Is it time to give up with calcineurin inhibitors in kidney transplantation?

scientific article published on June 2013

Is it time to give up with calcineurin inhibitors in kidney transplantation? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.5500/WJT.V3.I2.7
P932PMC publication ID3782241
P698PubMed publication ID24175203
P5875ResearchGate publication ID258205415

P2093author name stringMaurizio Salvadori
Elisabetta Bertoni
P2860cites workMycophenolate mofetil-based immunosuppression with sirolimus in renal transplantation: a randomized, controlled Spare-the-Nephron trialQ83059944
Three-year outcomes from BENEFIT-EXT: a phase III study of belatacept versus cyclosporine in recipients of extended criteria donor kidneysQ83387311
Novel strategies in immunosuppression: issues in perspectiveQ83632643
Everolimus and minimization of cyclosporine in renal transplantation: 24-month follow-up of the EVEREST studyQ84028906
Cyclosporine immunosuppression does not prevent the production of donor-specific antibody capable of mediating allograft vasculopathyQ84066133
A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study)Q84102539
Immunosuppression: does one regimen fit all?Q84143487
Using donor-specific antibodies to monitor the need for immunosuppressionQ84149083
Does everolimus increase donor-specific HLA antibodies in kidney transplant recipients?Q84589004
De novo donor-specific antibody at the time of kidney transplant biopsy associates with microvascular pathology and late graft failureQ84752864
Specificity of histological markers of long-term CNI nephrotoxicity in kidney-transplant recipients under low-dose cyclosporine therapyQ84870337
Chronic renal failure after transplantation of a nonrenal organQ28204928
Sirolimus allows early cyclosporine withdrawal in renal transplantation resulting in improved renal function and lower blood pressureQ33339056
Improved renal function in sirolimus-treated renal transplant patients after early cyclosporine eliminationQ33345776
Histopathologic clusters differentiate subgroups within the nonspecific diagnoses of CAN or CR: preliminary data from the DeKAF studyQ33521348
Pathological and clinical characterization of the 'troubled transplant': data from the DeKAF studyQ33522450
Alemtuzumab induction therapy in kidney transplantation: a systematic review and meta-analysis.Q34290459
Alemtuzumab induction in renal transplantationQ34660489
Calcineurin inhibitor nephrotoxicityQ34945314
Immunosuppression minimization: current and future trends in transplant immunosuppressionQ35159346
Strategies for minimizing immunosuppression in kidney transplantationQ35990853
Calcineurin inhibitor withdrawal from sirolimus-based therapy in kidney transplantation: a systematic review of randomized trialsQ36155850
A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppressionQ36447586
Conversion from calcineurin inhibitors to sirolimus for chronic renal allograft dysfunction: a systematic review of the evidenceQ36653136
Long-term efficacy and safety of a calcineurin inhibitor-free regimen in live-donor renal transplant recipientsQ36677625
Tacrolimus trough levels after month 3 as a predictor of acute rejection following kidney transplantation: a lesson learned from DeKAF GenomicsQ37209745
Can immune monitoring help to minimize immunosuppression in kidney transplantation?Q37258707
Calcineurin inhibitor sparing with mycophenolate in kidney transplantation: a systematic review and meta-analysis.Q37421212
Novel B cell therapeutic targets in transplantation and immune-mediated glomerular diseasesQ37653018
The (re)emergence of B cells in organ transplantationQ37770912
Steroid and calcineurin inhibitor-sparing protocols in kidney transplantationQ37858189
Meta-analysis of calcineurin-inhibitor-sparing regimens in kidney transplantationQ37939057
The impact of donor-specific anti-HLA antibodies on late kidney allograft failureQ38003049
Are calcineurin inhibitors-free regimens ready for prime time?Q38012603
Incidence and impact of de novo donor-specific alloantibody in primary renal allograftsQ39472834
Cyclosporin and renal graft histologyQ39558964
Renal function, efficacy, and safety of sirolimus and mycophenolate mofetil after short-term calcineurin inhibitor-based quadruple therapy in de novo renal transplant patients: one-year analysis of a randomized multicenter trialQ42171624
Evidence for antibody-mediated injury as a major determinant of late kidney allograft failureQ42171636
A phase III prospective, randomized study to evaluate concentration-controlled sirolimus (rapamune) with cyclosporine dose minimization or elimination at six months in de novo renal allograft recipients.Q42598004
Kidney transplantation with minimized maintenance: alemtuzumab induction with tacrolimus monotherapy--an open label, randomized trialQ42612762
Efficacy on renal function of early conversion from cyclosporine to sirolimus 3 months after renal transplantation: concept study.Q42620122
Fixed- or controlled-dose mycophenolate mofetil with standard- or reduced-dose calcineurin inhibitors: the Opticept trialQ42621907
Sirolimus versus cyclosporine therapy increases circulating regulatory T cells, but does not protect renal transplant patients given alemtuzumab induction from chronic allograft injury.Q42636572
Multicenter, randomized study of the use of everolimus with tacrolimus after renal transplantation demonstrates its effectivenessQ42649016
Randomized Trial of Thymoglobulin Versus Alemtuzumab (with Lower Dose Maintenance Immunosuppression) Versus Daclizumab in Living Donor Renal TransplantationQ42795564
Everolimus plus reduced-exposure CsA versus mycophenolic acid plus standard-exposure CsA in renal-transplant recipients.Q43067943
Thymoglobulin induction and sirolimus versus tacrolimus in kidney transplant recipients receiving mycophenolate mofetil and steroidsQ43102233
Sotrastaurin, a novel small molecule inhibiting protein kinase C: first clinical results in renal-transplant recipients.Q43178465
Everolimus with very low-exposure cyclosporine a in de novo kidney transplantation: a multicenter, randomized, controlled trialQ43236444
Calcineurin inhibitors affect B cell antibody responses indirectly by interfering with T cell help.Q43239536
Calcineurin-inhibitor-free immunosuppression based on the JAK inhibitor CP-690,550: a pilot study in de novo kidney allograft recipientsQ43297611
Chronic allograft nephropathy: prospective randomised trial of cyclosporin withdrawal and mycophenolate mofetil or tacrolimus substitutionQ43620732
Multicenter trial exploring calcineurin inhibitors avoidance in renal transplantationQ43633987
A controlled trial comparing two doses of cyclosporine in conjunction with mycophenolate mofetil and corticosteroids.Q43680980
Comparison of sirolimus-based calcineurin inhibitor-sparing and calcineurin inhibitor-free regimens in cadaveric renal transplantationQ43703063
