Vitamin D receptor agonists target CXCL10: new therapeutic tools for resolution of inflammation

scientific article published on 17 April 2013

Vitamin D receptor agonists target CXCL10: new therapeutic tools for resolution of inflammation is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2013/876319
P932PMC publication ID3652186
P698PubMed publication ID23690671
P5875ResearchGate publication ID236924858

P50authorMarta CollettiQ56863270
P2093author name stringLuigi Di Luigi
Sabino Scolletta
Clara Crescioli
P2860cites workTopically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodesQ46942111
Serum levels of a Th1 chemoattractant IP-10 and Th2 chemoattractants, TARC and MDC, are elevated in patients with systemic sclerosisQ47353546
Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation.Q51973496
1,25-Dihydroxyvitamin D3 prolongs graft survival without compromising host resistance to infection or bone mineral density.Q54118701
Chemokine and chemokine receptor gene expression indicates acute rejection of human cardiac transplants.Q54793731
A vitamin D analogue (MC 1288) has immunomodulatory properties and suppresses collagen-induced arthritis (CIA) without causing hypercalcaemiaQ57351169
SERUM LEVELS OF IFN-INDUCIBLE PROTEIN-10 RELATING TO THE ACTIVITY OF SYSTEMIC LUPUS ERYTHEMATOSUSQ58205027
Inflammatory response in human skeletal muscle cells: CXCL10 as a potential therapeutic targetQ59813820
1,25-Dihydroxyvitamin D3 suppresses human T helper/inducer lymphocyte activity in vitroQ67280107
The role of monocytes and T cells in 1,25-dihydroxyvitamin D3 mediated inhibition of B cell function in vitroQ67957412
25-Hydroxyvitamin D3 metabolism by lipopolysaccharide-stimulated normal human macrophagesQ69664632
1 alpha,25-Dihydroxyvitamin D3 (calcitriol) stimulates proliferation of human circulating monocytes in vitroQ69802550
An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4Q24303828
Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cellsQ24307649
Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytesQ24336187
Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patientsQ24563395
The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactionsQ24564834
Requirement of the chemokine receptor CXCR3 for acute allograft rejectionQ24676298
A novel mechanism for the regulation of IFN-gamma inducible protein-10 expression in rheumatoid arthritisQ24804035
Vitamin D and colon cancerQ27027710
1,25-Dihydroxyvitamin D3Receptors in Human LeukocytesQ70161320
Comparison of the effects of 1,25-dihydroxyvitamin D3 on T lymphocyte subpopulationsQ70336407
Impaired bone marrow-derived macrophage differentiation in vitamin D deficiencyQ70488328
Enhancement of antiproliferative activity of 1alpha,25-dihydroxyvitamin D3 (analogs) by cytochrome P450 enzyme inhibitors is compound- and cell-type specificQ71114381
MC1288, a vitamin D analogue, reduces short- and long-term renal allograft rejection in the ratQ71878976
Two novel vitamin D analogues, KH 1060 and CB 966, prolong skin allograft survival in miceQ72177828
MC 1288--a vitamin D analogue with immunosuppressive effects on heart and small bowel graftsQ72566987
Prevention of type I diabetes in NOD mice by nonhypercalcemic doses of a new structural analog of 1,25-dihydroxyvitamin D3, KH1060Q72572312
Analogs of 1,25-dihydroxyvitamin D3 as dose-reducing agents for classical immunosuppressantsQ73832066
Prevention of type I diabetes in nonobese diabetic mice by late intervention with nonhypercalcemic analogs of 1,25-dihydroxyvitamin D3 in combination with a short induction course of cyclosporin AQ74013224
Effect of a vitamin D3 analogue on keratinocyte growth factor-induced cell proliferation in benign prostate hyperplasiaQ74024194
The regulatory effects of all-trans-retinoic acid on isotype switching: retinoic acid induces IgA switch rearrangement in cooperation with IL-5 and inhibits IgG1 switchingQ74583047
Receptors for 1alpha,25(OH)2D3: past, present, and futureQ77301816
Vitamin D3: a transcriptional modulator of the interferon-gamma geneQ77530666
Lymphocyte-specific chemokine receptor CXCR3: regulation, chemokine binding and gene localizationQ77647010
Donor T cell activation initiates small bowel allograft rejection through an IFN-gamma-inducible protein-10-dependent mechanismQ77800973
Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS)Q79314633
Allergic humans are hyporesponsive to a CXCR3 ligand-mediated Th1 immunity-promoting loopQ79346423
Novel insights in the immune function of the vitamin D system: synergism with interferon-betaQ79664824
Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: implication for assessment of disease activity and treatmentQ81475298
Vitamin D and diabetesQ81877790
The vitamin D analog TX527 ameliorates disease symptoms in a chemically induced model of inflammatory bowel diseaseQ87352281
Expression of the chemokine receptor CXCR3 and its ligand IP-10 during human cardiac allograft rejectionQ94028922
Immunosuppression in cardiac graft rejection: a human in vitro model to study the potential use of new immunomodulatory drugs.Q46740652
CXCR3 surface expression in human airway epithelial cells: cell cycle dependence and effect on cell proliferationQ46844200
Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns.Q46886748
Oral treatment with a vitamin D3 analogue (BXL628) has anti-inflammatory effects in rodent model of interstitial cystitisQ46936670
The steroid and thyroid hormone receptor superfamilyQ27861095
NF-kappaB regulation in the immune systemQ28205043
Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytesQ28251802
Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathyQ28258849
1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activationQ28370605
A vitamin D analog down-regulates proinflammatory chemokine production by pancreatic islets inhibiting T cell recruitment and type 1 diabetes development.Q33205503
Inhibition of acute and chronic allograft rejection in mouse models by BXL-628, a nonhypercalcemic vitamin D receptor agonistQ33218425
Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3.Q33219961
Prevention of chronic allograft rejection by Vitamin D receptor agonistsQ33220675
1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3.Q33606850
The vitamin D receptor: new paradigms for the regulation of gene expression by 1,25-dihydroxyvitamin D(3).Q33888800
Expression of chemokines and chemokine receptors during human renal transplant rejectionQ33936064
Vitamin effects on the immune system: vitamins A and D take centre stageQ34005584
Serum 25-OH vitamin D concentrations are linked with various clinical aspects in patients with systemic sclerosis: a retrospective cohort study and review of the literatureQ34164524
1,25(OH)2D2 production by T lymphocytes and alveolar macrophages recovered by lavage from normocalcemic patients with tuberculosisQ34251340
Calcipotriol ointment. A review of its use in the management of psoriasisQ34436374
Vitamin D: its role and uses in immunologyQ34451101
Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance.Q34516841
Transpleural gradient of 1,25-dihydroxyvitamin D in tuberculous pleuritisQ34572129
The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agentsQ34583816
Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol)Q34617856
1 alpha,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytesQ34624558
The role of chemokines and chemokine receptors in alloantigen-independent and alloantigen-dependent transplantation injuryQ35031907
Vitamin D in preventive medicine: are we ignoring the evidence?Q35117137
Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3Q35462970
Chemokines and their receptors as markers of allograft rejection and targets for immunosuppressionQ35538137
Vitamin D and breast cancerQ35705253
Cxcr3 and its ligand CXCL10 are expressed by inflammatory cells infiltrating lung allografts and mediate chemotaxis of T cells at sites of rejectionQ35842094
The fate of bone after renal transplantationQ35855604
Expansion of antigen-specific regulatory T cells with the topical vitamin d analog calcipotriol.Q36066638
Intervention in autoimmunity: the potential of vitamin D receptor agonistsQ36152308
Immunoregulation by 1,25-dihydroxyvitamin D3: basic conceptsQ36208185
Dendritic cell modulation by 1alpha,25 dihydroxyvitamin D3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivoQ36236655
Non-genomic effects of the androgen receptor and vitamin D agonist are involved in suppressing invasive phenotype of prostate cancer cellsQ36313495
Biochemical characterization of a gamma interferon-inducible cytokine (IP-10).Q36353962
Donor-derived IP-10 initiates development of acute allograft rejectionQ36369253
Vitamin D receptor agonists: opportunities and challenges in drug discoveryQ36539572
Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptorQ36555534
Primary and secondary prevention of Type 1 diabetesQ36631971
Role of chemokines in endocrine autoimmune diseasesQ36809557
1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cellsQ36993676
Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function.Q37073695
