| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1013560893 |
| P356 | DOI | 10.1007/S00232-012-9461-3 |
| P2888 | exact match | https://scigraph.springernature.com/pub.10.1007/s00232-012-9461-3 |
| P698 | PubMed publication ID | 22772442 |
| P2093 | author name string | Alan F Lau | |
| Vivian Su | |||
| Kimberly Cochrane | |||
| P2860 | cites work | Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes | Q41925596 |
| Gap junction endocytosis and lysosomal degradation of connexin43-P2 in WB-F344 rat liver epithelial cells treated with DDT and lindane | Q41930257 | ||
| A mitosis-specific phosphorylation of the gap junction protein connexin43 in human vascular cells: biochemical characterization and localization. | Q42031368 | ||
| Functioning of cx43 hemichannels demonstrated by single channel properties | Q42615731 | ||
| Turnover and phosphorylation dynamics of connexin43 gap junction protein in cultured cardiac myocytes. | Q42859718 | ||
| The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1. | Q43091576 | ||
| Role of the ubiquitin-proteasome pathway in downregulation of the gap-junction protein Connexin43 by TNF-{alpha} in human corneal fibroblasts | Q43244092 | ||
| Targeted gap junction protein constructs reveal connexin-specific differences in oligomerization | Q43945269 | ||
| Phosphorylation of connexin 43 acts as a stimuli for proteasome-dependent degradation of the protein in lens epithelial cells. | Q44302609 | ||
| Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells | Q44454865 | ||
| Degradation of ornithine decarboxylase in reticulocyte lysate is ATP-dependent but ubiquitin-independent | Q44617013 | ||
| Degradation of connexins from the plasma membrane is regulated by inhibitors of protein synthesis | Q44697323 | ||
| High glucose down-regulates intercellular communication in retinal endothelial cells by enhancing degradation of connexin 43 by a proteasome-dependent mechanism | Q44881124 | ||
| Ubiquitination and down-regulation of gap junction protein connexin-43 in response to 12-O-tetradecanoylphorbol 13-acetate treatment | Q45061774 | ||
| Assembly of heteromeric connexons in guinea-pig liver en route to the Golgi apparatus, plasma membrane and gap junctions | Q45345949 | ||
| Articular chondrocytes express connexin 43 hemichannels and P2 receptors - a putative mechanoreceptor complex involving the primary cilium? | Q46126251 | ||
| Cx31 is assembled and trafficked to cell surface by ER-Golgi pathway and degraded by proteasomal or lysosomal pathways | Q46574879 | ||
| Cholesterol modulates membrane traffic along the endocytic pathway in sphingolipid-storage diseases | Q47622411 | ||
| Endocytic delivery to lysosomes mediated by concurrent fusion and kissing events in living cells. | Q50777337 | ||
| Implications and challenges of connexin connections to cancer. | Q55052930 | ||
| Sequestration of connexin43 in the early endosomes: An early event of Leydig cell tumor progression | Q57660640 | ||
| Fate of intercellular junctions in isolated adult rat cardiac cells | Q70058441 | ||
| Fate of annular gap junctions in the papillary cells of the enamel organ in the rat incisor | Q70156831 | ||
| Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts | Q70470418 | ||
| Gap junction assembly and endocytosis correlated with patterns of growth in a cultured adrenocortical tumor cell (SW-13) | Q70937758 | ||
| The gap junction protein connexin43 is degraded via the ubiquitin proteasome pathway | Q71823921 | ||
| Ubiquitinylation is not an absolute requirement for degradation of c-Jun protein by the 26 S proteasome | Q72223331 | ||
| Mutations in the connexin 32 gene in X-linked dominant Charcot-Marie-Tooth disease (CMTX1) | Q72372626 | ||
| Expression of multiple connexins in cultured neonatal rat ventricular myocytes | Q72553617 | ||
| Assembly of hepatic gap junctions. Topography and distribution of connexin 32 in intracellular and plasma membranes determined using sequence-specific antibodies | Q72940533 | ||
| Ultrastructural analysis of gap junctions in C6 glioma cells transfected with connexin43 cDNA | Q72967517 | ||
| Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia | Q73071883 | ||
| Connexin and gap junction degradation | Q73441404 | ||
| Degradation of connexin43 gap junctions involves both the proteasome and the lysosome | Q73876395 | ||
| Differential oligomerization of endoplasmic reticulum-retained connexin43/connexin32 chimeras | Q75184835 | ||
| Rapid turnover of connexin43 in the adult rat heart | Q77315007 | ||
| Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation | Q24294859 | ||
| Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex | Q24295120 | ||
| Ubiquitin-independent proteasomal degradation of endoplasmic reticulum-localized connexin43 mediated by CIP75 | Q24302500 | ||
| SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors | Q24304125 | ||
| Life cycle of connexins in health and disease | Q24541428 | ||
| Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradation | Q24653719 | ||
| Road to ruin: targeting proteins for degradation in the endoplasmic reticulum | Q26866096 | ||
| Proteasome subunit Rpn13 is a novel ubiquitin receptor | Q27650664 | ||
| Proteasome subunit Rpn1 binds ubiquitin-like protein domains | Q27930136 | ||
| The regulatory particle of the Saccharomyces cerevisiae proteasome. | Q27936746 | ||
| Ubiquitin-independent degradation of proteins by the proteasome | Q28284043 | ||
| Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43) | Q28513014 | ||
| Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum | Q28564736 | ||
| Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101 | Q28573992 | ||
| Endocytic processing of connexin43 gap junctions: a morphological study | Q28575069 | ||
| Eps15 interacts with ubiquitinated Cx43 and mediates its internalization | Q28583911 | ||
| A 26 S protease subunit that binds ubiquitin conjugates | Q29614362 | ||
| The 26S proteasome: a molecular machine designed for controlled proteolysis | Q29619692 | ||
| Degradation of oxidized proteins in mammalian cells. | Q30427697 | ||
| Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process | Q30478918 | ||
| ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear | Q30484892 | ||
| Internalized gap junctions are degraded by autophagy | Q30516553 | ||
| Selective degradation of oxidized calmodulin by the 20 S proteasome | Q31442080 | ||
| Supramolecular dynamics of gap junctions | Q32043496 | ||
| Beyond the gap: functions of unpaired connexon channels | Q33186594 | ||
| Altered patterns of gap junction distribution in ischemic heart disease. An immunohistochemical study of human myocardium using laser scanning confocal microscopy | Q33237793 | ||
| A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43. | Q33310245 | ||
| Posttranslational modifications in lens fiber connexins identified by off-line-HPLC MALDI-quadrupole time-of-flight mass spectrometry | Q33326791 | ||
| Post-translational modifications of connexin26 revealed by mass spectrometry | Q33506159 | ||
| Remodelling of gap junctions and connexin expression in diseased myocardium. | Q36870641 | ||
| Key connexin 43 phosphorylation events regulate the gap junction life cycle | Q37001308 | ||
| Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease | Q37035773 | ||
| Connexins, pannexins, innexins: novel roles of "hemi-channels" | Q37130086 | ||
| ERp29 restricts Connexin43 oligomerization in the endoplasmic reticulum | Q37193492 | ||
| Proteomics of the lysosome | Q37196950 | ||
| Hemichannels in cerebral ischemia | Q37411391 | ||
| Connexin43 phosphorylation: structural changes and biological effects | Q37421795 | ||
| Physiological significance of selective degradation of p62 by autophagy | Q37691820 | ||
| Regulation of gap junction intercellular communication by the ubiquitin system | Q37703671 | ||
| Endocytosis and post-endocytic sorting of connexins | Q37945366 | ||
| Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication | Q38288694 | ||
| The large GTPase dynamin2: a new player in connexin 43 gap junction endocytosis, recycling and degradation | Q39545825 | ||
| Gap junctions sensitize cancer cells to proteasome inhibitor MG132-induced apoptosis | Q39766909 | ||
| Interplay between PKC and the MAP kinase pathway in Connexin43 phosphorylation and inhibition of gap junction intercellular communication | Q39877643 | ||
| The TSG101 protein binds to connexins and is involved in connexin degradation. | Q39884960 | ||
| Molecular reorganization of Cx43, Zo-1 and Src complexes during the endocytosis of gap junction plaques in response to a non-genomic carcinogen | Q39912403 | ||
| The 2,2',4,4',5,5'-hexachlorobiphenyl-enhanced degradation of connexin 43 involves both proteasomal and lysosomal activities. | Q39933103 | ||
| Adaptation of connexin 43-hemichannel prostaglandin release to mechanical loading | Q39954576 | ||
| The detergent resistance of Connexin43 is lost upon TPA or EGF treatment and is an early step in gap junction endocytosis | Q39965117 | ||
| Akt phosphorylates Connexin43 on Ser373, a "mode-1" binding site for 14-3-3. | Q40030085 | ||
| The proteasome regulates the interaction between Cx43 and ZO-1. | Q40125363 | ||
| Cytosolic stress reduces degradation of connexin43 internalized from the cell surface and enhances gap junction formation and function | Q40379222 | ||
| Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase | Q40533718 | ||
| Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43. | Q40588863 | ||
| A tyrosine-based sorting signal is involved in connexin43 stability and gap junction turnover. | Q40650152 | ||
| Regulation of connexin degradation as a mechanism to increase gap junction assembly and function | Q40862155 | ||
| Connexins, connexons, and intercellular communication | Q41114815 | ||
| Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling | Q41337499 | ||