Chronic calcineurin inhibitor nephrotoxicity-lest we forgetQ43759235
Open randomized trial comparing early withdrawal of either cyclosporine or mycophenolate mofetil in stable renal transplant recipients initially treated with a triple drug regimenQ43862998
Withdrawal of cyclosporine or prednisone six months after kidney transplantation in patients on triple drug therapy: a randomized, prospective, multicenter studyQ43964548
Early cyclosporine withdrawal from a sirolimus-based regimen results in better renal allograft survival and renal function at 48 months after transplantationQ43984395
A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study).Q44247085
Cyclosporine withdrawal from a mycophenolate mofetil-containing immunosuppressive regimen in stable kidney transplant recipients: a randomized, controlled study.Q44260926
Effect on kidney graft survival of reducing or discontinuing maintenance immunosuppression after the first year posttransplantQ44495681
Calcineurin inhibitor-free immunosuppression based on antithymocyte globulin and mycophenolate mofetil in cadaveric kidney transplantation: results after 5 yearsQ44524563
Side effects and toxicity of immunosuppressive agentsQ44667042
The natural history of chronic allograft nephropathyQ44688416
Withdrawal of cyclosporine or tacrolimus after addition of mycophenolate mofetil in patients with chronic allograft nephropathyQ44800871
De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function at two years.Q45100299
Everolimus and reduced-exposure cyclosporine in de novo renal-transplant recipients: a three-year phase II, randomized, multicenter, open-label studyQ45153736
Mycophenolate mofetil substitution for cyclosporine a in renal transplant recipients with chronic progressive allograft dysfunction: the "creeping creatinine" studyQ45281312
Calcineurin inhibitor minimization in the Symphony study: observational results 3 years after transplantation.Q45948071
Three-year outcomes from BENEFIT, a randomized, active-controlled, parallel-group study in adult kidney transplant recipients.Q46007205
Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trialQ46155747
The ORION study: comparison of two sirolimus-based regimens versus tacrolimus and mycophenolate mofetil in renal allograft recipientsQ46233987
A randomized trial of thymoglobulin vs. alemtuzumab (with lower dose maintenance immunosuppression) vs. daclizumab in renal transplantation at 24 months of follow-upQ46486529
Cyclosporine withdrawal from a mycophenolate mofetil-containing immunosuppressive regimen: results of a five-year, prospective, randomized studyQ46510645
Costimulation blockade with belatacept in renal transplantationQ46569880
Long-term results in renal transplant patients with allograft dysfunction after switching from calcineurin inhibitors to sirolimusQ46572818
Sirolimus in combination with tacrolimus is associated with worse renal allograft survival compared to mycophenolate mofetil combined with tacrolimusQ46645995
Randomized trial of Alemtuzumab for prevention of graft rejection and preservation of renal function after kidney transplantationQ46740554
Rapamycin for treatment of chronic allograft nephropathy in renal transplant patientsQ46763752
Predictive value of HLA antibodies and serum creatinine in chronic rejection: results of a 2-year prospective trialQ46825301
Superior outcomes in renal transplantation after early cyclosporine withdrawal and sirolimus maintenance therapy, regardless of baseline renal functionQ46825310
Reduced exposure to calcineurin inhibitors in renal transplantationQ46840533
Complete avoidance of calcineurin inhibitors in renal transplantation: a randomized trial comparing sirolimus and tacrolimusQ46936585
Randomized controlled study comparing reduced calcineurin inhibitors exposure versus standard cyclosporine-based immunosuppressionQ46983305
Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant.Q48005087
Frequency and clinical implications of development of donor-specific and non-donor-specific HLA antibodies after kidney transplantation.Q50765005
Predicting kidney graft failure by HLA antibodies: a prospective trial.Q51038562
Conversion from cyclosporine to everolimus at 4.5 months posttransplant: 3-year results from the randomized ZEUS study.Q52888129
Donor-specific HLA antibodies in a cohort comparing everolimus with cyclosporine after kidney transplantation.Q52889823
A randomized trial of alemtuzumab versus antithymocyte globulin induction in renal and pancreas transplantation.Q54286979
Randomized phase 2b trial of tofacitinib (CP-690,550) in de novo kidney transplant patients: efficacy, renal function and safety at 1 year.Q54505605
Early conversion to a sirolimus-based, calcineurin-inhibitor-free immunosuppression in the SMART trial: observational results at 24 and 36months after transplantation.Q54530926
Can the nephron be spared?Q54599994
Calcineurin inhibitor sparing regimens using m-target of rapamycin inhibitors: an opportunity to improve cardiovascular risk following kidney transplantation?Q54661902
Sirolimus Versus Cyclosporine in Kidney Recipients Receiving Thymoglobulin®, Mycophenolate Mofetil and a 6-Month Course of SteroidsQ56908156
Everolimus plus early tacrolimus minimization: a phase III, randomized, open-label, multicentre trial in renal transplantationQ61945820
Kidney Transplantation With Sirolimus and Mycophenolate Mofetil???Based Immunosuppression: 5-Year Results of a Randomized Prospective Trial Compared to Calcineurin Inhibitor DrugsQ61946028
Risk factors for cyclosporine-induced nephropathy in patients with autoimmune diseases. International Kidney Biopsy Registry of Cyclosporine in Autoimmune DiseasesQ68129476
Cyclosporine-associated chronic nephropathyQ70376376
Elective cyclosporine withdrawal after renal transplantation. A meta-analysisQ70525158
Cyclosporine sparing with mycophenolate mofetil, daclizumab and corticosteroids in renal allograft recipients: the CAESAR StudyQ79576315
Evaluation of the efficacy and safety of a slow conversion from calcineurin inhibitor- to sirolimus-based therapies in maintenance renal-transplant patients presenting with moderate renal insufficiencyQ79613466
Long-term renal allograft survival: have we made significant progress or is it time to rethink our analytic and therapeutic strategies?Q80369913
Evolution and pathophysiology of renal-transplant glomerulosclerosisQ80465077
Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histologyQ80783273
Predicting subsequent decline in kidney allograft function from early surveillance biopsiesQ81214502
Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherenceQ82496190
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectkidney transplantationQ740909
P304page(s)7-25
P577publication date2013-06-01
P1433published inWorld journal of transplantationQ27725045
P1476titleIs it time to give up with calcineurin inhibitors in kidney transplantation?
P478volume3

