An eye on the future of inflammasomes and drug development in AMD.

scientific article published on 10 May 2013

An eye on the future of inflammasomes and drug development in AMD. is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1003651866
P356DOI10.1007/S00109-013-1050-0
P698PubMed publication ID23661041

P50authorSarah L DoyleQ55948328
P2093author name stringMatthew Campbell
P2860cites workThe inflammasomesQ24304087
Complement factor H polymorphism in age-related macular degenerationQ24553334
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 miceQ24604235
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88Q24621930
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilizationQ24631966
Pyogenic bacterial infections in humans with MyD88 deficiencyQ24653859
Innate immune recognitionQ27860721
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptorsQ27860900
A role for mitochondria in NLRP3 inflammasome activationQ28131794
Gout-associated uric acid crystals activate the NALP3 inflammasomeQ28131797
Genetic variation in Toll-like receptors and disease susceptibilityQ28267031
Influenza virus activates inflammasomes via its intracellular M2 ion channelQ28279385
Cryopyrin activates the inflammasome in response to toxins and ATPQ28291313
Inflammation, atherosclerosis, and coronary artery diseaseQ29547232
Origin and physiological roles of inflammationQ29614298
Thioredoxin-interacting protein links oxidative stress to inflammasome activationQ29614471
The family of five: TIR-domain-containing adaptors in Toll-like receptor signallingQ29615457
Pathogen recognition by the innate immune systemQ29615592
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetesQ29615593
The NALP3 inflammasome is involved in the innate immune response to amyloid-betaQ29615595
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystalsQ29615704
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signalingQ29616024
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistanceQ29616026
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosisQ29619852
Points of control in inflammationQ29620319
NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen componentsQ30576000
Early detection and treatment of neovascular age-related macular degenerationQ31052084
Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptorsQ33382103
Forecasting age-related macular degeneration through the year 2050: the potential impact of new treatmentsQ33429803
Toll-like receptor polymorphisms and age-related macular degeneration: replication in three case-control samplesQ33950814
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.Q34246151
Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.Q34378842
Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and agingQ34556311
DICER1 deficit induces Alu RNA toxicity in age-related macular degenerationQ34796058
The biology of IL-12: coordinating innate and adaptive immune responsesQ35209127
Inflammasome is a central player in the induction of obesity and insulin resistanceQ35216914
Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degenerationQ36311846
Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activationQ36332983
Interleukin 1 and interleukin 18 as mediators of inflammation and the aging processQ36392611
NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degenerationQ36530569
Endogenous TLR ligands and autoimmunityQ36580095
Immunosenescence of ageingQ36698262
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseasesQ36816872
IL-1, IL-18, and IL-33 families of cytokinesQ37211243
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasomeQ37453447
Para-inflammation in the aging retina.Q37533486
Molecular mechanisms involved in inflammasome activationQ37588947
The NLRP3 inflammasome: a sensor for metabolic danger?Q37675505
The sterile inflammatory responseQ37716003
Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration?Q37767300
Disease-associated amyloid and misfolded protein aggregates activate the inflammasomeQ37849966
5'-Adenosine monophosphate-activated protein kinase--mammalian target of rapamycin axis as therapeutic target for age-related macular degeneration.Q37946935
Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration.Q37960172
Biochemical regulation of the inflammasomeQ38017287
Inflammation and neurodegeneration: the story 'retolled'.Q38040234
Inflammation, wound repair, and fibrosis: reassessing the spectrum of tissue injury and resolutionQ38055448
Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degenerationQ38328036
Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells--implications for age-related macular degeneration (AMD).Q39331392
Antivascular endothelial growth factor agents for neovascular age-related macular degenerationQ39519501
Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligandsQ39647439
Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cellsQ39754366
Lipofuscin fluorophore inhibits lysosomal protein degradation and may cause early stages of macular degenerationQ41121335
Toll-like receptor 3 and geographic atrophy in age-related macular degenerationQ41888443
Interleukin-1β inhibition prevents choroidal neovascularization and does not exacerbate photoreceptor degeneration.Q41981791
The privileged immunity of immune privileged organs: the case of the eye.Q42326687
Geographic atrophy in age-related macular degeneration and TLR3.Q42727637
Isolation of intact lysosomes from human RPE cells and effects of A2-E on the integrity of the lysosomal and other cellular membranesQ44250118
Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration.Q44552145
Relationship of drusen and abnormalities of the retinal pigment epithelium to the prognosis of neovascular macular degeneration. The Macular Photocoagulation Study GroupQ46603963
Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration.Q53529956
Toll-like Receptor Polymorphisms and Age-Related Macular DegenerationQ56879650
Granulomatous reaction to Bruch's membrane in age-related macular degenerationQ71627644
Pharmacokinetics of IL-18 binding protein in healthy volunteers and subjects with rheumatoid arthritis or plaque psoriasisQ80084113
Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variantQ84964300
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectinflammasome complexQ412405
P304page(s)1059-1070
P577publication date2013-05-10
P1433published inJournal of Molecular MedicineQ6295593
P1476titleAn eye on the future of inflammasomes and drug development in AMD
P478volume91

Reverse relations

cites work (P2860)
Q35322953A comparative analysis of C57BL/6J and 6N substrains; chemokine/cytokine expression and susceptibility to laser-induced choroidal neovascularization
Q91865960Adding a Corticosteroid or Switching to Another Anti-VEGF in Insufficiently Responsive Wet Age-Related Macular Degeneration
Q34588628Age-related macular degeneration: insights into inflammatory genes
Q89637028Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration
Q96351404Characterization of Polymeric Syringes Used for Intravitreal Injection
Q91644810Cytokines in Inflammatory Disease
Q35159598Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degeneration.
Q35610761Interleukin-1β Level Is Increased in Vitreous of Patients with Neovascular Age-Related Macular Degeneration (nAMD) and Polypoidal Choroidal Vasculopathy (PCV).
Q48263177Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration.
Q38596857Nanoceria: a Potential Therapeutic for Dry AMD.
Q38828895Risk factors and biomarkers of age-related macular degeneration
Q28394174Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide
Q38596848The NLRP3 Inflammasome and its Role in Age-Related Macular Degeneration
Q35592392Upregulation of NLRP3 Inflammasome in the Tears and Ocular Surface of Dry Eye Patients

Search more.