Matching chelators to radiometals for radiopharmaceuticals

scientific article published on 30 October 2013

Matching chelators to radiometals for radiopharmaceuticals is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1039/C3CS60304K
P8608Fatcat IDrelease_5xk76bqclffybodd72m6usvxoy
P698PubMed publication ID24173525

P2093author name stringChris Orvig
Eric W Price
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HER1-targeted 86Y-panitumumab possesses superior targeting characteristics than 86Y-cetuximab for PET imaging of human malignant mesothelioma tumors xenograftsQ33862523
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PET imaging of HER1-expressing xenografts in mice with 86Y-CHX-A''-DTPA-cetuximab.Q33939881
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[111In-DTPA-D-Phe1]-octreotide, a potential radiopharmaceutical for imaging of somatostatin receptor-positive tumors: synthesis, radiolabeling and in vitro validationQ48830083
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Performance of immuno-positron emission tomography with zirconium-89-labeled chimeric monoclonal antibody U36 in the detection of lymph node metastases in head and neck cancer patients.Q53543032
Alpha- versus beta-particle radiopeptide therapy in a human prostate cancer model (213Bi-DOTA-PESIN and 213Bi-AMBA versus 177Lu-DOTA-PESIN).Q54744326
Synthesis of novel 1,3,5-cis,cis-triaminocyclohexane ligand based Cu(II) complexes as potential radiopharmaceuticals and correlation of structure and serum stabilityQ57087314
Preparation of the Novel Chelating AgentN-(2-Aminoethyl)-trans-1,2-diaminocyclohexane-N,N‘,N‘‘-pentaacetic Acid (H5CyDTPA), a Preorganized Analogue of Diethylenetriaminepentaacetic Acid (H5DTPA), and the Structures of BiIII(CyDTPA)2-and BiIII(HQ57087495
68Ga-DOTA-Tyr3-Octreotide PET in Neuroendocrine Tumors: Comparison with Somatostatin Receptor Scintigraphy and CTQ57757715
Mechanism and Energetics for Complexation of90Y with 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid (DOTA), a Model for Cancer RadioimmunotherapyQ58473551
A comparative study of aluminum(III), gallium(III), indium(III), and thallium(III) binding to human serum transferrinQ58859008
Technetium and gallium derived radiopharmaceuticals: comparing and contrasting the chemistry of two important radiometals for the molecular imaging era.Q34111790
Complexation of metal ions with TRAP (1,4,7-triazacyclononane phosphinic acid) ligands and 1,4,7-triazacyclononane-1,4,7-triacetic acid: phosphinate-containing ligands as unique chelators for trivalent gallium.Q34119384
PET imaging of tumor angiogenesis in mice with VEGF-A-targeted (86)Y-CHX-A″-DTPA-bevacizumab.Q34126406
Bifunctional chelators for therapeutic lanthanide radiopharmaceuticalsQ34136549
Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligandsQ34160678
(68)Ga-labeled DOTA-peptides and (68)Ga-labeled radiopharmaceuticals for positron emission tomography: current status of research, clinical applications, and future perspectivesQ34188331
Bioorthogonal reaction pairs enable simultaneous, selective, multi-target imagingQ34240233
Alpha-particle emitting atomic generator (Actinium-225)-labeled trastuzumab (herceptin) targeting of breast cancer spheroids: efficacy versus HER2/neu expressionQ34331845
89Zr-DFO-J591 for immunoPET of prostate-specific membrane antigen expression in vivo.Q34389457
The development of the alpha-particle emitting radionuclides 212Bi and 213Bi, and their decay chain related radionuclides, for therapeutic applicationsQ34440633
Novel chelating agents for potential clinical applications of copperQ34489850
Yttrium 90 ibritumomab tiuxetan radioimmunotherapy for relapsed or refractory low-grade non-Hodgkin's lymphomaQ34528384
Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody.Q34555716
Synthesis, characterization and in vivo studies of Cu(II)-64-labeled cross-bridged tetraazamacrocycle-amide complexes as models of peptide conjugate imaging agentsQ34622747
In vitro and in vivo evaluation of 64Cu-labeled SarAr-bombesin analogs in gastrin-releasing peptide receptor-expressing prostate cancerQ34942281
