Cutaneous toxicities of RAF inhibitors.

scientific article published on January 2013

Cutaneous toxicities of RAF inhibitors. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S1470-2045(12)70413-8
P698PubMed publication ID23276366

P50authorGeorgina V. LongQ42947998
Pablo Fernandez-PeñasQ54286183
P2093author name stringRachael Anforth
P2860cites workKinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAFQ24298749
Survival in BRAF V600-mutant advanced melanoma treated with vemurafenibQ24594790
Improved survival with vemurafenib in melanoma with BRAF V600E mutationQ24631953
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growthQ27659493
NRAS mutation status is an independent prognostic factor in metastatic melanomaQ27851695
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.Q27851801
Inhibition of Mutated, Activated BRAF in Metastatic MelanomaQ27860458
Targeting cancer with small molecule kinase inhibitorsQ29547395
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trialQ29547903
Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trialQ29614756
Improving melanoma classification by integrating genetic and morphologic featuresQ33340639
Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanomaQ33384029
Skin tumors induced by sorafenib; paradoxic RAS-RAF pathway activation and oncogenic mutations of HRAS, TP53, and TGFBR1Q82567338
Activation of Akt by mechanical stretching in human epidermal keratinocytesQ83185491
Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinomaQ83195713
Ultraviolet A and photosensitivity during vemurafenib therapyQ83378765
Systemic retinoid therapy for chemoprevention of nonmelanoma skin cancer in a patient treated with vemurafenibQ84292261
Vemurafenib in melanoma with BRAF V600E mutationQ85087769
A phase II trial of sorafenib in metastatic melanoma with tissue correlatesQ33785790
RAS mutations are associated with the development of cutaneous squamous cell tumors in patients treated with RAF inhibitorsQ35721081
Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysisQ36612290
Distinct clinical and pathological features are associated with the BRAF(T1799A(V600E)) mutation in primary melanomaQ36679188
Diverse cutaneous side effects associated with BRAF inhibitor therapy: a clinicopathologic studyQ36816946
Atypical melanocytic proliferations and new primary melanomas in patients with advanced melanoma undergoing selective BRAF inhibitionQ36822126
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitorsQ37048053
Dermatologic symptoms associated with the multikinase inhibitor sorafenibQ37333134
Phase II Trial of Temozolomide and Sorafenib in Advanced Melanoma Patients with or without Brain MetastasesQ37480713
BRAF as therapeutic target in melanomaQ37720832
British Association of Dermatologists guidelines on the efficacy and use of acitretin in dermatologyQ37737765
Meta-analysis of dermatological toxicities associated with sorafenibQ37867169
Cutaneous toxicities of the multikinase inhibitors sorafenib and sunitinibQ37930711
Cutaneous manifestations of dabrafenib (GSK2118436): a selective inhibitor of mutant BRAF in patients with metastatic melanomaQ38026916
Cutaneous adverse effects in patients treated with the multitargeted kinase inhibitors sorafenib and sunitinibQ38494010
BRAF(V600) inhibitor GSK2118436 targeted inhibition of mutant BRAF in cancer patients does not impair overall immune competencyQ39649761
The oncogenic BRAF kinase inhibitor PLX4032/RG7204 does not affect the viability or function of human lymphocytes across a wide range of concentrationsQ39803993
Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression.Q39874679
Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanomaQ39971699
BRAF targeted therapy changes the treatment paradigm in melanomaQ42733647
Phase II study of sorafenib in patients with sunitinib-refractory metastatic renal cell cancerQ43299267
Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trialQ44442912
Keratoacanthomas and squamous cell carcinomas in patients receiving sorafenib.Q45930106
Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial.Q46006772
Multiple keratoacanthomas arising in the setting of sorafenib therapy: novel chemoprophylaxis with bexaroteneQ46200338
A phase I trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxelQ46448115
Hand foot skin reaction in cancer patients treated with the multikinase inhibitors sorafenib and sunitinibQ46542862
Hand-foot skin reaction in patients treated with sorafenib: a clinicopathological study of cutaneous manifestations due to multitargeted kinase inhibitor therapyQ46857527
Panniculitis with arthralgia in patients with melanoma treated with selective BRAF inhibitors and its management.Q50518821
Cutaneous toxic effects associated with vemurafenib and inhibition of the BRAF pathway.Q53178811
First-in-human, phase I dose-escalation study of the safety, pharmacokinetics, and pharmacodynamics of RO5126766, a first-in-class dual MEK/RAF inhibitor in patients with solid tumors.Q54499836
Epithelial tissue hyperplasia induced by the RAF inhibitor PF-04880594 is attenuated by a clinically well-tolerated dose of the MEK inhibitor PD-0325901.Q54500306
Mutational analysis of cutaneous squamous cell carcinomas and verrucal keratosis in patients taking BRAF inhibitors.Q54502379
Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma.Q54610975
Distinguishing Clinicopathologic Features of Patients with V600E and V600K BRAF-Mutant Metastatic MelanomaQ58024726
Phase I/II study to assess safety, pharmacokinetics, and efficacy of the oral MEK 1/2 inhibitor GSK1120212 (GSK212) dosed in combination with the oral BRAF inhibitor GSK2118436 (GSK436)Q58024747
Number of Nevi and Early-Life Ambient UV Exposure Are Associated with BRAF-Mutant MelanomaQ59626442
P433issue1
P921main subjectdabrafenibQ3011604
P304page(s)e11-8
P577publication date2013-01-01
P1433published inLancet Oncology CommissionQ13747613
P1476titleCutaneous toxicities of RAF inhibitors
P478volume14

