Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond

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Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond is …
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review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1031306051
P356DOI10.1038/NRC3396
P698PubMed publication ID23192231

P50authorVincent GiguèreQ30089966
P2093author name stringGeneviève Deblois
P2860cites workGenomic convergence among ERRα, PROX1, and BMAL1 in the control of metabolic clock outputsQ21092423
Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3Q22010451
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscleQ24564824
The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesisQ24564869
The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesisQ24613186
Links between metabolism and cancerQ24626229
ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart.Q51579173
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma.Q51915435
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb.Q51942778
Estrogen receptor-related receptor alpha 1 interacts with coactivator and constitutively activates the estrogen response elements of the human lactoferrin gene.Q52168946
Estrogen-related receptor alpha1 transcriptional activities are regulated in part via the ErbB2/HER2 signaling pathway.Q52576604
The interplay between MYC and HIF in cancer.Q53513869
The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload.Q55044173
A role for estrogen-related receptor alpha in the control of mitochondrial fatty acid beta-oxidation during brown adipocyte differentiationQ73935057
Activation of the osteopontin promoter by the orphan nuclear receptor estrogen receptor related alphaQ77737584
METabolic adaptations in the tumor MYCroenvironmentQ83425517
Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifenQ24632895
Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alphaQ24650075
Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesisQ24682625
Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanismQ27645400
Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2Q28140298
Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alphaQ28218141
X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulationQ28264769
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cellsQ28275988
An acetylation switch modulates the transcriptional activity of estrogen-related receptor alphaQ28282893
Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alphaQ28290106
Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptorQ28292335
Identification of a new class of steroid hormone receptorsQ28294293
Regulation of cancer cell metabolismQ28303890
4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gammaQ28343744
Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR betaQ28362262
Dissecting self-renewal in stem cells with RNA interferenceQ28506922
The orphan nuclear estrogen receptor-related receptor alpha (ERRalpha) is expressed throughout osteoblast differentiation and regulates bone formation in vitroQ28580424
Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-betaQ28591718
Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogrammingQ28910179
Constitutive Activation of Transcription and Binding of Coactivator by Estrogen-Related Receptors 1 and 2Q29039763
Integration of external signaling pathways with the core transcriptional network in embryonic stem cellsQ29547179
Estrogen-related receptor beta/NR3B2 controls epithelial cell fate and endolymph production by the stria vascularisQ29568481
On respiratory impairment in cancer cellsQ29617276
Otto Warburg's contributions to current concepts of cancer metabolismQ29617601
Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactionsQ33260963
Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motifQ33643260
Physiological genomics identifies estrogen-related receptor alpha as a regulator of renal sodium and potassium homeostasis and the renin-angiotensin pathwayQ33670484
Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expressionQ33766811
Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancerQ34181456
Recent advance in the design of small molecular modulators of estrogen-related receptors.Q34283013
Transcriptional amplification in tumor cells with elevated c-Myc.Q34302542
MiR-137 targets estrogen-related receptor alpha and impairs the proliferative and migratory capacity of breast cancer cellsQ34314172
Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivityQ34322874
WNT11 Expression Is Induced by Estrogen-Related Receptor α and β-Catenin and Acts in an Autocrine Manner to Increase Cancer Cell MigrationQ39651531
The homeobox protein Prox1 is a negative modulator of ERR{alpha}/PGC-1{alpha} bioenergetic functionsQ39691060
Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth.Q39814340
Estrogen-related receptor alpha expression and function is associated with the transcriptional coregulator AIB1 in breast carcinomaQ39843631
Modulation of adipogenesis-related gene expression by estrogen-related receptor gamma during adipocytic differentiation.Q39937084
The significance of the expression of ERRalpha as a potential biomarker in breast cancerQ40010856
