Arousal from sleep: implications for obstructive sleep apnea pathogenesis and treatment.

scientific article published on 29 August 2013

Arousal from sleep: implications for obstructive sleep apnea pathogenesis and treatment. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/JAPPLPHYSIOL.00649.2013
P698PubMed publication ID23990246

P50authorDanny J EckertQ43063110
P2093author name stringMagdy K Younes
P2860cites workEffect of topical upper airway anesthesia on apnea duration through the night in obstructive sleep apnea.Q51555494
Role of airway receptors in the reflex responses of human inspiratory muscles to airway occlusion.Q51596754
Upper airway anesthesia delays arousal from airway occlusion induced during human NREM sleepQ51686510
'Air hunger' from increased PCO2 persists after complete neuromuscular block in humans.Q51732020
Effect of zopiclone on sleep, night-time ventilation, and daytime vigilance in upper airway resistance syndrome.Q54150262
Effect of hyperoxia on the arousal response to airway occlusion during sleep in normal subjectsQ54264997
Mechanism of detection of resistive loads in conscious humansQ54268639
Role of the chest wall in detection of added elastic loads.Q54324518
The occurrence of sleep-disordered breathing among middle-aged adultsQ29547889
Termination of respiratory events with and without cortical arousal in obstructive sleep apneaQ30460893
General anesthesia and altered states of arousal: a systems neuroscience analysisQ34179988
Obstructive sleep apnea as a risk factor for stroke and deathQ34466726
A method for measuring and modeling the physiological traits causing obstructive sleep apneaQ35057101
Response of genioglossus muscle to increasing chemical drive in sleeping obstructive apnea patientsQ35110556
Contributions of upper airway mechanics and control mechanisms to severity of obstructive apneaQ35139520
Clinical effects of sleep fragmentation versus sleep deprivationQ35541481
Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunctionQ35634084
The extracellular matrix of the lateral pharyngeal wall in obstructive sleep apnea.Q35812457
Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal thresholdQ36152611
Pathogenesis of obstructive and central sleep apneaQ36229238
Effects of pentobarbital on upper airway patency during sleepQ36395503
The influence of aging on pharyngeal collapsibility during sleep.Q36516012
Contribution of arousal from sleep to postevent tachycardia in patients with obstructive sleep apneaQ36831272
Respiratory Movement of Upper Airway Tissue in Obstructive Sleep ApneaQ36891728
Role of respiratory control mechanisms in the pathogenesis of obstructive sleep disordersQ37267023
Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets.Q37304390
Trazodone increases arousal threshold in obstructive sleep apnoeaQ37319348
Digital recording and analysis of esophageal pressure for patients with obstructive sleep apnea-hypopnea syndromeQ39715759
Mechanisms used to restore ventilation after partial upper airway collapse during sleep in humansQ40644836
Respiratory effort during obstructive sleep apnea: role of age and sleep stateQ40880611
The influence of increasing ventilatory effort on arousal from sleepQ41237080
Reflex tachycardia with airway opening in obstructive sleep apnea.Q43045018
Systemic vs. central administration of common hypnotics reveals opposing effects on genioglossus muscle activity in ratsQ43089819
Sleep apnea impairs the arousal response to airway occlusionQ43497779
The effect of sleep fragmentation on sleep and performance in younger and older subjectsQ43654878
Within-night variation in respiratory effort preceding apnea termination and EEG delta power in sleep apneaQ44029417
Experimental sleep fragmentation in normal subjectsQ44635108
Sleep restoration as a function of periodic awakening, movement, or electroencephalographic change.Q45971977
Evolution of changes in upper airway collapsibility during slow induction of anesthesia with propofol.Q45975951
Effect of hypercapnia on the arousal response to airway occlusion during sleep in normal subjectsQ46129848
Effect of CPAP treatment on inspiratory arousal threshold during NREM sleep in OSAS.Q47827686
The role of mean inspiratory effort on daytime sleepinessQ47894694
Effects of hypoxia on genioglossus and scalene reflex responses to brief pulses of negative upper-airway pressure during wakefulness and sleep in healthy men.Q47897044
The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humansQ47964173
