The role of glia in α-synucleinopathies

scientific article published on 02 September 2012

The role of glia in α-synucleinopathies is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1028254054
P356DOI10.1007/S12035-012-8340-3
P932PMC publication ID3589649
P698PubMed publication ID22941028
P5875ResearchGate publication ID230783273

P2093author name stringNadia Stefanova
Lisa Fellner
P2860cites workAnti-inflammatory drugs and risk of Parkinson disease: A meta-analysisQ22241651
The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementiaQ22252705
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stressQ24301895
p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathiesQ24320549
HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtinQ24337155
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson diseaseQ24596763
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cellsQ24633663
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synucleinQ24655848
p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophyQ24682056
Multiple system atrophy: a clinical and neuropathological perspectiveQ26829838
Mutation in the alpha-synuclein gene identified in families with Parkinson's diseaseQ27860459
alpha-Synuclein locus triplication causes Parkinson's diseaseQ27860533
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivoQ27860578
Tumour necrosis factor-induced death of adult human oligodendrocytes is mediated by apoptosis inducing factor.Q40362975
Grading of neuropathology in multiple system atrophy: proposal for a novel scaleQ40398217
Alpha-synuclein overexpression in oligodendrocytic cells results in impaired adhesion to fibronectin and cell deathQ40418370
Mutant alpha-synuclein overexpression mediates early proinflammatory activityQ40778644
Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2.Q40870297
Rifampicin reduces alpha-synuclein in a transgenic mouse model of multiple system atrophyQ41078288
Neuropathology of Parkinson's diseaseQ41095404
Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophyQ42455519
The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlationsQ42469816
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's diseaseQ42484469
Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.Q42486578
Nitrated alpha-synuclein-activated microglial profiling for Parkinson's diseaseQ42521775
Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson diseaseQ42571006
Minocycline 1-year therapy in multiple-system-atrophy: effect on clinical symptoms and [(11)C] (R)-PK11195 PET (MEMSA-trial).Q43219125
Striatal transplantation for multiple system atrophy--are grafts affected by alpha-synucleinopathy?Q43600606
Glial cell death induced by overexpression of alpha-synucleinQ43728426
Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism.Q43875599
Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.Q43906992
Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease.Q44086465
Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome functionQ44552114
Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation.Q44702932
Microglial activation parallels system degeneration in multiple system atrophyQ44745872
Effects of alpha-synuclein immunization in a mouse model of Parkinson's diseaseQ44769508
Microglial MyD88 signaling regulates acute neuronal toxicity of LPS-stimulated microglia in vitroQ44964904
Failure of neuronal protection by inhibition of glial activation in a rat model of striatonigral degenerationQ45062530
Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains.Q45201632
Microglial activation and dopamine terminal loss in early Parkinson's diseaseQ45237159
Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice.Q45297626
alpha-Synuclein promotes the recruitment of tau to protein inclusions in oligodendroglial cells: effects of oxidative and proteolytic stressQ46097999
Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's diseaseQ46404588
Role of activated astrocytes in neuronal damage: potential links to HIV-1-associated dementiaQ46493395
Microglial cells and Parkinson's diseaseQ46567817
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body diseaseQ46593989
A possible role for humoral immunity in the pathogenesis of Parkinson's diseaseQ46748023
Non-steroidal anti-inflammatory drugs have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitroQ46829340
Elevated glial brain-derived neurotrophic factor in Parkinson's diseased nigraQ47397177
Poor and protracted myelination as a contributory factor to neurodegenerative disordersQ48116261
Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's diseaseQ48132477
The distribution of oligodendroglial inclusions in multiple system atrophy and its relevance to clinical symptomatologyQ48142791
Differential expression of interferon-gamma receptor on human glial cells in vivo and in vitroQ48163261
Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brainsQ48187073
Tumor necrosis factor-alpha-induced cell death in U373 cells overexpressing alpha-synucleinQ48251119
Argyrophilic glial inclusions in the midbrain of patients with Parkinson's disease and diffuse Lewy body disease are immunopositive for NACP/alpha-synucleinQ48280288
Non-steroidal anti-inflammatory drugs in Parkinson's diseaseQ28222289
Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trialQ28296434
αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunctionQ28506296
Alpha-synuclein cooperates with CSPalpha in preventing neurodegenerationQ28587785
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementiaQ29547174
Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brainsQ29616293
A pilot clinical trial of creatine and minocycline in early Parkinson disease: 18-month resultsQ30407150
Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice.Q30494594
Macrophage-mediated GDNF delivery protects against dopaminergic neurodegeneration: a therapeutic strategy for Parkinson's diseaseQ30496234
Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutantsQ30991616
Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neuronsQ33312931
Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease.Q33526342
Consensus statement on the diagnosis of multiple system atrophy.Q33605440
Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathiesQ33726660
CSF from Parkinson disease patients differentially affects cultured microglia and astrocytes.Q33757872
Prevalence of progressive supranuclear palsy and multiple system atrophy: a cross-sectional studyQ33782156
Neurodegeneration in a transgenic mouse model of multiple system atrophy is associated with altered expression of oligodendroglial-derived neurotrophic factorsQ33958289
Targeted overexpression of human alpha-synuclein in oligodendroglia induces lesions linked to MSA-like progressive autonomic failureQ34032393
Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease.Q34287439
The role of glial cells in Parkinson's diseaseQ34318207
Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytesQ34472472
Demonstration of alpha-synuclein immunoreactivity in neuronal and glial cytoplasm in normal human brain tissue using proteinase K and formic acid pretreatmentQ34524887
HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration.Q34615988
Clinical outcomes of progressive supranuclear palsy and multiple system atrophyQ34767058
Astrocytes in Parkinson's disease and DJ-1Q34792091
α-Synuclein impairs macroautophagy: implications for Parkinson's disease.Q35005567
Expression of mutant alpha-synuclein modulates microglial phenotype in vitroQ35014520
Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages).Q35045422
IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's diseaseQ35064839
Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neuronsQ35167964
Description of Parkinson's disease as a clinical syndrome.Q35170978
Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's diseaseQ35320917
Neuropathological spectrum of synucleinopathiesQ35540178
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locusQ35692589
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.Q35764504
Glutathione peroxidase, glial cells and Parkinson's diseaseQ48359939
Aspirin and salicylate protect against MPTP-induced dopamine depletion in miceQ48388037
Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodiesQ48401512
Degeneration in different parkinsonian syndromes relates to astrocyte type and astrocyte protein expressionQ48405912
Contribution of somal Lewy bodies to neuronal deathQ48557845
Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocyclineQ48599725
Some Immunohistochemical Features of Argyrophilic Grain Dementia With Normal Cortical Choline Acetyltransferase Levels but Extensive Subcortical Pathology and Markedly Reduced DopamineQ48601161
Absence of alpha-synuclein mRNA expression in normal and multiple system atrophy oligodendroglia.Q48697425
Myeloperoxidase inhibition ameliorates multiple system atrophy-like degeneration in a transgenic mouse model.Q48786266
Analysis of the expression level of alpha-synuclein mRNA using postmortem brain samples from pathologically confirmed cases of multiple system atrophy.Q48787937
Inhibition of lipopolysaccharide-induced nitric oxide and cytokine production by ultralow concentrations of dynorphins in mixed glia cultures.Q48821941
Low glutathione and high iron govern the susceptibility of oligodendroglial precursors to oxidative stress.Q48938738
Evaluation of markers of oxidative stress, antioxidant function and astrocytic proliferation in the striatum and frontal cortex of Parkinson's disease brains.Q51804442
alpha-synuclein is developmentally expressed in cultured rat brain oligodendrocytes.Q52165042
Activated microglia in dementia with Lewy bodies.Q53236387
[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy.Q53642827
Genetic mouse models for Parkinson's disease display severe pathology in glial cell mitochondria.Q54621912
Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease.Q54626622
Multiple system atrophyQ56442789
Dementia with Lewy bodiesQ57813917
NSAID use and risk of Parkinson disease: a population-based case-control studyQ57950713
Microglial activation mediates neurodegeneration related to oligodendroglial α-synucleinopathy: Implications for multiple system atrophyQ59273827
Survival in multiple system atrophyQ63352447
The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson's diseaseQ64797268
NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brainsQ64797306
Lewy bodies in Parkinson's disease are recognized by antibodies to complement proteinsQ68015727
Neuroinflammatory processes in Parkinson's diseaseQ70606957
Expression of the endocytosis regulatory proteins Rab5 and Rabaptin-5 in glial cytoplasmic inclusions from brains with multiple system atrophyQ73629508
Naloxone prevents microglia-induced degeneration of dopaminergic substantia nigra neurons in adult ratsQ73755556
MicrogliaQ81034804
Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degenerationQ81589639
Accumulation of histone deacetylase 6, an aggresome-related protein, is specific to Lewy bodies and glial cytoplasmic inclusionsQ83339692
???Q64767196
Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injuryQ35768729
Pro-regenerative properties of cytokine-activated astrocytes.Q35775364
Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's diseaseQ35918549
Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy.Q36085162
SNCA variants are associated with increased risk for multiple system atrophyQ36460907
Cellular pathology in multiple system atrophyQ36589164
"Minimal change" multiple system atrophy.Q36751604
Multiple system atrophy: a review of 203 pathologically proven casesQ36852143
Protein aggregation mechanisms in synucleinopathies: commonalities and differencesQ36994070
The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's diseaseQ37054679
Agonism of Peroxisome Proliferator Receptor-Gamma may have Therapeutic Potential for Neuroinflammation and Parkinson's DiseaseQ37211800
Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegenerationQ37241917
Multiple system atrophy: a primary oligodendrogliopathy.Q37282526
Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse modelQ37289669
Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survivalQ37347595
Neuroanatomy and pathology of sporadic Parkinson's disease.Q37397139
Gliogenesis: historical perspectives, 1839-1985.Q37397181
NSAID use and the risk of Parkinson's disease: systematic review and meta-analysis of observational studiesQ37591516
Papp-Lantos inclusions and the pathogenesis of multiple system atrophy: an updateQ37716685
Microglia and neuroprotection: from in vitro studies to therapeutic applicationsQ37770636
Glia: initiators and progressors of pathology in Parkinson's diseaseQ37842235
Autophagic pathways in Parkinson disease and related disordersQ37854912
Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging conceptsQ37874476
Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophyQ38585651
Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophyQ39340274
Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line.Q39604586
Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfideQ39821041
Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.Q39885727
Astrocyte-secreted GDNF and glutathione antioxidant system protect neurons against 6OHDA cytotoxicityQ39899392
Clearance and deposition of extracellular alpha-synuclein aggregates in microglia.Q39980342
Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinson's diseaseQ39986517
Interferon-gamma-dependent cytotoxic activation of human astrocytes and astrocytoma cellsQ39997221
Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's diseaseQ40098160
Synuclein activates microglia in a model of Parkinson's diseaseQ40126232
Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microgliaQ40197055
Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cellsQ40225441
Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: role of neuron-glia crosstalkQ40269212
Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030.Q40273125
P433issue2
P921main subjectneurogliaQ177105
neurodegenerationQ1755122
cellQ7868
nerve tissue proteinQ6996861
nervous systemQ9404
Parkinson disease associated proteinsQ77946709
P304page(s)575-586
P577publication date2012-09-02
2013-04-01
P1433published inMolecular NeurobiologyQ15716645
P1476titleThe role of glia in α-synucleinopathies
P478volume47

