Pharmacodynamic properties of antiplatelet agents: current knowledge and future perspectives

scientific article published on May 2012

Pharmacodynamic properties of antiplatelet agents: current knowledge and future perspectives is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1586/ECP.12.19
P698PubMed publication ID22697594

P2093author name stringAlexandros D Tselepis
Kallirroi I Kalantzi
Ioannis A Goudevenos
Maria E Tsoumani
P2860cites workCollaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patientsQ24555072
Aspirin "resistance" and risk of cardiovascular morbidity: systematic review and meta-analysisQ24645413
Aspirin and extended-release dipyridamole versus clopidogrel for recurrent strokeQ24646522
Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapyQ28171295
Meta-analysis of randomized and registry comparisons of ticlopidine with clopidogrel after stentingQ28191931
Overestimation of platelet aspirin resistance detection by thrombelastograph platelet mapping and validation by conventional aggregometry using arachidonic acid stimulationQ28192958
Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trialQ28194232
Antiplatelet drugsQ28194430
Comparison of triflusal and aspirin for prevention of vascular events in patients after cerebral infarction: the TACIP Study: a randomized, double-blind, multicenter trialQ28195452
Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregatesQ28213662
Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trialQ28218263
Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevationQ28218789
Lack of evidence of a clopidogrel-statin interaction in the CHARISMA trialQ28218952
Association of laboratory-defined aspirin resistance with a higher risk of recurrent cardiovascular events: a systematic review and meta-analysisQ28219463
Cyclic nucleotide phosphodiesterases: molecular regulation to clinical useQ28263273
Epitope mapping of inhibitory antibodies against platelet glycoprotein Ibalpha reveals interaction between the leucine-rich repeat N-terminal and C-terminal flanking domains of glycoprotein Ibalpha.Q30691871
A consensus tetrapeptide selected by phage display adopts the conformation of a dominant discontinuous epitope of a monoclonal anti-VWF antibody that inhibits the von Willebrand factor-collagen interactionQ30961540
The Fab fragment of a novel anti-GPVI monoclonal antibody, OM4, reduces in vivo thrombosis without bleeding risk in ratsQ33374356
Bioequivalence and tolerability of two clopidogrel salt preparations, besylate and bisulfate: a randomized, open-label, crossover study in healthy Korean male subjectsQ33384521
Discovery and development of therapeutic aptamers.Q33522441
Thromboxane and the thromboxane receptor in cardiovascular diseaseQ33899567
Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study.Q34020220
Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interactionQ34168972
Thrombin-receptor antagonist vorapaxar in acute coronary syndromesQ34231934
Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary artery diseaseQ34255442
Vorapaxar in the secondary prevention of atherothrombotic eventsQ34263311
Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysisQ34564576
Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysisQ34624862
Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular diseaseQ34633709
Clopidogrel with or without omeprazole in coronary artery diseaseQ34660303
The pharmacology of cilostazolQ34785781
Cytochrome p-450 polymorphisms and response to clopidogrelQ34910228
Novel agents for anti-platelet therapyQ35574825
Protease-activated receptors: contribution to physiology and diseaseQ35715253
Protease-activated receptors in hemostasis, thrombosis and vascular biologyQ36230881
Access of HTB, main metabolite of triflusal, to cerebrospinal fluid in healthy volunteers.Q45265599
A randomised study comparing the antiplatelet and antiinflammatory effect of clopidogrel 150 mg/day versus 75 mg/day in patients with ST-segment elevation acute myocardial infarction and poor responsiveness to clopidogrel: results from the DOUBLE stQ45928517
Aspirin plus dipyridamole versus aspirin for prevention of vascular events after stroke or TIA: a meta-analysis.Q45969556
Clopidogrel 150 mg/day to overcome low responsiveness in patients undergoing elective percutaneous coronary intervention: results from the VASP-02 (Vasodilator-Stimulated Phosphoprotein-02) randomized study.Q46000156
Multicenter randomized trial evaluating the efficacy of cilostazol on ischemic vascular complications after drug-eluting stent implantation for coronary heart disease: results of the CILON-T (influence of CILostazol-based triple antiplatelet therapyQ46046935
Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30 mg/day versus aspirin 100 mg/day in stroke patients: the prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patientsQ46047927
Randomized comparison of adjunctive cilostazol versus high maintenance dose clopidogrel in patients with high post-treatment platelet reactivity: results of the ACCEL-RESISTANCE (Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in PatiQ46073177
Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II studyQ46088369
Tailored clopidogrel loading dose according to platelet reactivity monitoring to prevent acute and subacute stent thrombosisQ46187200
Basic and translational research on proteinase-activated receptors: antagonism of the proteinase-activated receptor 1 for thrombin, a novel approach to antiplatelet therapy for atherothrombotic diseaseQ46189242
Multiple antiplatelet effects of clopidogrel are not modulated by statin type in patients undergoing percutaneous coronary interventionQ46374395
The specific thromboxane receptor antagonist S18886: pharmacokinetic and pharmacodynamic studies.Q46566202
Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective studyQ46665436
Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in MyocQ46868498
Oral antiplatelet therapy for atherothrombotic disease: current evidence and new directions.Q50525288
Gastrointestinal safety of triflusal solution in healthy volunteers: a proof of concept endoscopic study.Q51602399
The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA*CER) trial: study design and rationale.Q53499051
Pharmacology and clinical trials of reversibly-binding P2Y12 inhibitors.Q55054169
Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2°P)-Q57313076
Platelet activation and atherothrombosisQ37031278
Cell adhesion mechanisms in plateletsQ37049884
von Willebrand factor in cardiovascular disease: focus on acute coronary syndromes.Q37112364
The genetics of antiplatelet drug resistanceQ37344920
Advances in antiplatelet therapy: agents in clinical developmentQ37376472
TP receptor antagonism: a new concept in atherothrombosis and stroke preventionQ37480448
P2Y(12) inhibitors: differences in properties and mechanisms of action and potential consequences for clinical use.Q37562606
Stroke prevention by cilostazol in patients with atherothrombosis: meta-analysis of placebo-controlled randomized trialsQ37629990
Antiplatelet therapies for the treatment of cardiovascular diseaseQ37684794
Mechanism of action and clinical development of platelet thrombin receptor antagonists.Q37776518
Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate.Q37786695
Glycoprotein IIb/IIIa inhibitors: an update on the mechanism of action and use of functional testing methods to assess antiplatelet efficacyQ37841572
Clopidogrel-drug interactionsQ37851658
Antiplatelet therapy: thrombin receptor antagonistsQ37929838
Antiplatelet agents for the treatment and prevention of atherothrombosisQ37948506
First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteersQ38296268
Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779.Q38354361
Safety and tolerability of atopaxar in the treatment of patients with acute coronary syndromes: the lessons from antagonizing the cellular effects of Thrombin–Acute Coronary Syndromes TrialQ38492131
Randomized trial of atopaxar in the treatment of patients with coronary artery disease: the lessons from antagonizing the cellular effect of Thrombin–Coronary Artery Disease TrialQ38492142
Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trialQ38493350
Ticagrelor versus clopidogrel in acute coronary syndromes in relation to renal function: results from the Platelet Inhibition and Patient Outcomes (PLATO) trialQ38500562
GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flowQ42194347
European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of strokeQ42551725
Safety and feasibility of adjunctive antiplatelet therapy with intravenous elinogrel, a direct-acting and reversible P2Y12 ADP-receptor antagonist, before primary percutaneous intervention in patients with ST-elevation myocardial infarction: the EarQ42641710
Secondary prevention of stroke: can we do better than aspirin?Q42910107
Rationale and design of the randomized, double-blind trial testing INtraveNous and Oral administration of elinogrel, a selective and reversible P2Y(12)-receptor inhibitor, versus clopidogrel to eVAluate Tolerability and Efficacy in nonurgent PercutaQ42990922
Engineering and characterization of a chimeric anti-platelet glycoprotein Ibalpha monoclonal antibody and preparation of its Fab fragmentQ43073628
Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndromeQ43177299
Adding cilostazol to dual antiplatelet therapy achieves greater platelet inhibition than high maintenance dose clopidogrel in patients with acute myocardial infarction: Results of the adjunctive cilostazol versus high maintenance dose clopidogrel inQ43179454
Association of platelet responsiveness with clopidogrel metabolism: role of compliance in the assessment of "resistance".Q43230594
Intravenous platelet blockade with cangrelor during PCI.Q43241907
Platelet inhibition with cangrelor in patients undergoing PCI.Q43241909
The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP2C19*2 genotype: first experience in patientsQ43264421
Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomesQ43445863
Pharmacokinetics and pharmacodynamics of AJW200, a humanized monoclonal antibody to von Willebrand factor, in monkeysQ43852844
Intensifying platelet inhibition with tirofiban in poor responders to aspirin, clopidogrel, or both agents undergoing elective coronary intervention: results from the double-blind, prospective, randomized Tailoring Treatment with Tirofiban in PatienQ44475877
GPVI levels in platelets: relationship to platelet function at high shearQ44493355
Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibodyQ44592655
Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function — a flow cytometry studyQ44604925
Effect of synthetic peptides corresponding to residues 313-332 of the alphaIIb subunit on platelet activation and fibrinogen binding to alphaIIbbeta3.Q44756625
Atorvastatin does not affect the antiplatelet potency of clopidogrel when it is administered concomitantly for 5 weeks in patients with acute coronary syndromes.Q44801358
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpharmacodynamicsQ725307
P304page(s)319-336
P577publication date2012-05-01
P1433published inExpert Review of Clinical PharmacologyQ15793519
P1476titlePharmacodynamic properties of antiplatelet agents: current knowledge and future perspectives
P478volume5