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Positron emission tomography imaging of CD105 expression with 89Zr-Df-TRC105.Q35587248
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68Ga-DOTA-affibody molecule for in vivo assessment of HER2/neu expression with PETQ36085489
[111In-DOTA]Somatostatin-14 analogs as potential pansomatostatin-like radiotracers - first results of a preclinical studyQ36125639
Synthesis and preclinical evaluation of bifunctional ligands for improved chelation chemistry of 90Y and 177Lu for targeted radioimmunotherapyQ36247600
Synthesis, Cu(II) complexation, 64Cu-labeling and biological evaluation of cross-bridged cyclam chelators with phosphonate pendant armsQ36291655
PET imaging with ⁸⁹Zr: from radiochemistry to the clinicQ36454584
Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma.Q36580750
Sensitization of tumor to ²¹²Pb radioimmunotherapy by gemcitabine involves initial abrogation of G2 arrest and blocked DNA damage repair by interference with Rad51.Q36674828
Copper chelation chemistry and its role in copper radiopharmaceuticals.Q36724065
Novel bimodal bifunctional ligands for radioimmunotherapy and targeted MRI.Q36813571
Synthesis of a cross-bridged cyclam derivative for peptide conjugation and 64Cu radiolabeling.Q36826058
Synthesis and in vivo imaging of a 18F-labeled PARP1 inhibitor using a chemically orthogonal scavenger-assisted high-performance method.Q39590473
ScVEGF-PEG-HBED-CC and scVEGF-PEG-NOTA conjugates: comparison of easy-to-label recombinant proteins for [68Ga]PET imaging of VEGF receptors in angiogenic vasculatureQ39706929
Magnitude of enhanced permeability and retention effect in tumors with different phenotypes: 89Zr-albumin as a model systemQ39769801
The influence of Bz-DOTA and CHX-A''-DTPA on the biodistribution of ABD-fused anti-HER2 Affibody molecules: implications for (114m)In-mediated targeting therapy.Q39853390
In vivo VEGF imaging with radiolabeled bevacizumab in a human ovarian tumor xenograft.Q40107068
In vivo evaluation and small-animal PET/CT of a prostate cancer mouse model using 64Cu bombesin analogs: side-by-side comparison of the CB-TE2A and DOTA chelation systemsQ40107074
Nuclear uptake and dosimetry of 64Cu-labeled chelator somatostatin conjugates in an SSTr2-transfected human tumor cell line.Q40107091
Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A''-DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478.Q40365959
Radioimmunotherapy of non-Hodgkin's lymphoma: a critical appraisalQ40426685
Imaging of melanoma using 64Cu- and 86Y-DOTA-ReCCMSH(Arg11), a cyclized peptide analogue of alpha-MSH.Q40435678
Conjugation of DOTA using isolated phenolic active esters: the labeling and biodistribution of albumin as blood pool marker.Q40453707
Preclinical characterisation of 111In-DTPA-trastuzumab.Q40491931
Stability of (47)Sc-complexes with acyclic polyamino-polycarboxylate ligands.Q40679525
Search of ligands suitable for (212)Pb/(212)Bi in vivo generators.Q40679548
Synthesis and evaluation of a macrocyclic bifunctional chelating agent for use with bismuth radionuclidesQ40800753
Comparison of cyclic RGD peptides for αvβ3 integrin detection in a rat model of myocardial infarctionQ40858096
Copper radionuclides and radiopharmaceuticals in nuclear medicineQ40921172
Alternative positron emission tomography with non-conventional positron emitters: effects of their physical properties on image quality and potential clinical applicationsQ41607195
Synthesis and biodistribution of lipophilic and monocationic gallium radiopharmaceuticals derived from N,N'-bis(3-aminopropyl)-N,N'-dimethylethylenediamine: potential agents for PET myocardial imaging with 68GaQ41997142
THERANOSTICS: From Molecular Imaging Using Ga-68 Labeled Tracers and PET/CT to Personalized Radionuclide Therapy - The Bad Berka ExperienceQ42068740
A triazacyclononane-based bifunctional phosphinate ligand for the preparation of multimeric 68Ga tracers for positron emission tomography.Q42167262
68Ga-labeled bombesin studies in patients with gastrointestinal stromal tumors: comparison with 18F-FDG.Q42626389
Development of a new radioligand for cholecystokinin receptor subtype 2 scintigraphy: from molecular modeling to in vivo evaluation.Q42825863