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cites work (P2860)
Q39419895ASP2409, A Next-Generation CTLA4-Ig, Versus Belatacept in Renal Allograft Survival in Cynomolgus Monkeys
Q90465784Adverse Events and Discontinuation Rates Associated with Sirolimus Treatment in Adult Renal Transplant Patients in Latin America vs Non-Latin American Countries
Q38453650Avoiding immunological rejection in regenerative medicine.
Q38230449Calcineurin inhibitor sparing strategies in renal transplantation, part one: Late sparing strategies
Q53702610Calcineurin inhibitors and nephrotoxicity in children.
Q30279164Differential Effects of Tacrolimus versus Sirolimus on the Proliferation, Activation and Differentiation of Human B Cells
Q93074116Early Switch to Mammalian Target of Rapamycin Inhibitors Is a Sustainable Treatment Approach in Renal Transplant Recipients: 7-Year Results
Q41352306Effect of CD40 silenced dendritic cells by RNA interference on mice skin allograft rejection
Q38214871Focus on mTOR inhibitors and tacrolimus in renal transplantation: pharmacokinetics, exposure-response relationships, and clinical outcomes
Q90599620High Dimensional Renal Profiling: Towards a Better Understanding or Renal Transplant Immune Suppression
Q26751433Immunosuppressive potency of mechanistic target of rapamycin inhibitors in solid-organ transplantation
Q41313340Is Early Conversion to mTOR Inhibitors Represent a Suitable Choice in Renal Transplant Recipients? A Systemic Review of Medium-term Outcomes
Q36087779Minimization vs tailoring: Where do we stand with personalized immunosuppression during renal transplantation in 2015?
Q43158054Moving Beyond Minimization Trials in Kidney Transplantation
Q40479200Surveillance Registry of Sirolimus Use in Recipients of Kidney Allografts From Expanded Criteria Donors.
Q33617408Systemic meta-analysis assessing the short term applicability of early conversion to mammalian target of rapamycin inhibitors in kidney transplant
Q38237365Through a glass darkly: seeking clarity in preventing late kidney transplant failure
Q34761349What's new in clinical solid organ transplantation by 2013.

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