Reverse relations

cites work (P2860)
Q90672492Antithrombotic Agents and Cancer
Q39089774Curbing tumorigenesis and malignant progression through the pharmacological control of the wound healing process
Q39660267Dynamic platelet adhesion in patients with an acute coronary syndrome: The effect of antiplatelet therapy
Q36094523Increased Benefit With Vorapaxar Use in Patients With a History of Myocardial Infarction and Diabetes Mellitus: What the Data Show Us.
Q37139179Influence of genetic variations on levels of inflammatory markers of healthy subjects at baseline and one week after clopidogrel therapy; results of a preliminary study
Q47256757Microfludic platforms for the evaluation of anti-platelet agent efficacy under hyper-shear conditions associated with ventricular assist devices.
Q92068084Molecular Requirements for the Expression of Antiplatelet Effects by Synthetic Structural Optimized Analogues of the Anticancer Drugs Imatinib and Nilotinib
Q36314883P2Y12 Receptor Localizes in the Renal Collecting Duct and Its Blockade Augments Arginine Vasopressin Action and Alleviates Nephrogenic Diabetes Insipidus.
Q35602671Targeting renal purinergic signalling for the treatment of lithium-induced nephrogenic diabetes insipidus.
Q92013764The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species
Q92025973The Role of Eicosanoids in Alzheimer's Disease

Search more.