GABA metabolism and transport: effects on synaptic efficacy

scientific article published on 23 February 2012

GABA metabolism and transport: effects on synaptic efficacy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1155/2012/805830
P932PMC publication ID3316990
P698PubMed publication ID22530158
P5875ResearchGate publication ID224822301

P50authorFabian C. RothQ83018947
P2093author name stringAndreas Draguhn
Fabian C Roth
P2860cites workMolecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system. Cloning of two novel high affinity GABA transporters from rat brainQ24293640
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptorsQ24308093
International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. UpdateQ24608968
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortexQ24620160
Regulation of cortical microcircuits by unitary GABA-mediated volume transmissionQ24646245
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.Q27863346
Inhibition-based rhythms: experimental and mathematical observations on network dynamicsQ28139233
Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampusQ28145794
Localization of neuronal and glial glutamate transportersQ28238076
Homeostatic plasticity in the developing nervous systemQ28239907
Normal and pathological oscillatory communication in the brainQ28242916
Small-conductance Ca2+-activated K+ channels: form and functionQ28248940
GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillationsQ28252805
Feedforward and feedback inhibition in neostriatal GABAergic spiny neuronsQ28259633
Neuronal and glial localization of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in human cerebral cortex: with a note on its distribution in monkey cortexQ28273432
Molecular anatomy of a trafficking organelleQ28274481
International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor functionQ28275171
Plasticity of rat central inhibitory synapses through GABA metabolismQ28348767
Cloning and expression of a rat brain GABA transporterQ28566313
Presynaptic CLC-3 determines quantal size of inhibitory transmission in the hippocampusQ28568030
Immunohistochemical localization of the amino acid transporter SNAT2 in the rat brainQ28581137
Interneurons of the neocortical inhibitory systemQ29547509
Interneurons of the hippocampusQ29618946
Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operationsQ29620030
Modulation of GABAA receptors and neuropeptide secretion by the neurosteroid allopregnanolone in posterior and intermediate pituitaryQ42445640
Quantitative determination of extracellular glutamine concentration in rat brain, and its elevation in vivo by system A transport inhibitor, alpha-(methylamino)isobutyrateQ42463177
GABA plasma membrane transporters, GAT-1 and GAT-3, display different distributions in the rat hippocampusQ42520734
In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysisQ42526175
Activity deprivation reduces miniature IPSC amplitude by decreasing the number of postsynaptic GABA(A) receptors clustered at neocortical synapses.Q42670226
GABAB receptor-dependent modulation of network activity in the rat prefrontal cortex in vitroQ43044085
Activation of the tonic GABAC receptor current in retinal bipolar cell terminals by nonvesicular GABA release.Q43073777
Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network.Q43578193
Vesicular GABA transporter mRNA expression in the dentate gyrus and in mossy fiber synaptosomesQ43758939
GABA(A) receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatmentQ43843063
Fast network oscillations in the rat dentate gyrus in vitroQ43875550
Hippocampal network patterns of activity in the mouse.Q44283571
Neuronal glutamate uptake Contributes to GABA synthesis and inhibitory synaptic strength.Q44376535
GABA uptake regulates cortical excitability via cell type-specific tonic inhibitionQ44393104
Regional distribution and extracellular levels of amino acids in rat central nervous systemQ44420047
A novel network of multipolar bursting interneurons generates theta frequency oscillations in neocortexQ44472361
Modulation of GABA(A) receptors by hydrogen ions reveals synaptic GABA transient and a crucial role of the desensitization process.Q44572986
Inhibition of GABA release by presynaptic ionotropic GABA receptors in hippocampal CA3.Q44839041
Presynaptic source of quantal size variability at GABAergic synapses in rat hippocampal neurons in cultureQ45067716
Perisomatic feedback inhibition underlies cholinergically induced fast network oscillations in the rat hippocampus in vitro.Q45209724
The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus.Q46039131
GABA transporter 1 tunes GABAergic synaptic transmission at output neurons of the mouse neostriatumQ46334084
Hebbian LTP in feed-forward inhibitory interneurons and the temporal fidelity of input discriminationQ46529346
Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area.Q46610679
Programmed and induced phenotype of the hippocampal granule cells.Q46622571
Analysis of glutamine, glutamate, pyroglutamate, and GABA in cerebrospinal fluid using ion pairing HPLC with positive electrospray LC/MS/MS.Q46629177
Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1.Q46693595
Gamma oscillations and spontaneous network activity in the hippocampus are highly sensitive to decreases in pO2 and concomitant changes in mitochondrial redox state.Q46782254
Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the formsQ46807511
Local and diffuse synaptic actions of GABA in the hippocampusQ46890795
Corelease of two fast neurotransmitters at a central synapse.Q47837764
Cell type-specific tuning of hippocampal interneuron firing during gamma oscillations in vivoQ47838606
Nerve growth factor: two receptors, multiple functionsQ47958133
Localization of the clustering protein gephyrin at GABAergic synapses in the main olfactory bulb of the rat.Q48036133
Effects of valproate, vigabatrin and aminooxyacetic acid on release of endogenous and exogenous GABA from cultured neuronsQ48106989
Role of synaptic vesicle proton gradient and protein phosphorylation on ATP-mediated activation of membrane-associated brain glutamate decarboxylaseQ48137567
Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsyQ48140558
Glutamine uptake by System A transporters maintains neurotransmitter GABA synthesis and inhibitory synaptic transmissionQ48167007
How quickly can GABAA receptors open?Q48196098
Axon terminal hyperexcitability associated with epileptogenesis in vitro. II. Pharmacological regulation by NMDA and GABAA receptorsQ48229607
Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrinQ48240102
Voltage-activated sodium channels amplify inhibition in neocortical pyramidal neuronsQ48242436
GABAergic spill-over transmission onto hippocampal mossy fiber boutons.Q48298571
The effect of 4-amino hex-5-ynoic acid (gamma-acetylenic GABA, gammma-ethynyl GABA) a catalytic inhibitor of GABA transaminase, on brain GABA metabolism in vivoQ48300768
Activity-dependent survival of neurons in culture: a model of slow neurodegenerationQ48421971
Mass transfer in brain dialysis devices--a new method for the estimation of extracellular amino acids concentrationQ48437132
EAAC1, a high-affinity glutamate tranporter, is localized to astrocytes and gabaergic neurons besides pyramidal cells in the rat cerebral cortexQ48460860
Activity-dependent regulation of inhibitory synaptic transmission in hippocampal neuronsQ48595994
Functional reconstitution of the gamma-aminobutyric acid transporter from synaptic vesicles using artificial ion gradientsQ48607802
Activity-dependent changes of the presynaptic synaptophysin-synaptobrevin complex in adult rat brainQ48709584
Injury-induced reorganization of somatosensory cortex is accompanied by reductions in GABA staining.Q48828094
Different mechanisms regulate IPSC kinetics in early postnatal and juvenile hippocampal granule cells.Q48846668
Gamma oscillation by synaptic inhibition in a hippocampal interneuronal network model.Q48890720
GAT-3, a high-affinity GABA plasma membrane transporter, is localized to astrocytic processes, and it is not confined to the vicinity of GABAergic synapses in the cerebral cortex.Q48911963
A novel single-cell staining procedure performed in vivo under electrophysiological control: morpho-functional features of juxtacellularly labeled thalamic cells and other central neurons with biocytin or Neurobiotin.Q49027606
Cellular correlate of assembly formation in oscillating hippocampal networks in vitroQ30503969
Cloning of a Na(+)- and Cl(-)-dependent betaine transporter that is regulated by hypertonicityQ31167686
Fast homeostatic plasticity of inhibition via activity-dependent vesicular fillingQ33361568
Homeostatic plasticity in neuronal networks: the more things change, the more they stay the sameQ33633054
New antiepileptic drugs: comparison of key clinical trials.Q33674144
Presynaptic inhibition in the vertebrate spinal cord revisitedQ33768002
Hebb and homeostasis in neuronal plasticityQ33905421
Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation modelQ34001982
GABA: homeostatic and pharmacological aspectsQ34004125
Depolarizing actions of GABA in immature neurons depend neither on ketone bodies nor on pyruvate.Q34025223
Spillover and synaptic cross talk mediated by glutamate and GABA in the mammalian brain.Q34093945
Demonstration of functional coupling between gamma -aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesiclesQ34183366
Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networksQ34192262
Transfer of glutamine between astrocytes and neuronsQ34237601
Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons.Q34288636
Localization of the glutamine transporter SNAT1 in rat cerebral cortex and neighboring structures, with a note on its localization in human cortex.Q34309826
Cell death and synaptic reorganizations produced by seizuresQ34345001
Distinguishing between GABA(A) receptors responsible for tonic and phasic conductancesQ34431918
The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypesQ34481002
Role of heteromer formation in GABAB receptor functionQ34485603
Effect of zolpidem on miniature IPSCs and occupancy of postsynaptic GABAA receptors in central synapsesQ34486510
