Human DCXR - another 'moonlighting protein' involved in sugar metabolism, carbonyl detoxification, cell adhesion and male fertility?

scientific article published on 10 April 2014

Human DCXR - another 'moonlighting protein' involved in sugar metabolism, carbonyl detoxification, cell adhesion and male fertility? is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/BRV.12108
P698PubMed publication ID24720935

P2093author name stringEdmund Maser
Bettina Ebert
Michael Kisiela
P2860cites workMolecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidneyQ24292412
Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormonesQ24532164
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiativeQ24620663
Different evolutionary patterns between young duplicate genes in the human genomeQ24797121
Molecular basis for peroxisomal localization of tetrameric carbonyl reductaseQ27650053
Structure/function analysis of a critical disulfide bond in the active site of L-xylulose reductaseQ27654531
Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase familyQ27733359
Epithelial-mesenchymal transitions in development and diseaseQ27860630
The evolutionary fate and consequences of duplicate genesQ27861065
A Jurassic eutherian mammal and divergence of marsupials and placentalsQ28246368
Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's diseaseQ28260248
Dicarbonyl/L-xylulose reductase: a potential biomarker identified by laser-capture microdissection-micro serial analysis of gene expression of human prostate adenocarcinomaQ28261369
On the nature of L-xylulose reductase deficiency in essential pentosuriaQ28308027
Surface localization of P34H an epididymal protein, during maturation, capacitation, and acrosome reaction of human spermatozoaQ28637743
Transgenic mice over-expressing dicarbonyl/L-xylulose reductase gene crossed with KK-Ay diabetic model mice: an animal model for the metabolism of renal carbonyl compoundsQ33229935
Identification of a hamster sperm 26-kilodalton dehydrogenase/reductase that is exclusively localized to the mitochondria of the flagellumQ33243031
Novel epididymal proteins as targets for the development of post-testicular male contraceptionQ33398478
Asymmetric sequence divergence of duplicate genesQ33678884
Purification and characterization of pig lung carbonyl reductaseQ53849018
Analysis of human transcriptomes.Q55033453
Evolution by gene duplication: an updateQ55879025
Capacitation of Mammalian SpermatozoaQ59073250
Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53.Q34045740
Moonlighting proteins: old proteins learning new tricks.Q34220091
Differentially expressed transcripts from phenotypically identified olfactory sensory neuronsQ34257895
Steroid hormone transforming aldo-keto reductases and cancerQ34571239
The evolution of gene duplicatesQ34586458
Garrod's fourth inborn error of metabolism solved by the identification of mutations causing pentosuriaQ35546663
Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesisQ35759101
WW domain-containing oxidoreductase promotes neuronal differentiation via negative regulation of glycogen synthase kinase 3β.Q35965852
A growth factor-repressible gene associated with protein kinase C-mediated inhibition of adipocyte differentiationQ36219130
Aldo-keto reductases and bioactivation/detoxication.Q36592650
Cloning and sequence analysis of a cDNA encoding tetrameric carbonyl reductase of pig lungQ36767165
WWOX in biological control and tumorigenesisQ36801619
Reduced expression of AP27 protein, the product of a growth factor-repressible gene, is associated with diminished adipocyte differentiationQ36818686
Epididymosomes are involved in the acquisition of new sperm proteins during epididymal transitQ36858965
Genes required for the common miracle of fertilization in Caenorhabditis elegansQ37224740
Gene expression in the epididymis of normal and vasectomized men: what can we learn about human sperm maturation?Q37858299
Involvement of two basic residues (Lys-17 and Arg-39) of mouse lung carbonyl reductase in NADP(H)-binding and fatty acid activation: site-directed mutagenesis and kinetic analysesQ38354455
Crystallization of mouse lung carbonyl reductase complexed with NADPH and analysis of symmetry of its tetrameric molecule.Q38562663
