Neuroinflammation and neurodegeneration in overnutrition-induced diseases

scientific article published on 20 December 2012

Neuroinflammation and neurodegeneration in overnutrition-induced diseases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.TEM.2012.11.003
P932PMC publication ID3556486
P698PubMed publication ID23265946

P2093author name stringDongsheng Cai
P2860cites workEndoplasmic reticulum stress plays a central role in development of leptin resistanceQ46178586
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus.Q46588693
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesityQ47314567
Neuronal PTP1B regulates body weight, adiposity and leptin action.Q47329751
Neuroscience. The fat-brain axis enters a new dimensionQ47819287
Stem cells and neurogenesis in the adult brainQ48352655
High-fat diet exacerbates MPTP-induced dopaminergic degeneration in miceQ48860838
Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration.Q51966311
Different early ER-stress responses in the CLN8(mnd) mouse model of neuronal ceroid lipofuscinosis.Q53288091
Evidence for constitutive neural cell proliferation in the adult murine hypothalamus.Q53528240
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.Q53607069
Alzheimer's diseaseQ55880664
Mitochondrial diseasesQ83827338
Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysisQ22242405
Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic nicheQ24600668
From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behaviorQ26828589
IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidaseQ27349298
A role for mitochondria in NLRP3 inflammasome activationQ28131794
Oxidative stress in neurodegeneration: cause or consequence?Q28275946
Disruption of neuronal autophagy by infected microglia results in neurodegenerationQ28473257
Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin geneQ28505444
Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesityQ28570529
Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal dietQ28572572
The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weightQ29031436
Shared principles in NF-kappaB signalingQ29547234
Mammalian neural stem cellsQ29547657
Parkinson's diseaseQ29616302
Inflammasomes in health and diseaseQ29616356
Type 2 diabetes as an inflammatory diseaseQ29617184
Inflammatory mechanisms in obesityQ29617932
Central nervous system control of food intake and body weightQ29619020
NF-kappaB at the crossroads of life and deathQ29619302
High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signalingQ30496730
Diabetes and the risk of multi-system aging phenotypes: a systematic review and meta-analysisQ33398039
High-fat diet induces apoptosis of hypothalamic neuronsQ33425926
ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathologyQ33589732
Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1Q33612356
Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behaviorQ33664173
PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in miceQ33685586
Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis.Q33750727
Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolismQ33778499
Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feedingQ33994402
Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis.Q34059225
Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up.Q34132288
Obesity and leptin resistance: distinguishing cause from effectQ34259053
Obesity-associated hypertension: new insights into mechanisms.Q34374149
Anatomy and regulation of the central melanocortin systemQ34414149
Neurogenesis in the hypothalamus of adult mice: potential role in energy balanceQ34463524
Circuitry of nuclear factor kappaB signalingQ34514908
Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stressQ34583052
Toll-like receptors modulate adult hippocampal neurogenesisQ34664161
Autophagy, inflammation and neurodegenerative diseaseQ34686890
Mechanisms of leptin action and leptin resistanceQ34701125
De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balanceQ34822309
Inflammatory links between obesity and metabolic diseaseQ35015802
Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammationQ35086140
Feeding signals and brain circuitry.Q37624854
Toll-like receptors: linking inflammation to metabolismQ37796144
CNS leptin and insulin action in the control of energy homeostasisQ37808730
A role for astrocytes in the central control of metabolismQ37849519
Inflammation and lipid signaling in the etiology of insulin resistanceQ38007632
Metabolic syndrome: a brain diseaseQ38036734
Low-grade hypothalamic inflammation leads to defective thermogenesis, insulin resistance, and impaired insulin secretionQ39602835
Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesityQ39734121
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutationsQ40389365
Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese ratsQ41064709
Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB.Q42058427
Getting away from glucose: fanning the flames of obesity-induced inflammationQ42110382
Activation of the unfolded protein response enhances motor recovery after spinal cord injuryQ42143560
Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver.Q42175864
Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?Q42514046
IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetesQ42530961
Grape seed and skin extract prevents high-fat diet-induced brain lipotoxicity in rat.Q44388561
Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin.Q45960060
Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathwayQ35213340
Hypothalamic inflammation: a double-edged sword to nutritional diseasesQ35318592
IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington diseaseQ35370058
Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese miceQ35640540
Obesity is associated with hypothalamic injury in rodents and humansQ35640638
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistanceQ35686688
One step from prediabetes to diabetes: hypothalamic inflammation?Q35762665
Inflammatory cause of metabolic syndrome via brain stress and NF-κB.Q35857192
Modeling mitochondrial function in aging neuronsQ35890772
Hypothalamic sensing of fatty acidsQ36108719
Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cellsQ36137689
Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasisQ36299540
The hormonal control of food intakeQ36387304
Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditionsQ36521690
Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response.Q36546991
Attenuation of leptin and insulin signaling by SOCS proteinsQ36607776
Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivoQ36662772
How widespread is adult neurogenesis in mammals?Q36827189
Insulin sensitivity: modulation by nutrients and inflammationQ36848937
Obesity-induced inflammation: a metabolic dialogue in the language of inflammationQ36944100
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesityQ36981204
The integrative role of CNS fuel-sensing mechanisms in energy balance and glucose regulation.Q36995543
Anti-inflammatory Agents: Present and FutureQ37118156
Allopregnanolone treatment delays cholesterol accumulation and reduces autophagic/lysosomal dysfunction and inflammation in Npc1-/- mouse brainQ37179554
Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat dietQ37190092
Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidenceQ37197121
Obesity and vulnerability of the CNS.Q37234576
Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesisQ37479267
Central insulin and leptin-mediated autonomic control of glucose homeostasis.Q37499206
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesityQ37502701
NFkappaB-mediated metabolic inflammation in peripheral tissues versus central nervous systemQ37562707
Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis.Q37602608
Hypothalamic inflammation and energy homeostasis: resolving the paradoxQ37613162
The stressed CNS: when glucocorticoids aggravate inflammation.Q37617620
P433issue1
P921main subjectovernutritionQ16956975
neuronitisQ17157137
P304page(s)40-47
P577publication date2012-12-20
P1433published inTrends in Endocrinology and MetabolismQ15265727
P1476titleNeuroinflammation and neurodegeneration in overnutrition-induced diseases
P478volume24