Neuronal metabolism governs cortical network response stateQ34600432
GABA: an excitatory transmitter in early postnatal lifeQ34607633
Do mossy fibers release GABA?Q34744126
Glutamate and gamma-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampusQ34958420
GABA action in immature neocortical neurons directly depends on the availability of ketone bodies.Q34989280
Mechanisms of GABAA receptor assembly and trafficking: implications for the modulation of inhibitory neurotransmission.Q34995058
Visual experience modulates spatio-temporal dynamics of circuit activationQ35079124
Tonically active GABA A receptors: modulating gain and maintaining the tone.Q35757312
Diversity of inhibitory neurotransmission through GABA(A) receptorsQ35872326
Defined types of cortical interneurone structure space and spike timing in the hippocampusQ35946394
GABA-enhanced collective behavior in neuronal axons underlies persistent gamma-frequency oscillations.Q35978890
Steroid hormone fluctuations and GABA(A)R plasticity.Q36101683
The dual glutamatergic-GABAergic phenotype of hippocampal granule cellsQ36146212
Cell type- and synapse-specific variability in synaptic GABAA receptor occupancy.Q51407218
Giant synaptic potentials in immature rat CA3 hippocampal neurones.Q51749893
Tonic GABAergic control of mouse dentate granule cells during postnatal developmentQ51899741
Decorrelating actions of Renshaw interneurons on the firing of spinal motoneurons within a motor nucleus: a simulation study.Q52240001
Ontogenetic development of glutamate and GABA metabolizing enzymes in cultured cerebral cortex interneurons and in cerebral cortex in vivo.Q52269025
Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites.Q53259451
Desensitized states prolong GABAA channel responses to brief agonist pulses.Q54007822
Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy.Q55044608
Über das Elektrenkephalogramm des MenschenQ55881406
An update on GABAA receptorsQ56601749
CLC-3 spices up GABAergic synaptic vesiclesQ57978881
Miniature inhibitory postsynaptic currents in CA1 pyramidal neurons after kindling epileptogenesisQ57988099
Oscillatory Coupling of Hippocampal Pyramidal Cells and Interneurons in the Behaving RatQ58046300
Hippocampal GABA transporter function in temporal-lobe epilepsyQ59093542
The cloning of GABAB receptorsQ60087174
The GABAergic cerebello-olivary projection in the ratQ67862436
A study of the effects of vigabatrin on the central nervous system and retina of Sprague Dawley and Lister-Hooded ratsQ69170723
Anticonvulsant and proconvulsant effects of inhibitors of GABA degradation in the amygdala-kindling modelQ69649999
GABAergic projections from the thalamic reticular nucleus to the anteroventral and anterodorsal thalamic nuclei of the ratQ70970403
Kinetic differences between synaptic and extrasynaptic GABA(A) receptors in CA1 pyramidal cellsQ73387274
GABA spillover activates postsynaptic GABA(B) receptors to control rhythmic hippocampal activityQ73697347
The specific ionic conductances and the ionic movements across the motoneuronal membrane that produce the inhibitory post-synaptic potentialQ73882749
Chlorpromazine inhibits miniature GABAergic currents by reducing the binding and by increasing the unbinding rate of GABAA receptorsQ74624716
Progress report on new antiepileptic drugs: a summary of the fourth Eilat conference (EILAT IV)Q77292948
Presynaptic inhibition of the spinal monosynaptic reflex pathwayQ79381325
Activation of presynaptic GABA(A) receptors induces glutamate release from parallel fiber synapsesQ80834144
Incongruent restoration of inhibitory transmission and general metabolic activity during reorganization of somatosensory cortexQ80953296
Activity-dependent regulation of vesicular glutamate and GABA transporters: a means to scale quantal sizeQ36424862
Effects of seizures on developmental processes in the immature brainQ36655600
BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?Q36663584
Dynamic regulation of synaptic GABA release by the glutamate-glutamine cycle in hippocampal area CA1Q36774202
Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected].Q36775039
A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsyQ36790479
Role of GABAergic inhibition in hippocampal network oscillations.Q36833061
Presynaptic ionotropic GABA receptors.Q36869862
The continuing case for the Renshaw cellQ36886651
The structural and functional heterogeneity of glutamic acid decarboxylase: A reviewQ36930608
The neurotransmitter cycle and quantal sizeQ36946152
Multiple modes of network homeostasis in visual cortical layer 2/3.Q37127176
Translational control of long-lasting synaptic plasticity and memoryQ37369258
Feed-forward inhibition as a buffer of the neuronal input-output relationQ37394498
Maintenance of thalamic epileptiform activity depends on the astrocytic glutamate-glutamine cycle.Q37422303
Two pharmacologically distinct sodium- and chloride-coupled high-affinity gamma-aminobutyric acid transporters are present in plasma membrane vesicles and reconstituted preparations from rat brainQ37729393
Sparse and powerful cortical spikesQ37733114