Alterations in the human blood-epididymis barrier in obstructive azoospermia and the development of novel epididymal cell lines from infertile men.Q39699970
Assessing the role of claudins in maintaining the integrity of epididymal tight junctions using novel human epididymal cell linesQ39738024
L-Xylulose reductase is involved in 9,10-phenanthrenequinone-induced apoptosis in human T lymphoma cellsQ40022703
WOX1 is essential for UVB irradiation-induced apoptosis and down-regulated via translational blockade in UVB-induced cutaneous squamous cell carcinoma in vivoQ40382363
Activation of carbonyl reductase from pig lung by fatty acidsQ42147726
Kinetic mechanism of pulmonary carbonyl reductaseQ42164207
Bioinformatic and biochemical characterization of DCXR and DHRS2/4 from Caenorhabditis elegansQ42752174
Enzymatic characteristics and subcellular distribution of a short-chain dehydrogenase/reductase family protein, P26h, in hamster testis and epididymis.Q43515908
Molecular cloning, expression and tissue distribution of hamster diacetyl reductase. Identity with L-xylulose reductaseQ43577729
Prostasome-like particles are involved in the transfer of P25b from the bovine epididymal fluid to the sperm surfaceQ43596817
Sperm-zona pellucida interaction involves a carbonyl reductase activity in the hamsterQ43844194
Characterization of pulmonary carbonyl reductase of mouse and guinea pig.Q44030408
Crystallization and preliminary crystallographic analysis of human L-xylulose reductaseQ44075746
Cloning, expression and tissue distribution of a tetrameric form of pig carbonyl reductaseQ44326938
Identification of amino acid residues involved in substrate recognition of L-xylulose reductase by site-directed mutagenesisQ44326985
Structural determinant for cold inactivation of rodent L-xylulose reductaseQ44532169
Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesisQ44855348
P26h and dicarbonyl/L-xylulose reductase are two distinct proteins present in the hamster epididymisQ45006634
The enzymatic defect in essential pentosuriaQ45345324
Structure of the tetrameric form of human L-Xylulose reductase: probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis.Q46500567
Suppression of renal alpha-dicarbonyl compounds generated following ureteral obstruction by kidney-specific alpha-dicarbonyl/L-xylulose reductaseQ46850780
DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegansQ47068974
Hamster sperm protein, p26h: a member of the short-chain dehydrogenase/reductase superfamilyQ48914829
Inhibition of in vivo fertilization by active immunization of male hamsters against a 26-kDa sperm glycoproteinQ49078590
Decreased expression of the human carbonyl reductase 2 gene HCR2 in hepatocellular carcinoma.Q51162288
P433issue1
P921main subjectcell adhesionQ187640
P304page(s)254-278
P577publication date2014-04-10
P1433published inBiological ReviewsQ2500948
P1476titleHuman DCXR - another 'moonlighting protein' involved in sugar metabolism, carbonyl detoxification, cell adhesion and male fertility?
P478volume90

Reverse relations

cites work (P2860)
Q57135534Androgen-dependent alternative mRNA isoform expression in prostate cancer cells
Q23912586Diacetyl and 2,3-pentanedione exposure of human cultured airway epithelial cells: ion transport effects and metabolism of butter flavoring agents
Q46354112Diacetyl/l-Xylulose Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells.
Q35588493Dicarbonyl L-xylulose reductase (DCXR), a "moonlighting protein" in the bovine epididymis.
Q35923444Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/β-catenin-driven trans-differentiation of murine alveolar epithelial cells
Q92884447Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease
Q48185615Phylogenetic Studies, Gene Cluster Analysis, and Enzymatic Reaction Support Anthrahydroquinone Reduction as the Physiological Function of Fungal 17β-Hydroxysteroid Dehydrogenase
Q26745812The human epididymis: its function in sperm maturation
Q39642939Transcriptional regulation of human and murine short-chain dehydrogenase/reductases (SDRs) - an in silico approach

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