Ocular disorders and the utility of animal models in the discovery of melatoninergic drugs with therapeutic potential

scientific article published on 04 August 2012

Ocular disorders and the utility of animal models in the discovery of melatoninergic drugs with therapeutic potential is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1517/17460441.2012.714769
P698PubMed publication ID22860991
P5875ResearchGate publication ID230617582

P2093author name stringFernando Huete-Toral
Almudena Crooke
Jesus Pintor
Alejandro Martínez-Águila
Basilio Colligris
P2860cites workInternational Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptorsQ24623433
Influence of dietary melatonin on photoreceptor survival in the rat retina: an ocular toxicity studyQ24656986
Age related macular degeneration and sun exposure, iris colour, and skin sensitivity to sunlightQ24679626
Phototransduction by retinal ganglion cells that set the circadian clockQ28217956
Ocular axial length and choroidal thickness in newly hatched chicks and one-year-old chickens fluctuate in a diurnal pattern that is influenced by visual experience and intraocular pressure changesQ32071956
Effect of 5-MCA-NAT, a putative melatonin MT3 receptor agonist, on intraocular pressure in glaucomatous monkey eyesQ33206561
Use of melatonin to prevent selenite-induced cataract formation in rat eyesQ33260815
Protective effects of melatonin and aminoguanidine on the cornea in streptozotocin-induced diabetic ratsQ33354370
Oxidative damage and protection of the RPE.Q33837754
Ocular hypotensive effects of melatonin receptor agonists in the rabbit: further evidence for an MT3 receptorQ33964991
Sunlight and the 10-year incidence of age-related maculopathy: the Beaver Dam Eye StudyQ34319912
The immune response in glaucoma: a perspective on the roles of oxidative stressQ34388254
Alteration of melatonin secretion in patients with type 2 diabetes and proliferative diabetic retinopathyQ35015863
Pharmacologic neuroprotection with an inhibitor of nitric oxide synthase for the treatment of glaucomaQ35704069
Genetic aspects of melatonin biologyQ35882505
Basis of chloride transport in ciliary epitheliumQ35896172
The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contractionQ35900703
Agomelatine, a melatonin receptor agonist with 5-HT(2C) receptor antagonist properties, protects the developing murine white matter against excitotoxicityQ46604799
Melatonin inhibitory effect on cAMP accumulation in the chick retina developmentQ46700301
Melatonin pharmacokinetics in premenopausal and postmenopausal healthy female volunteersQ46856808
Inhibition of experimental proliferative vitreoretinopathy with protein kinase C inhibitor (chelerythrine chloride) and melatoninQ46865150
Melatonin receptors in chick ocular tissues: implications for a role of melatonin in ocular growth regulationQ46872518
Effects of melatonin in age-related macular degenerationQ46884759
Effects of intraperitoneal vitamin E, melatonin and aprotinin on leptin expression in the guinea pig eye during experimental uveitisQ46918197
Pineal indoleamines and vitamin E reduce nitric oxide-induced lipid peroxidation in rat retinal homogenatesQ48106892
Cataractogenesis and lipid peroxidation in newborn rats treated with buthionine sulfoximine: preventive actions of melatoninQ48734156
Retinal Localization of the Hydroxyindole-O-methyl Transferase (HIOMT) in the RatQ48811214
Early-stage retinal melatonin synthesis impairment in streptozotocin-induced diabetic wistar rats.Q48913574
Effect of experimental glaucoma on the non-image forming visual system.Q50279367
Influence of different artificial lighting regimes on intraocular pressure circadian profile in the dog (Canis familiaris).Q51564886
Aqueous humor dynamics during the day and night in healthy mature volunteers.Q51592670
Aqueous humor dynamics during the day and night in juvenile and adult rabbits.Q51726050
Blood-retinal barrier disruption and ultrastructural changes in the hypoxic retina in adult rats: the beneficial effect of melatonin administration.Q52579934
Confirmation of the rat model of chronic, moderately elevated intraocular pressure.Q53746354
Microglia in the optic nerve head and the region of parapapillary chorioretinal atrophy in glaucoma.Q53926835
Inhibitory effect of melatonin on cataract formation in newborn rats: evidence for an antioxidative role for melatonin.Q54024633
Involvement of carbonic anhydrases in the ocular hypotensive effect of melatonin analogue 5-MCA-NAT.Q54337814
Potential of melatonin to treat or prevent age-related macular degeneration through stimulation of telomerase activityQ54646753
Protective effects of melatonin in experimental free radical-related ocular diseases.Q36379509
Melatonin: Nature's most versatile biological signal?Q36525997
Melatonin in the eye: implications for glaucomaQ36686363
