Serotonin-glutamate and serotonin-dopamine reciprocal interactions as putative molecular targets for novel antipsychotic treatments: from receptor heterodimers to postsynaptic scaffolding and effector proteins.

scientific article

Serotonin-glutamate and serotonin-dopamine reciprocal interactions as putative molecular targets for novel antipsychotic treatments: from receptor heterodimers to postsynaptic scaffolding and effector proteins. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P6179Dimensions Publication ID1017531157
P356DOI10.1007/S00213-012-2921-8
P698PubMed publication ID23179966

P50authorAndrea de BartolomeisQ42961470
P2093author name stringF Iasevoli
E F Buonaguro
P2860cites workThe dopamine hypothesis of schizophrenia: version III--the final common pathwayQ22242827
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behaviorQ24310712
F15063, a compound with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. II. Activity in models of positive symptoms of schizophrenia.Q24564963
G-protein-coupled receptor heterodimerization modulates receptor functionQ24603239
Group II metabotropic glutamate receptor agonist ameliorates MK801-induced dysfunction of NMDA receptors via the Akt/GSK-3β pathway in adult rat prefrontal cortexQ24612550
Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptorsQ24630429
Building a new conceptual framework for receptor heteromersQ24644975
Identification of a serotonin/glutamate receptor complex implicated in psychosisQ24655484
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse modelsQ28119018
Behavioral evidence for interactions between a hallucinogenic drug and group II metabotropic glutamate receptorsQ28140916
Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate releaseQ28142342
Mutation screening of the Homer gene family and association analysis in schizophreniaQ28180472
A single dose of lysergic acid diethylamide influences gene expression patterns within the mammalian brainQ28211993
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificityQ28262782
Unraveling monoamine receptors involved in the action of typical and atypical antipsychotics on glutamatergic and serotonergic transmission in prefrontal cortexQ28264575
Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localizationQ28267111
Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in ratsQ28280906
Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behaviorQ28286238
Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonistQ28296508
Regulation of Akt signaling by D2 and D3 dopamine receptors in vivoQ28512114
Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtypeQ28569264
Methylation of the CpG sites only on the sense strand of the APC gene is specific for hepatocellular carcinomaQ28743228
Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoringQ28754716
Cell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the BrainQ30437957
The presynaptic component of the serotonergic system is required for clozapine's efficacy.Q30471071
A phenomenological comparison of LSD and schizophrenic states.Q52250605
Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients.Q52506986
Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania.Q53444102
A comparison of the acute effects of zotepine and other antipsychotics on rat cortical dopamine release, in vivo.Q54352495
Regulation of Akt and Wnt signaling by the group II metabotropic glutamate receptor antagonist LY341495 and agonist LY379268.Q54597890
Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi valuesQ69374550
"Psychedelic" Experiences in Acute PsychosesQ72779740
Striatal and extra-striatal D(2)/D(3) dopamine receptor occupancy by quetiapine in vivo. [(123)I]-epidepride single photon emission tomography(SPET) studyQ73144735
Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in miceQ73276377
Low GSK-3beta immunoreactivity in postmortem frontal cortex of schizophrenic patientsQ73719191
Ultrastructural localization of the serotonin 2A receptor in dopaminergic neurons in the ventral tegmental areaQ73763841
Endogenous serotonin enhances the release of dopamine in the striatum only when nigro-striatal dopaminergic transmission is activatedQ74238236
A two-year evaluation of chlorpromazine in clinical research and practiceQ74284277
Pharmacological characterizations of memantine-induced disruption of prepulse inhibition of the acoustic startle response in mice: involvement of dopamine D2 and 5-HT2A receptorsQ82734499
Attention deficit induced by blockade of N-methyl D-aspartate receptors in the prefrontal cortex is associated with enhanced glutamate release and cAMP response element binding protein phosphorylation: role of metabotropic glutamate receptors 2/3Q83067494
Hallucinogenic drug induced states resemble acute endogenous psychoses: results of an empirical studyQ84447367
Hetero-dimerization of serotonin 5-HT(2A) and dopamine D(2) receptorsQ39657147
A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesiaQ39908449
Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat.Q40072204
Clozapine functions through the prefrontal cortex serotonin 1A receptor to heighten neuronal activity via calmodulin kinase II-NMDA receptor interactions.Q40226041
KKHA-761, a potent D3 receptor antagonist with high 5-HT1A receptor affinity, exhibits antipsychotic properties in animal models of schizophreniaQ40363514
A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depressionQ40485025
Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory CortexQ40629393
A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transductionQ40654414
M100907, a serotonin 5-HT2A receptor antagonist and putative antipsychotic, blocks dizocilpine-induced prepulse inhibition deficits in Sprague-Dawley and Wistar ratsQ41615477
Mechanism of activation and function of protein kinase B.Q41732739
Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in ratsQ41876191
Chronic antidepressants induce redistribution and differential activation of alphaCaM kinase II between presynaptic compartments.Q42171463
Clozapine and haloperidol differently suppress the MK-801-increased glutamatergic and serotonergic transmission in the medial prefrontal cortex of the rat.Q42171479
Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive miceQ42500923
Characterization of the proteome, diseases and evolution of the human postsynaptic density.Q42610204
Effect of tandospirone, a serotonin-1A receptor partial agonist, on information processing and locomotion in dizocilpine-treated ratsQ42949866
Divergent acute and chronic modulation of glutamatergic postsynaptic density genes expression by the antipsychotics haloperidol and sertindoleQ42961384
Haloperidol induces higher Homer1a expression than risperidone, olanzapine and sulpiride in striatal sub-regionsQ43122987
Pattern of acute induction of Homer1a gene is preserved after chronic treatment with first- and second-generation antipsychotics: effect of short-term drug discontinuation and comparison with Homer1a-interacting genesQ43165997
Effect of pretreatment with risperidone on phencyclidine-induced disruptions in object recognition memory and prefrontal cortex parvalbumin immunoreactivity in the rat.Q43242125
Chronic infusion of PCP via osmotic mini-pumps: a new rodent model of cognitive deficit in schizophrenia characterized by impaired attentional set-shifting (ID/ED) performanceQ43275264
Evaluation of NMDA receptor models of schizophrenia: divergences in the behavioral effects of sub-chronic PCP and MK-801.Q43283706
Effect of clozapine on the dimerization of serotonin 5-HT(2A) receptor and its genetic variant 5-HT(2A)H425Y with dopamine D(2) receptorQ43555535
The administration of psilocybin to healthy, hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerabilityQ43842117
Acute administration of antipsychotics modulates Homer striatal gene expression differentiallyQ43880337
The selective serotonin(1A)-receptor antagonist WAY 100635 blocks behavioral stimulating effects of cocaine but not ventral striatal dopamine increaseQ44111455
Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patientsQ44182405
Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactionsQ44193907
Clozapine-induced reduction of glutamate transport in the frontal cortex is not mediated by GLAST and EAAC1.Q44295851
Regulation of PI3K/Akt signaling by N-desmethylclozapine through activation of δ-opioid receptorQ44350433
Dynamic changes in prefrontal cortex gene expression following lysergic acid diethylamide administrationQ44374196
The 5-HT2A receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonismQ44540861
Effect of antipsychotic treatment on the prepulse inhibition deficit of mGluR5 knockout miceQ44654536
The difference between the experienced reality of hallucinations in young drug abusers and schizophrenic patientsQ44677537
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophreniaQ44743796
Metabotropic glutamate 2/3 receptors as drug targetsQ44798168
Cocaine acts on accumbens monoamines and locomotor behavior via a 5-HT2A/2C receptor mechanism as shown by ketanserin: 24-h follow-up studiesQ44849193
AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim testQ45021524
Effects of acute treatment with antidepressant drugs on sensorimotor gating deficits in ratsQ45037369
Antidepressants activate CaMKII in neuron cell body by Thr286 phosphorylationQ45217305
Antipsychotics alter the protein expression levels of beta-catenin and GSK-3 in the rat medial prefrontal cortex and striatumQ45287391
Differential expression of glutamate transporter genes after chronic oral treatment with aripiprazole in rats.Q45970112
Complex, multimodal behavioral profile of the Homer1 knockout mouse.Q45990816
Decreased density of serotonin 2A receptors in the superior temporal gyrus in schizophrenia--a postmortem study.Q46039002
Dopamine receptor subtypes contribution to Homer1a induction: insights into antipsychotic molecular actionQ46109007