Obstructive sleep apnea associated with cerebral hypoxemia and death.Q48020687
Genioglossus activity available via non-arousal mechanisms vs. that required for opening the airway in obstructive apnea patientsQ48282797
Phenotyping interindividual variability in obstructive sleep apnoea response to temazepam using ventilatory chemoreflexes during wakefulnessQ48298175
Upper airway function and arousability to ventilatory challenge in slow wave versus stage 2 sleep in obstructive sleep apnoeaQ48384523
Electroencephalographic spectral analysis: detection of cortical activity changes in sleep apnoea patientsQ48439427
Analysis of the interplay between neurochemical control of respiration and upper airway mechanics producing upper airway obstruction during sleep in humansQ48454438
Mechanisms of breathing instability in patients with obstructive sleep apneaQ48457747
Pentobarbital sedation increases genioglossus respiratory activity in sleeping ratsQ48468155
A pilot study evaluating acute use of eszopiclone in patients with mild to moderate obstructive sleep apnea syndromeQ48468537
Safety of ramelteon in individuals with mild to moderate obstructive sleep apneaQ48477289
Neuromechanical control of upper airway patency during sleepQ48489322
The cardiorespiratory activation response at an arousal from sleep is independent of the level of CO(2).Q48500465
Brief airway occlusion produces prolonged reflex inhibition of inspiratory muscles in obstructive sleep apneaQ48508333
Arousal responses from apneic events during non-rapid-eye-movement sleep.Q48531019
Activation of a distinct arousal state immediately after spontaneous awakening from sleepQ48536891
Role of arousals in the pathogenesis of obstructive sleep apneaQ48607323
Ventilatory Response to Brief Arousal from Non–Rapid Eye Movement Sleep Is Greater in Men Than in WomenQ48617227
Arousability in sleep apnoea/hypopnoea syndrome patientsQ48649436
Comparison of upper airway collapse during general anaesthesia and sleepQ48664652
The ventilatory response to arousal from sleep is not fully explained by differences in CO(2) levels between sleep and wakefulnessQ48686243
The prone sleeping position impairs arousability in term infantsQ48692084
Chemical control stability in patients with obstructive sleep apneaQ48695955
Cardiac and respiratory activity at arousal from sleep under controlled ventilation conditionsQ48700791
Esophageal pressure and apnea hypopnea index in sleep-disordered breathingQ48704381
Hypercapnia can induce arousal from sleep in the absence of altered respiratory mechanoreceptionQ48713932
The effects of trazodone with L-tryptophan on sleep-disordered breathing in the English bulldogQ48739007
The association between sleep apnea and the risk of traffic accidents. Cooperative Group Burgos-SantanderQ48769862
Nocturnal evolution of respiratory effort in obstructive sleep apnoea syndrome: influence on arousal thresholdQ48775103
Pharyngeal critical pressure in patients with obstructive sleep apnea syndrome. Clinical implicationsQ48775624
Effect of upper airway anesthesia on obstructive sleep apneaQ48819417
Determinants of effective continuous positive airway pressure in obstructive sleep apnea. Role of respiratory effortQ48819428
Effect of induced transient arousal on obstructive apnea durationQ48823089
Triazolam in patients with obstructive sleep apneaQ48824962
Interaction of hyperventilation and arousal in the pathogenesis of idiopathic central sleep apneaQ48835890
Mechanisms of apnea termination in obstructive sleep apnea. Role of chemoreceptor and mechanoreceptor stimuliQ48849464
The effect of triazolam on the arousal response to airway occlusion during sleep in normal subjectsQ48882334
Effect of Ethanol on the Arousal Response to Airway Occlusion during Sleep in Normal SubjectsQ48888617
Performance and sleepiness as a function of frequency and placement of sleep disruptionQ49012959
Ventilation and arousal responses to hypercapnia in normal sleeping humansQ49073543
Ventilatory and heart rate responses to hypoxia and hypercapnia during sleep in adultsQ49137005
The effect of nonvisible sleep fragmentation on daytime function.Q51103861
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpathogenesisQ372016
obstructive sleep apneaQ16606552
P304page(s)302-313
P577publication date2013-08-29
P1433published inJournal of Applied PhysiologyQ1091719
P1476titleArousal from sleep: implications for obstructive sleep apnea pathogenesis and treatment
P478volume116