Melatonin receptors in the eye: location, second messengers and role in ocular physiologyQ36710431
Melatonin pharmacokinetics following two different oral surge-sustained release doses in older adultsQ36928856
Hypoxia-ischemia and retinal ganglion cell damageQ37236104
Pharmacological management of primary open-angle glaucoma: second-line options and beyondQ37253030
Diabetic retinopathy and angiogenesisQ37387307
Is the medication used to achieve the target intraocular pressure in glaucoma therapy of relevance?--an exemplary analysis on the basis of two beta-blockersQ37592669
Melatonin reprogrammes proteomic profile in light-exposed retina in vivoQ37625190
Recent advances in the development of melatonin MT(1) and MT(2) receptor agonists.Q37763715
Neuroprotection in glaucoma – Is there a future role?Q37783712
The role of melatonin in glaucoma: implications concerning pathophysiological relevance and therapeutic potentialQ37809108
Emerging drugs for ocular hypertensionQ37847182
The molecular basis of retinal ganglion cell death in glaucomaQ37966513
Novel therapies for glaucoma: a patent review 2007 - 2011.Q37970701
Melatonin synthetic analogs as nitric oxide synthase inhibitorsQ38003431
An unexpected effect of 5-MCA-NAT in chick retinal development.Q38434597
Molecular and cellular pharmacological properties of 5-methoxycarbonylamino-N-acetyltryptamine (MCA-NAT): a nonspecific MT3 ligand.Q39731055
Melatonin protects human retinal pigment epithelial (RPE) cells against oxidative stressQ40562642
Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implicationsQ41377025
Studies on the role of the retinal dopamine/melatonin system in experimental refractive errors in chickensQ41675878
Therapeutic effect of melatonin in experimental uveitis.Q41895570
5-MCA-NAT does not act through NQO2 to reduce intraocular pressure in New-Zealand white rabbitQ41937917
Identification of the melatonin-binding site MT3 as the quinone reductase 2.Q42630663
Effect of chondroitin sulfate on intraocular pressure in ratsQ43007259
Melatonin: a novel neuroprotectant for the treatment of glaucomaQ43107101
Pharmacokinetics of orally administered melatonin in critically ill patientsQ43195642
Involvement of melatonin MT(3) receptors in the regulation of intraocular pressure in rabbitsQ43566827
Melatonin delays photoreceptor degeneration in the rds/rds mouseQ43575894
The effect of melatonin on eye lens of rats exposed to ultraviolet radiationQ43615041
Sun exposure and age-related macular degeneration. An Australian case-control studyQ43909889
Effects of pinealectomy and melatonin on the retrograde degeneration of retinal ganglion cells in a novel model of intraorbital optic nerve transection in miceQ44032675
The effects of constant and diurnal illumination of the pineal gland and the eyes on ocular growth in chicksQ44526933
Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatoninQ44532250
Antioxidant protection in cultured corneal cells and whole corneas submitted to UV-B exposureQ44713465
Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activitiesQ44763557
Retinal oxidative stress induced by high intraocular pressureQ45071741
Sympathetic nervous system modulates the ocular hypotensive action of MT2-melatonin receptors in normotensive rabbitsQ45082610
Cellular and vascular changes in the retina of neonatal rats after an acute exposure to hypoxia.Q45993787
Melatonin provides anxiolysis, enhances analgesia, decreases intraocular pressure, and promotes better operating conditions during cataract surgery under topical anesthesiaQ46082009
Melatonin reduces oxidative stress in the rat lens due to radiation-induced oxidative injuryQ46268380
Effects of 530 nm green light on refractive status, melatonin, MT1 receptor, and melanopsin in the guinea pig.Q46415458
Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma.Q46433031
A new experimental model of glaucoma in rats through intracameral injections of hyaluronic acidQ46566379
Radioprotective effects of melatonin on radiation-induced cataractQ46575504
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)989-1001
P577publication date2012-08-04
P1433published inExpert Opinion on Drug DiscoveryQ5421204
P1476titleOcular disorders and the utility of animal models in the discovery of melatoninergic drugs with therapeutic potential
P478volume7

Reverse relations

cites work (P2860)
Q46931865Beneficial effect of the antioxidant riboflavin on gene expression of extracellular matrix elements, antioxidants and oxidases in keratoconic stromal cells
Q33689431Diadenosine tetraphosphate as a potential therapeutic nucleotide to treat glaucoma.
Q53628648Effect of Melatonin and 5-Methoxycarbonylamino-N-Acetyltryptamine on the Intraocular Pressure of Normal and Glaucomatous Mice.
Q89964068Intravitreal Delivery of Melatonin Is Protective Against the Photoreceptor Loss in Mice: A Potential Therapeutic Strategy for Degenerative Retinopathy