Indolyl aryl sulphones as HIV-1 reverse transcriptase inhibitors: docking and 3D QSAR studies

scientific article published on January 2007

Indolyl aryl sulphones as HIV-1 reverse transcriptase inhibitors: docking and 3D QSAR studies is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1517/17460441.2.1.87
P698PubMed publication ID23496039

P2093author name stringRomano Silvestri
Giuseppe La Regina
Antonia Coluccia
Rino Ragno
P2860cites workStructural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptaseQ27628304
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Structure-based design, synthesis, and biological evaluation of novel pyrrolyl aryl sulfones: HIV-1 non-nucleoside reverse transcriptase inhibitors active at nanomolar concentrationsQ28378285
L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptaseQ28378789
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitorQ29547710
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Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.Q39267636
Simple, short peptide derivatives of a sulfonylindolecarboxamide (L-737,126) active in vitro against HIV-1 wild type and variants carrying non-nucleoside reverse transcriptase inhibitor resistance mutations.Q40538441
3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studiesQ40582883
Computer-aided design, synthesis, and anti-HIV-1 activity in vitro of 2-alkylamino-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as novel potent non-nucleoside reverse transcriptase inhibitors, also active against the Y181CQ40592867
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studiesQ40644238
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5H-pyrrolo[1,2-b] [1,2,5]benzothiadiazepines (PBTDs): a novel class of non-nucleoside reverse transcriptase inhibitors.Q41193730
2-Sulfonyl-4-chloroanilino moiety: a potent pharmacophore for the anti-human immunodeficiency virus type 1 activity of pyrrolyl aryl sulfonesQ41238181
Design, synthesis and QSAR studies on N-aryl heteroarylisopropanolamines, a new class of non-peptidic HIV-1 protease inhibitorsQ44022775
Therapies. Raising the limitsQ44044876
HIV-reverse transcriptase inhibition: inclusion of ligand-induced fit by cross-docking studiesQ45212830
Docking and 3-D QSAR studies on indolyl aryl sulfones. Binding mode exploration at the HIV-1 reverse transcriptase non-nucleoside binding site and design of highly active N-(2-hydroxyethyl)carboxamide and N-(2-hydroxyethyl)carbohydrazide derivativesQ45212833
Smart region definition: a new way to improve the predictive ability and interpretability of three-dimensional quantitative structure-activity relationships.Q52264578
Design, Molecular Modeling, Synthesis, and Anti-HIV-1 Activity of New Indolyl Aryl Sulfones. Novel Derivatives of the Indole-2-carboxamideQ57266181
Comparative Molecular Field Analysis Using GRID Force-Field and GOLPE Variable Selection Methods in a Study of Inhibitors of Glycogen Phosphorylase bQ58137179
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)87-114
P577publication date2007-01-01
P1433published inExpert Opinion on Drug DiscoveryQ5421204
P1476titleIndolyl aryl sulphones as HIV-1 reverse transcriptase inhibitors: docking and 3D QSAR studies
P478volume2

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