No simple brake--the complex functions of inhibitory synapsesQ37756038
Neurogliaform cells and other interneurons of stratum lacunosum-moleculare gate entorhinal-hippocampal dialogue.Q37816747
GABAA-receptors: structural requirements and sites of gene expression in mammalian brainQ37876852
Impact of synaptic neurotransmitter concentration time course on the kinetics and pharmacological modulation of inhibitory synaptic currents.Q37898524
The physiological role of calcium-dependent channelsQ38208887
Uptake and metabolism of glutamate in astrocytes cultured from dissociated mouse brain hemispheresQ39179571
In situ measurements of enzyme activities in the brainQ40710872
Nonvesicular release of neurotransmitter.Q40713047
A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous systemQ40929779
Nuclear calcium sensors reveal that repetition of trains of synaptic stimuli boosts nuclear calcium signaling in CA1 pyramidal neuronsQ41116137
Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamateQ41278939
A GABA transporter operates asymmetrically and with variable stoichiometryQ41440797
How does a vesicle know it is full?Q41496805
GABA uptake and release by a mammalian cell line stably expressing a cloned rat brain GABA transporterQ41501146
Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1.Q41761189
Intramitochondrial localization of the 4-aminobutyrate-2-oxoglutarate transaminase from ox brainQ41823419
Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsyQ41837512
Activity- and age-dependent modulation of GABAergic neurotransmission by system A-mediated glutamine uptakeQ41863803
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectcellQ7868
carboxylic acidQ134856
butyrateQ1018145
amino acidQ8066
nervous systemQ9404
chemical synaptic transmissionQ14330653
P304page(s)805830
P577publication date2012-02-23
P1433published inNeural PlasticityQ15716605
P1476titleGABA metabolism and transport: effects on synaptic efficacy
P478volume2012

Reverse relations

cites work (P2860)
Q39558567Age-related changes in tonic activation of presynaptic versus extrasynaptic γ-amniobutyric acid type B receptors in rat medial prefrontal cortex
Q36831893CUG-BP, Elav-like family (CELF)-mediated alternative splicing regulation in the brain during health and disease.
Q34669020Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias
Q97066954Dorsal-Ventral Differences in Modulation of Synaptic Transmission in the Hippocampus
Q27319910Drosophila Vision Depends on Carcinine Uptake by an Organic Cation Transporter
Q46571018Effect of GABA on oxidative stress in the skeletal muscles and plasma free amino acids in mice fed high-fat diet
Q26744661Energy and Potassium Ion Homeostasis during Gamma Oscillations
Q36681608Expression of Glutamate and GABA during the Process of Rat Retinal Synaptic Plasticity Induced by Acute High Intraocular Pressure
Q36271608From Molecular Circuit Dysfunction to Disease: Case Studies in Epilepsy, Traumatic Brain Injury, and Alzheimer's Disease.
Q48615960Functional analysis of the inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 in astrocytes of the lateral superior olive
Q38136071GABAA receptor-mediated tonic depolarization in developing neural circuits
Q41370905GABAergic Mechanisms in Schizophrenia: Linking Postmortem and In Vivo Studies
Q30662832Glutamate and GABA in Appetite Regulation
Q34722279Glutamic acid decarboxylase 67 expression by a distinct population of mouse vestibular supporting cells
Q34018648Highly energized inhibitory interneurons are a central element for information processing in cortical networks
Q34042170Increased GABA contributes to enhanced control over motor excitability in Tourette syndrome
Q38912505Irritable bowel syndrome, the microbiota and the gut-brain axis.
Q30572596Long-distance mechanism of neurotransmitter recycling mediated by glial network facilitates visual function in Drosophila
Q55395607Metabolic Changes Associated with a Rat Model of Diabetic Depression Detected by Ex Vivo 1H Nuclear Magnetic Resonance Spectroscopy in the Prefrontal Cortex, Hippocampus, and Hypothalamus.
Q33659830Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives
Q47791079Modulation of synaptic depression of the calyx of Held synapse by GABA(B) receptors and spontaneous activity
Q98164398Novel microwire-based biosensor probe for simultaneous real-time measurement of glutamate and GABA dynamics in vitro and in vivo
Q60053956RNA-seq of spinal cord from nerve-injured rats after spinal cord stimulation
Q47324836Response of the GABAergic System to Axotomy of the Rat Facial Nerve.
Q35923418Shifts in excitatory/inhibitory balance by juvenile stress: A role for neuron-astrocyte interaction in the dentate gyrus
Q64959139Subcellular Targeting of VIP Boutons in Mouse Barrel Cortex is Layer-Dependent and not Restricted to Interneurons.
Q28067017The Neuro-endocrinological Role of Microbial Glutamate and GABA Signaling
Q30839340Tiagabine treatment in kainic acid induced cerebellar lesion of dystonia rat model
Q91832202Transcriptional Regulation of the Glutamate/GABA/Glutamine Cycle in Adult Glia Controls Motor Activity and Seizures in Drosophila

Search more.