Antipsychotic and antidepressant co-treatment: effects on transcripts of inducible postsynaptic density genes possibly implicated in behavioural disordersQ46135298
Striatal D2/D3 receptor occupancy, clinical response and side effects with amisulpride: an iodine-123-iodobenzamide SPET studyQ46397161
Social interaction deficits caused by chronic phencyclidine administration are reversed by oxytocinQ46411318
The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gatingQ46429862
Analysis of the role of 5-HT1A receptors in spatial and aversive learning in the rat.Q46436815
Role of serotonin-1A receptors in the action of antipsychotic drugs: comparison of prepulse inhibition studies in mice and rats and relevance for human pharmacologyQ46438539
Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptorsQ46446352
5-HT2A and muscarinic receptors in schizophrenia: a postmortem studyQ46447717
PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptorsQ30482703
LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptorQ30484494
Role of serotonin 2A receptors in the D-amphetamine-induced release of dopamine: comparison with previous data on alpha1b-adrenergic receptorsQ30965915
On the fitting of binding data when receptor dimerization is suspectedQ31158245
5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine releaseQ32134744
Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.Q33186255
Prostate cancer immunotherapy yields superior long-term survival in TRAMP mice when administered at an early stage of carcinogenesis prior to the establishment of tumor-associated immunosuppression at later stagesQ33606027
The role of serotonin in antipsychotic drug actionQ33702888
Abnormalities in α/β-CaMKII and related mechanisms suggest synaptic dysfunction in hippocampus of LPA1 receptor knockout mice.Q33717636
Differential expression of metabotropic glutamate receptors 2 and 3 in schizophrenia: a mechanism for antipsychotic drug action?Q33812982
An animal model of schizophrenia based on chronic LSD administration: old idea, new resultsQ33830284
Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortexQ33884206
5-HT(1A) receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortexQ33912242
Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell groupQ33958613
Practice guideline for the treatment of patients with schizophrenia, second edition.Q33976372
Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients.Q34096914
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic DrugsQ34192438
Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs.Q34236107
Prefrontal DA Transmission at D1 Receptors and the Pathology of SchizophreniaQ34272454
Diverse psychotomimetics act through a common signaling pathwayQ34278280
Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens.Q34310093
GSK3 takes centre stage more than 20 years after its discoveryQ34374129
Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a ß-arrestin2/Src/Akt signaling complex in vivoQ34402623
Psychological effects of (S)-ketamine and N,N-dimethyltryptamine (DMT): a double-blind, cross-over study in healthy volunteersQ34475011
Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist actionQ34485906
DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophreniaQ34508840
Lifetime prevalence of psychotic and bipolar I disorders in a general populationQ34596831
DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in schizophrenic patients--support for the glutamate hypothesis of schizophreniasQ34617115
A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosisQ34631718
Treatment with olanzapine is associated with modulation of the default mode network in patients with SchizophreniaQ34660641
Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cellsQ34693656
Interactive effects of mGlu5 and 5-HT2A receptors on locomotor activity in miceQ34770846
Molecular biology of 5-HT receptorsQ34788155
Modulation of striatal dopamine release by 5-HT2A and 5-HT2C receptor antagonists: [11C]raclopride PET studies in the rat.Q34791678
Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stabilityQ35128324
Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson's diseaseQ35603265
Postsynaptic density scaffolding proteins at excitatory synapse and disorders of synaptic plasticity: implications for human behavior pathologies.Q35684713
GPCR-interacting proteins (GIPs): nature and functionsQ35922926
Elevated dopa decarboxylase activity in living brain of patients with psychosisQ35927690
Chronic treatment with lithium or valproate modulates the expression of Homer1b/c and its related genes Shank and Inositol 1,4,5-trisphosphate receptor.Q35992454
In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brainQ36002807
Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography methodQ36050571
Principles: a model for the allosteric interactions between ligand binding sites within a dimeric GPCR.Q36157407
Akt as a mediator of cell deathQ36161549
