scholarly article | Q13442814 |
P356 | DOI | 10.1517/17460441.2010.511473 |
P698 | PubMed publication ID | 22823992 |
P2093 | author name string | Mellar P Davis | |
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Kappa receptor bivalent ligands. | Q36737996 | ||
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Agmatine and imidazoline receptors: their role in opioid analgesia, tolerance and dependence | Q36892267 | ||
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Multiple ligands in opioid research | Q37265078 | ||
A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists | Q37333022 | ||
Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists | Q37342344 | ||
Designing multiple ligands - medicinal chemistry strategies and challenges | Q37387562 | ||
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Membrane functional organisation and dynamic of mu-opioid receptors | Q37419004 | ||
Comparison of the antinociceptive and antirewarding profiles of novel bifunctional nociceptin receptor/mu-opioid receptor ligands: implications for therapeutic applications | Q37444456 | ||
Tapentadol immediate release for the relief of moderate-to-severe acute pain | Q37606489 | ||
Delta and kappa opioid receptors as suitable drug targets for pain | Q37660843 | ||
Recent developments in the design of receptor specific opioid peptides | Q38282505 | ||
Pharmacological characterization of the dermorphin analog [Dmt(1)]DALDA, a highly potent and selective mu-opioid peptide | Q38300930 | ||
Opioid rotation from high-dose morphine to transdermal buprenorphine (Transtec) in chronic pain patients | Q39334344 | ||
Dying from cancer: results of a national population-based investigation | Q39417667 | ||
Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability | Q39428676 | ||
Heterodimerization of ORL1 and opioid receptors and its consequences for N-type calcium channel regulation. | Q39779553 | ||
Pentapeptides displaying mu opioid receptor agonist and delta opioid receptor partial agonist/antagonist properties | Q39793785 | ||
Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier | Q40960259 | ||
A pharmacological profile of the novel, peripherally-selective kappa-opioid receptor agonist, EMD 61753. | Q41978227 | ||
Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity | Q42014419 | ||
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Differential effect of opioids in patients with chronic pancreatitis: an experimental pain study | Q42167015 | ||
Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain | Q42379212 | ||
Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis | Q42691918 | ||
mu-Opioid/5-HT4 dual pharmacologically active agents-efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I). | Q43287655 | ||
NT69L, a novel analgesic, shows synergy with morphine | Q43299481 | ||
Managing cancer pain and symptoms of outpatients by rotation to sustained-release hydromorphone: a prospective clinical trial | Q43340074 | ||
[Dmt(1)]DALDA is highly selective and potent at mu opioid receptors, but is not cross-tolerant with systemic morphine | Q43892437 | ||
Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity | Q43962766 | ||
Endomorphin-1 analogues containing beta-proline are mu-opioid receptor agonists and display enhanced enzymatic hydrolysis resistance | Q44010088 | ||
In vitro quantitative study of the degradation of endomorphins | Q44129032 | ||
Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling | Q44330346 | ||
Antinociceptive interactions of opioid delta receptor agonists with morphine in mice: supra- and sub-additivity | Q44330959 | ||
Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the mu-opioid receptor and I2-imidazoline binding sites | Q44331089 | ||
Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties | Q44331872 | ||
Beta-casomorphins: substitution of phenylalanine with beta-homo phenylalanine increases the mu-type opioid receptor affinity | Q44332043 | ||
Synthesis of stereoisomeric analogues of endomorphin-2, H-Tyr-Pro-Phe-Phe-NH(2), and examination of their opioid receptor binding activities and solution conformation | Q44333208 | ||
Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2). | Q44333625 | ||
Arylacetamides as peripherally restricted kappa opioid receptor agonists | Q44333858 | ||
Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores | Q44334464 | ||
From models to molecules: opioid receptor dimers, bivalent ligands, and selective opioid receptor probes | Q44335899 | ||
Analgesic activity of a novel bivalent opioid peptide compared to morphine via different routes of administration | Q44336454 | ||
Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists | Q44336565 | ||
Update on opioid receptors. | Q44336699 | ||
Combination of opioid agonist and agonist-antagonist: patient-controlled analgesia requirement and adverse events among different-ratio morphine and nalbuphine admixtures for postoperative pain. | Q44339568 | ||
Dermorphin analogues carrying an increased positive net charge in their "message" domain display extremely high mu opioid receptor selectivity | Q44339837 | ||
Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers. | Q44340332 | ||
Attenuation of morphine tolerance and dependence with the highly selective delta-opioid receptor antagonist TIPP[psi]. | Q44341172 | ||
Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain | Q44341214 | ||
Two distinct mechanisms mediate acute mu-opioid receptor desensitization in native neurons. | Q44341856 | ||
Efforts aim to curb opioid deaths, injuries | Q44342053 | ||
Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors | Q44343448 | ||
Fentanyl derivatives bearing aliphatic alkaneguanidinium moieties: a new series of hybrid molecules with significant binding affinity for mu-opioid receptors and I2-imidazoline binding sites. | Q44344013 | ||
P433 | issue | 10 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | pain management | Q621261 |
P304 | page(s) | 1007-1022 | |
P577 | publication date | 2010-08-15 | |
P1433 | published in | Expert Opinion on Drug Discovery | Q5421204 |
P1476 | title | Opioid receptor targeting ligands for pain management: a review and update | |
P478 | volume | 5 |
Q55716780 | Antinociceptive potency of a fluorinated cyclopeptide Dmt-c[D-Lys-Phe-p-CF3-Phe-Asp]NH2. |
Q36274635 | Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives |
Q44347360 | Efficacy and safety of dual opioid therapy |
Q40269619 | Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations |
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