Epidermal growth factor-induced signaling in breast cancer cells results in selective target gene activation by orphan nuclear receptor estrogen-related receptor alphaQ40396885
Identification of an agonist ligand for estrogen-related receptors ERRbeta/gamma.Q40458060
The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).Q40678460
Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor gamma (ERRgamma) with high constitutive activityQ42502907
Exercise and PGC-1α-independent synchronization of type I muscle metabolism and vasculature by ERRγ.Q42723877
Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agentsQ42759813
The tyrosine kinase receptor HER2 (erbB-2): from oncogenesis to adipogenesisQ42808101
Transcriptional regulation of the estrogen-inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptorsQ43739428
4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related (ERR) nuclear receptors beta and gammaQ43743283
Estrogen-related receptor alpha and estrogen-related receptor gamma associate with unfavorable and favorable biomarkers, respectively, in human breast cancer.Q44220756
Estrogen-related receptor alpha in human breast carcinoma as a potent prognostic factorQ44961902
Estrogen-related receptor-alpha antagonist inhibits both estrogen receptor-positive and estrogen receptor-negative breast tumor growth in mouse xenograftsQ46093148
Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgammaQ46460035
Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgammaQ46820185
Adaptation of energy metabolism in breast cancer brain metastasesQ48269541
A polymorphic autoregulatory hormone response element in the human estrogen-related receptor alpha (ERRalpha) promoter dictates peroxisome proliferator-activated receptor gamma coactivator-1alpha control of ERRalpha expression.Q51024981
Selective estrogen-receptor modulators and antihormonal resistance in breast cancerQ34692670
Estrogen-related receptor gamma promotes mesenchymal-to-epithelial transition and suppresses breast tumor growthQ34762100
The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth.Q34771704
Metabolic positron emission tomography imaging in cancer detection and therapy responseQ34786518
To ERR in the estrogen pathwayQ34788536
Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) is a metabolic regulator of intestinal epithelial cell fateQ34836415
A century of deciphering the control mechanisms of sex steroid action in breast and prostate cancer: the origins of targeted therapy and chemopreventionQ34942152
Estrogen-related receptor gamma (ERRgamma) mediates oxygen-dependent induction of aromatase (CYP19) gene expression during human trophoblast differentiation.Q35193170
Estrogen-related receptor α regulates skeletal myocyte differentiation via modulation of the ERK MAP kinase pathwayQ35216853
The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancerQ35421284
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiationQ35546707
Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defenseQ35917062
Regulation of glycolysis and the Warburg effect by estrogen-related receptorsQ36213663
The NR3B subgroup: an ovERRviewQ36238317
PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesityQ36350223
Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistanceQ36472242
The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene.Q36572042
Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancerQ37079303
Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cellsQ37188645
Transcriptional control of energy homeostasis by the estrogen-related receptorsQ37229563
ERRgamma mediates tamoxifen resistance in novel models of invasive lobular breast cancerQ37240697
ERRalpha: a metabolic function for the oldest orphanQ37263563
Modulating estrogen receptor-related receptor-alpha activity inhibits cell proliferationQ37358073
Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: molecular mechanisms and therapeutic perspectives.Q37603645
Estrogen related receptors (ERRs): a new dawn in transcriptional control of mitochondrial gene networksQ37865795
Targeting cancer metabolism: a therapeutic window opensQ37924094
Estrogen-related receptor alpha (ERRalpha) is a transcriptional regulator of apolipoprotein A-IV and controls lipid handling in the intestineQ38335798
Genome-wide identification of direct target genes implicates estrogen-related receptor alpha as a determinant of breast cancer heterogeneity.Q38352075
Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoterQ38360573
PGC-1α promotes the growth of ErbB2/Neu-induced mammary tumors by regulating nutrient supplyQ39408474
Dual function of ERRα in breast cancer and bone metastasis formation: implication of VEGF and osteoprotegerinQ39511667
Transcriptional control of the ERBB2 amplicon by ERRalpha and PGC-1beta promotes mammary gland tumorigenesisQ39641829
miR-378(∗) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathwayQ39648802
Estrogen-related receptor γ modulates cell proliferation and estrogen signaling in breast cancerQ39649549
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectbreast cancerQ128581
P304page(s)27-36
P577publication date2012-11-29
P1433published inNature Reviews CancerQ641657
P1476titleOestrogen-related receptors in breast cancer: control of cellular metabolism and beyond
P478volume13

Reverse relations

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