Dopamine-glutamate interaction and antipsychotics mechanism of action: implication for new pharmacological strategies in psychosis.Q36296703
Break on through to the other side-biophysics and cell biology shed light on cell-penetrating peptidesQ36299512
The postsynaptic densityQ36545830
Selective potentiation of the metabotropic glutamate receptor subtype 2 blocks phencyclidine-induced hyperlocomotion and brain activationQ36687682
Serotonin and dopamine interactions in rodents and primates: implications for psychosis and antipsychotic drug developmentQ36756374
Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profileQ36798643
Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics.Q36870038
The nature of dopamine dysfunction in schizophrenia and what this means for treatmentQ37062793
Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia.Q37092462
In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systemsQ37260898
Changes in prefrontal and amygdala activity during olanzapine treatment in schizophreniaQ37329216
Protein-protein interactions as therapeutic targets in neuropsychopharmacologyQ37349672
The 'atypicality' of antipsychotics: a concept re-examined and re-definedQ37391972
Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascadeQ37416273
Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytesQ37515921
Antipsychotic drug actions on gene modulation and signaling mechanismsQ37525390
Serotonin 2A receptor antagonists for treatment of schizophreniaQ37899193
Glutamatergic transmission in schizophrenia: from basic research to clinical practiceQ37980657
Targeting glutamate system for novel antipsychotic approaches: relevance for residual psychotic symptoms and treatment resistant schizophrenia.Q37990329
A frontier in the understanding of synaptic plasticity: solving the structure of the postsynaptic density.Q38005085
Calcium-dependent networks in dopamine-glutamate interaction: the role of postsynaptic scaffolding proteins.Q38024032
Scaffolding proteins of the post-synaptic density contribute to synaptic plasticity by regulating receptor localization and distribution: relevance for neuropsychiatric diseasesQ38044699
Acute Effects of Ketamine on Memory Systems and Psychotic Symptoms in Healthy VolunteersQ38425577
Dopamine D2 and 5-hydroxytryptamine 5-HT(₂A) receptors assemble into functionally interacting heteromers.Q39648976
Serotonin 5-HT1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanism.Q46535519
Role of 5-HT2A and 5-HT2C/B receptors in the acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on striatal single-unit activity and locomotion in freely moving ratsQ46587077
Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice: implications for Tourette's syndromeQ46620328
The effects of antipsychotics on beta-catenin, glycogen synthase kinase-3 and dishevelled in the ventral midbrain of ratsQ46689005
5-Hydroxytryptamine 1A receptor blockade facilitates aversive learning in mice: interactions with cholinergic and glutamatergic mechanismsQ46751918
Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function.Q46851475
Stress-induced dopamine release in humans at risk of psychosis: a [11C]raclopride PET studyQ46934815
Chronic phenethylamine hallucinogen treatment alters behavioral sensitivity to a metabotropic glutamate 2/3 receptor agonistQ46934817
Comparison between intraperitoneal and subcutaneous phencyclidine administration in Sprague-Dawley rats: a locomotor activity and gene induction studyQ46943015
Homer splice variants modulation within cortico-subcortical regions by dopamine D2 antagonists, a partial agonist, and an indirect agonist: implication for glutamatergic postsynaptic density in antipsychotics actionQ46966416
Discovering the neural basis of human social anxiety: a diagnostic and therapeutic imperativeQ48102710
Dopamine depletion and subsequent treatment with L-DOPA, but not the long-lived dopamine agonist pergolide, enhances activity of the Akt pathway in the rat striatumQ48104853
Increased dopamine synthesis rate in medial prefrontal cortex and striatum in schizophrenia indicated by L-(beta-11C) DOPA and PET.Q48121459
The role of 5-hydroxytryptamine 7 receptors in the phencyclidine-induced novel object recognition deficit in ratsQ48137014
The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response taskQ48185891
Inhibition of glycogen synthase kinase-3 attenuates psychotomimetic effects of ketamineQ48187914
Differential expression of Homer 1 gene by acute and chronic administration of antipsychotics and dopamine transporter inhibitors in the rat forebrainQ48234714
Ketamine-related expression of glutamatergic postsynaptic density genes: possible implications in psychosisQ48265498
Association of AKT1 gene variants and protein expression in both schizophrenia and bipolar disorderQ48278865
Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophreniaQ48283671
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memoryQ48285410