Reverse relations

cites work (P2860)
Q38679035A resource of potential drug targets and strategic decision-making for obstructive sleep apnoea pharmacotherapy
Q37406606Arousal Intensity is a Distinct Pathophysiological Trait in Obstructive Sleep Apnea
Q47740931Arousal-Induced Hypocapnia Does Not Reduce Genioglossus Activity in Obstructive Sleep Apnea.
Q44347558Association of opioid prescription and perioperative complications in obstructive sleep apnea patients undergoing total joint arthroplasties
Q47646304Cardioventilatory Control in Preterm Born Children and the Risk of Obstructive Sleep Apnea.
Q35044703Clinical predictors of the respiratory arousal threshold in patients with obstructive sleep apnea.
Q99631014Concomitant benzodiazepine and opioids decrease sleep apnoea risk in chronic pain patients
Q48093842CrossTalk proposal: elevated loop gain is a consequence of obstructive sleep apnoea
Q92553090Detecting central sleep apnea in adult patients using WatchPAT-a multicenter validation study
Q55332171Does a Low Arousal Threshold Equal Low PAP Adherence?
Q24197566Effect of opioid, hypnotic and sedating medications on sleep-disordered breathing in adults with obstructive sleep apnoea
Q47747383Effects of Tiagabine on Slow Wave Sleep and Arousal Threshold in Patients With Obstructive Sleep Apnea
Q24186476Effects of opioid, hypnotic and sedating medications on sleep-disordered breathing in adults with obstructive sleep apnoea
Q37530140Eszopiclone and Zolpidem Do Not Affect the Prevalence of the Low Arousal Threshold Phenotype
Q48030586Healthy humans with a narrow upper airway maintain patency during quiet breathing by dilating the airway during inspiration.
Q55512536Heart rate phenotypes and clinical correlates in a large cohort of adults without sleep apnea.
Q47904573Immediate postarousal sleep dynamics: an important determinant of sleep stability in obstructive sleep apnea
Q89464698Impaired central control of sleep depth propensity as a common mechanism for excessive overnight wake time: implications for sleep apnea, insomnia and beyond
Q91729444Inflammatory cytokines tumor necrosis factor-α, interleukin-8 and sleep monitoring in patients with obstructive sleep apnea syndrome
Q91829393Is there a threshold that triggers cortical arousals in obstructive sleep apnea
Q38771024Loop Gain Predicts the Response to Upper Airway Surgery in Patients With Obstructive Sleep Apnea.
Q35615492Neural Respiratory Drive and Arousal in Patients with Obstructive Sleep Apnea Hypopnea
Q26783732New developments in the use of positive airway pressure for obstructive sleep apnea
Q92881545Obstructive Sleep Apnea in Neurodegenerative Disorders: Current Evidence in Support of Benefit from Sleep Apnea Treatment
Q37530189Obstructive Sleep Apnea without Obesity Is Common and Difficult to Treat: Evidence for a Distinct Pathophysiological Phenotype
Q28084261Obstructive sleep apnea, pain, and opioids: is the riddle solved?
Q49374416Obstructive sleep apnea: current perspectives.
Q47631346Obstructive sleep apnoea and the need for its introduction into dental curricula
Q28078503Obstructive sleep apnoea pathogenesis from mild to severe: Is it all the same?
Q90195268Occurrence of Cortical Arousal at Recovery from Respiratory Disturbances during Deep Propofol Sedation
Q37114229Origins of and implementation concepts for upper airway stimulation therapy for obstructive sleep apnea
Q47646878Phenotyping the pathophysiology of obstructive sleep apnea using polygraphy/polysomnography: a review of the literature
Q39235003Physiology of Arousal in OSA and Potential Impacts for Sedative Treatment.
Q47682462Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea.
Q88593673Prevalence, Associated Clinical Features, and Impact on Continuous Positive Airway Pressure Use of a Low Respiratory Arousal Threshold Among Male United States Veterans With Obstructive Sleep Apnea
Q42372090Reply: Arousal threshold in obstructive sleep apnea
Q92921438Respiratory Mandibular Movement Signals Reliably Identify Obstructive Hypopnea Events During Sleep
Q34333937Short-term potentiation in the control of pharyngeal muscles in obstructive apnea patients
Q59328947Silencing of Hypoglossal Motoneurons Leads to Sleep Disordered Breathing in Lean Mice
Q97589114Spontaneous and apnea arousals from sleep in preterm infants
Q26858790State-dependent and reflex drives to the upper airway: basic physiology with clinical implications
Q90186881The Association Between Obstructive Sleep Apnea Characterized by a Minimum 3 Percent Oxygen Desaturation or Arousal Hypopnea Definition and Hypertension
Q42724795The Effect of Donepezil on Arousal Threshold and Apnea-Hypopnea Index. A Randomized, Double-Blind, Cross-Over Study.
Q47610571The Influence of CO2 on Genioglossus Muscle After-Discharge Following Arousal From Sleep
Q26778246The Interaction between Obstructive Sleep Apnea and Parkinson's Disease: Possible Mechanisms and Implications for Cognitive Function
Q52647341The effect of temazepam on assessment of severity of obstructive sleep apnea by polysomnography.
Q47699676The effects of arousal accompanying an apneic event on blood pressure and sympathetic nerve activity in severe obstructive sleep apnea.
Q45802193The human upper airway: more than a floppy tube
Q26771414The role of flow limitation as an important diagnostic tool and clinical finding in mild sleep-disordered breathing
Q47954720Time of day affects the frequency and duration of breathing events and the critical closing pressure during NREM sleep in participants with sleep apnea
Q33708781Trazodone increases the respiratory arousal threshold in patients with obstructive sleep apnea and a low arousal threshold
Q36606347Upper Airway Collapsibility (Pcrit) and Pharyngeal Dilator Muscle Activity are Sleep Stage Dependent
Q26998825Where there is smoke…there is sleep apnea: exploring the relationship between smoking and sleep apnea
Q36686466Zopiclone Increases the Arousal Threshold without Impairing Genioglossus Activity in Obstructive Sleep Apnea.

Search more.