The translocator protein as a drug target in Alzheimer's disease.

scientific article published on April 2014

The translocator protein as a drug target in Alzheimer's disease. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1586/14737175.2014.896201
P698PubMed publication ID24625007
P5875ResearchGate publication ID260808278

P50authorLars M. IttnerQ30347436
Michael KassiouQ48744540
P2093author name stringSook W Chua
P2860cites workAlzheimer's DiseaseQ22248111
Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular functionQ24296269
Cholesterol binding at the cholesterol recognition/ interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptideQ24546891
An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28Q24599479
The positron emission tomography ligand DAA1106 binds with high affinity to activated microglia in human neurological disordersQ24641816
Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologiesQ24642726
Translocator protein (18 kDa) TSPO: an emerging therapeutic target in neurotraumaQ24649929
Neuropathological stageing of Alzheimer-related changesQ27860862
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptideQ28131750
Inflammation and Alzheimer's diseaseQ28138617
Peripheral benzodiazepine receptors and mitochondrial functionQ28201926
Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effectsQ28249253
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseasesQ28269333
Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's diseaseQ28290730
Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesisQ28301125
Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesisQ28303440
The mitochondrial permeability transition pore and its role in cell deathQ29614183
Tau-mediated neurodegeneration in Alzheimer's disease and related disordersQ29618148
Mouse TSPO in a lipid environment interacting with a functionalized monolayerQ30418916
Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated stateQ30649552
Microglial activation and amyloid deposition in mild cognitive impairment: a PET studyQ33634089
Convergence of amyloid-beta and tau pathologies on mitochondria in vivoQ33876147
Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammationQ34171364
Molecular imaging of microglia/macrophages in the brainQ34276818
Mitochondrial benzodiazepine receptors regulate steroid biosynthesisQ34325284
Development of ligands for the peripheral benzodiazepine receptorQ34547615
Porphyrins are endogenous ligands for the mitochondrial (peripheral-type) benzodiazepine receptorQ34612661
Neuroprotective effect of Ro5-4864 following brain injuryQ34826756
A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBRQ34872399
Neuroprotective effects of a ligand of translocator protein-18 kDa (Ro5-4864) in experimental diabetic neuropathy.Q34996330
Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam bindingQ35050152
Inflammatory processes in Alzheimer's diseaseQ35201137
Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture.Q35202286
Mitochondrial Benzodiazepine Receptors and the Regulation of Steroid BiosynthesisQ35229114
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disordersQ35654128
Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]R05-4864 and [3H]PK 11195, by thermodynamic studiesQ51852591
Evaluation of [¹²³I]-CLINDE as a potent SPECT radiotracer to assess the degree of astroglia activation in cuprizone-induced neuroinflammation.Q54378366
A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammationQ36684216
In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease.Q36953874
Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptorQ37044498
Characterization and modeling of the oligomeric state and ligand binding behavior of purified translocator protein 18 kDa from Rhodobacter sphaeroidesQ37130302
Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.Q37153379
Imaging microglial activation during neuroinflammation and Alzheimer's diseaseQ37340359
PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET.Q37351230
The translocator protein (18 kDa): central nervous system disease and drug designQ37365598
Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease miceQ37414108
Mitochondrial permeability transition pore in Alzheimer's disease: cyclophilin D and amyloid betaQ37555305
Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disordersQ37814088
Amyloid-β and tau--a toxic pas de deux in Alzheimer's diseaseQ37824813
Shedding light on the mitochondrial permeability transition.Q37850094
Inflammation in Alzheimer disease-a brief review of the basic science and clinical literatureQ37982377
Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondriaQ38335116
Three-dimensional structure of TspO by electron cryomicroscopy of helical crystalsQ39864742
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progressionQ40301497
Characterization of peripheral benzodiazepine type sites in a cultured murine BV-2 microglial cell lineQ41249632
Effects of translocator protein (18 kDa) ligands on microglial activation and neuronal death in the quinolinic-acid-injected rat striatumQ41964688
Structural and functional study of reconstituted peripheral benzodiazepine receptorQ43631731
In-vivo measurement of activated microglia in dementiaQ43713539
Etifoxine analgesia in experimental monoarthritis: a combined action that protects spinal inhibition and limits central inflammatory processes.Q43869315
In vivo and in vitro peripheral-type benzodiazepine receptor polymerization: functional significance in drug ligand and cholesterol binding.Q44402442
Assessment of neuroinflammation and microglial activation in Alzheimer's disease with radiolabelled PK11195 and single photon emission computed tomography. A pilot studyQ44490089
Age and disease related changes in the translocator protein (TSPO) system in the human brain: positron emission tomography measurements with [11C]vinpocetineQ44786130
Cell surface localization of the peripheral-type benzodiazepine receptor (PBR) in adrenal cortexQ44845409
Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatumQ45296984
Differential effect of detergents on [3H]Ro 5-4864 and [3H]PK 11195 binding to peripheral-type benzodiazepine-binding sitesQ46227832
Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET studyQ46373170
Binding of [3H]Ro 5-4864 and [3H]PK 11195 to cerebral cortex and peripheral tissues of various species: species differences and heterogeneity in peripheral benzodiazepine binding sitesQ46596862
Synthesis and in vivo evaluation of a novel peripheral benzodiazepine receptor PET radioligandQ46614777
Secondary and tertiary structures of the transmembrane domains of the translocator protein TSPO determined by NMR. Stabilization of the TSPO tertiary fold upon ligand bindingQ46639005
Adult mouse astrocytes degrade amyloid-beta in vitro and in situQ46779933
Dihydropyridine and peripheral type benzodiazepine binding sites: subcellular distribution and molecular size determinationQ47216704
In situ molecular weight determination of brain and peripheral benzodiazepine binding sitesQ47274987
Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic miceQ47814284
In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer's disease patientsQ48151150
Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging.Q48415784
Microglial activation in Alzheimer's disease: an (R)-[¹¹C]PK11195 positron emission tomography studyQ48426445
Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's diseaseQ48512773
Peripheral-type benzodiazepine receptors in endocrine organs: autoradiographic localization in rat pituitary, adrenal, and testisQ48532076
Peripheral benzodiazepine binding sites in Alzheimer's disease frontal and temporal cortexQ48737055
P433issue4
P921main subjectAlzheimer's diseaseQ11081
P304page(s)439-448
P577publication date2014-04-01
P1433published inExpert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disordersQ15760319
P1476titleThe translocator protein as a drug target in Alzheimer's disease
P478volume14