Gallium(III) complexes of DOTA and DOTA-monoamide: kinetic and thermodynamic studies.Q42837828
Acyclic chelate with ideal properties for (68)Ga PET imaging agent elaborationQ42854505
Conjugation and radiolabeling of monoclonal antibodies with zirconium-89 for PET imaging using the bifunctional chelate p-isothiocyanatobenzyl-desferrioxamineQ43111522
Site-specifically 89Zr-labeled monoclonal antibodies for ImmunoPET.Q43116972
Eight-coordinate Zn(II), Cd(II), and Pb(II) complexes based on a 1,7-diaza-12-crown-4 platform endowed with a remarkable selectivity over Ca(II).Q43242815
Selective chelation of Cd(II) and Pb(II) versus Ca(II) and Zn(II) by using octadentate ligands containing pyridinecarboxylate and pyridyl pendantsQ43251889
Novel gallium(III) complexes transported by MDR1 P-glycoprotein: potential PET imaging agents for probing P-glycoprotein-mediated transport activity in vivoQ43502823
Development of an in vitro model for assessing the in vivo stability of lanthanide chelatesQ43570130
A cyclen-based tetraphosphinate chelator for the preparation of radiolabeled tetrameric bioconjugates.Q43595161
In vivo evaluation of bismuth-labeled monoclonal antibody comparing DTPA-derived bifunctional chelatesQ43625800
Synthesis and characterization of two (111)In-labeled DTPA-peptide conjugatesQ43679714
Radiolabeling and in vivo behavior of copper-64-labeled cross-bridged cyclam ligands.Q43849736
Conjugation of monoclonal antibodies with TETA using activated esters: biological comparison of 64Cu-TETA-1A3 with 64Cu-BAT-2IT-1A3.Q43853239
NODAGATOC, a new chelator-coupled somatostatin analogue labeled with [67/68Ga] and [111In] for SPECT, PET, and targeted therapeutic applications of somatostatin receptor (hsst2) expressing tumorsQ43992775
In vivo comparison of macrocyclic and acyclic ligands for radiolabeling of monoclonal antibodies with 177Lu for radioimmunotherapeutic applicationsQ44007089
Comparison of yttrium and indium complexes of DOTA-BA and DOTA-MBA: models for (90)Y- and (111)In-labeled DOTA-biomolecule conjugatesQ44066333
Synthesis and biological evaluation of novel macrocyclic ligands with pendent donor groups as potential yttrium chelators for radioimmunotherapy with improved complex formation kineticsQ44078080
Equilibrium and kinetic properties of the lanthanoids(III) and various divalent metal complexes of the heptadentate ligand AAZTA.Q44295594
Optimising conditions for radiolabelling of DOTA-peptides with 90Y, 111In and 177Lu at high specific activitiesQ44391489
Isotachophoretic determination of stability constants of Ho and Y complexes with diethylenetriaminepentaacetic acid and 1,4,7,10-tetraazadodecane-N,N',N'',N'''-tetraacetic acidQ44397038
Synthesis and evaluation of novel bifunctional chelating agents based on 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid for radiolabeling proteinsQ44538103
Labeling anti-HER2/neu monoclonal antibodies with 111In and 90Y using a bifunctional DTPA chelating agentQ44572339
Synthesis, characterization, and X-ray crystal structure of In(DOTA-AA) (AA = p-aminoanilide): a model for 111In-labeled DOTA-biomolecule conjugatesQ44700200
Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes.Q44784872
Synthesis of hexa aza cages, SarAr-NCS and AmBaSar and a study of their metal complexation, conjugation to nanomaterials and proteins for application in radioimaging and therapyQ44934054
Development and characterization of clinical-grade 89Zr-trastuzumab for HER2/neu immunoPET imagingQ44944204
68Ga- and 111In-labelled DOTA-RGD peptides for imaging of alphavbeta3 integrin expressionQ45399826
Radioimmunotherapy with (90)Y-ibritumomab tiuxetan is a safe and efficient treatment for patients with B-cell lymphoma relapsed after auto-SCT: an analysis of the international RIT-Network.Q45748256
Hexadentate bispidine derivatives as versatile bifunctional chelate agents for copper(II) radioisotopesQ46144326
Zn(ii), Cd(ii) and Pb(ii) complexation with pyridinecarboxylate containing ligands.Q46304800
Comparative biodistribution studies of DTPA-derivative bifunctional chelates for radiometal labeled monoclonal antibodiesQ46362578