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cites work (P2860)
Q36086721A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy
Q35544737Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy
Q60947930Extracellular Interactions of Alpha-Synuclein in Multiple System Atrophy
Q35627057Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy
Q26851153Glia and alpha-synuclein in neurodegeneration: A complex interaction
Q34491177Glucocerebrosidase mutations in primary parkinsonism
Q55085565Glutathione S-Transferase Alpha 4 Prevents Dopamine Neurodegeneration in a Rat Alpha-Synuclein Model of Parkinson's Disease.
Q38126332Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration
Q55242370Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis.
Q59335641Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?
Q36513407Models of multiple system atrophy
Q49562668Multiple System Atrophy: An Oligodendroglioneural Synucleinopathy.
Q26771536Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation
Q38173380Neuroprotective function of 14-3-3 proteins in neurodegeneration
Q35857994Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity
Q39152836Potential Modes of Intercellular α-Synuclein Transmission
Q47663712Potential clinical utility of multiple system atrophy biomarkers
Q35043731Preconditioning of microglia by α-synuclein strongly affects the response induced by toll-like receptor (TLR) stimulation
Q55691017Region-Specific Effects of Immunotherapy With Antibodies Targeting α-synuclein in a Transgenic Model of Synucleinopathy.
Q34548551Regulation of the mammalian heat shock factor 1.
Q26770919Review: Multiple system atrophy: emerging targets for interventional therapies
Q44294417Screening of Toll-like receptors expression in multiple system atrophy brains
Q38039857Targeting the chameleon: a focused look at α-synuclein and its roles in neurodegeneration
Q35833984The Interplay between Alpha-Synuclein Clearance and Spreading
Q38944057The Potential Role of Gut-Derived Inflammation in Multiple System Atrophy.
Q52374337The Role of LRRK2 in Neurodegeneration of Parkinson Disease.
Q35427654The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies.
Q26853537The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease
Q33868678Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy
Q33797532Towards translational therapies for multiple system atrophy
Q48465555Transcriptome analysis of grey and white matter cortical tissue in multiple system atrophy

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