Using human intestinal biopsies to study the pathogenesis of irritable bowel syndrome

scientific article published on 14 February 2014

Using human intestinal biopsies to study the pathogenesis of irritable bowel syndrome is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1111/NMO.12316
P698PubMed publication ID24602069

P50authorMichael SchemannQ37383877
P2093author name stringM M Wouters
Y Nasser
S Vanner
G E Boeckxstaens
P2860cites workRole for protease activity in visceral pain in irritable bowel syndromeQ22241892
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Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsiaQ33805605
Luminal cysteine-proteases degrade colonic tight junction structure and are responsible for abdominal pain in constipation-predominant IBS.Q45189883
Colonic mucosal mediators from patients with irritable bowel syndrome excite enteric cholinergic motor neuronsQ46258357
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Trypsinogen IV, serotonin transporter transcript levels and serotonin content are increased in small intestine of irritable bowel syndrome patientsQ46684728
Sensitization of peripheral sensory nerves by mediators from colonic biopsies of diarrhea-predominant irritable bowel syndrome patients: a role for PAR2.Q47746673
Mucosal immune cell numbers and visceral sensitivity in patients with irritable bowel syndrome: is there any relationship?Q47926641
Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier.Q48492553
Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS.Q51010528
Mast cell tryptase reduces junctional adhesion molecule-A (JAM-A) expression in intestinal epithelial cells: implications for the mechanisms of barrier dysfunction in irritable bowel syndrome.Q51067173
Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms.Q51660489
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Enteroendocrine cell counts correlate with visceral hypersensitivity in patients with diarrhoea-predominant irritable bowel syndrome.Q53595244
Mucosal mast cell counts correlate with visceral hypersensitivity in patients with diarrhea predominant irritable bowel syndrome.Q53622343
The jejunum of diarrhea-predominant irritable bowel syndrome shows molecular alterations in the tight junction signaling pathway that are associated with mucosal pathobiology and clinical manifestations.Q54319433
SERT and TPH-1 mRNA expression are reduced in irritable bowel syndrome patients regardless of visceral sensitivity state in large intestine.Q54324853
Differential expression of toll-like receptors in patients with irritable bowel syndrome.Q54400679
Increased proteasome-mediated degradation of occludin in irritable bowel syndrome.Q54451070
Neuroimmune interactions at different intestinal sites are related to abdominal pain symptoms in children with IBS.Q54491760
Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators.Q54513905
Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndromeQ56985161
Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndromeQ56996391
Submucous rather than myenteric neurons are activated by mucosal biopsy supernatants from irritable bowel syndrome patientsQ57097924
MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndromeQ33939639
Serotonin signaling is altered in irritable bowel syndrome with diarrhea but not in functional dyspepsia in pediatric age patients.Q33987389
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Mucosal permeability and immune activation as potential therapeutic targets of probiotics in irritable bowel syndrome.Q34297954
Role of toll like receptors in irritable bowel syndrome: differential mucosal immune activation according to the disease subtypeQ34426677
Review article: intestinal serotonin signalling in irritable bowel syndromeQ34566461
Decreased expression of serotonin in the jejunum and increased numbers of mast cells in the terminal ileum in patients with irritable bowel syndromeQ34606239
Elevated expression of c-fos in central nervous system correlates with visceral hypersensitivity in irritable bowel syndrome (IBS): a new target for IBS treatmentQ35120008
Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndromeQ35362266
Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesisQ35596747
Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum.Q35761348
Low densities of serotonin and peptide YY cells in the colon of patients with irritable bowel syndromeQ35837381
Association of HLA-DQ gene with bowel transit, barrier function, and inflammation in irritable bowel syndrome with diarrheaQ36494385
Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndromeQ36776163
Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal painQ36930795
Intestinal membrane permeability and hypersensitivity in the irritable bowel syndromeQ37390132
Functions and imaging of mast cell and neural axis of the gut.Q37580697
Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transitQ37716041
Mechanisms underlying visceral hypersensitivity in irritable bowel syndromeQ37871421
Bacterial proteases in IBD and IBS.Q37928851
Pharmacology of the new treatments for lower gastrointestinal motility disorders and irritable bowel syndromeQ37954521
Intestinal barrier function in health and gastrointestinal diseaseQ38009940
Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndromeQ38029994
Novel functional roles for enteric glia in the gastrointestinal tract.Q38034376
Review article: Associations between immune activation, intestinal permeability and the irritable bowel syndrome.Q38052154
Genetics of human gastrointestinal sensationQ38099692
Immune activation in irritable bowel syndrome: can neuroimmune interactions explain symptoms?Q38104610
Mucosal mast cell count is associated with intestinal permeability in patients with diarrhea predominant irritable bowel syndromeQ40402334
Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome.Q42462847
Subjects with diarrhea-predominant IBS have increased rectal permeability responsive to tryptaseQ42466084
Sensory neuro-immune interactions differ between irritable bowel syndrome subtypesQ42509169
Abnormal small-intestinal endocrine cells in patients with irritable bowel syndromeQ43124191
Sensitivity testing in irritable bowel syndrome with rectal capsaicin stimulations: role of TRPV1 upregulation and sensitization in visceral hypersensitivity?Q43420598
Distinctive clinical, psychological, and histological features of postinfective irritable bowel syndromeQ44520650
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome.Q44779671
Elevated vasoactive intestinal peptide concentrations in patients with irritable bowel syndromeQ45074387
P433issue4
P921main subjectbiopsyQ179991
pathogenesisQ372016
P304page(s)455-469
P577publication date2014-02-14
P1433published inNeurogastroenterology and MotilityQ15767493
P1476titleUsing human intestinal biopsies to study the pathogenesis of irritable bowel syndrome
P478volume26

Reverse relations

cites work (P2860)
Q64059856Activation of Peripheral Blood CD4+ T-Cells in IBS is not Associated with Gastrointestinal or Psychological Symptoms
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Q38299351Changes in nitrergic and tachykininergic pathways in rat proximal colon in response to chronic treatment with otilonium bromide.
Q41955092Claudin-2 expression is upregulated in the ileum of diarrhea predominant irritable bowel syndrome patients.
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Q42498868Supernatants of irritable bowel syndrome mucosal biopsies impair human colonic smooth muscle contractility.
Q37578593The Role of Mast Cells in Irritable Bowel Syndrome
Q34486007The role of mast cells in functional GI disorders.
Q41484472Visceral pain
Q40373925miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea