AAV2-neurturin (CERE-120) for Parkinson's disease

scientific article published on January 2013

AAV2-neurturin (CERE-120) for Parkinson's disease is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1517/14712598.2013.754420
P698PubMed publication ID23228025

P2093author name stringMark Stacy
Patrick Hickey
P2860cites workA double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's diseaseQ44571920
Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatumQ44631221
Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease. A detailed account of methodology and a 6-month follow-upQ44995599
Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC.Q45859568
Medical treatment of Parkinson disease.Q45952832
Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's diseaseQ48184014
Sequential bilateral transplantation in Parkinson's disease: effects of the second graftQ48194358
Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeysQ48197305
Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeysQ48325968
Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?Q48390998
Unilateral transplantation of human fetal mesencephalic tissue into the caudate nucleus of patients with Parkinson's diseaseQ48405897
A randomized trial of deep-brain stimulation for Parkinson's diseaseQ48433139
Dopaminergic differentiation of neural progenitors derived from placental mesenchymal stem cells in the brains of Parkinson's disease model rats and alleviation of asymmetric rotational behaviorQ48493117
Short- and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's diseaseQ48671006
Acute and Long-Term Effects of Subthalamic Nucleus Stimulation in Parkinson's DiseaseQ51647407
Neurturin, a relative of glial-cell-line-derived neurotrophic factorQ24324692
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neuronsQ24336322
Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trialQ28296434
Axonal transport defects: a common theme in neurodegenerative diseasesQ28302119
AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's diseaseQ28304068
AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trialQ28307713
Transplantation of embryonic dopamine neurons for severe Parkinson's diseaseQ29617304
Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseasesQ33542013
Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeysQ33819946
Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trialQ33870490
Results from a phase I safety trial of hAADC gene therapy for Parkinson diseaseQ34656075
Bilateral transplantation of allogenic adult human bone marrow-derived mesenchymal stem cells into the subventricular zone of Parkinson's disease: a pilot clinical studyQ35893878
Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cellsQ36288360
Levodopa for the treatment of Parkinson's diseaseQ37340190
Restorative approaches in Parkinson's Disease: which cell type wins the race?Q37592613
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Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson's diseaseQ37872232
Neurotrophic moleculesQ38721363
Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity.Q39507945
Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: support for nigral targeting in Parkinson's diseaseQ39518245
Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's diseaseQ39519102
Bioactivity of AAV2-neurturin gene therapy (CERE-120): differences between Parkinson's disease and nonhuman primate brains.Q39782948
Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkinson's diseaseQ39863620
Striatal delivery of neurturin by CERE-120, an AAV2 vector for the treatment of dopaminergic neuron degeneration in Parkinson's diseaseQ40197232
Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030.Q40273125
Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson diseaseQ40326219
Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD.Q40678042
Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's diseaseQ40737427
Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factorQ40843723
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's diseaseQ40846012
Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's diseaseQ40929764
Bilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of foetal ventral mesencephalon.Q41031978
Dopaminergic neurons protected from degeneration by GDNF gene therapyQ41128316
Gene transfer provides a practical means for safe, long-term, targeted delivery of biologically active neurotrophic factor proteins for neurodegenerative diseasesQ41195395
Pharmacology of neurotrophic factorsQ41455744
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trialQ42650874
Parkinson's disease, primates, and gene therapy: vive la différence?Q42719725
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectParkinson's diseaseQ11085
P304page(s)137-145
P577publication date2013-01-01
P1433published inExpert Opinion on Biological TherapyQ5421201
P1476titleAAV2-neurturin (CERE-120) for Parkinson's disease
P478volume13

Reverse relations

cites work (P2860)
Q99584192CERE-120 Prevents Irradiation-Induced Hypofunction and Restores Immune Homeostasis in Porcine Salivary Glands
Q35472697Interrogating the aged striatum: robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration
Q47162932Neurturin overexpression in dopaminergic neurons induces presynaptic and postsynaptic structural changes in rats with chronic 6-hydroxydopamine lesion
Q39229450Non-human primate models of PD to test novel therapies
Q35183919Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson's disease patients
Q38121120Small RNA drugs for prion disease: a new frontier
Q38136096Synthetic nucleic acids delivered by exosomes: a potential therapeutic for generelated metabolic brain diseases
Q42094999The α7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions

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