Reverse relations

cites work (P2860)
Q41129294A case report of Grover's disease from immunotherapy-a skin toxicity induced by inhibition of CTLA-4 but not PD-1.
Q38989374Approved and Experimental Small-Molecule Oncology Kinase Inhibitor Drugs: A Mid-2016 Overview
Q38764961BRAF inhibitor-associated cutaneous squamous cell carcinoma: new mechanistic insight, emerging evidence for viral involvement and perspectives on clinical management
Q38281838BRAF inhibitors: experience in thyroid cancer and general review of toxicity
Q38373941Beyond CTLA-4: novel immunotherapy strategies for metastatic melanoma
Q54403712Clearance of BRAF inhibitor-associated keratoacanthomas by systemic retinoids.
Q57035646Clinical management of cutaneous adverse events in patients on targeted anticancer therapies and immunotherapies: a national consensus statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology
Q54325214Clinico-morphological features of BRAF inhibition-induced proliferative skin lesions in cancer patients.
Q38634557Combinatorial Therapies in Melanoma: MAPK Inhibitors and Beyond
Q42587971Comprehensive molecular tumor profiling in radiation oncology: How it could be used for precision medicine
Q90473356Cutaneous Adverse Events of Anti-PD-1 Therapy and BRAF Inhibitors
Q38958844Cutaneous Complications of Targeted Melanoma Therapy
Q55054189Cutaneous Papillomaviruses and Non-melanoma Skin Cancer: Causal Agents or Innocent Bystanders?
Q61453878Cutaneous Side Effects of Targeted Therapy and Immunotherapy for Advanced Melanoma
Q42229504Cutaneous adverse effects of BRAF inhibitors in metastatic malignant melanoma, a prospective study in 20 patients
Q38227760Cutaneous adverse events during vemurafenib therapy
Q54336734Cutaneous adverse events in patients treated with BRAF inhibitor-based therapies for metastatic melanoma for longer than 52 weeks.
Q38139282Cutaneous adverse events to type I BRAF inhibitors: an analysis of effects associated with each inhibitor and therapeutic time interval to onset
Q28070095Cutaneous complications of molecular targeted therapy used in oncology
Q60566835Cutaneous toxicities of new treatments for melanoma.
Q38938690DNA repair inhibition by UVA photoactivated fluoroquinolones and vemurafenib
Q34646614Dabrafenib and its potential for the treatment of metastatic melanoma
Q48149188Dabrafenib-induced pemphigoid-like reaction
Q42035405Dermoscopic clues to diagnose acantholytic dyskeratosis
Q34653547Drug safety evaluation of vemurafenib in the treatment of melanoma.
Q28829587Epidermal RAF prevents allergic skin disease
Q51834848Human papillomavirus evaluation of vemurafenib-induced skin epithelial tumors: a case series.
Q44470914Incidence and relative risk of cutaneous squamous cell carcinoma with single-agent BRAF inhibitor and dual BRAF/MEK inhibitors in cancer patients: a meta-analysis
Q54382589Long-term effects of BRAF inhibitors in melanoma treatment: friend or foe?
Q56893430Management of the cutaneous adverse effects of antimelanoma therapy
Q38215416Managing the skin toxicities from new melanoma drugs
Q38146707Melanoma mutagenesis and aberrant cell signaling
Q21284811Melanoma: from melanocyte to genetic alterations and clinical options
Q26798379Nanoparticle-mediated drug delivery for treating melanoma
Q53936959Neutrophilic eccrine hidradenitis can be induced by BRAF inhibitors.
Q53616737Neutrophilic eccrine hidradenitis in two patients treated with BRAF inhibitors: a new cutaneous adverse event.
Q41950059Optimizing combination dabrafenib and trametinib therapy in BRAF mutation-positive advanced melanoma patients: Guidelines from Australian melanoma medical oncologists.
Q37697778Paradoxical oncogenesis--the long-term effects of BRAF inhibition in melanoma
Q54349772Rapid and complete hematological response of refractory hairy cell leukemia to the BRAF inhibitor dabrafenib.
Q34459751Recommendations of the SFH (French Society of Haematology) for the diagnosis, treatment and follow-up of hairy cell leukaemia
Q49893201Regressed melanocytic nevi secondary to pembrolizumab therapy: an emerging melanocytic dermatologic effect from immune checkpoint antibody blockade
Q44867413Sequence analysis of RAS and RAF mutation hot spots in canine carcinoma.
Q37527772Severe cutaneous and neurologic toxicity in melanoma patients during vemurafenib administration following anti-PD-1 therapy.
Q47229445Squamoproliferative skin lesion during braf inhibitors:one size does not fit all.
Q64947731Successful Treatment of Generalized Eruptive Keratoacanthoma of Grzybowski with Acitretin.
Q43702411Systemic retinoids for the chemoprevention of cutaneous squamous cell carcinoma and verrucal keratosis in a cohort of patients on BRAF inhibitors
Q27026323Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond
Q26827092The GIST of targeted therapy for malignant melanoma
Q58781631The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions
Q47549324The safety and efficacy of dabrafenib and trametinib for the treatment of melanoma
Q38203019The use of vemurafenib in Australian patients with unresectable or metastatic melanoma containing the V600 BRAF gene mutation
Q54378191Vemurafenib-induced interface dermatitis manifesting as radiation-recall and a keratosis pilaris-like eruption.
Q42191643Virologic and genetic evaluation of vemurafenib-induced skin cancers
Q89499879[Abdominal papules in a patient with psoriasis and tinea manuum]
Q53063698[Cutaneous side effects of anti-tumor therapy with BRAF and MEK inhibitors].