Large-scale production of human mesenchymal stem cells for clinical applications.

scientific article published on March 2012

Large-scale production of human mesenchymal stem cells for clinical applications. is …
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scholarly articleQ13442814

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P356DOI10.1002/BAB.1006
P698PubMed publication ID23586791
P5875ResearchGate publication ID236183423

P50authorKrishna M PanchalingamQ58898505
P2093author name stringSunghoon Jung
Leo A Behie
Lawrence Rosenberg
Reynold D Wuerth
P2860cites workExpansion and hepatic differentiation of rat multipotent adult progenitor cells in microcarrier suspension cultureQ39669482
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Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells.Q43222889
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"Stemness" does not explain the repair of many tissues by mesenchymal stem/multipotent stromal cells (MSCs).Q43897756
Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applicationsQ43898390
Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapyQ44878272
Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow.Q45501605
Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiateQ45863683
Modeled microgravity inhibits osteogenic differentiation of human mesenchymal stem cells and increases adipogenesisQ46285888
Comparison of human serum with fetal bovine serum for expansion and differentiation of human synovial MSC: potential feasibility for clinical applicationsQ46421017
Rapid large-scale expansion of functional mesenchymal stem cells from unmanipulated bone marrow without animal serum.Q46488249
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Defining the risks of mesenchymal stromal cell therapyQ47584701
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Human AB serum and thrombin-activated platelet-rich plasma are suitable alternatives to fetal calf serum for the expansion of mesenchymal stem cells from adipose tissue.Q50707616
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Cyclic flexure and laminar flow synergistically accelerate mesenchymal stem cell-mediated engineered tissue formation: Implications for engineered heart valve tissues.Q51141337
Human autologous serum obtained using a completely closed bag system as a substitute for foetal calf serum in human mesenchymal stem cell cultures.Q51225476
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From stem cells to viable autologous semilunar heart valve.Q51447883
Selection of CD271(+) cells and human AB serum allows a large expansion of mesenchymal stromal cells from human bone marrow.Q51757933
Bone formation by mesenchymal progenitor cells cultured on dense and microporous hydroxyapatite particles.Q51786371
Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH).Q51953623
Expansion of Human Hematopoietic Cells from Umbilical Cord Blood Using Roller Bottles in CO2and CO2-Free AtmosphereQ53301863
Influence of culture parameters on ear mesenchymal stem cells expanded on microcarriers.Q53306427
Humanized system to propagate cord blood-derived multipotent mesenchymal stromal cells for clinical application.Q53540450
Bioreactor development for stem cell expansion and controlled differentiationQ24676967
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statementQ27861120
Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II studyQ29617267
Mesenchymal stem cells reside in virtually all post-natal organs and tissuesQ29617740
Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6Q29620590
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Aging of mesenchymal stem cell in vitro.Q33236089
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Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid: comparison to bone marrow mesenchymal stem cellsQ33307769
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Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot studyQ34132522
RhoA and cytoskeletal disruption mediate reduced osteoblastogenesis and enhanced adipogenesis of human mesenchymal stem cells in modeled microgravityQ34312867
The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessmentsQ34686955
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Toward a clinical-grade expansion of mesenchymal stem cells from human sources: a microcarrier-based culture system under xeno-free conditionsQ35579672
Wharton's jelly-derived cells are a primitive stromal cell populationQ35849157
Bead-to-bead transfer of Vero cells in microcarrier cultureQ36254780
A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarctionQ36634299
Concise review: no breakthroughs for human mesenchymal and embryonic stem cell culture: conditioned medium, feeder layer, or feeder-free; medium with fetal calf serum, human serum, or enriched plasma; serum-free, serum replacement nonconditioned medQ36775037
Concise review: adipose tissue-derived stromal cells--basic and clinical implications for novel cell-based therapiesQ36786235
Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.Q36874456
UC blood-derived mesenchymal stromal cells: an overviewQ36961702
Immunomodulation by mesenchymal stem cells and clinical experienceQ36975987
Functional Cells Cultured on Microcarriers for Use in Regenerative Medicine ResearchQ37795961
Good manufacturing practices production of mesenchymal stem/stromal cells.Q37804393
Stem cell cultivation in bioreactorsQ37897334
A novel serum-free medium for the expansion of human mesenchymal stem cells.Q39448462
Culturing of human mesenchymal stem cells as three-dimensional aggregates induces functional expression of CXCR4 that regulates adhesion to endothelial cellsQ39647492
P433issue2
P304page(s)106-120
P577publication date2012-03-01
P1433published inBiotechnology and Applied BiochemistryQ4915336
P1476titleLarge-scale production of human mesenchymal stem cells for clinical applications
P478volume59