Impact of the UGT1A1*28 allele on response to irinotecan: a systematic review and meta-analysis

scientific article published on June 2012

Impact of the UGT1A1*28 allele on response to irinotecan: a systematic review and meta-analysis is …
instance of (P31):
scholarly articleQ13442814
meta-analysisQ815382

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P356DOI10.2217/PGS.12.68
P698PubMed publication ID22676194
P5875ResearchGate publication ID225281476

P2093author name stringMichael J Sorich
Ross A McKinnon
Mafalda M Dias
P2860cites workThe UGT1A1*28 genotype and the toxicity of low-dose irinotecan in patients with advanced lung cancerQ43106213
Weekly regimen of irinotecan/docetaxel in previously treated non-small cell lung cancer patients and correlation with uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) polymorphismQ44637207
UGT1A and irinotecan toxicity: keeping it in the familyQ46052031
Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trialQ46570394
Cost-effectiveness of UGT1A1 genotyping in second-line, high-dose, once every 3 weeks irinotecan monotherapy treatment of colorectal cancer.Q46605316
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaborationQ21092360
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statementQ21562278
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysisQ27851573
UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapyQ27851574
Meta-analysis of Observational Studies in Epidemiology: A Proposal for ReportingQ27861077
Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapyQ27863360
Clinical significance of UDP-glucuronosyltransferase 1A1*6 for toxicities of combination chemotherapy with irinotecan and cisplatin in gynecologic cancers: a prospective multi-institutional studyQ33383787
Phase III trial of irinotecan/cisplatin compared with etoposide/cisplatin in extensive-stage small-cell lung cancer: clinical and pharmacogenomic results from SWOG S0124.Q33384024
Cost effectiveness of pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 before irinotecan administration for metastatic colorectal cancer.Q33783293
Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741.Q33990876
Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancerQ34565071
Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan.Q34975510
UGT1A1*28 genotype and irinotecan dosage in patients with metastatic colorectal cancer: a Dutch Colorectal Cancer Group study.Q36785973
Irinotecan and uridine diphosphate glucuronosyltransferase 1A1 pharmacogenetics: to test or not to test, that is the questionQ37249563
Methodological quality of pharmacogenetic studies: issues of concernQ37287588
Recommendations from the EGAPP Working Group: can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan?Q37345971
Can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan? An evidence-based reviewQ37345974
UGT1A1 gene polymorphism: impact on toxicity and efficacy of irinotecan-based regimens in metastatic colorectal cancerQ37402459
Assessing tumor response to therapyQ37452321
Dose-dependent association between UGT1A1*28 polymorphism and irinotecan-induced diarrhoea: a meta-analysisQ37718359
Molecular predictive and prognostic markers in colon cancerQ37723882
UGT1A1*28 polymorphism predicts irinotecan-induced severe toxicities without affecting treatment outcome and survival in patients with metastatic colorectal carcinomaQ40426198
Dose-dependent association between UGT1A1*28 genotype and irinotecan-induced neutropenia: low doses also increase riskQ43012426
Pharmacogenetic assessment of toxicity and outcome in patients with metastatic colorectal cancer treated with LV5FU2, FOLFOX, and FOLFIRI: FFCD 2000-05.Q43102323
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectgeneticsQ7162
irinotecanQ412197
meta-analysisQ815382
systematic reviewQ1504425
P304page(s)889-899
P577publication date2012-06-01
P1433published inPharmacogenomicsQ15724625
P1476titleImpact of the UGT1A1*28 allele on response to irinotecan: a systematic review and meta-analysis
P478volume13

Reverse relations

cites work (P2860)
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Q35603648An internally and externally validated nomogram for predicting the risk of irinotecan-induced severe neutropenia in advanced colorectal cancer patients
Q34629650Association between UGT1A1*28 polymorphisms and clinical outcomes of irinotecan-based chemotherapies in colorectal cancer: a meta-analysis in Caucasians
Q45590471Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features.
Q26768427Colorectal cancer tumour markers and biomarkers: Recent therapeutic advances
Q43358640Cost Evaluation of Irinotecan-Related Toxicities Associated With the UGT1A1*28 Patient Genotype.
Q26851060FOLFOX/FOLFIRI pharmacogenetics: the call for a personalized approach in colorectal cancer therapy
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