| Spermidine mediates degradation of ornithine decarboxylase by a non-lysosomal, ubiquitin-independent mechanism | Q41369476 | ||
| Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination | Q41589996 | ||
| Preparation, characterization, and structure of half gap junctional layers split with urea and EGTA. | Q41634369 | ||
| Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery | Q41849226 | ||
| Fate of gap junctions in isolated adult mammalian cardiomyocytes | Q41901202 | ||
| Ultrastructure and regulation of lateralized connexin43 in the failing heart. | Q41912488 | ||
| Genetic diseases and gene knockouts reveal diverse connexin functions. | Q33547231 | ||
| An overview of the molecular mechanism of autophagy | Q33703918 | ||
| Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin | Q33876996 | ||
| Degradation of oxidized proteins by the 20S proteasome. | Q33941917 | ||
| Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome. | Q33962101 | ||
| Cardiac gap junction channels: modulation of expression and channel properties | Q34317993 | ||
| Connexins and cell signaling in development and disease | Q34357394 | ||
| Assembly of connexin43 into gap junctions is regulated differentially by E-cadherin and N-cadherin in rat liver epithelial cells | Q34360941 | ||
| FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels | Q34450040 | ||
| Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart | Q34582749 | ||
| Autophagy: a pathway that contributes to connexin degradation. | Q34625117 | ||
| Intracellular transport, assembly, and degradation of wild-type and disease-linked mutant gap junction proteins | Q34719366 | ||
| Molecular basis of calcium regulation in connexin-32 hemichannels | Q34794839 | ||
| Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function | Q34996827 | ||
| Ubiquitin-independent proteolytic functions of the proteasome | Q35152119 | ||
| Androgen-regulated formation and degradation of gap junctions in androgen-responsive human prostate cancer cells | Q35191051 | ||
| Regulation of connexin biosynthesis, assembly, gap junction formation, and removal | Q35700076 | ||
| Activation of Akt, not connexin 43 protein ubiquitination, regulates gap junction stability | Q35709981 | ||
| Trafficking and recycling of the connexin43 gap junction protein during mitosis | Q35738193 | ||
| Incorporation of connexins into plasma membranes and gap junctions | Q35750008 | ||
| A field guide to ubiquitylation | Q35821299 | ||
| Connexins: functions without junctions | Q35885621 | ||
| The gap junction channel protein connexin 43 is covalently modified and regulated by SUMOylation | Q35939846 | ||
| Ubiquitination, intracellular trafficking, and degradation of connexins | Q36035273 | ||
| Regulation of ubiquitin-proteasome system mediated degradation by cytosolic stress | Q36095718 | ||
| Connexin phosphorylation as a regulatory event linked to gap junction channel assembly | Q36162583 | ||
| The splitting of hepatocyte gap junctions and zonulae occludentes with hypertonic disaccharides | Q36196516 | ||
| Five-hour half-life of mouse liver gap-junction protein | Q36205160 | ||
| Storage solutions: treating lysosomal disorders of the brain | Q36210235 | ||
| Connexins and their channels in cell growth and cell death | Q36267415 | ||
| Regulation of connexin hemichannels by monovalent cations | Q36295532 | ||
| Dislocation and degradation from the ER are regulated by cytosolic stress | Q36324141 | ||
| Pathways and control of connexin oligomerization. | Q36401843 | ||
| Life cycle of connexins: regulation of connexin synthesis and degradation | Q36463229 | ||
| P433 | issue | 7 | |
| P1104 | number of pages | 12 | |
| P304 | page(s) | 389-400 | |
| P577 | publication date | 2012-07-08 | |
| P1433 | published in | Journal of Membrane Biology | Q6295550 |
| P1476 | title | Degradation of connexins through the proteasomal, endolysosomal and phagolysosomal pathways | |
| P478 | volume | 245 |
| Q36031118 | Connexins: substrates and regulators of autophagy |
| Q37707273 | Degradation of connexins and gap junctions |
| Q38851729 | Differential effects of polyoma virus middle tumor antigen mutants upon gap junctional, intercellular communication |
| Q26823004 | Gap junction modulation and its implications for heart function |
| Q55048000 | Multifaceted Roles of Connexin 43 in Stem Cell Niches. |
| Q53563577 | New cellular mechanisms of gap junction degradation and recycling. |
| Q48909500 | Nutrient Starvation Decreases Cx43 Levels and Limits Intercellular Communication in Primary Bovine Corneal Endothelial Cells. |
| Q64244360 | PI3k and Stat3: Oncogenes that are Required for Gap Junctional, Intercellular Communication |
| Q30575661 | Protein kinase Cδ-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation |
| Q37158482 | Proteins and mechanisms regulating gap-junction assembly, internalization, and degradation |
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