Dual alteration of limbic dopamine D1 receptor-mediated signalling and the Akt/GSK3 pathway in dopamine D3 receptor mutants during the development of methamphetamine sensitizationQ48372061
Haloperidol induces neurotoxicity by the NMDA receptor downstream signaling pathway, alternative from glutamate excitotoxicity.Q48375937
Atypical antipsychotics attenuate a sub-chronic PCP-induced cognitive deficit in the novel object recognition task in the rat.Q48390432
Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosisQ48394255
WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole]: A novel 5-hydroxytryptamine 2C receptor-selective agonist with preclinical antipsychotic-like activityQ48397691
Subchronic phencyclidine administration increases mesolimbic dopaminergic system responsivity and augments stress- and psychostimulant-induced hyperlocomotionQ48448242
Long-term soluble Abeta1-40 activates CaM kinase II in organotypic hippocampal cultures.Q48469484
Not only lithium: regulation of glycogen synthase kinase-3 by antipsychotics and serotonergic drugsQ48493255
Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics.Q48556742
Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brainQ48629603
Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascadesQ48679393
Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosisQ48723515
Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortexQ48728126
Decreased frontal cortical serotonin2A receptors in schizophreniaQ48915737
The acute and chronic effects of combined antipsychotic-mood stabilizing treatment on the expression of cortical and striatal postsynaptic density genesQ48967410
Phencyclidine-induced stereotyped behaviour and social isolation in rats: a possible animal model of schizophrenia.Q49128057
The 5-HT2A receptor antagonist M100907 is more effective in counteracting NMDA antagonist- than dopamine agonist-induced hyperactivity in miceQ50313913
Interaction of mGlu2/3 agonism with clozapine and lurasidone to restore novel object recognition in subchronic phencyclidine-treated rats.Q51015703
Ketamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers: implications for models of cognitive deficits in schizophrenia.Q51370914
Density of metabotropic glutamate receptors 2 and 3 (mGluR2/3) in the dorsolateral prefrontal cortex does not differ with schizophrenia diagnosis but decreases with age.Q51601516
Allosteric modulation of binding properties between units of chemokine receptor homo- and hetero-oligomers.Q51810340
Risperidone attenuates MK-801-induced hyperlocomotion in mice via the blockade of serotonin 5-HT 2A/2C receptors.Q51905348
Reversal of PCP-induced learning and memory deficits in the Morris' water maze by sertindole and other antipsychotics.Q51976441
Delayed alternation performance following subchronic phencyclidine administration in rats depends on task parameters.Q51987036
Habituation deficits induced by metabotropic glutamate receptors 2/3 receptor blockade in mice: reversal by antipsychotic drugs.Q52000561
Selective abnormalities of prefrontal serotonergic receptors in schizophrenia. A postmortem study.Q52033175
5HT antagonists attenuate MK801-impaired radial arm maze performance in rats.Q52178014
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectserotoninQ167934
dopamineQ170304
P304page(s)1-19
P577publication date2012-11-21
P1433published inPsychopharmacologyQ1422802
P1476titleSerotonin-glutamate and serotonin-dopamine reciprocal interactions as putative molecular targets for novel antipsychotic treatments: from receptor heterodimers to postsynaptic scaffolding and effector proteins
P478volume225

Reverse relations

cites work (P2860)
Q50015658A comprehensive review of the genetic and biological evidence supports a role for MicroRNA-137 in the etiology of schizophrenia.
Q35174979A double-blind, randomized pilot trial of chromium picolinate for binge eating disorder: results of the Binge Eating and Chromium (BEACh) study
Q39767786A heuristic model for working memory deficit in schizophrenia
Q38248566Antipsychotic treatment modulates glutamate transport and NMDA receptor expression
Q60229355Big Lessons from Tiny Flies: as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems
Q59329370COMT, 5-HTR2A, and SLC6A4 mRNA Expressions in First-Episode Antipsychotic-Naïve Schizophrenia and Association With Treatment Outcomes
Q48682603Cane Toad Skin Extract-Induced Upregulation and Increased Interaction of Serotonin 2A and D2 Receptors via Gq/11 Signaling Pathway in CLU213 Cells
Q42969381Clozapine augmentation with amisulpride
Q48423771Clozapine influences cytoskeleton structure and calcium homeostasis in rat cerebral cortex and has a different proteomic profile than risperidone
Q35928195Dietary chromium supplementation for targeted treatment of diabetes patients with comorbid depression and binge eating
Q45054111Differences in 5-HT2A and mGlu2 Receptor Expression Levels and Repressive Epigenetic Modifications at the 5-HT2A Promoter Region in the Roman Low- (RLA-I) and High- (RHA-I) Avoidance Rat Strains.