1 alpha,25-dihydroxyvitamin D3 promotes fusion of mouse alveolar macrophages both by a direct mechanism and by a spleen cell-mediated indirect mechanismQ37348815
Vitamin D nutritional policy needs a vision for the futureQ37776370
Effects of vitamin D on the peripheral adaptive immune system: a reviewQ37881236
Vitamin D3: a helpful immuno-modulatorQ37927252
CXCL10: a candidate biomarker in transplantation.Q37988245
Investigation of hypercalcemiaQ38008558
Molecular aspects of vitamin D anticancer activityQ38042081
The role of the vitamin D endocrine system in health and diseaseQ38611160
Phenotypic and functional markers for 1alpha,25-dihydroxyvitamin D(3)-modified regulatory dendritic cellsQ39957476
Structure-function relationships in the vitamin D endocrine systemQ40545127
Vitamin D3 analogue inhibits keratinocyte growth factor signaling and induces apoptosis in human prostate cancer cellsQ40760687
Identification and immune regulation of 25-hydroxyvitamin D-1-alpha-hydroxylase in murine macrophagesQ40887948
24,25-dihydroxyvitamin D3 suppresses the rapid actions of 1, 25-dihydroxyvitamin D3 and parathyroid hormone on calcium transport in chick intestineQ42476960
Identification of a specific binding protein for 1 alpha,25-dihydroxyvitamin D3 in basal-lateral membranes of chick intestinal epithelium and relationship to transcaltachiaQ42497305
Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitolQ42505016
gamma-Interferon stimulates production of 1,25-dihydroxyvitamin D3 by normal human macrophagesQ42527804
Prolongation of allograft survival by 1,25-dihydroxyvitamin D3.Q42538603
Elevated serum interferon-gamma-inducible chemokine-10/CXC chemokine ligand-10 in autoimmune primary adrenal insufficiency and in vitro expression in human adrenal cells primary cultures after stimulation with proinflammatory cytokines.Q42645407
Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytesQ43077082
Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune systemQ43123528
Comparison between VDR analogs and current immunosuppressive drugs in relation to CXCL10 secretion by human renal tubular cells.Q43123671
Effect of 1,25-dihydroxyvitamin D3 on preventing allograft from acute rejection following rat orthotoic liver transplantationQ43186258
Immunomodulatory properties of a 1,25(OH)(2) vitamin D(3) analog combined with IFNbeta in an animal model of syngeneic islet transplantationQ43620821
A combination of KH1060, a vitamin D(3) analogue, and cyclosporin prevents early graft failure and prolongs graft survival of xenogeneic islets in nonobese diabetic miceQ43620842
1 alpha,25-Dihydroxycholecalciferol reduces rejection and improves survival in rat liver allograftsQ43779213
1alpha,25-dihydroxyvitamin D3 shows strong and additive immunomodulatory effects with cyclosporine A in rat renal allotransplantsQ43850962
The role of tacrolimus (FK506)-based immunosuppression on bone mineral density and bone turnover after cardiac transplantation: a prospective, longitudinal, randomized, double-blind trial with calcitriolQ43914153
A 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD miceQ43972530
1,25(OH)2-vitamin D3 induces translocation of the vitamin D receptor (VDR) to the plasma membrane in skeletal muscle cellsQ44060028
A retrospective evaluation of 1,25-dihydroxyvitamin D(3) and its potential effects on renal allograft functionQ44181048
Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cellsQ44448880
Generation of antigen-specific, interleukin-10-producing T-cells using dendritic cell stimulation and steroid hormone conditioning.Q44580641
1,25-Dihydroxycholecalciferol inhibits the progression of arthritis in murine models of human arthritisQ44853183
1,25-Dihydroxyvitamin D3 enhances the generation of nonspecific suppressor cells while inhibiting the induction of cytotoxic cells in a human MLRQ45269262
Prolongation of the survival of murine cardiac allografts by the vitamin D3 analogue 1,25-dihydroxy-delta 16-cholecalciferolQ46050394
Immunomodulatory effects of BXL-01-0029, a less hypercalcemic vitamin D analogue, in human cardiomyocytes and T cellsQ46241666
Elocalcitol inhibits inflammatory responses in human thyroid cells and T cells.Q46677379
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectintracellular receptorQ117980
peptideQ172847
vitamin DQ175621
anti-inflammatory agentQ581996
inflammationQ101991
P304page(s)876319
P577publication date2013-04-17
P1433published inMediators of InflammationQ2144494
P1476titleVitamin D receptor agonists target CXCL10: new therapeutic tools for resolution of inflammation
P478volume2013

Reverse relations

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