Tetrafluorophenolate of HBED-CC: a versatile conjugation agent for 68Ga-labeled small recombinant antibodiesQ46569961
"Click-to-chelate": design and incorporation of triazole-containing metal-chelating systems into biomolecules of diagnostic and therapeutic interestQ46584205
Preclinical evaluation of NETA-based bifunctional ligand for radioimmunotherapy applications using 212Bi and 213Bi: radiolabeling, serum stability, and biodistribution and tumor uptake studiesQ36881146
Methodology for labeling proteins and peptides with lead-212 (212Pb)Q36881360
212Pb-radioimmunotherapy potentiates paclitaxel-induced cell killing efficacy by perturbing the mitotic spindle checkpointQ36896084
A versatile bifunctional chelate for radiolabeling humanized anti-CEA antibody with In-111 and Cu-64 at either thiol or amino groups: PET imaging of CEA-positive tumors with whole antibodiesQ36908712
Immuno-PET: a navigator in monoclonal antibody development and applications.Q37047713
68Ga-PET: a powerful generator-based alternative to cyclotron-based PET radiopharmaceuticalsQ37126389
In vivo biodistribution, PET imaging, and tumor accumulation of 86Y- and 111In-antimindin/RG-1, engineered antibody fragments in LNCaP tumor-bearing nude mice.Q37129823
H(2)azapa: a versatile acyclic multifunctional chelator for (67)Ga, (64)Cu, (111)In, and (177)LuQ37142624
89Zr-Radiolabeled Trastuzumab Imaging in Orthotopic and Metastatic Breast TumorsQ37148669
A practical guide to the construction of radiometallated bioconjugates for positron emission tomography.Q37172093
H(4)octapa-trastuzumab: versatile acyclic chelate system for 111In and 177Lu imaging and therapyQ37209655
(64)Cu-labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: comparison of their biological activityQ37218456
Newer approaches to the radiolabeling of monoclonal antibodies by use of metal chelatesQ37223898
Tumor-targeted HPMA copolymer-(RGDfK)-(CHX-A''-DTPA) conjugates show increased kidney accumulationQ37226124
Melanoma imaging using (111)In-, (86)Y- and (68)Ga-labeled CHX-A''-Re(Arg11)CCMSH.Q37364790
(S)-5-(p-nitrobenzyl)-PCTA, a promising bifunctional ligand with advantageous metal ion complexation kineticsQ37395793
H6phospa-trastuzumab: bifunctional methylenephosphonate-based chelator with 89Zr, 111In and 177Lu.Q37412579
Radioimmunotherapy of breast cancer metastases with alpha-particle emitter 225Ac: comparing efficacy with 213Bi and 90Y.Q37460994
Efficient bifunctional gallium-68 chelators for positron emission tomography: tris(hydroxypyridinone) ligandsQ37594420
Efficient preparation and biological evaluation of a novel multivalency bifunctional chelator for 64Cu radiopharmaceuticalsQ37722948
Iodine-124: a promising positron emitter for organic PET chemistryQ37739199
Radiometallated peptides for molecular imaging and targeted therapy.Q37847064
Dosimetry of yttrium-labelled radiopharmaceuticals for internal therapy: 86Y or 90Y imaging?Q37864161
Theranostics: combining imaging and therapyQ37914847
Radiometals for combined imaging and therapyQ38063924
Tumour targeting with radiometals for diagnosis and therapyQ38100112
A pretargeted PET imaging strategy based on bioorthogonal Diels-Alder click chemistry.Q39147376
[⁶⁸Ga]NS₃-RGD and [⁶⁸Ga] Oxo-DO3A-RGD for imaging α(v)β₃ integrin expression: synthesis, evaluation, and comparison.Q39252884
(68)Ga small peptide imaging: comparison of NOTA and PCTA.Q39266092
A monoreactive bifunctional triazacyclononane phosphinate chelator with high selectivity for gallium-68.Q39332186
Imaging of protein synthesis: in vitro and in vivo evaluation of (44)Sc-DOTA-puromycin.Q39352243
RGD conjugates of the H2dedpa scaffold: synthesis, labeling and imaging with 68GaQ39387478
Synthesis and evaluation of a novel 68Ga-chelate-conjugated bisphosphonate as a bone-seeking agent for PET imagingQ39461465
Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugationQ39467640
Novel (64)Cu- and (68)Ga-labeled RGD conjugates show improved PET imaging of α(ν)β(3) integrin expression and facile radiosynthesisQ39505469
P433issue1
P304page(s)260-290
P577publication date2013-10-30
P1433published inChemical Society ReviewsQ2962268
P1476titleMatching chelators to radiometals for radiopharmaceuticals
P478volume43