in patients at elevated cardiovascular risk and persistent atrial fibrillation: a prospective observational studyQ43152056
Altered pharmacokinetics of oral flecainide by cimetidine.Q43240553
Short- and long-term efficacy and safety of flecainide acetate for supraventricular arrhythmiasQ43641442
Flecainide acetate in the prevention of paroxysmal atrial fibrillation: a nine-month follow-up of more than 500 patientsQ43826181
Flecainide in the intrauterine treatment of fetal supraventricular tachycardiaQ43904385
Amiodarone used in successful resuscitation after near-fatal flecainide overdoseQ43955542
Meta-analysis of flecainide safety in patients with supraventricular arrhythmiasQ44110400
Safety of a controlled-release flecainide acetate formulation in the prevention of paroxysmal atrial fibrillation in outpatientsQ44413384
Flecainide versus ibutilide for immediate cardioversion of atrial fibrillation of recent onset.Q45002973
Outpatient treatment of recent-onset atrial fibrillation with the "pill-in-the-pocket" approachQ45170339
Oral flecainide pharmacokinetics in patients with impaired renal functionQ45180817
Antiarrhythmic therapy and risk of death in patients with atrial fibrillation: a nationwide study.Q46011482
Pharmacokinetics of flecainide acetate in patients with severe renal impairmentQ46064281
Flecainide-induced neuropathyQ46632209
Flecainide: safety and efficacyQ46674363
Usefulness of flecainide for prevention of paroxysmal atrial fibrillation and flutter. Danish-Norwegian Flecainide Multicenter Study Group.Q50545052
Paranoid psychosis due to flecainide toxicity in malignant neuropathic pain.Q52868280
Flecainide versus quinidine in the prevention of paroxysms of atrial fibrillation.Q54118671
Hemodynamic effects of intravenous flecainide in acute noncomplicated myocardial infarction.Q54439949
Comparative haemodynamic effects of intravenous flecainide in patients with and without heart failure and with and without beta-blocker therapy.Q54446063
Hemodynamic effects of intravenous flecainide relative to the level of ventricular function in patients with coronary artery disease.Q54458024
Effects of flecainide on ventricular function: clinical and experimental correlations.Q54479320
Suppression of resistant ventricular arrhythmias by twice daily dosing with flecainide.Q54527568
Conversion of recent-onset atrial fibrillation to sinus rhythm: effects of different drug protocolsQ57013753
Influence of amiodarone on genetically determined drug metabolism in humansQ57314137
Conversion of recent-onset atrial fibrillation by a single oral loading dose of propafenone or flecainideQ58819306
Effectiveness of loading oral flecainide for converting recent-onset atrial fibrillation to sinus rhythm in patients without organic heart disease or with only systemic hypertensionQ58819310
Flecainide: evidence of non-linear kineticsQ58819313
Efficacy and safety of flecainide acetate in the maintenance of sinus rhythm after electrical cardioversion of chronic atrial fibrillation or atrial flutterQ61965304
Block of delayed rectifier potassium current, IK, by flecainide and E-4031 in cat ventricular myocytesQ68339880
Flecainide excretion in human breast milkQ68355620
Late proarrhythmia and understanding the time of occurrence of proarrhythmiaQ68361332
Identification of drug interactions by meta-analysis of premarketing trials: the effect of smoking on the pharmacokinetics and dosage requirements for flecainide acetateQ69211390
Pharmacodynamics and side effects of flecainide acetateQ69543967
The effect of flecainide acetate, a new antiarrhythmic, on plasma digoxin levelsQ70017964
Effect of flecainide on cardiac outputQ70058793
Oral flecainide acetate for the treatment of ventricular arrhythmiasQ70162383
Influence of left ventricular dysfunction on flecainide therapyQ70316369
Pharmacokinetics of flecainide in patients with mild and moderate renal failure compared with patients with normal renal functionQ70331568
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P433issue4
P304page(s)273-289
P577publication date2012-04-01
P1433published inDrug SafetyQ15724462
P1476titleSafety of flecainide
P478volume35

Reverse relations

cites work (P2860)
Q306530452014 AATS guidelines for the prevention and management of perioperative atrial fibrillation and flutter for thoracic surgical procedures
Q45162471A Micropatterned Human Pluripotent Stem Cell-Based Ventricular Cardiac Anisotropic Sheet for Visualizing Drug-Induced Arrhythmogenicity
Q48272406An 89-year-old man presents with worsening heart failure.
Q38072091Flecainide acetate for the treatment of atrial and ventricular arrhythmias
Q33643591Flecainide and elevated liver enzymes in α1-antitrypsin deficiency
Q36437641Flecainide in Amyotrophic Lateral Sclerosis as a Neuroprotective Strategy (FANS): A Randomized Placebo-Controlled Trial.
Q33625455Intermittent failure to capture: What is the mechanism?
Q35547234Narrow therapeutic index drugs: a clinical pharmacological consideration to flecainide.
Q54954354Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.
Q38072867Sotalol as first-line treatment for fetal tachycardia and neonatal follow-up

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