Q27693888Drug elucidation: invertebrate genetics sheds new light on the molecular targets of CNS drugs
Q47412781GSK-3β inhibitors reverse cocaine-induced synaptic transmission dysfunction in the nucleus accumbens
Q38166456Genetics of antipsychotic-induced weight gain: update and current perspectives
Q38133757Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral disorders pathophysiology, and implications for novel therapeutic approaches.
Q35167939Hypomania after augmenting venlafaxine and olanzapine with sarcosine in a patient with schizophrenia: a case study
Q92082552Intra-Nasally Administered Oligopeptide Lunasin Acts as a Possible Anti-Psychotic Agent in Mice Models
Q48475935Investigation of the role of alpha-2 adrenergic receptors on prepulse inhibition of acoustic startle reflex in rats
Q38267957MicroRNAs in Schizophrenia: Implications for Synaptic Plasticity and Dopamine-Glutamate Interaction at the Postsynaptic Density. New Avenues for Antipsychotic Treatment Under a Theranostic Perspective.
Q26747736Multiple D2 heteroreceptor complexes: new targets for treatment of schizophrenia
Q89896535N-(2-Hydroxyphenyl)-1-[3-(2-oxo-2,3-dihydro-1H- benzimidazol-1-yl)propyl]piperidine-4-Carboxamide (D2AAK4), a Multi-Target Ligand of Aminergic GPCRs, as a Potential Antipsychotic
Q37583157Neurophysiological Measures and Alcohol Use Disorder (AUD): Hypothesizing Links between Clinical Severity Index and Molecular Neurobiological Patterns
Q41573540New Targets for Schizophrenia Treatment beyond the Dopamine Hypothesis
Q35021488Olanzapine antipsychotic treatment of adolescent rats causes long term changes in glutamate and GABA levels in the nucleus accumbens
Q30379983Perspectives on the mGluR2/3 agonists as a therapeutic target for schizophrenia: Still promising or a dead end?
Q47706234Pharmacological approaches to the management of binge eating disorder
Q58719221Polymorphisms in the human serotonin receptor 1B (HTR1B) gene are associated with schizophrenia: a case control study
Q63433406Preclinical characterization of toluene as a non-classical hallucinogen drug in rats: participation of 5-HT, dopamine and glutamate systems
Q38258215Psychopharmacology of atypical antipsychotic drugs: From the receptor binding profile to neuroprotection and neurogenesis
Q26863507Response inhibition and interference control in obsessive-compulsive spectrum disorders
Q35118239Ribosomal DNA transcription in the dorsal raphe nucleus is increased in residual but not in paranoid schizophrenia
Q38223390Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task
Q33685248Superior effects of quetiapine compared with aripiprazole and iloperidone on MK-801-induced olfactory memory impairment in female mice
Q92259371The Effect of Chromium Nanoparticles and Chromium Picolinate in the Diet of Chickens on Levels of Selected Hormones and Tissue Antioxidant Status
Q35405088The ascending median raphe projections are mainly glutamatergic in the mouse forebrain.
Q38213709The glutamatergic aspects of schizophrenia molecular pathophysiology: role of the postsynaptic density, and implications for treatment
Q30417825The role of cannabinoid 1 receptor expressing interneurons in behavior
Q30437188The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue
Q64108690Treatment-Resistant Schizophrenia: Genetic and Neuroimaging Correlates
Q41945244Two grams of sarcosine in schizophrenia - is it too much? A potential role of glutamate-serotonin interaction.
Q36300230Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease
Q28084069Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism
Q37024867Variation in Dopamine D2 and Serotonin 5-HT2A Receptor Genes is Associated with Working Memory Processing and Response to Treatment with Antipsychotics

Search more.