Telavancin for the treatment of hospital-acquired pneumonia: findings from the ATTAIN studies.

scientific article published on August 2012

Telavancin for the treatment of hospital-acquired pneumonia: findings from the ATTAIN studies. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1586/ERI.12.81
P698PubMed publication ID23030322

P50authorEsteban C NanniniQ39392197
G Ralph CoreyQ115862748
Martin E StryjewskiQ115862786
P2860cites workTelavancin, a multifunctional lipoglycopeptide, disrupts both cell wall synthesis and cell membrane integrity in methicillin-resistant Staphylococcus aureusQ24556635
Telavancin penetration into human epithelial lining fluid determined by population pharmacokinetic modeling and Monte Carlo simulationQ39686295
Predictors of mortality for methicillin-resistant Staphylococcus aureus health-care-associated pneumonia: specific evaluation of vancomycin pharmacokinetic indicesQ39771366
In vitro activity of TD-6424 against Staphylococcus aureusQ40130630
Evaluation of the extracellular and intracellular activities (human THP-1 macrophages) of telavancin versus vancomycin against methicillin-susceptible, methicillin-resistant, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureusQ40216245
Activity of telavancin against staphylococci and enterococci determined by MIC and resistance selection studiesQ41807543
Telavancin disrupts the functional integrity of the bacterial membrane through targeted interaction with the cell wall precursor lipid II.Q42049579
Pharmacodynamic effects of telavancin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains in the presence of human albumin or serum and in an in vitro kinetic modelQ42627265
Telavancin activity against Gram-positive bacteria isolated from respiratory tract specimens of patients with nosocomial pneumoniaQ42905478
Activity of telavancin against heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) in vitro and in an in vivo mouse model of bacteraemiaQ43170102
Effect of Telavancin on the pharmacokinetics of the cytochrome P450 3A probe substrate midazolam: a randomized, double-blind, crossover study in healthy subjectsQ43184655
Telavancin versus standard therapy for treatment of complicated skin and soft-tissue infections due to gram-positive bacteriaQ43553034
Continuation of a randomized, double-blind, multicenter study of linezolid versus vancomycin in the treatment of patients with nosocomial pneumoniaQ43781411
Nosocomial infections in medical intensive care units in the United States. National Nosocomial Infections Surveillance SystemQ44727502
Comparative in vitro activity of telavancin (TD-6424), a rapidly bactericidal, concentration-dependent anti-infective with multiple mechanisms of action against Gram-positive bacteriaQ44803993
Effects of a new antibacterial, telavancin, on cardiac repolarization (QTc interval duration) in healthy subjectsQ44938149
Hydrophobic vancomycin derivatives with improved ADME properties: discovery of telavancin (TD-6424).Q45013095
High-dose vancomycin therapy for methicillin-resistant Staphylococcus aureus infections: efficacy and toxicityQ45302930
Lack of effect of moderate hepatic impairment on the pharmacokinetics of telavancinQ46489824
Pharmacokinetics and intrapulmonary concentrations of linezolid administered to critically ill patients with ventilator-associated pneumoniaQ46589068
Telavancin versus vancomycin for the treatment of complicated skin and skin-structure infections caused by gram-positive organismsQ46620675
Influence of vancomycin minimum inhibitory concentration on the treatment of methicillin-resistant Staphylococcus aureus bacteremiaQ46826194
Comparative activity of telavancin against isolates of community-associated methicillin-resistant Staphylococcus aureus.Q53544946
Ventilator-associated pneumoniaQ28212947
A measurement of the efficacy of nosocomial infection control using the 95 per cent confidence interval for infection ratesQ30463029
Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: a systematic review and meta-analysisQ33390834
Pharmacokinetics, serum inhibitory and bactericidal activity, and safety of telavancin in healthy subjectsQ33554391
In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolatesQ33876626
Nosocomial MRSA pneumonia: data from recent clinical trialsQ33935295
Efficacy of telavancin (TD-6424), a rapidly bactericidal lipoglycopeptide with multiple mechanisms of action, in a murine model of pneumonia induced by methicillin-resistant Staphylococcus aureusQ34077052
Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summaryQ34158152
The impact of hospital-acquired bloodstream infectionsQ34213597
Comparative Efficacies of Human Simulated Exposures of Telavancin and Vancomycin against Methicillin-Resistant Staphylococcus aureus with a Range of Vancomycin MICs in a Murine Pneumonia ModelQ34309620
Tissue penetration of telavancin after intravenous administration in healthy subjectsQ34352132
Telavancin versus standard therapy for treatment of complicated skin and skin structure infections caused by gram-positive bacteria: FAST 2 studyQ34509652
Telavancin versus vancomycin for hospital-acquired pneumonia due to gram-positive pathogensQ34699108
Relationship of MIC and bactericidal activity to efficacy of vancomycin for treatment of methicillin-resistant Staphylococcus aureus bacteremiaQ34783668
Correlation of daptomycin bactericidal activity and membrane depolarization in Staphylococcus aureusQ35166213
Penetration of vancomycin into epithelial lining fluid in healthy volunteersQ35598408
Analysis of vancomycin entry into pulmonary lining fluid by bronchoalveolar lavage in critically ill patientsQ35808723
Vancomycin in vitro bactericidal activity and its relationship to efficacy in clearance of methicillin-resistant Staphylococcus aureus bacteremiaQ35879117
Glycopeptides in clinical development: pharmacological profile and clinical perspectives.Q35879826
Clinical and economic consequences of ventilator-associated pneumonia: a systematic review.Q36282000
Intrapulmonary distribution of intravenous telavancin in healthy subjects and effect of pulmonary surfactant on in vitro activities of telavancin and other antibioticsQ36422696
Larger vancomycin doses (at least four grams per day) are associated with an increased incidence of nephrotoxicityQ36538707
Pharmacodynamics of telavancin (TD-6424), a novel bactericidal agent, against gram-positive bacteriaQ36670352
Microbial etiologies of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumoniaQ37769547
P433issue8
P921main subjectpneumoniaQ12192
hospital-acquired pneumoniaQ1957663
telavancinQ7695658
P304page(s)847-854
P577publication date2012-08-01
P1433published inExpert Review of Anti-infective TherapyQ15734432
P1476titleTelavancin for the treatment of hospital-acquired pneumonia: findings from the ATTAIN studies
P478volume10

Reverse relations

cites work (P2860)
Q57153846Antimicrobial Therapy in Community-Acquired Pneumonia in Children
Q35669688Reversing resistance: The next generation antibacterials
Q28078557Systematic Review and Meta-Analysis of the Efficacy and Safety of Telavancin for Treatment of Infectious Disease: Are We Clearer?
Q38170557Treating paediatric community-acquired pneumonia in the era of antimicrobial resistance
Q27015976Treatment of Gram-positive infections in critically ill patients

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